drugs damgo  (Millipore)


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  • 93
    Name:
    2 Aminobenzoyl Ala Phe Ala Phe Asp Val Phe Tyr NO2 Asp
    Description:

    Catalog Number:
    a9971
    Price:
    None
    Applications:
    Fluorogenic substrate for Asp-specific proteases from Staphylococcus aureus, Bacillus lichenformis, and Streptomyces griseus.
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    Structured Review

    Millipore drugs damgo

    https://www.bioz.com/result/drugs damgo/product/Millipore
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    drugs damgo - by Bioz Stars, 2020-09
    93/100 stars

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    Related Articles

    Marker:

    Article Title: Novel therapeutic mechanisms determine the effectiveness of lipid-core nanocapsules on melanoma models
    Article Snippet: .. Quantification of NO2 − Levels of nitrite (NO2 −2 ), a marker of NO levels, were measured in supernatant of SK-Mel-28 cells (1×104 /well) pretreated or not with N -ω-nitro-L-arginine methyl ester hydrochloride (L-NAME; 10−3 M, Sigma Chemicals) for 30 minutes and then treated with LNC (3×109 , 9×109 , or 18×109 particles/mL), AcE (10, 30, or 60 µM), or AcE-LNC (10, 30, or 60 µM of AcE; 3×109 , 9×109 , or 18×109 particles/mL, respectively) for 24 hours. .. The levels of NO2 − were quantified by chemiluminescence of the reaction between ozone and NO generated by the reduction of the sample with vanadium chloride, in acidic medium, at 95°C, using an NO analyzer (Model 208A; Sievers Instruments, Inc., Boulder, CO, USA) according to the manufacturer’s protocols.

    Concentration Assay:

    Article Title: Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species
    Article Snippet: .. NO concentration was assessed by determining the NO3 − and NO2 − levels using Griess reagent (modified; Sigma-Aldrich). ..

    other:

    Article Title: Effects of Maharishi Amrit Kalash 5 as an Ayurvedic herbal food supplement on immune functions in aged mice
    Article Snippet: Lipopolysaccharide (LPS, E. coli 050: B5), concanavalin A (Con A) and other common chemicals for the NO2 - and mitogenicity assay were purchased from Sigma (Sigma Chemical Co., St. Louis, USA).

    Enzyme-linked Immunosorbent Assay:

    Article Title: Nicotinamide adenine dinucleotide phosphate (reduced) oxidase 2 modulates inflammatory vigor during nonalcoholic fatty liver disease progression in mice
    Article Snippet: .. Serum leptin (Millipore) and NO2 (Sigma‐Aldrich) levels were quantified using commercially available enzyme‐linked immunosorbent assay kits. ..

    Modification:

    Article Title: Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species
    Article Snippet: .. NO concentration was assessed by determining the NO3 − and NO2 − levels using Griess reagent (modified; Sigma-Aldrich). ..

