coxsackievirus b4 antiserum  (ATCC)


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    ATCC coxsackievirus b4 antiserum

    Coxsackievirus B4 Antiserum, supplied by ATCC, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    1) Product Images from "Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination"

    Article Title: Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination

    Journal: iScience

    doi: 10.1016/j.isci.2022.105070


    Figure Legend Snippet:

    Techniques Used: Infection, Recombinant, Mutagenesis, Software

    coxsackievirus b4 antiserum  (ATCC)


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    ATCC coxsackievirus b4 antiserum

    Coxsackievirus B4 Antiserum, supplied by ATCC, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/coxsackievirus b4 antiserum/product/ATCC
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    1) Product Images from "Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination"

    Article Title: Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination

    Journal: iScience

    doi: 10.1016/j.isci.2022.105070


    Figure Legend Snippet:

    Techniques Used: Infection, Recombinant, Mutagenesis, Software

    human coxsackievirus b4  (ATCC)


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    ATCC human coxsackievirus b4
    Human Coxsackievirus B4, supplied by ATCC, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    hrv b4  (ATCC)


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    ATCC hrv b4
    Hrv B4, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    strain j v b  (ATCC)


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    ATCC strain j v b
    Strain J V B, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    coxsackievirus b4  (ATCC)


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    ATCC coxsackievirus b4
    Coxsackievirus B4, supplied by ATCC, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    coxsackievirus b4  (ATCC)


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    ATCC coxsackievirus b4
    Coxsackievirus B4, supplied by ATCC, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    strain j v b  (ATCC)


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    ATCC strain j v b
    Strain J V B, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    hek293t cells  (ATCC)


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    ATCC hek293t cells
    Hek293t Cells, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    human coxsackievirus b4 jvb strain  (ATCC)


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    ATCC human coxsackievirus b4 jvb strain
    <t>CVB4</t> Infection Causes URI Loss and Affects β Cell Function and Identity (A) Immunofluorescence (IF) of insulin and glucagon from human islet xenografts in CVB4- or mock-infected mice. (B and C) Quantification of the proportion of insulin (B)- and glucagon (C)-positive cells. At least 100 cells in the pancreatic grafts were counted per field, with up to 5 fields per sample (n = 10 and 7). (D) Immunohistochemistry (IHC) of PDX1 from CVB4-infected human islet xenografts in mice. The dotted outlines represent the limit between the kidney and the human graft. (E) Quantification of PDX1 + cells (n = 10 and 7). (F) IHC of URI from CVB4- or mock-infected human islet xenografts in mice. (G) Quantification of URI staining intensity (n = 10 and 7). (H) Western blot (WB) of URI, PDX1, and vinculin in CVB4- or mock-infected primary human islets (representative blot from 2 donors). (I) IF of viral protein 1 (VP1) and PDX1 in INS-1E cells infected with CVB4 (or inactivated CVB4). Asterisk denotes CVB4-infected cells. (J) Quantification of PDX1 + INS-1E cells infected with CVB4 or inactivated CVB4. At least 100 cells per field and 3 fields per samples were counted (N = 3). (K) Quantification of PDX1 nuclear-positive cells from VP1 + cells (VP1) and VP1 − cells (NO VP1) in CVB4-infected INS-1E cells. At least 100 cells per field and 3 fields per sample were counted (N = 3). (L) WB of URI, PDX1, caspase-3, and vinculin in INS-1 cells infected with CVB4 (MOI 5, 0.5, 0.05, and 0.005) or inactivated CVB. Data are means ± SEMs. Statistical analysis done using Student’s t test. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001. Scale bars, 50 μm in (D) and (F); 25 μm in (A) and (I).
    Human Coxsackievirus B4 Jvb Strain, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 99 stars, based on 1 article reviews
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    1) Product Images from "Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing"

