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Serum <t>anti-DOK2</t> antibody levels in AIH patients following PSL treatment. (A) Comparison of serum anti-DOK2 antibody levels at onset and posttreatment among AIH patients who achieved biochemical remission (left). Comparison of serum anti-DOK2 antibody levels at onset and posttreatment among AIH patients who did not achieve biochemical remission (right). p-v alues were calculated via the Wilcoxon matched-pairs signed-rank test; p <0.05 was considered significant. (B) Relationship between serum anti-DOK2 antibody and IgG levels posttreatment in patients with AIH. (C) Relationships between serum anti-DOK2 antibody levels and serum AST levels posttreatment in AIH patients. (D) Relationships between serum anti-DOK2 antibody levels and serum ALT levels posttreatment in AIH patients. p - v alues were calculated via the Wilcoxon matched-pairs signed-rank test. Abbreviations: AIH, autoimmune hepatitis; AU, arbitrary units; DOK, docking protein; PSL, prednisolone.
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Serum <t>anti-DOK2</t> antibody levels in AIH patients following PSL treatment. (A) Comparison of serum anti-DOK2 antibody levels at onset and posttreatment among AIH patients who achieved biochemical remission (left). Comparison of serum anti-DOK2 antibody levels at onset and posttreatment among AIH patients who did not achieve biochemical remission (right). p-v alues were calculated via the Wilcoxon matched-pairs signed-rank test; p <0.05 was considered significant. (B) Relationship between serum anti-DOK2 antibody and IgG levels posttreatment in patients with AIH. (C) Relationships between serum anti-DOK2 antibody levels and serum AST levels posttreatment in AIH patients. (D) Relationships between serum anti-DOK2 antibody levels and serum ALT levels posttreatment in AIH patients. p - v alues were calculated via the Wilcoxon matched-pairs signed-rank test. Abbreviations: AIH, autoimmune hepatitis; AU, arbitrary units; DOK, docking protein; PSL, prednisolone.
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Serum <t>anti-DOK2</t> antibody levels in AIH patients following PSL treatment. (A) Comparison of serum anti-DOK2 antibody levels at onset and posttreatment among AIH patients who achieved biochemical remission (left). Comparison of serum anti-DOK2 antibody levels at onset and posttreatment among AIH patients who did not achieve biochemical remission (right). p-v alues were calculated via the Wilcoxon matched-pairs signed-rank test; p <0.05 was considered significant. (B) Relationship between serum anti-DOK2 antibody and IgG levels posttreatment in patients with AIH. (C) Relationships between serum anti-DOK2 antibody levels and serum AST levels posttreatment in AIH patients. (D) Relationships between serum anti-DOK2 antibody levels and serum ALT levels posttreatment in AIH patients. p - v alues were calculated via the Wilcoxon matched-pairs signed-rank test. Abbreviations: AIH, autoimmune hepatitis; AU, arbitrary units; DOK, docking protein; PSL, prednisolone.
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Serum anti-DOK2 antibody levels in AIH patients following PSL treatment. (A) Comparison of serum anti-DOK2 antibody levels at onset and posttreatment among AIH patients who achieved biochemical remission (left). Comparison of serum anti-DOK2 antibody levels at onset and posttreatment among AIH patients who did not achieve biochemical remission (right). p-v alues were calculated via the Wilcoxon matched-pairs signed-rank test; p <0.05 was considered significant. (B) Relationship between serum anti-DOK2 antibody and IgG levels posttreatment in patients with AIH. (C) Relationships between serum anti-DOK2 antibody levels and serum AST levels posttreatment in AIH patients. (D) Relationships between serum anti-DOK2 antibody levels and serum ALT levels posttreatment in AIH patients. p - v alues were calculated via the Wilcoxon matched-pairs signed-rank test. Abbreviations: AIH, autoimmune hepatitis; AU, arbitrary units; DOK, docking protein; PSL, prednisolone.