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  • 95
    Millipore mmp 9 inhibitor i
    <t>MMP-9</t> deficiency does not alter opioid-induced hyperalgesia after subcutaneous morphine . (A, B) Western blot gel (A) and band density (B) showing MMP-9 expression in lumbar DRGs 24 h after morphine (MORPH) injection. * P > 0.05, compared to naive control (CTRL), Student's t-test, n = 4 mice. (C, D) Subcutaneous morphine (5 mg/kg) induces comparable heat hyperalgesia in both wild-type and Mmp9 -KO mice (C) and also in wild-type mice pretreated with intrathecal MMP-9 <t>inhibitor-I</t> (0.2 μg) or vehicle (10% DMSO). * P
    Mmp 9 Inhibitor I, supplied by Millipore, used in various techniques. Bioz Stars score: 95/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mmp 9 inhibitor i/product/Millipore
    Average 95 stars, based on 4 article reviews
    Price from $9.99 to $1999.99
    mmp 9 inhibitor i - by Bioz Stars, 2020-09
    95/100 stars
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    96
    Millipore gdnf
    Cross tolerance with repeated DAMGO treatment Both <t>SNC</t> (delta-opioid agonist), which significantly attenuated NGF and <t>GDNF–induced</t> hyperalgesia in naïve animals failed to attenuate NGF or GDNF-induced hyperalgesia in repeated DAMGO (1 µg, hourly, 3 times) treated rats (both n = 6). Similarly, DAMGO (mu-opioid agonist), which attenuated NGF-induced hyperalgesia in naïve animals, failed to attenuate NGF-induced hyperalgesia in repeated DAMGO (1 µg, hourly, 3 times) treated rats (n = 4).
    Gdnf, supplied by Millipore, used in various techniques. Bioz Stars score: 96/100, based on 34 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gdnf/product/Millipore
    Average 96 stars, based on 34 article reviews
    Price from $9.99 to $1999.99
    gdnf - by Bioz Stars, 2020-09
    96/100 stars
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    89
    Millipore mmp 9 inhibitor
    Role of matrix metalloproteinases in DAMGO-induced prolongation of PGE 2 hyperalgesia Rats received an intradermal injection of vehicle (5 μL; black bars ), ilomastat (a general MMP inhibitor, 1 μg; gray bars ) or <t>MMP-9</t> inhibitor (1 μg; dotted bars ) followed, 10 min later, by repeated (hourly × 4) injections of DAMGO (1 μg) at the same site. The average baseline mechanical nociceptive threshold, before treatments, was 129.4 ± 2.2 g for the vehicle group, 131.3 ± 1.9 g for the MMP inhibitor group, and 130.7 ± 1.1 g for the MMP-9 inhibitor group. Five days later, when the mechanical nociceptive threshold was not different from the pre-DAMGO baseline (127.0 ± 2.5 g, t (5) = 1.395; p = 0.2215, for the vehicle-treated group; 132.3 ± 1.7 g, t (5) = 0.4416; p = 0.6772, for the general MMP inhibitor-treated group, 127.7 ± 2.2 g, t (5) = 0.2548; p = 0.8090, for the MMP-9 inhibitor-treated group, when the mechanical nociceptive threshold is compared before and 5 days after DAMGO; paired Student's t test), PGE 2 (100 ng) was injected intradermally on the dorsum of the hind paw and, a significant inhibition of PGE 2 hyperalgesia at the 4 th hour was observed in both MMP and MMP-9 inhibitor-treated groups ( F (2,30) = 223.71, *** p
    Mmp 9 Inhibitor, supplied by Millipore, used in various techniques. Bioz Stars score: 89/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mmp 9 inhibitor/product/Millipore
    Average 89 stars, based on 3 article reviews
    Price from $9.99 to $1999.99
    mmp 9 inhibitor - by Bioz Stars, 2020-09
    89/100 stars
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    MMP-9 deficiency does not alter opioid-induced hyperalgesia after subcutaneous morphine . (A, B) Western blot gel (A) and band density (B) showing MMP-9 expression in lumbar DRGs 24 h after morphine (MORPH) injection. * P > 0.05, compared to naive control (CTRL), Student's t-test, n = 4 mice. (C, D) Subcutaneous morphine (5 mg/kg) induces comparable heat hyperalgesia in both wild-type and Mmp9 -KO mice (C) and also in wild-type mice pretreated with intrathecal MMP-9 inhibitor-I (0.2 μg) or vehicle (10% DMSO). * P

    Journal: Molecular Pain

    Article Title: Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice

    doi: 10.1186/1744-8069-8-19

    Figure Lengend Snippet: MMP-9 deficiency does not alter opioid-induced hyperalgesia after subcutaneous morphine . (A, B) Western blot gel (A) and band density (B) showing MMP-9 expression in lumbar DRGs 24 h after morphine (MORPH) injection. * P > 0.05, compared to naive control (CTRL), Student's t-test, n = 4 mice. (C, D) Subcutaneous morphine (5 mg/kg) induces comparable heat hyperalgesia in both wild-type and Mmp9 -KO mice (C) and also in wild-type mice pretreated with intrathecal MMP-9 inhibitor-I (0.2 μg) or vehicle (10% DMSO). * P

    Article Snippet: Drugs and administration We purchased morphine sulphate and remifentanil from Hospira Inc, MMP-9 inhibitor-I from Calbiochem (Catalogue # 444278), D-Ala(2), N-Me-Phe(4), Gly-ol(5))-enkephalin (DAMGO), naloxone, and CTAP (D -Phe-Cys-Tyr-D -Trp-Arg-Thr-Pen-Thr-NH2 ) from Sigma, and tissue inhibitor of MMP-I (TIMP-1) from R & D. Morphine, DAMGO, and remifentanil were freshly prepared in saline and administered subcutaneously [5 or 10 mg/kg for morphine and DAMGO, or intrathecally (10 nmol for morphine and 1 nmol for remifentanil)].

    Techniques: Western Blot, Expressing, Injection, Mouse Assay

    Cross tolerance with repeated DAMGO treatment Both SNC (delta-opioid agonist), which significantly attenuated NGF and GDNF–induced hyperalgesia in naïve animals failed to attenuate NGF or GDNF-induced hyperalgesia in repeated DAMGO (1 µg, hourly, 3 times) treated rats (both n = 6). Similarly, DAMGO (mu-opioid agonist), which attenuated NGF-induced hyperalgesia in naïve animals, failed to attenuate NGF-induced hyperalgesia in repeated DAMGO (1 µg, hourly, 3 times) treated rats (n = 4).

    Journal: Neuroscience

    Article Title: Mu and Delta Opioid Receptors on Nociceptors Attenuate Mechanical Hyperalgesia in Rat

    doi: 10.1016/j.neuroscience.2010.08.035

    Figure Lengend Snippet: Cross tolerance with repeated DAMGO treatment Both SNC (delta-opioid agonist), which significantly attenuated NGF and GDNF–induced hyperalgesia in naïve animals failed to attenuate NGF or GDNF-induced hyperalgesia in repeated DAMGO (1 µg, hourly, 3 times) treated rats (both n = 6). Similarly, DAMGO (mu-opioid agonist), which attenuated NGF-induced hyperalgesia in naïve animals, failed to attenuate NGF-induced hyperalgesia in repeated DAMGO (1 µg, hourly, 3 times) treated rats (n = 4).