    Article Title: Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing

    Journal: Cell Reports Medicine

    doi: 10.1016/j.xcrm.2020.100125

    CVB4 Infection Causes URI Loss and Affects β Cell Function and Identity (A) Immunofluorescence (IF) of insulin and glucagon from human islet xenografts in CVB4- or mock-infected mice. (B and C) Quantification of the proportion of insulin (B)- and glucagon (C)-positive cells. At least 100 cells in the pancreatic grafts were counted per field, with up to 5 fields per sample (n = 10 and 7). (D) Immunohistochemistry (IHC) of PDX1 from CVB4-infected human islet xenografts in mice. The dotted outlines represent the limit between the kidney and the human graft. (E) Quantification of PDX1 + cells (n = 10 and 7). (F) IHC of URI from CVB4- or mock-infected human islet xenografts in mice. (G) Quantification of URI staining intensity (n = 10 and 7). (H) Western blot (WB) of URI, PDX1, and vinculin in CVB4- or mock-infected primary human islets (representative blot from 2 donors). (I) IF of viral protein 1 (VP1) and PDX1 in INS-1E cells infected with CVB4 (or inactivated CVB4). Asterisk denotes CVB4-infected cells. (J) Quantification of PDX1 + INS-1E cells infected with CVB4 or inactivated CVB4. At least 100 cells per field and 3 fields per samples were counted (N = 3). (K) Quantification of PDX1 nuclear-positive cells from VP1 + cells (VP1) and VP1 − cells (NO VP1) in CVB4-infected INS-1E cells. At least 100 cells per field and 3 fields per sample were counted (N = 3). (L) WB of URI, PDX1, caspase-3, and vinculin in INS-1 cells infected with CVB4 (MOI 5, 0.5, 0.05, and 0.005) or inactivated CVB. Data are means ± SEMs. Statistical analysis done using Student’s t test. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001. Scale bars, 50 μm in (D) and (F); 25 μm in (A) and (I).
    Figure Legend Snippet: CVB4 Infection Causes URI Loss and Affects β Cell Function and Identity (A) Immunofluorescence (IF) of insulin and glucagon from human islet xenografts in CVB4- or mock-infected mice. (B and C) Quantification of the proportion of insulin (B)- and glucagon (C)-positive cells. At least 100 cells in the pancreatic grafts were counted per field, with up to 5 fields per sample (n = 10 and 7). (D) Immunohistochemistry (IHC) of PDX1 from CVB4-infected human islet xenografts in mice. The dotted outlines represent the limit between the kidney and the human graft. (E) Quantification of PDX1 + cells (n = 10 and 7). (F) IHC of URI from CVB4- or mock-infected human islet xenografts in mice. (G) Quantification of URI staining intensity (n = 10 and 7). (H) Western blot (WB) of URI, PDX1, and vinculin in CVB4- or mock-infected primary human islets (representative blot from 2 donors). (I) IF of viral protein 1 (VP1) and PDX1 in INS-1E cells infected with CVB4 (or inactivated CVB4). Asterisk denotes CVB4-infected cells. (J) Quantification of PDX1 + INS-1E cells infected with CVB4 or inactivated CVB4. At least 100 cells per field and 3 fields per samples were counted (N = 3). (K) Quantification of PDX1 nuclear-positive cells from VP1 + cells (VP1) and VP1 − cells (NO VP1) in CVB4-infected INS-1E cells. At least 100 cells per field and 3 fields per sample were counted (N = 3). (L) WB of URI, PDX1, caspase-3, and vinculin in INS-1 cells infected with CVB4 (MOI 5, 0.5, 0.05, and 0.005) or inactivated CVB. Data are means ± SEMs. Statistical analysis done using Student’s t test. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001. Scale bars, 50 μm in (D) and (F); 25 μm in (A) and (I).

    Techniques Used: Infection, Cell Function Assay, Immunofluorescence, Immunohistochemistry, Staining, Western Blot