Journal: Hepatology Communications

Article Title: Identification of anti-DOK2 antibodies in patients with autoimmune hepatitis via a human protein microarray

doi: 10.1097/HC9.0000000000000807

Figure Lengend Snippet: Serum anti-DOK2 antibody levels in AIH patients following PSL treatment. (A) Comparison of serum anti-DOK2 antibody levels at onset and posttreatment among AIH patients who achieved biochemical remission (left). Comparison of serum anti-DOK2 antibody levels at onset and posttreatment among AIH patients who did not achieve biochemical remission (right). p-v alues were calculated via the Wilcoxon matched-pairs signed-rank test; p <0.05 was considered significant. (B) Relationship between serum anti-DOK2 antibody and IgG levels posttreatment in patients with AIH. (C) Relationships between serum anti-DOK2 antibody levels and serum AST levels posttreatment in AIH patients. (D) Relationships between serum anti-DOK2 antibody levels and serum ALT levels posttreatment in AIH patients. p - v alues were calculated via the Wilcoxon matched-pairs signed-rank test. Abbreviations: AIH, autoimmune hepatitis; AU, arbitrary units; DOK, docking protein; PSL, prednisolone.

Article Snippet: The following antibodies were used: DOK2 mouse monoclonal antibody (clone E-10; Santa Cruz Biotechnology, Inc.), CK7 mouse monoclonal antibody (clone OV-TL 12/30; Abcam, ab68459), HepPar-1 mouse monoclonal antibody (clone OCH1E5; Santa Cruz Biotechnology, Inc.).

Techniques: Comparison

Serum anti-DOK2 antibody levels in AIH patients following PSL treatment. (A) Comparison of serum anti-DOK2 antibody levels at onset and posttreatment among AIH patients who achieved biochemical remission (left). Comparison of serum anti-DOK2 antibody levels at onset and posttreatment among AIH patients who did not achieve biochemical remission (right). p-v alues were calculated via the Wilcoxon matched-pairs signed-rank test; p <0.05 was considered significant. (B) Relationship between serum anti-DOK2 antibody and IgG levels posttreatment in patients with AIH. (C) Relationships between serum anti-DOK2 antibody levels and serum AST levels posttreatment in AIH patients. (D) Relationships between serum anti-DOK2 antibody levels and serum ALT levels posttreatment in AIH patients. p - v alues were calculated via the Wilcoxon matched-pairs signed-rank test. Abbreviations: AIH, autoimmune hepatitis; AU, arbitrary units; DOK, docking protein; PSL, prednisolone.

Journal: Hepatology Communications

Article Title: Identification of anti-DOK2 antibodies in patients with autoimmune hepatitis via a human protein microarray

doi: 10.1097/HC9.0000000000000807

Figure Lengend Snippet: Serum anti-DOK2 antibody levels in AIH patients following PSL treatment. (A) Comparison of serum anti-DOK2 antibody levels at onset and posttreatment among AIH patients who achieved biochemical remission (left). Comparison of serum anti-DOK2 antibody levels at onset and posttreatment among AIH patients who did not achieve biochemical remission (right). p-v alues were calculated via the Wilcoxon matched-pairs signed-rank test; p <0.05 was considered significant. (B) Relationship between serum anti-DOK2 antibody and IgG levels posttreatment in patients with AIH. (C) Relationships between serum anti-DOK2 antibody levels and serum AST levels posttreatment in AIH patients. (D) Relationships between serum anti-DOK2 antibody levels and serum ALT levels posttreatment in AIH patients. p - v alues were calculated via the Wilcoxon matched-pairs signed-rank test. Abbreviations: AIH, autoimmune hepatitis; AU, arbitrary units; DOK, docking protein; PSL, prednisolone.

Article Snippet: The tissue sections were incubated with a primary mouse anti-DOK2 monoclonal antibody (sc-17830; dilution 1:25; Santa Cruz Biotechnology Inc.) or a CD68 mouse monoclonal antibody (AT1379-1; Nichirei Bioscience Inc.) for 20 minutes at 25°C.

Techniques: Comparison