cnqx  (Alomone Labs)


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    Alomone Labs cnqx
    a,c,f,i,l, Chemical structure of <t>CNQX,</t> <t>Memantine,</t> <t>CGP39551,</t> CPP and L-Aminoadipic acid (L-AA). b , Summary data showing 10 μM CNQX, an AMPA receptor antagonist, had no effect on I ASICs . n =11 cells. d , e , Memantine, an open channel blocker of NMDA receptors, had no effect on I ASICs . n =15 cells ( d ) and 9 cells ( e ). g , h , j , k , 100 μM CGP39551 and CPP, competitive antagonists of NMDA receptors, had no effect on I ASICs and cannot block glutamateinduced potentiation of I ASICs . n =9 cells ( g ), 9 cells ( h ), 13 cells ( j ) and 14 cells ( k ). m , n , 100 μM L-AA, an agonist for NMDAR and metabotropic glutamate receptors (mGluRs), had no effect on I ASICs , however, can eliminate glutamate-induced potentiation of I ASICs . n =13 cells ( m ) and 13 cells ( n ). Data are mean±s.e.m.; two-tailed paired t -test ( b , d , g , j , m ); one-way ANOVA with Tukey post hoc correction ( e , h , k , n ). P values are indicated.
    Cnqx, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    1) Product Images from "Glutamate as a co-agonist for acid-sensing ion channels to aggravate ischemic brain damage"

    Article Title: Glutamate as a co-agonist for acid-sensing ion channels to aggravate ischemic brain damage

    Journal: bioRxiv

    doi: 10.1101/2024.02.17.580727

    a,c,f,i,l, Chemical structure of CNQX, Memantine, CGP39551, CPP and L-Aminoadipic acid (L-AA). b , Summary data showing 10 μM CNQX, an AMPA receptor antagonist, had no effect on I ASICs . n =11 cells. d , e , Memantine, an open channel blocker of NMDA receptors, had no effect on I ASICs . n =15 cells ( d ) and 9 cells ( e ). g , h , j , k , 100 μM CGP39551 and CPP, competitive antagonists of NMDA receptors, had no effect on I ASICs and cannot block glutamateinduced potentiation of I ASICs . n =9 cells ( g ), 9 cells ( h ), 13 cells ( j ) and 14 cells ( k ). m , n , 100 μM L-AA, an agonist for NMDAR and metabotropic glutamate receptors (mGluRs), had no effect on I ASICs , however, can eliminate glutamate-induced potentiation of I ASICs . n =13 cells ( m ) and 13 cells ( n ). Data are mean±s.e.m.; two-tailed paired t -test ( b , d , g , j , m ); one-way ANOVA with Tukey post hoc correction ( e , h , k , n ). P values are indicated.
    Figure Legend Snippet: a,c,f,i,l, Chemical structure of CNQX, Memantine, CGP39551, CPP and L-Aminoadipic acid (L-AA). b , Summary data showing 10 μM CNQX, an AMPA receptor antagonist, had no effect on I ASICs . n =11 cells. d , e , Memantine, an open channel blocker of NMDA receptors, had no effect on I ASICs . n =15 cells ( d ) and 9 cells ( e ). g , h , j , k , 100 μM CGP39551 and CPP, competitive antagonists of NMDA receptors, had no effect on I ASICs and cannot block glutamateinduced potentiation of I ASICs . n =9 cells ( g ), 9 cells ( h ), 13 cells ( j ) and 14 cells ( k ). m , n , 100 μM L-AA, an agonist for NMDAR and metabotropic glutamate receptors (mGluRs), had no effect on I ASICs , however, can eliminate glutamate-induced potentiation of I ASICs . n =13 cells ( m ) and 13 cells ( n ). Data are mean±s.e.m.; two-tailed paired t -test ( b , d , g , j , m ); one-way ANOVA with Tukey post hoc correction ( e , h , k , n ). P values are indicated.