    URI Controls PDX1 Expression and β Cell Identity in Mice (A) WB of 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases, normalized to GLUT2 expression. (B) qRT-PCR of indicated mRNA from 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases, normalized to β-actin mRNA expression (n = 6 and 5). (C) IF of insulin and PXD1 in 2-day-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases (post-natal). (D–F) Quantification of PDX1 nuclear expression (D), percentage of PDX1 + cells (E), and insulin expression (F) in 2-day-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases (n = 6 and 7). (G) Pancreas to body weight of 2-day-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre mice (n = 5). (H) Area of pancreatic islets per field in 2-day-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases (n = 6 and 7). (I) Fasting glucose levels of 2-day-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre mice (n = 7 and 8). (J) Fasting glucagon levels of 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre mice (n = 12 and 11). (K) Confocal IF of insulin (red) and glucagon (green) in 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases. (L) Quantification of polyhormonal cells per field in 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases. Up to 5 fields in 1 cut per sample were examined (n = 5 and 6). (M) Confocal IF of insulin and glucagon from CVB4-infected human pancreas xenografts in mice. Asterisks represent bihormonal cells. (N) Quantification of bihormonal—insulin and glucagon—positive cells. Up to 5 fields in 1 cut per sample were examined (n = 10 and 7). Data are means ± SEMs. Statistical analysis done using Student’s t test. ∗p < 0.05; ∗∗p < 0.01. Scale bar, 25 μm in (C) and 50 μm in (K) and (M).
    Figure Legend Snippet: URI Controls PDX1 Expression and β Cell Identity in Mice (A) WB of 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases, normalized to GLUT2 expression. (B) qRT-PCR of indicated mRNA from 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases, normalized to β-actin mRNA expression (n = 6 and 5). (C) IF of insulin and PXD1 in 2-day-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases (post-natal). (D–F) Quantification of PDX1 nuclear expression (D), percentage of PDX1 + cells (E), and insulin expression (F) in 2-day-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases (n = 6 and 7). (G) Pancreas to body weight of 2-day-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre mice (n = 5). (H) Area of pancreatic islets per field in 2-day-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases (n = 6 and 7). (I) Fasting glucose levels of 2-day-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre mice (n = 7 and 8). (J) Fasting glucagon levels of 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre mice (n = 12 and 11). (K) Confocal IF of insulin (red) and glucagon (green) in 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases. (L) Quantification of polyhormonal cells per field in 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases. Up to 5 fields in 1 cut per sample were examined (n = 5 and 6). (M) Confocal IF of insulin and glucagon from CVB4-infected human pancreas xenografts in mice. Asterisks represent bihormonal cells. (N) Quantification of bihormonal—insulin and glucagon—positive cells. Up to 5 fields in 1 cut per sample were examined (n = 10 and 7). Data are means ± SEMs. Statistical analysis done using Student’s t test. ∗p < 0.05; ∗∗p < 0.01. Scale bar, 25 μm in (C) and 50 μm in (K) and (M).

    Techniques Used: Expressing, Quantitative RT-PCR, Infection

    Procainamide-Mediated DNMT1 Inhibition Reinstates PDX1 Expression and Glucose Tolerance by Reducing Hypermethylation of Pdx1 Promoter in Mice (A) Glucose tolerance test in Pdx1-cre and Uri1 flox/flox ; Pdx1-cre males treated or not treated with procainamide (n = 6 and 5). (B) IF of 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases treated or not treated with procainamide and stained for insulin and PXD1. (C and D) Quantification of nuclear PDX1 expression (C) and percentage of positive cells (D) in 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases treated or not treated with procainamide (n = 5, 6, 6, and 7). (E) WB of URI, PDX1, and vinculin in 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases treated or not treated with procainamide. (F) qRT-PCR of Pdx1 in Uri1 flox/flox ; Pdx1-cre males treated or not treated with procainamide (n = 6). (G) Percentage of methylation in 2 different sites of Pdx1 promotor in Uri1 flox/flox ; Pdx1-cre males treated or not treated with procainamide (n = 5 and 4). (H) IHC of DNMT1 in CVB4-infected human pancreas xenografts in mice. Dashed lines denote endocrine compartment. (I) Quantification of DNMT1 + cells (n = 5 and 6). Data are means ± SEMs. Statistical analysis done using Student’s t test and 2-way ANOVA. ∗p < 0.05. Scale bar, 50 μm in (B) and (H).
    Figure Legend Snippet: Procainamide-Mediated DNMT1 Inhibition Reinstates PDX1 Expression and Glucose Tolerance by Reducing Hypermethylation of Pdx1 Promoter in Mice (A) Glucose tolerance test in Pdx1-cre and Uri1 flox/flox ; Pdx1-cre males treated or not treated with procainamide (n = 6 and 5). (B) IF of 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases treated or not treated with procainamide and stained for insulin and PXD1. (C and D) Quantification of nuclear PDX1 expression (C) and percentage of positive cells (D) in 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases treated or not treated with procainamide (n = 5, 6, 6, and 7). (E) WB of URI, PDX1, and vinculin in 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases treated or not treated with procainamide. (F) qRT-PCR of Pdx1 in Uri1 flox/flox ; Pdx1-cre males treated or not treated with procainamide (n = 6). (G) Percentage of methylation in 2 different sites of Pdx1 promotor in Uri1 flox/flox ; Pdx1-cre males treated or not treated with procainamide (n = 5 and 4). (H) IHC of DNMT1 in CVB4-infected human pancreas xenografts in mice. Dashed lines denote endocrine compartment. (I) Quantification of DNMT1 + cells (n = 5 and 6). Data are means ± SEMs. Statistical analysis done using Student’s t test and 2-way ANOVA. ∗p < 0.05. Scale bar, 50 μm in (B) and (H).

