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cpass surrogate virus neutralization test (svnt)  (GenScript corporation)

 
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    GenScript corporation cpass surrogate virus neutralization test (svnt)
    Cpass Surrogate Virus Neutralization Test (Svnt), supplied by GenScript corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cpass+test/cpass+surrogate+virus+neutralization+test/pm40288233-38-38-44
    Average 90 stars, based on 1 article reviews
    cpass surrogate virus neutralization test (svnt) - by Bioz Stars, 2026-09
    90/100 stars

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    Article Title: Validation of a SARS-CoV-2 Surrogate Neutralization Test Detecting Neutralizing Antibodies against the Major Variants of Concern.
    Article Snippet: Our results are in agreement with the study of Adams O. and colleagues who reported that the Genscript cPass test harbored a low specificity with a specificity of 0.288 for convalescent samples and 0.500 for vaccinee samples [55].

    Neutralization:

    Article Title: Validation of a SARS-CoV-2 Surrogate Neutralization Test Detecting Neutralizing Antibodies against the Major Variants of Concern
    Article Snippet: .. In contrast, the Genscript cPass test presented discrepancies for samples with low–no neutralization activity (NT50 < 40), thus resulting in considerably more false positive results ( C,E,H). .. Nonetheless, correlations between the neutralization activity assessed by surrogate tests and the whole-virus NT50 were good, ranging from 0.7262 for the Genscript cPass to −0.8528 for the Icosagen kit, while the WT-sVNT harbored an interesting midway profile (r = 0.8458, p < 0.0001) ( and and D–E, and see ).

    Article Title: Validation of a SARS-CoV-2 Surrogate Neutralization Test Detecting Neutralizing Antibodies against the Major Variants of Concern.
    Article Snippet: .. In contrast, the Genscript cPass test presented discrepancies for samples with low–no neutralization activity (NT50 < 40), thus resulting in considerably more false positive results (Figure 2C,E,H). .. Nonetheless, correlations between the neutralization activity assessed by surrogate tests and the whole-virus NT50 were good, ranging from 0.7262 for the Genscript cPass to −0.8528 for the Icosagen kit, while the WT-sVNT harbored an interesting midway profile (r = 0.8458, p < 0.0001) (Tables 1 and 2 and Figure 2D–E, and see Figure S1A).

    Article Title: Validation of a SARS-CoV-2 Surrogate Neutralization Test Detecting Neutralizing Antibodies against the Major Variants of Concern.
    Article Snippet: .. Similar correlation strengths were found in a recent study comparing four SARS-CoV-2 surrogate virus neutralization assays using plasma samples from vaccinated and convalescent individuals, ranging from 0.7152 for the TECOmedical SARS-CoV-2-AK surrogate neutralization test to r = 0.8300 for the Genscript cPass test [52]. ..

    Activity Assay:

    Article Title: Validation of a SARS-CoV-2 Surrogate Neutralization Test Detecting Neutralizing Antibodies against the Major Variants of Concern
    Article Snippet: .. In contrast, the Genscript cPass test presented discrepancies for samples with low–no neutralization activity (NT50 < 40), thus resulting in considerably more false positive results ( C,E,H). .. Nonetheless, correlations between the neutralization activity assessed by surrogate tests and the whole-virus NT50 were good, ranging from 0.7262 for the Genscript cPass to −0.8528 for the Icosagen kit, while the WT-sVNT harbored an interesting midway profile (r = 0.8458, p < 0.0001) ( and and D–E, and see ).

    Article Title: Validation of a SARS-CoV-2 Surrogate Neutralization Test Detecting Neutralizing Antibodies against the Major Variants of Concern.
    Article Snippet: .. In contrast, the Genscript cPass test presented discrepancies for samples with low–no neutralization activity (NT50 < 40), thus resulting in considerably more false positive results (Figure 2C,E,H). .. Nonetheless, correlations between the neutralization activity assessed by surrogate tests and the whole-virus NT50 were good, ranging from 0.7262 for the Genscript cPass to −0.8528 for the Icosagen kit, while the WT-sVNT harbored an interesting midway profile (r = 0.8458, p < 0.0001) (Tables 1 and 2 and Figure 2D–E, and see Figure S1A).