    Article Snippet: Drugs employed in this study were NGF, D-Ala2, N-MePhe4, Gly-ol]-enkephalin (DAMGO) and 4-[( R )-[(2 S ,5 R )-4-allyl-2,5-dimethylpiperazin-1-yl](3-methoxyphenyl)methyl]- N,N -diethylbenzamide (SNC), from Sigma (St. Louis, MO), and GDNF from EMD Biosciences (La Jolla, CA).

    Techniques:

    Role of matrix metalloproteinases in DAMGO-induced prolongation of PGE 2 hyperalgesia Rats received an intradermal injection of vehicle (5 μL; black bars ), ilomastat (a general MMP inhibitor, 1 μg; gray bars ) or MMP-9 inhibitor (1 μg; dotted bars ) followed, 10 min later, by repeated (hourly × 4) injections of DAMGO (1 μg) at the same site. The average baseline mechanical nociceptive threshold, before treatments, was 129.4 ± 2.2 g for the vehicle group, 131.3 ± 1.9 g for the MMP inhibitor group, and 130.7 ± 1.1 g for the MMP-9 inhibitor group. Five days later, when the mechanical nociceptive threshold was not different from the pre-DAMGO baseline (127.0 ± 2.5 g, t (5) = 1.395; p = 0.2215, for the vehicle-treated group; 132.3 ± 1.7 g, t (5) = 0.4416; p = 0.6772, for the general MMP inhibitor-treated group, 127.7 ± 2.2 g, t (5) = 0.2548; p = 0.8090, for the MMP-9 inhibitor-treated group, when the mechanical nociceptive threshold is compared before and 5 days after DAMGO; paired Student's t test), PGE 2 (100 ng) was injected intradermally on the dorsum of the hind paw and, a significant inhibition of PGE 2 hyperalgesia at the 4 th hour was observed in both MMP and MMP-9 inhibitor-treated groups ( F (2,30) = 223.71, *** p

    Journal: Pain

    Article Title: Role of GPCR (Mu-Opioid)-RTK (Epidermal Growth Factor) Crosstalk in Opioid-Induced Hyperalgesic Priming (Type II)

    doi: 10.1097/j.pain.0000000000001155

    Figure Lengend Snippet: Role of matrix metalloproteinases in DAMGO-induced prolongation of PGE 2 hyperalgesia Rats received an intradermal injection of vehicle (5 μL; black bars ), ilomastat (a general MMP inhibitor, 1 μg; gray bars ) or MMP-9 inhibitor (1 μg; dotted bars ) followed, 10 min later, by repeated (hourly × 4) injections of DAMGO (1 μg) at the same site. The average baseline mechanical nociceptive threshold, before treatments, was 129.4 ± 2.2 g for the vehicle group, 131.3 ± 1.9 g for the MMP inhibitor group, and 130.7 ± 1.1 g for the MMP-9 inhibitor group. Five days later, when the mechanical nociceptive threshold was not different from the pre-DAMGO baseline (127.0 ± 2.5 g, t (5) = 1.395; p = 0.2215, for the vehicle-treated group; 132.3 ± 1.7 g, t (5) = 0.4416; p = 0.6772, for the general MMP inhibitor-treated group, 127.7 ± 2.2 g, t (5) = 0.2548; p = 0.8090, for the MMP-9 inhibitor-treated group, when the mechanical nociceptive threshold is compared before and 5 days after DAMGO; paired Student's t test), PGE 2 (100 ng) was injected intradermally on the dorsum of the hind paw and, a significant inhibition of PGE 2 hyperalgesia at the 4 th hour was observed in both MMP and MMP-9 inhibitor-treated groups ( F (2,30) = 223.71, *** p

    Article Snippet: The following drugs were used in this study: Prostaglandin-E2 (PGE2 , a direct-acting hyperalgesic agent that sensitizes nociceptors), DAMGO ([D-Ala2 , N-Me-Phe4 , Gly5 -ol]-enkephalin acetate salt, a MOR agonist), salirasib (a RAS inhibitor), GW5074 (a cRaf1 kinase inhibitor), SU 6656 (a Src family kinase inhibitor), and Ilomastat (an inhibitor of a wide variety of matrix metalloproteases/MMPs), all from Sigma-Aldrich (St. Louis, MO, USA); recombinant rat EGF protein (an EGF ligand [EGFR agonist]) from Abcam (Cambridge, MA, USA); MMP-9 inhibitor from Calbiochem (Billerica, MA, USA); Tyrphostin AG 1478 hydrochloride (an EGFR inhibitor), U0126 (MAPK/ERK inhibitor), and N -Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu (peptide SH2; a phosphopeptide ligand for the Src SH2 domain that blocks Src interactions with EGFR and FAK) from Tocris (Avonmouth, Bristol, UK).

    Techniques: Injection, Inhibition