    Techniques Used: Blocking Assay, Two Tailed Test

    cnqx  (Alomone Labs)


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    Alomone Labs cnqx
    Cnqx, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    cnqx  (Alomone Labs)


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    Alomone Labs cnqx
    A. The expression of ChR2-EYFP in OB mitral and tufted cells. B. Fluorescent OB output axons (LOT) within layer 1 of the NLOT. C. A biocytin-labeled cell (red), and the LOT within layer 1. Note that the LOT contacts the dendrite at its distal end. D. Example LOT-evoked EPSCs (top) and EPSPs (bottom). Gray traces show individual trials and black lines show the average response across trials. Red line shows EPSC obtained in the presence of <t>CNQX</t> <t>and</t> <t>APV.</t> Blue ticks indicate the timing of light pulses. E. Voltage dependence of an example LOT-evoked EPSC. Red cross indicates reversal potential. F. Box plots showing the distribution of EPSC amplitudes (at -70 mV holding potential) and reversal potentials of LOT inputs. n=25 cells and 8 cells for the amplitude and reversal, respectively. G. LOT-evoked action potentials are only triggered when the cell is depolarized with current injection. H. LOT-evoked dendritic spikes recorded under voltage clamp (top) and current clamp (bottom) conditions (from two different cells). 10 repetitions of the same stimulation are shown for each. In the voltage clamp mode, the cell was held at -20 mV. Note the all- or-none nature of the responses that is indicative of a regenerative process (red). I-J. Paired-pulse dynamics of LOT inputs into NLOT neurons. I. Example data from one neuron. J. Paired-pulse ratio as a function of the inter-pulse interval averaged across cells (n=4). Note that LOT inputs are facilitating at intervals that are less than 100 ms.
    Cnqx, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    1) Product Images from "Synaptic connectivity and electrophysiological properties of the nucleus of the lateral olfactory tract"

    Article Title: Synaptic connectivity and electrophysiological properties of the nucleus of the lateral olfactory tract

    Journal: bioRxiv

    doi: 10.1101/2023.12.31.573522

    A. The expression of ChR2-EYFP in OB mitral and tufted cells. B. Fluorescent OB output axons (LOT) within layer 1 of the NLOT. C. A biocytin-labeled cell (red), and the LOT within layer 1. Note that the LOT contacts the dendrite at its distal end. D. Example LOT-evoked EPSCs (top) and EPSPs (bottom). Gray traces show individual trials and black lines show the average response across trials. Red line shows EPSC obtained in the presence of CNQX and APV. Blue ticks indicate the timing of light pulses. E. Voltage dependence of an example LOT-evoked EPSC. Red cross indicates reversal potential. F. Box plots showing the distribution of EPSC amplitudes (at -70 mV holding potential) and reversal potentials of LOT inputs. n=25 cells and 8 cells for the amplitude and reversal, respectively. G. LOT-evoked action potentials are only triggered when the cell is depolarized with current injection. H. LOT-evoked dendritic spikes recorded under voltage clamp (top) and current clamp (bottom) conditions (from two different cells). 10 repetitions of the same stimulation are shown for each. In the voltage clamp mode, the cell was held at -20 mV. Note the all- or-none nature of the responses that is indicative of a regenerative process (red). I-J. Paired-pulse dynamics of LOT inputs into NLOT neurons. I. Example data from one neuron. J. Paired-pulse ratio as a function of the inter-pulse interval averaged across cells (n=4). Note that LOT inputs are facilitating at intervals that are less than 100 ms.
    Figure Legend Snippet: A. The expression of ChR2-EYFP in OB mitral and tufted cells. B. Fluorescent OB output axons (LOT) within layer 1 of the NLOT. C. A biocytin-labeled cell (red), and the LOT within layer 1. Note that the LOT contacts the dendrite at its distal end. D. Example LOT-evoked EPSCs (top) and EPSPs (bottom). Gray traces show individual trials and black lines show the average response across trials. Red line shows EPSC obtained in the presence of CNQX and APV. Blue ticks indicate the timing of light pulses. E. Voltage dependence of an example LOT-evoked EPSC. Red cross indicates reversal potential. F. Box plots showing the distribution of EPSC amplitudes (at -70 mV holding potential) and reversal potentials of LOT inputs. n=25 cells and 8 cells for the amplitude and reversal, respectively. G. LOT-evoked action potentials are only triggered when the cell is depolarized with current injection. H. LOT-evoked dendritic spikes recorded under voltage clamp (top) and current clamp (bottom) conditions (from two different cells). 10 repetitions of the same stimulation are shown for each. In the voltage clamp mode, the cell was held at -20 mV. Note the all- or-none nature of the responses that is indicative of a regenerative process (red). I-J. Paired-pulse dynamics of LOT inputs into NLOT neurons. I. Example data from one neuron. J. Paired-pulse ratio as a function of the inter-pulse interval averaged across cells (n=4). Note that LOT inputs are facilitating at intervals that are less than 100 ms.