    Virus:

    Article Title: Validation of a SARS-CoV-2 Surrogate Neutralization Test Detecting Neutralizing Antibodies against the Major Variants of Concern.
    Article Snippet: .. Similar correlation strengths were found in a recent study comparing four SARS-CoV-2 surrogate virus neutralization assays using plasma samples from vaccinated and convalescent individuals, ranging from 0.7152 for the TECOmedical SARS-CoV-2-AK surrogate neutralization test to r = 0.8300 for the Genscript cPass test [52]. ..

    Clinical Proteomics:

    Article Title: Validation of a SARS-CoV-2 Surrogate Neutralization Test Detecting Neutralizing Antibodies against the Major Variants of Concern.
    Article Snippet: .. Similar correlation strengths were found in a recent study comparing four SARS-CoV-2 surrogate virus neutralization assays using plasma samples from vaccinated and convalescent individuals, ranging from 0.7152 for the TECOmedical SARS-CoV-2-AK surrogate neutralization test to r = 0.8300 for the Genscript cPass test [52]. ..



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    Peripheral blood samples obtained from the patient on the days indicated were tested by the quantitative Abbott Anti-RBD-CMIA (a) and the GenScript <t>cPass</t> sVNT (b) . Antibody levels detected by Anti-RBD-CMIA and sVNT are given as arbitrary units (AU)/mL, cut-off ≥50 AU/mL, and signal reduction (% inhibition, cut-off >30%) as compared to the negative control. The GenScript cPass sVNT was performed with technical duplicates at a serum dilution of 1:20. The cut-off of the sVNT is indicated by the horizontal dotted line. (c) Qualitative results of the Mikrogen line blot testing for Anti-N IgG, as well as Anti-S1 and Anti-RBD IgM and IgG, are indicated as follows: open squares: non-reactive, grey squares: reactive below cut-off, black squares: reactive above cut-off. Administration of bamlanivimab (B), first vaccination (V) and therapy with sotrovimab (S) is indicated by vertical dotted lines.
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    Image Search Results


    Antibody titers from the first and second blood samples by the participants’ demographics.

    Journal: Vaccines

    Article Title: The Humoral Immune Response Against COVID-19 Through Vaccination in Hemodialysis Patients

    doi: 10.3390/vaccines13020170

    Figure Lengend Snippet: Antibody titers from the first and second blood samples by the participants’ demographics.

    Article Snippet: NAb was measured using the GenScript SARS-CoV-2 cPASS surrogate virus neutralization test (sVNT) kit (Genscript Biotech Corporation, Piscataway, NJ, USA) and spike-specific immunoglobulin G (IgG) was measured with the Euroimmun anti-SARS-CoV-2 IgG enzyme-linked immunosorbent assay (ELISA) (Euroimmun, Lübeck, Germany).

    Techniques: Infection, Sampling

    Locally estimated scatterplot smoothing curve based on data from the first blood sample collection, illustrating the relationship of antibody levels as follows: ( A – C ) inhibition rates (%) for the surrogate virus neutralization test (sVNT) against the wild-type (WT) strain, ( D – F ) inhibition rates (%) against the Omicron variant, and ( G – I ) IgG levels. The curves are plotted against the number of days since COVID-19 infection ( A , D , G ), the last vaccination ( B , E , H ), and the last exposure to COVID-19 ( C , F , I ). The blue line represents the regression line, and the shaded gray area indicates the 95% confidence interval.

    Journal: Vaccines

    Article Title: The Humoral Immune Response Against COVID-19 Through Vaccination in Hemodialysis Patients

    doi: 10.3390/vaccines13020170

    Figure Lengend Snippet: Locally estimated scatterplot smoothing curve based on data from the first blood sample collection, illustrating the relationship of antibody levels as follows: ( A – C ) inhibition rates (%) for the surrogate virus neutralization test (sVNT) against the wild-type (WT) strain, ( D – F ) inhibition rates (%) against the Omicron variant, and ( G – I ) IgG levels. The curves are plotted against the number of days since COVID-19 infection ( A , D , G ), the last vaccination ( B , E , H ), and the last exposure to COVID-19 ( C , F , I ). The blue line represents the regression line, and the shaded gray area indicates the 95% confidence interval.

    Article Snippet: NAb was measured using the GenScript SARS-CoV-2 cPASS surrogate virus neutralization test (sVNT) kit (Genscript Biotech Corporation, Piscataway, NJ, USA) and spike-specific immunoglobulin G (IgG) was measured with the Euroimmun anti-SARS-CoV-2 IgG enzyme-linked immunosorbent assay (ELISA) (Euroimmun, Lübeck, Germany).

