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d1018  (ATCC)
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ATCC d1018
The MICs of IDR-1018, <t> D1018, </t> 1018M, D1018M, and polymyxin against E. coli ATCC25922.
D1018, supplied by ATCC, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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The MICs of IDR-1018, D1018, 1018M, D1018M, and polymyxin against E. coli ATCC25922.

Journal: Frontiers in Microbiology

Article Title: D1018 with higher stability and excellent lipopolysaccharide binding affinity has potent anti-bacterial and anti-inflammatory activity

doi: 10.3389/fmicb.2022.1010017

Figure Lengend Snippet: The MICs of IDR-1018, D1018, 1018M, D1018M, and polymyxin against E. coli ATCC25922.

Article Snippet: D1018 stood out among all these peptides, showing particularly excellent capability of inhibiting the migration of E. coli ATCC 25922 genomic DNA.

Techniques:

The killing curves, stability, toxicity and resistance of peptides. (A) The killing curves of IDR-1018, D1018, 1018M, and D1018M. (B) The protease stability of IDR-1018, D1018, 1018M, and D1018M. (C) The hemolysis of D1018 and D1018M. (D) The cytotoxicity of D1018 and D1018M against RAW264.7 cells. (E) The cytotoxicity of D1018 and D1018M against Vero cells. (F) The resistant of E. coli ATCC25922 against IDR-1018, D1018, 1018M, and D1018M.

Journal: Frontiers in Microbiology

Article Title: D1018 with higher stability and excellent lipopolysaccharide binding affinity has potent anti-bacterial and anti-inflammatory activity

doi: 10.3389/fmicb.2022.1010017

Figure Lengend Snippet: The killing curves, stability, toxicity and resistance of peptides. (A) The killing curves of IDR-1018, D1018, 1018M, and D1018M. (B) The protease stability of IDR-1018, D1018, 1018M, and D1018M. (C) The hemolysis of D1018 and D1018M. (D) The cytotoxicity of D1018 and D1018M against RAW264.7 cells. (E) The cytotoxicity of D1018 and D1018M against Vero cells. (F) The resistant of E. coli ATCC25922 against IDR-1018, D1018, 1018M, and D1018M.

Article Snippet: D1018 stood out among all these peptides, showing particularly excellent capability of inhibiting the migration of E. coli ATCC 25922 genomic DNA.

Techniques:

Effects of peptides on cell wall and membrane. (A) Scanning electron microscope. (B) Transmission electron microscope. Flow cytometric analysis of PI-staining in E. coli ATCC25922 cells treated with 1×, 2×, or 4× MIC IDR-1018 (C) , D1018 (D) , 1018M (E) , and D1018M (F) for 30 or 120 min, respectively. Red line: no peptide, negative control; Blue line: treatment with 1 × MIC peptides for 30 min; Orange line: treatment with 1 × MIC peptides for 120 min; Green line: treatment with 2 × MIC peptides for 30 min; Dark green line: treatment with 2 × MIC peptides for 120 min; Pink line: treatment with 4 × MIC peptides for 30 min; Purple line: treatment with 4 × MIC peptides for 120 min.

Journal: Frontiers in Microbiology

Article Title: D1018 with higher stability and excellent lipopolysaccharide binding affinity has potent anti-bacterial and anti-inflammatory activity

doi: 10.3389/fmicb.2022.1010017

Figure Lengend Snippet: Effects of peptides on cell wall and membrane. (A) Scanning electron microscope. (B) Transmission electron microscope. Flow cytometric analysis of PI-staining in E. coli ATCC25922 cells treated with 1×, 2×, or 4× MIC IDR-1018 (C) , D1018 (D) , 1018M (E) , and D1018M (F) for 30 or 120 min, respectively. Red line: no peptide, negative control; Blue line: treatment with 1 × MIC peptides for 30 min; Orange line: treatment with 1 × MIC peptides for 120 min; Green line: treatment with 2 × MIC peptides for 30 min; Dark green line: treatment with 2 × MIC peptides for 120 min; Pink line: treatment with 4 × MIC peptides for 30 min; Purple line: treatment with 4 × MIC peptides for 120 min.

