drugs am404  (Alomone Labs)


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    Structured Review

    Alomone Labs drugs am404
    Effects of <t>AM404</t> on [ 3 H]D-Asp release in hippocampal synaptosomes and intracellular Ca 2+ responses. (A) Time course of [ 3 H]D-Asp release induced by NMDA plus Gly and effects of AM404 in hippocampal synaptosomes. Results are expressed as fractional rate percent. (B) AM404 inhibition of the NMDA plus Glycine-evoked-[ 3 H]D-Asp release in hippocampal synaptosomes. (C) Data of calcium imaging expressed as fluorescence intensity (ΔF/F baseline) vs. time. (D) Data of calcium imaging calculated the area under the curve (AUC). Data are means ± SEM of three independent experiments. # p
    Drugs Am404, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/drugs am404/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    drugs am404 - by Bioz Stars, 2022-08
    93/100 stars

    Images

    1) Product Images from "Neuroprotective Effect of AM404 Against NMDA-Induced Hippocampal Excitotoxicity"

    Article Title: Neuroprotective Effect of AM404 Against NMDA-Induced Hippocampal Excitotoxicity

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2019.00566

    Effects of AM404 on [ 3 H]D-Asp release in hippocampal synaptosomes and intracellular Ca 2+ responses. (A) Time course of [ 3 H]D-Asp release induced by NMDA plus Gly and effects of AM404 in hippocampal synaptosomes. Results are expressed as fractional rate percent. (B) AM404 inhibition of the NMDA plus Glycine-evoked-[ 3 H]D-Asp release in hippocampal synaptosomes. (C) Data of calcium imaging expressed as fluorescence intensity (ΔF/F baseline) vs. time. (D) Data of calcium imaging calculated the area under the curve (AUC). Data are means ± SEM of three independent experiments. # p
    Figure Legend Snippet: Effects of AM404 on [ 3 H]D-Asp release in hippocampal synaptosomes and intracellular Ca 2+ responses. (A) Time course of [ 3 H]D-Asp release induced by NMDA plus Gly and effects of AM404 in hippocampal synaptosomes. Results are expressed as fractional rate percent. (B) AM404 inhibition of the NMDA plus Glycine-evoked-[ 3 H]D-Asp release in hippocampal synaptosomes. (C) Data of calcium imaging expressed as fluorescence intensity (ΔF/F baseline) vs. time. (D) Data of calcium imaging calculated the area under the curve (AUC). Data are means ± SEM of three independent experiments. # p

    Techniques Used: Inhibition, Imaging, Fluorescence

    Effects of AM404 on NMDA-induced inflammatory mediators in organotypic hippocampal slices cultures (OHSC). OHSCs were pre-treated with two concentrations of AM404 (25 or 50 μM) for 30 min before stimulating with 10 ng/ml LPS or 25 μM NMDA. After 4 h, interleukin (IL)-1β (A) , IL-6 (B) , TNFα (C) , mPGES-1 (D) , and iNOS (E) were measured by PCR. After 24 h, COX-2 (F) was evaluated by western blot (WB). Data are expressed as mean ± SEM of at least three OHSCs/group. * p
    Figure Legend Snippet: Effects of AM404 on NMDA-induced inflammatory mediators in organotypic hippocampal slices cultures (OHSC). OHSCs were pre-treated with two concentrations of AM404 (25 or 50 μM) for 30 min before stimulating with 10 ng/ml LPS or 25 μM NMDA. After 4 h, interleukin (IL)-1β (A) , IL-6 (B) , TNFα (C) , mPGES-1 (D) , and iNOS (E) were measured by PCR. After 24 h, COX-2 (F) was evaluated by western blot (WB). Data are expressed as mean ± SEM of at least three OHSCs/group. * p

    Techniques Used: Polymerase Chain Reaction, Western Blot

    Effect of AM404 on microglia and astrocyte after 25 μM NMDA in OHSC. The OHSCs were pre-treated with two concentrations of AM404 (25 or 50 μM) for 30 min before stimulating with 25 μM NMDA. After 4 h, microglia markers, Iba-1 (A) , CSF1R (B) and CD11b (C) , an astrocyte marker, GFAP (D) were measured by qPCR. Data are expressed as mean ± SEM of at least three OHSCs/group. * p
    Figure Legend Snippet: Effect of AM404 on microglia and astrocyte after 25 μM NMDA in OHSC. The OHSCs were pre-treated with two concentrations of AM404 (25 or 50 μM) for 30 min before stimulating with 25 μM NMDA. After 4 h, microglia markers, Iba-1 (A) , CSF1R (B) and CD11b (C) , an astrocyte marker, GFAP (D) were measured by qPCR. Data are expressed as mean ± SEM of at least three OHSCs/group. * p

    Techniques Used: Marker, Real-time Polymerase Chain Reaction

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  • 93
    Alomone Labs drugs am404
    Effects of <t>AM404</t> on [ 3 H]D-Asp release in hippocampal synaptosomes and intracellular Ca 2+ responses. (A) Time course of [ 3 H]D-Asp release induced by NMDA plus Gly and effects of AM404 in hippocampal synaptosomes. Results are expressed as fractional rate percent. (B) AM404 inhibition of the NMDA plus Glycine-evoked-[ 3 H]D-Asp release in hippocampal synaptosomes. (C) Data of calcium imaging expressed as fluorescence intensity (ΔF/F baseline) vs. time. (D) Data of calcium imaging calculated the area under the curve (AUC). Data are means ± SEM of three independent experiments. # p
    Drugs Am404, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/drugs am404/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    drugs am404 - by Bioz Stars, 2022-08
    93/100 stars
      Buy from Supplier