    Techniques Used: Inhibition, Expressing, Staining, Quantitative RT-PCR, Methylation, Infection


    Figure Legend Snippet:

    Techniques Used: Blocking Assay, Recombinant, Electrophoresis, Bradford Protein Assay, Protease Inhibitor, Electron Microscopy, Avidin-Biotin Assay, Plasmid Preparation, Activity Assay, Fluorescence, Transfection, In Situ, Labeling, Gel Extraction, Purification, Enzyme-linked Immunosorbent Assay, Sequencing, Software

    vr 184  (ATCC)


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    ATCC vr 184
    Vr 184, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    ATCC coxsackievirus b4 antiserum

    Coxsackievirus B4 Antiserum, supplied by ATCC, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    ATCC human coxsackievirus b4

    Human Coxsackievirus B4, supplied by ATCC, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    hrv b4  (ATCC)
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    ATCC hrv b4

    Hrv B4, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    ATCC strain j v b

    Strain J V B, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    ATCC coxsackievirus b4

    Coxsackievirus B4, supplied by ATCC, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    ATCC hek293t cells

    Hek293t Cells, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    99
    ATCC human coxsackievirus b4 jvb strain
    <t>CVB4</t> Infection Causes URI Loss and Affects β Cell Function and Identity (A) Immunofluorescence (IF) of insulin and glucagon from human islet xenografts in CVB4- or mock-infected mice. (B and C) Quantification of the proportion of insulin (B)- and glucagon (C)-positive cells. At least 100 cells in the pancreatic grafts were counted per field, with up to 5 fields per sample (n = 10 and 7). (D) Immunohistochemistry (IHC) of PDX1 from CVB4-infected human islet xenografts in mice. The dotted outlines represent the limit between the kidney and the human graft. (E) Quantification of PDX1 + cells (n = 10 and 7). (F) IHC of URI from CVB4- or mock-infected human islet xenografts in mice. (G) Quantification of URI staining intensity (n = 10 and 7). (H) Western blot (WB) of URI, PDX1, and vinculin in CVB4- or mock-infected primary human islets (representative blot from 2 donors). (I) IF of viral protein 1 (VP1) and PDX1 in INS-1E cells infected with CVB4 (or inactivated CVB4). Asterisk denotes CVB4-infected cells. (J) Quantification of PDX1 + INS-1E cells infected with CVB4 or inactivated CVB4. At least 100 cells per field and 3 fields per samples were counted (N = 3). (K) Quantification of PDX1 nuclear-positive cells from VP1 + cells (VP1) and VP1 − cells (NO VP1) in CVB4-infected INS-1E cells. At least 100 cells per field and 3 fields per sample were counted (N = 3). (L) WB of URI, PDX1, caspase-3, and vinculin in INS-1 cells infected with CVB4 (MOI 5, 0.5, 0.05, and 0.005) or inactivated CVB. Data are means ± SEMs. Statistical analysis done using Student’s t test. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001. Scale bars, 50 μm in (D) and (F); 25 μm in (A) and (I).
    Human Coxsackievirus B4 Jvb Strain, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human coxsackievirus b4 jvb strain/product/ATCC
    Average 99 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    human coxsackievirus b4 jvb strain - by Bioz Stars, 2024-04
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    vr 184  (ATCC)
    99
    ATCC vr 184
    <t>CVB4</t> Infection Causes URI Loss and Affects β Cell Function and Identity (A) Immunofluorescence (IF) of insulin and glucagon from human islet xenografts in CVB4- or mock-infected mice. (B and C) Quantification of the proportion of insulin (B)- and glucagon (C)-positive cells. At least 100 cells in the pancreatic grafts were counted per field, with up to 5 fields per sample (n = 10 and 7). (D) Immunohistochemistry (IHC) of PDX1 from CVB4-infected human islet xenografts in mice. The dotted outlines represent the limit between the kidney and the human graft. (E) Quantification of PDX1 + cells (n = 10 and 7). (F) IHC of URI from CVB4- or mock-infected human islet xenografts in mice. (G) Quantification of URI staining intensity (n = 10 and 7). (H) Western blot (WB) of URI, PDX1, and vinculin in CVB4- or mock-infected primary human islets (representative blot from 2 donors). (I) IF of viral protein 1 (VP1) and PDX1 in INS-1E cells infected with CVB4 (or inactivated CVB4). Asterisk denotes CVB4-infected cells. (J) Quantification of PDX1 + INS-1E cells infected with CVB4 or inactivated CVB4. At least 100 cells per field and 3 fields per samples were counted (N = 3). (K) Quantification of PDX1 nuclear-positive cells from VP1 + cells (VP1) and VP1 − cells (NO VP1) in CVB4-infected INS-1E cells. At least 100 cells per field and 3 fields per sample were counted (N = 3). (L) WB of URI, PDX1, caspase-3, and vinculin in INS-1 cells infected with CVB4 (MOI 5, 0.5, 0.05, and 0.005) or inactivated CVB. Data are means ± SEMs. Statistical analysis done using Student’s t test. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001. Scale bars, 50 μm in (D) and (F); 25 μm in (A) and (I).
    Vr 184, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/vr 184/product/ATCC
    Average 99 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    vr 184 - by Bioz Stars, 2024-04
    99/100 stars
      Buy from Supplier

