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FUJIFILM dcm
Both <t>1,2-DCP</t> and <t>DCM</t> show mutagenic activity in S.typhimurium strain TA100. The mutagenic activity levels of 1,2-DCP (closed circle) and DCM (closed square) were estimated from the number of revertant colonies.
Dcm, supplied by FUJIFILM, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1) Product Images from "Hypermutation and unique mutational signatures of occupational cholangiocarcinoma in printing workers exposed to haloalkanes"

Article Title: Hypermutation and unique mutational signatures of occupational cholangiocarcinoma in printing workers exposed to haloalkanes

Journal: Carcinogenesis

doi: 10.1093/carcin/bgw066

Both 1,2-DCP and DCM show mutagenic activity in S.typhimurium strain TA100. The mutagenic activity levels of 1,2-DCP (closed circle) and DCM (closed square) were estimated from the number of revertant colonies.
Figure Legend Snippet: Both 1,2-DCP and DCM show mutagenic activity in S.typhimurium strain TA100. The mutagenic activity levels of 1,2-DCP (closed circle) and DCM (closed square) were estimated from the number of revertant colonies.

Techniques Used: Activity Assay

The mutational signature of 1,2-DCP in S.typhimurium TA100 partially recapitulates the printing workers’ cholangiocarcinoma signature. ( A ) Number of SNVs in 1,2-DCP- and DCM-exposed TA100, except for the hisG gene target site. ( B ) Single-nucleotide DNA substitution profiles in TA100 exposed to 1,2-DCP or DCM except for the hisG gene target site. ( C ) Trinucleotide mutational pattern of TA100 exposed to 1,2-DCP or DCM except for the hisG gene target site. Clones exposed to 1,2-DCP harbored Np C pC to Np T pC changes (indicated by the asterisks). This signature partially recapitulates the printing workers’ cholangiocarcinoma signature as shown below the 1,2-DCP-exposed TA100 panel. The printing workers’ signature is the mean of the frequency of secondary characteristic mutational changes in four patients shown in Figure 1E . The mutational signatures were normalized using the trinucleotide frequency in the genome. The signature of 1,2-DCP was obtained from the sum of the 3000 and 6000 ppm exposure data.
Figure Legend Snippet: The mutational signature of 1,2-DCP in S.typhimurium TA100 partially recapitulates the printing workers’ cholangiocarcinoma signature. ( A ) Number of SNVs in 1,2-DCP- and DCM-exposed TA100, except for the hisG gene target site. ( B ) Single-nucleotide DNA substitution profiles in TA100 exposed to 1,2-DCP or DCM except for the hisG gene target site. ( C ) Trinucleotide mutational pattern of TA100 exposed to 1,2-DCP or DCM except for the hisG gene target site. Clones exposed to 1,2-DCP harbored Np C pC to Np T pC changes (indicated by the asterisks). This signature partially recapitulates the printing workers’ cholangiocarcinoma signature as shown below the 1,2-DCP-exposed TA100 panel. The printing workers’ signature is the mean of the frequency of secondary characteristic mutational changes in four patients shown in Figure 1E . The mutational signatures were normalized using the trinucleotide frequency in the genome. The signature of 1,2-DCP was obtained from the sum of the 3000 and 6000 ppm exposure data.

Techniques Used: Clone Assay

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