Article Snippet: D1018 stood out among all these peptides, showing particularly excellent capability of inhibiting the migration of E. coli ATCC 25922 genomic DNA.

Techniques: Microscopy, Transmission Assay, Staining, Negative Control

Interaction of peptides with E. coli ATCC25922 bacterial genomic DNA. (A) Interaction of IDR-1018, D1018, 1018M, and D1018M with bacterial genomic DNA by a gel migration assay. M: DNA marker; 1–6: The concentration of IDR-1018 were 0, 0.625, 1.25, 2.5, 5, and 10 μg/mL, respectively. 8–13: The concentration of D1018 were 0, 0.625, 1.25, 2.5, 5, and 10 μg/mL, respectively. 14–19: The concentration of 1018M were 0, 0.625, 1.25, 2.5, 5, and 10 μg/mL, respectively. 21–26: The concentration of D1018M were 0, 0.625, 1.25, 2.5, 5, and 10 μg/mL, respectively. 7 and 21: Genomic DNA from E. coli ATCC25922 with no peptide. (B) CD spectra of genomic DNA from E. coli ATCC25922 in the presence of IDR-1018, 1018M, D1018, and D1018M. The concentration of peptide and DNA were 40 and 150 μg/mL, respectively.

Journal: Frontiers in Microbiology

Article Title: D1018 with higher stability and excellent lipopolysaccharide binding affinity has potent anti-bacterial and anti-inflammatory activity

doi: 10.3389/fmicb.2022.1010017

Figure Lengend Snippet: Interaction of peptides with E. coli ATCC25922 bacterial genomic DNA. (A) Interaction of IDR-1018, D1018, 1018M, and D1018M with bacterial genomic DNA by a gel migration assay. M: DNA marker; 1–6: The concentration of IDR-1018 were 0, 0.625, 1.25, 2.5, 5, and 10 μg/mL, respectively. 8–13: The concentration of D1018 were 0, 0.625, 1.25, 2.5, 5, and 10 μg/mL, respectively. 14–19: The concentration of 1018M were 0, 0.625, 1.25, 2.5, 5, and 10 μg/mL, respectively. 21–26: The concentration of D1018M were 0, 0.625, 1.25, 2.5, 5, and 10 μg/mL, respectively. 7 and 21: Genomic DNA from E. coli ATCC25922 with no peptide. (B) CD spectra of genomic DNA from E. coli ATCC25922 in the presence of IDR-1018, 1018M, D1018, and D1018M. The concentration of peptide and DNA were 40 and 150 μg/mL, respectively.

Article Snippet: D1018 stood out among all these peptides, showing particularly excellent capability of inhibiting the migration of E. coli ATCC 25922 genomic DNA.

Techniques: Migration, Marker, Concentration Assay

LPS binding affinity of peptides and the effects of binding to LPS-induced proinflammatory response. (A) LPS Binding affinity of IDR-1018, 1018M, D1018, and D1018M. Effect of IDR-1018, 1018M, D1018, and D1018M on IL-6 (B) and TNF-α (C) produced by RAW 264.7 cells.

Journal: Frontiers in Microbiology

Article Title: D1018 with higher stability and excellent lipopolysaccharide binding affinity has potent anti-bacterial and anti-inflammatory activity

doi: 10.3389/fmicb.2022.1010017

Figure Lengend Snippet: LPS binding affinity of peptides and the effects of binding to LPS-induced proinflammatory response. (A) LPS Binding affinity of IDR-1018, 1018M, D1018, and D1018M. Effect of IDR-1018, 1018M, D1018, and D1018M on IL-6 (B) and TNF-α (C) produced by RAW 264.7 cells.

Article Snippet: D1018 stood out among all these peptides, showing particularly excellent capability of inhibiting the migration of E. coli ATCC 25922 genomic DNA.

Techniques: Binding Assay, Produced