    Image Search Results


    Journal: iScience

    Article Title: Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination

    doi: 10.1016/j.isci.2022.105070

    Figure Lengend Snippet:

    Article Snippet: Coxsackievirus B4 antiserum , ATCC , V-031-501-560.

    Techniques: Infection, Recombinant, Mutagenesis, Software

    CVB4 Infection Causes URI Loss and Affects β Cell Function and Identity (A) Immunofluorescence (IF) of insulin and glucagon from human islet xenografts in CVB4- or mock-infected mice. (B and C) Quantification of the proportion of insulin (B)- and glucagon (C)-positive cells. At least 100 cells in the pancreatic grafts were counted per field, with up to 5 fields per sample (n = 10 and 7). (D) Immunohistochemistry (IHC) of PDX1 from CVB4-infected human islet xenografts in mice. The dotted outlines represent the limit between the kidney and the human graft. (E) Quantification of PDX1 + cells (n = 10 and 7). (F) IHC of URI from CVB4- or mock-infected human islet xenografts in mice. (G) Quantification of URI staining intensity (n = 10 and 7). (H) Western blot (WB) of URI, PDX1, and vinculin in CVB4- or mock-infected primary human islets (representative blot from 2 donors). (I) IF of viral protein 1 (VP1) and PDX1 in INS-1E cells infected with CVB4 (or inactivated CVB4). Asterisk denotes CVB4-infected cells. (J) Quantification of PDX1 + INS-1E cells infected with CVB4 or inactivated CVB4. At least 100 cells per field and 3 fields per samples were counted (N = 3). (K) Quantification of PDX1 nuclear-positive cells from VP1 + cells (VP1) and VP1 − cells (NO VP1) in CVB4-infected INS-1E cells. At least 100 cells per field and 3 fields per sample were counted (N = 3). (L) WB of URI, PDX1, caspase-3, and vinculin in INS-1 cells infected with CVB4 (MOI 5, 0.5, 0.05, and 0.005) or inactivated CVB. Data are means ± SEMs. Statistical analysis done using Student’s t test. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001. Scale bars, 50 μm in (D) and (F); 25 μm in (A) and (I).

