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U73122 PLC compound c
Apelin-13 ameliorates MGO-induced apoptosis through AMPK pathway in HUVECs. Cells pretreated with wortmannin (50 nM), U73122 (1 µM), and <t>compound</t> C (1 µM) were stimulated with 100 µM MGO for 24 h in the presence or absence of 1 µM apelin-13. ( A ) HUVECs were lysed and then applied for Western blotting analysis. Protein level amounts were determined by immunoblotting with anti-PARP-1 and anti-caspase-3 antibodies. The graph shows the densitometric quantification of Western blot bands. ** p
Compound C, supplied by U73122 PLC, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 86 stars, based on 1 article reviews
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compound c - by Bioz Stars, 2021-05
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1) Product Images from "Apelin-13 Inhibits Methylglyoxal-Induced Unfolded Protein Responses and Endothelial Dysfunction via Regulating AMPK Pathway"

Article Title: Apelin-13 Inhibits Methylglyoxal-Induced Unfolded Protein Responses and Endothelial Dysfunction via Regulating AMPK Pathway

Journal: International Journal of Molecular Sciences

doi: 10.3390/ijms21114069

Apelin-13 ameliorates MGO-induced apoptosis through AMPK pathway in HUVECs. Cells pretreated with wortmannin (50 nM), U73122 (1 µM), and compound C (1 µM) were stimulated with 100 µM MGO for 24 h in the presence or absence of 1 µM apelin-13. ( A ) HUVECs were lysed and then applied for Western blotting analysis. Protein level amounts were determined by immunoblotting with anti-PARP-1 and anti-caspase-3 antibodies. The graph shows the densitometric quantification of Western blot bands. ** p
Figure Legend Snippet: Apelin-13 ameliorates MGO-induced apoptosis through AMPK pathway in HUVECs. Cells pretreated with wortmannin (50 nM), U73122 (1 µM), and compound C (1 µM) were stimulated with 100 µM MGO for 24 h in the presence or absence of 1 µM apelin-13. ( A ) HUVECs were lysed and then applied for Western blotting analysis. Protein level amounts were determined by immunoblotting with anti-PARP-1 and anti-caspase-3 antibodies. The graph shows the densitometric quantification of Western blot bands. ** p

Techniques Used: Western Blot

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Inhibition:

Article Title: Apelin-13 Inhibits Methylglyoxal-Induced Unfolded Protein Responses and Endothelial Dysfunction via Regulating AMPK Pathway
Article Snippet: In addition, MGO-induced ATF4 and CHOP expression was diminished by NAC ( C). .. Apelin-13 Ameliorates MGO-Induced Endothelial Apoptosis through AMPK PathwayTo identify the molecular mechanism by which apelin-13 regulates the inhibition of MGO-induced apoptosis, HUVECs were pretreated with wortmannin (PI3K inhibitor), U73122 (PLC inhibitor), and compound C (AMPK inhibitor) upon stimulation with MGO in the presence of apelin-13. .. Apelin-13 Ameliorates MGO-Induced Endothelial Apoptosis through AMPK PathwayTo identify the molecular mechanism by which apelin-13 regulates the inhibition of MGO-induced apoptosis, HUVECs were pretreated with wortmannin (PI3K inhibitor), U73122 (PLC inhibitor), and compound C (AMPK inhibitor) upon stimulation with MGO in the presence of apelin-13.

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    U73122 PLC compound c
    Apelin-13 ameliorates MGO-induced apoptosis through AMPK pathway in HUVECs. Cells pretreated with wortmannin (50 nM), U73122 (1 µM), and <t>compound</t> C (1 µM) were stimulated with 100 µM MGO for 24 h in the presence or absence of 1 µM apelin-13. ( A ) HUVECs were lysed and then applied for Western blotting analysis. Protein level amounts were determined by immunoblotting with anti-PARP-1 and anti-caspase-3 antibodies. The graph shows the densitometric quantification of Western blot bands. ** p
    Compound C, supplied by U73122 PLC, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/compound c/product/U73122 PLC
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    compound c - by Bioz Stars, 2021-05
    86/100 stars
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    Apelin-13 ameliorates MGO-induced apoptosis through AMPK pathway in HUVECs. Cells pretreated with wortmannin (50 nM), U73122 (1 µM), and compound C (1 µM) were stimulated with 100 µM MGO for 24 h in the presence or absence of 1 µM apelin-13. ( A ) HUVECs were lysed and then applied for Western blotting analysis. Protein level amounts were determined by immunoblotting with anti-PARP-1 and anti-caspase-3 antibodies. The graph shows the densitometric quantification of Western blot bands. ** p

    Journal: International Journal of Molecular Sciences

    Article Title: Apelin-13 Inhibits Methylglyoxal-Induced Unfolded Protein Responses and Endothelial Dysfunction via Regulating AMPK Pathway

    doi: 10.3390/ijms21114069

    Figure Lengend Snippet: Apelin-13 ameliorates MGO-induced apoptosis through AMPK pathway in HUVECs. Cells pretreated with wortmannin (50 nM), U73122 (1 µM), and compound C (1 µM) were stimulated with 100 µM MGO for 24 h in the presence or absence of 1 µM apelin-13. ( A ) HUVECs were lysed and then applied for Western blotting analysis. Protein level amounts were determined by immunoblotting with anti-PARP-1 and anti-caspase-3 antibodies. The graph shows the densitometric quantification of Western blot bands. ** p

    Article Snippet: Apelin-13 Ameliorates MGO-Induced Endothelial Apoptosis through AMPK PathwayTo identify the molecular mechanism by which apelin-13 regulates the inhibition of MGO-induced apoptosis, HUVECs were pretreated with wortmannin (PI3K inhibitor), U73122 (PLC inhibitor), and compound C (AMPK inhibitor) upon stimulation with MGO in the presence of apelin-13.

    Techniques: Western Blot