Journal: Antioxidants
Article Title: Microbial-Derived Antioxidants in Intestinal Inflammation: A Systematic Review of Their Therapeutic Potential
doi: 10.3390/antiox14030321
Figure Lengend Snippet: Research findings from recent in vitro studies on the role of postbiotics as novel therapeutic approaches for IBD. BMDM: bone marrow-derived macrophages; CAT: catalase; CD: Crohn’s Disease; DPPH: 1,1-dipheny-l,2-picrylhydrazyl; EPS: exopolysaccharides; GPx: glutathione peroxidase; LPS: lipopolysaccharide; MPO: myeloperoxidase; ROS: reactive oxygen species; SbS: Saccharomyces boulardii supernatant; SCFAs: short-chain fatty acids; SOD: superoxide dismutase; UC: ulcerative colitis.
Article Snippet: Postbiotics from Lactobacillus casei , Lactobacillus acidophilus , Saccharomyces boulardii , Lactobacillus reuteri , and Lactococcus lactis , - To regulate the inflammatory cytokine profile - Reduction of ROS levels in a dose-dependent manner - To reduce the concentration of hydrogen peroxide , HT-29 cell line (from human adenocarcinoma) Macrophages derived from monocytes stimulated with LPS , Evaluation of the effect of probiotic-derived metabolites in in vitro models of gut inflammation to assess their immunomodulatory role in the HT-29 cell line and macrophages. This included calculating the disease activity index and conducting metagenomic and proteomic studies. , [ ] .
Techniques: In Vitro, Activity Assay, Incubation, Migration, Isolation, Expressing, Produced, Activation Assay, Concentration Assay, Derivative Assay, Genetically Modified, Transfection, Bacteria, Probiotics, Cell Culture