    Techniques: Inhibition, Virus, Neutralization, Variant Assay, Infection

    Locally estimated scatterplot smoothing curve based on data from the second blood sample collection, illustrating the relationship of antibody levels as follows: ( A – C ) inhibition rates (%) for the surrogate virus neutralization test (sVNT) against the wild-type (WT) strain, ( D – F ) inhibition rates (%) against the Omicron variant, and ( G – I ) IgG levels. The curves are plotted against the number of days since COVID-19 infection ( A , D , G ), the last vaccination ( B , E , H ), and the last exposure to COVID-19 ( C , F , I ). The blue line represents the regression line, and the shaded gray area indicates the 95% confidence interval.

    Journal: Vaccines

    Article Title: The Humoral Immune Response Against COVID-19 Through Vaccination in Hemodialysis Patients

    doi: 10.3390/vaccines13020170

    Figure Lengend Snippet: Locally estimated scatterplot smoothing curve based on data from the second blood sample collection, illustrating the relationship of antibody levels as follows: ( A – C ) inhibition rates (%) for the surrogate virus neutralization test (sVNT) against the wild-type (WT) strain, ( D – F ) inhibition rates (%) against the Omicron variant, and ( G – I ) IgG levels. The curves are plotted against the number of days since COVID-19 infection ( A , D , G ), the last vaccination ( B , E , H ), and the last exposure to COVID-19 ( C , F , I ). The blue line represents the regression line, and the shaded gray area indicates the 95% confidence interval.

    Article Snippet: NAb was measured using the GenScript SARS-CoV-2 cPASS surrogate virus neutralization test (sVNT) kit (Genscript Biotech Corporation, Piscataway, NJ, USA) and spike-specific immunoglobulin G (IgG) was measured with the Euroimmun anti-SARS-CoV-2 IgG enzyme-linked immunosorbent assay (ELISA) (Euroimmun, Lübeck, Germany).

    Techniques: Inhibition, Virus, Neutralization, Variant Assay, Infection

    Peripheral blood samples obtained from the patient on the days indicated were tested by the quantitative Abbott Anti-RBD-CMIA (a) and the GenScript cPass sVNT (b) . Antibody levels detected by Anti-RBD-CMIA and sVNT are given as arbitrary units (AU)/mL, cut-off ≥50 AU/mL, and signal reduction (% inhibition, cut-off >30%) as compared to the negative control. The GenScript cPass sVNT was performed with technical duplicates at a serum dilution of 1:20. The cut-off of the sVNT is indicated by the horizontal dotted line. (c) Qualitative results of the Mikrogen line blot testing for Anti-N IgG, as well as Anti-S1 and Anti-RBD IgM and IgG, are indicated as follows: open squares: non-reactive, grey squares: reactive below cut-off, black squares: reactive above cut-off. Administration of bamlanivimab (B), first vaccination (V) and therapy with sotrovimab (S) is indicated by vertical dotted lines.

    Journal: PLOS Pathogens

    Article Title: Characterisation of the antibody-mediated selective pressure driving intra-host evolution of SARS-CoV-2 in prolonged infection

    doi: 10.1371/journal.ppat.1012624

    Figure Lengend Snippet: Peripheral blood samples obtained from the patient on the days indicated were tested by the quantitative Abbott Anti-RBD-CMIA (a) and the GenScript cPass sVNT (b) . Antibody levels detected by Anti-RBD-CMIA and sVNT are given as arbitrary units (AU)/mL, cut-off ≥50 AU/mL, and signal reduction (% inhibition, cut-off >30%) as compared to the negative control. The GenScript cPass sVNT was performed with technical duplicates at a serum dilution of 1:20. The cut-off of the sVNT is indicated by the horizontal dotted line. (c) Qualitative results of the Mikrogen line blot testing for Anti-N IgG, as well as Anti-S1 and Anti-RBD IgM and IgG, are indicated as follows: open squares: non-reactive, grey squares: reactive below cut-off, black squares: reactive above cut-off. Administration of bamlanivimab (B), first vaccination (V) and therapy with sotrovimab (S) is indicated by vertical dotted lines.

    Article Snippet: The commercial surrogate virus neutralisation test cPass (GenScript Biotech) was used to quantify levels of antibodies inhibiting the binding of the RBD to ACE2 [ , ].

    Techniques: Inhibition, Negative Control