    Journal: Cell Reports Medicine

    Article Title: Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing

    doi: 10.1016/j.xcrm.2020.100125

    Figure Lengend Snippet: CVB4 Infection Causes URI Loss and Affects β Cell Function and Identity (A) Immunofluorescence (IF) of insulin and glucagon from human islet xenografts in CVB4- or mock-infected mice. (B and C) Quantification of the proportion of insulin (B)- and glucagon (C)-positive cells. At least 100 cells in the pancreatic grafts were counted per field, with up to 5 fields per sample (n = 10 and 7). (D) Immunohistochemistry (IHC) of PDX1 from CVB4-infected human islet xenografts in mice. The dotted outlines represent the limit between the kidney and the human graft. (E) Quantification of PDX1 + cells (n = 10 and 7). (F) IHC of URI from CVB4- or mock-infected human islet xenografts in mice. (G) Quantification of URI staining intensity (n = 10 and 7). (H) Western blot (WB) of URI, PDX1, and vinculin in CVB4- or mock-infected primary human islets (representative blot from 2 donors). (I) IF of viral protein 1 (VP1) and PDX1 in INS-1E cells infected with CVB4 (or inactivated CVB4). Asterisk denotes CVB4-infected cells. (J) Quantification of PDX1 + INS-1E cells infected with CVB4 or inactivated CVB4. At least 100 cells per field and 3 fields per samples were counted (N = 3). (K) Quantification of PDX1 nuclear-positive cells from VP1 + cells (VP1) and VP1 − cells (NO VP1) in CVB4-infected INS-1E cells. At least 100 cells per field and 3 fields per sample were counted (N = 3). (L) WB of URI, PDX1, caspase-3, and vinculin in INS-1 cells infected with CVB4 (MOI 5, 0.5, 0.05, and 0.005) or inactivated CVB. Data are means ± SEMs. Statistical analysis done using Student’s t test. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001. Scale bars, 50 μm in (D) and (F); 25 μm in (A) and (I).

    Article Snippet: Human Coxsackievirus B4 JVB strain was purchased from the American Type Culture Collection (ATCC VR-184#), was propagated in HEK293T cells and culture supernatants containing the viruses kept at −80°C.

    Techniques: Infection, Cell Function Assay, Immunofluorescence, Immunohistochemistry, Staining, Western Blot

    URI Controls PDX1 Expression and β Cell Identity in Mice (A) WB of 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases, normalized to GLUT2 expression. (B) qRT-PCR of indicated mRNA from 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases, normalized to β-actin mRNA expression (n = 6 and 5). (C) IF of insulin and PXD1 in 2-day-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases (post-natal). (D–F) Quantification of PDX1 nuclear expression (D), percentage of PDX1 + cells (E), and insulin expression (F) in 2-day-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases (n = 6 and 7). (G) Pancreas to body weight of 2-day-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre mice (n = 5). (H) Area of pancreatic islets per field in 2-day-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases (n = 6 and 7). (I) Fasting glucose levels of 2-day-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre mice (n = 7 and 8). (J) Fasting glucagon levels of 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre mice (n = 12 and 11). (K) Confocal IF of insulin (red) and glucagon (green) in 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases. (L) Quantification of polyhormonal cells per field in 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases. Up to 5 fields in 1 cut per sample were examined (n = 5 and 6). (M) Confocal IF of insulin and glucagon from CVB4-infected human pancreas xenografts in mice. Asterisks represent bihormonal cells. (N) Quantification of bihormonal—insulin and glucagon—positive cells. Up to 5 fields in 1 cut per sample were examined (n = 10 and 7). Data are means ± SEMs. Statistical analysis done using Student’s t test. ∗p < 0.05; ∗∗p < 0.01. Scale bar, 25 μm in (C) and 50 μm in (K) and (M).

    Journal: Cell Reports Medicine

    Article Title: Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing

    doi: 10.1016/j.xcrm.2020.100125

    Figure Lengend Snippet: URI Controls PDX1 Expression and β Cell Identity in Mice (A) WB of 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases, normalized to GLUT2 expression. (B) qRT-PCR of indicated mRNA from 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases, normalized to β-actin mRNA expression (n = 6 and 5). (C) IF of insulin and PXD1 in 2-day-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases (post-natal). (D–F) Quantification of PDX1 nuclear expression (D), percentage of PDX1 + cells (E), and insulin expression (F) in 2-day-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases (n = 6 and 7). (G) Pancreas to body weight of 2-day-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre mice (n = 5). (H) Area of pancreatic islets per field in 2-day-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases (n = 6 and 7). (I) Fasting glucose levels of 2-day-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre mice (n = 7 and 8). (J) Fasting glucagon levels of 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre mice (n = 12 and 11). (K) Confocal IF of insulin (red) and glucagon (green) in 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases. (L) Quantification of polyhormonal cells per field in 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases. Up to 5 fields in 1 cut per sample were examined (n = 5 and 6). (M) Confocal IF of insulin and glucagon from CVB4-infected human pancreas xenografts in mice. Asterisks represent bihormonal cells. (N) Quantification of bihormonal—insulin and glucagon—positive cells. Up to 5 fields in 1 cut per sample were examined (n = 10 and 7). Data are means ± SEMs. Statistical analysis done using Student’s t test. ∗p < 0.05; ∗∗p < 0.01. Scale bar, 25 μm in (C) and 50 μm in (K) and (M).

