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Additive interactions of body composition indices or alanine aminotransferase with platelet parameters (men). AFI: allometric fat-mass index (cut-off: ≥13.703); ALT: alanine aminotransferase (cut-off: ≥28.65 IU/L); BMI: body mass index (cut-off: ≥28.982 kg/m 2 ); CI: confidence interval; HR: hazard ratio; MPV: mean platelet volume (cut-off: ≥9.17 fL); PLT: platelet count (cut-off: ≥234.0*10 9 /L); RERI: relative excess risk from interaction (additive interaction); cases: number of lung cancer cases; rate: incidence rate per 1*10 6 person years; p-value: p-value for RERI derived with the delta method or p-value from Wald test for the individual term. Cox proportional hazards models including a cross-classification between either PLT or MPV (dichotomised at the sex-specific median) and one of BMI, AFI, or ALT in men (dichotomised at the upper sex-specific tertile cut-off), stratified by age at recruitment, region, and smoking status and intensity, and adjusted for height, recent weight gain, alcohol consumption, physical activity, Townsend deprivation index, family history of lung cancer, time of blood collection, fasting time, diabetes, and use of lipid-lowering drugs, antihypertensive drugs, antiaggregant/anticoagulants, and paracetamol.

Journal: Scientific Reports

Article Title: Allometric fat mass index and alanine aminotransferase attenuate the associations of platelet parameters with lung cancer risk

doi: 10.1038/s41598-024-78281-x

Figure Lengend Snippet: Additive interactions of body composition indices or alanine aminotransferase with platelet parameters (men). AFI: allometric fat-mass index (cut-off: ≥13.703); ALT: alanine aminotransferase (cut-off: ≥28.65 IU/L); BMI: body mass index (cut-off: ≥28.982 kg/m 2 ); CI: confidence interval; HR: hazard ratio; MPV: mean platelet volume (cut-off: ≥9.17 fL); PLT: platelet count (cut-off: ≥234.0*10 9 /L); RERI: relative excess risk from interaction (additive interaction); cases: number of lung cancer cases; rate: incidence rate per 1*10 6 person years; p-value: p-value for RERI derived with the delta method or p-value from Wald test for the individual term. Cox proportional hazards models including a cross-classification between either PLT or MPV (dichotomised at the sex-specific median) and one of BMI, AFI, or ALT in men (dichotomised at the upper sex-specific tertile cut-off), stratified by age at recruitment, region, and smoking status and intensity, and adjusted for height, recent weight gain, alcohol consumption, physical activity, Townsend deprivation index, family history of lung cancer, time of blood collection, fasting time, diabetes, and use of lipid-lowering drugs, antihypertensive drugs, antiaggregant/anticoagulants, and paracetamol.

Article Snippet: We calculated the relative excess risk from interaction (RERI) and obtained confidence intervals and p-values with the delta method applied in function nlcom in STATA-13 : RERI = HR High−High – HR High−Low – HR Low−High + 1.

Techniques: Derivative Assay, Activity Assay