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    Effects of AM404 on [ 3 H]D-Asp release in hippocampal synaptosomes and intracellular Ca 2+ responses. (A) Time course of [ 3 H]D-Asp release induced by NMDA plus Gly and effects of AM404 in hippocampal synaptosomes. Results are expressed as fractional rate percent. (B) AM404 inhibition of the NMDA plus Glycine-evoked-[ 3 H]D-Asp release in hippocampal synaptosomes. (C) Data of calcium imaging expressed as fluorescence intensity (ΔF/F baseline) vs. time. (D) Data of calcium imaging calculated the area under the curve (AUC). Data are means ± SEM of three independent experiments. # p

    Journal: Frontiers in Cellular Neuroscience

    Article Title: Neuroprotective Effect of AM404 Against NMDA-Induced Hippocampal Excitotoxicity

    doi: 10.3389/fncel.2019.00566

    Figure Lengend Snippet: Effects of AM404 on [ 3 H]D-Asp release in hippocampal synaptosomes and intracellular Ca 2+ responses. (A) Time course of [ 3 H]D-Asp release induced by NMDA plus Gly and effects of AM404 in hippocampal synaptosomes. Results are expressed as fractional rate percent. (B) AM404 inhibition of the NMDA plus Glycine-evoked-[ 3 H]D-Asp release in hippocampal synaptosomes. (C) Data of calcium imaging expressed as fluorescence intensity (ΔF/F baseline) vs. time. (D) Data of calcium imaging calculated the area under the curve (AUC). Data are means ± SEM of three independent experiments. # p

    Article Snippet: Drugs AM404 (Alomone Labs) was dissolved in the physiological medium for the synaptosome experiment and in DMSO for the other experiments (Merck KGaA, Darmstadt, Germany).

    Techniques: Inhibition, Imaging, Fluorescence

    Effects of AM404 on NMDA-induced inflammatory mediators in organotypic hippocampal slices cultures (OHSC). OHSCs were pre-treated with two concentrations of AM404 (25 or 50 μM) for 30 min before stimulating with 10 ng/ml LPS or 25 μM NMDA. After 4 h, interleukin (IL)-1β (A) , IL-6 (B) , TNFα (C) , mPGES-1 (D) , and iNOS (E) were measured by PCR. After 24 h, COX-2 (F) was evaluated by western blot (WB). Data are expressed as mean ± SEM of at least three OHSCs/group. * p

    Journal: Frontiers in Cellular Neuroscience

    Article Title: Neuroprotective Effect of AM404 Against NMDA-Induced Hippocampal Excitotoxicity

    doi: 10.3389/fncel.2019.00566

    Figure Lengend Snippet: Effects of AM404 on NMDA-induced inflammatory mediators in organotypic hippocampal slices cultures (OHSC). OHSCs were pre-treated with two concentrations of AM404 (25 or 50 μM) for 30 min before stimulating with 10 ng/ml LPS or 25 μM NMDA. After 4 h, interleukin (IL)-1β (A) , IL-6 (B) , TNFα (C) , mPGES-1 (D) , and iNOS (E) were measured by PCR. After 24 h, COX-2 (F) was evaluated by western blot (WB). Data are expressed as mean ± SEM of at least three OHSCs/group. * p

    Article Snippet: Drugs AM404 (Alomone Labs) was dissolved in the physiological medium for the synaptosome experiment and in DMSO for the other experiments (Merck KGaA, Darmstadt, Germany).

    Techniques: Polymerase Chain Reaction, Western Blot

    Effect of AM404 on microglia and astrocyte after 25 μM NMDA in OHSC. The OHSCs were pre-treated with two concentrations of AM404 (25 or 50 μM) for 30 min before stimulating with 25 μM NMDA. After 4 h, microglia markers, Iba-1 (A) , CSF1R (B) and CD11b (C) , an astrocyte marker, GFAP (D) were measured by qPCR. Data are expressed as mean ± SEM of at least three OHSCs/group. * p

    Journal: Frontiers in Cellular Neuroscience

    Article Title: Neuroprotective Effect of AM404 Against NMDA-Induced Hippocampal Excitotoxicity

    doi: 10.3389/fncel.2019.00566

    Figure Lengend Snippet: Effect of AM404 on microglia and astrocyte after 25 μM NMDA in OHSC. The OHSCs were pre-treated with two concentrations of AM404 (25 or 50 μM) for 30 min before stimulating with 25 μM NMDA. After 4 h, microglia markers, Iba-1 (A) , CSF1R (B) and CD11b (C) , an astrocyte marker, GFAP (D) were measured by qPCR. Data are expressed as mean ± SEM of at least three OHSCs/group. * p

    Article Snippet: Drugs AM404 (Alomone Labs) was dissolved in the physiological medium for the synaptosome experiment and in DMSO for the other experiments (Merck KGaA, Darmstadt, Germany).

    Techniques: Marker, Real-time Polymerase Chain Reaction