    Article Snippet: Human Coxsackievirus B4 JVB strain was purchased from the American Type Culture Collection (ATCC VR-184#), was propagated in HEK293T cells and culture supernatants containing the viruses kept at −80°C.

    Techniques: Expressing, Quantitative RT-PCR, Infection

    Procainamide-Mediated DNMT1 Inhibition Reinstates PDX1 Expression and Glucose Tolerance by Reducing Hypermethylation of Pdx1 Promoter in Mice (A) Glucose tolerance test in Pdx1-cre and Uri1 flox/flox ; Pdx1-cre males treated or not treated with procainamide (n = 6 and 5). (B) IF of 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases treated or not treated with procainamide and stained for insulin and PXD1. (C and D) Quantification of nuclear PDX1 expression (C) and percentage of positive cells (D) in 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases treated or not treated with procainamide (n = 5, 6, 6, and 7). (E) WB of URI, PDX1, and vinculin in 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases treated or not treated with procainamide. (F) qRT-PCR of Pdx1 in Uri1 flox/flox ; Pdx1-cre males treated or not treated with procainamide (n = 6). (G) Percentage of methylation in 2 different sites of Pdx1 promotor in Uri1 flox/flox ; Pdx1-cre males treated or not treated with procainamide (n = 5 and 4). (H) IHC of DNMT1 in CVB4-infected human pancreas xenografts in mice. Dashed lines denote endocrine compartment. (I) Quantification of DNMT1 + cells (n = 5 and 6). Data are means ± SEMs. Statistical analysis done using Student’s t test and 2-way ANOVA. ∗p < 0.05. Scale bar, 50 μm in (B) and (H).

    Journal: Cell Reports Medicine

    Article Title: Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing

    doi: 10.1016/j.xcrm.2020.100125

    Figure Lengend Snippet: Procainamide-Mediated DNMT1 Inhibition Reinstates PDX1 Expression and Glucose Tolerance by Reducing Hypermethylation of Pdx1 Promoter in Mice (A) Glucose tolerance test in Pdx1-cre and Uri1 flox/flox ; Pdx1-cre males treated or not treated with procainamide (n = 6 and 5). (B) IF of 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases treated or not treated with procainamide and stained for insulin and PXD1. (C and D) Quantification of nuclear PDX1 expression (C) and percentage of positive cells (D) in 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases treated or not treated with procainamide (n = 5, 6, 6, and 7). (E) WB of URI, PDX1, and vinculin in 7-week-old Pdx1-cre and Uri1 flox/flox ; Pdx1-cre pancreases treated or not treated with procainamide. (F) qRT-PCR of Pdx1 in Uri1 flox/flox ; Pdx1-cre males treated or not treated with procainamide (n = 6). (G) Percentage of methylation in 2 different sites of Pdx1 promotor in Uri1 flox/flox ; Pdx1-cre males treated or not treated with procainamide (n = 5 and 4). (H) IHC of DNMT1 in CVB4-infected human pancreas xenografts in mice. Dashed lines denote endocrine compartment. (I) Quantification of DNMT1 + cells (n = 5 and 6). Data are means ± SEMs. Statistical analysis done using Student’s t test and 2-way ANOVA. ∗p < 0.05. Scale bar, 50 μm in (B) and (H).

    Article Snippet: Human Coxsackievirus B4 JVB strain was purchased from the American Type Culture Collection (ATCC VR-184#), was propagated in HEK293T cells and culture supernatants containing the viruses kept at −80°C.

    Techniques: Inhibition, Expressing, Staining, Quantitative RT-PCR, Methylation, Infection

    Journal: Cell Reports Medicine

    Article Title: Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing

    doi: 10.1016/j.xcrm.2020.100125

    Figure Lengend Snippet:

    Article Snippet: Human Coxsackievirus B4 JVB strain was purchased from the American Type Culture Collection (ATCC VR-184#), was propagated in HEK293T cells and culture supernatants containing the viruses kept at −80°C.

    Techniques: Blocking Assay, Recombinant, Electrophoresis, Bradford Protein Assay, Protease Inhibitor, Electron Microscopy, Avidin-Biotin Assay, Plasmid Preparation, Activity Assay, Fluorescence, Transfection, In Situ, Labeling, Gel Extraction, Purification, Enzyme-linked Immunosorbent Assay, Sequencing, Software