    Techniques Used: Expressing, Labeling, Injection

    A. A coronal section showing expression of ChR2-GFP in the BLA. B. A confocal image showing the spread of BLA axons within the NLOT. C. Example BLA-evoked EPSCs (top) and EPSPs (bottom). Gray traces show individual trials and black traces show their average. Red trace shows the EPSC obtained in the presence of CNQX and APV. Blue ticks mark the timing of light stimulation. D. Voltage dependence of BLA-evoked EPSCs from one example cell. Black line is a linear fit. Red cross denotes reversal potential. E. Box plots showing the distributions of amplitudes (n=25 cells) and reversal potentials (n=7 cells) of BLA-evoked EPSCs. F-G. Short-term synaptic plasticity of BLA inputs into NLOT. F. Example repeated stimulation with variable intervals. G. Average paired-pulse ratio as a function of inter-pulse interval. Shaded area shows the mean±SEM (n=15 cells). H. Example BLA-evoked action potential bursts. 5 repetitions of the same stimulation are shown.
    Figure Legend Snippet: A. A coronal section showing expression of ChR2-GFP in the BLA. B. A confocal image showing the spread of BLA axons within the NLOT. C. Example BLA-evoked EPSCs (top) and EPSPs (bottom). Gray traces show individual trials and black traces show their average. Red trace shows the EPSC obtained in the presence of CNQX and APV. Blue ticks mark the timing of light stimulation. D. Voltage dependence of BLA-evoked EPSCs from one example cell. Black line is a linear fit. Red cross denotes reversal potential. E. Box plots showing the distributions of amplitudes (n=25 cells) and reversal potentials (n=7 cells) of BLA-evoked EPSCs. F-G. Short-term synaptic plasticity of BLA inputs into NLOT. F. Example repeated stimulation with variable intervals. G. Average paired-pulse ratio as a function of inter-pulse interval. Shaded area shows the mean±SEM (n=15 cells). H. Example BLA-evoked action potential bursts. 5 repetitions of the same stimulation are shown.

    Techniques Used: Expressing

    cnqx  (Alomone Labs)


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    Alomone Labs cnqx
    Cnqx, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Alomone Labs cnqx
    Cnqx, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Alomone Labs cnqx
    Cnqx, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Cnqx, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Alomone Labs cnqx
    Cnqx, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Alomone Labs cnqx
    a,c,f,i,l, Chemical structure of <t>CNQX,</t> <t>Memantine,</t> <t>CGP39551,</t> CPP and L-Aminoadipic acid (L-AA). b , Summary data showing 10 μM CNQX, an AMPA receptor antagonist, had no effect on I ASICs . n =11 cells. d , e , Memantine, an open channel blocker of NMDA receptors, had no effect on I ASICs . n =15 cells ( d ) and 9 cells ( e ). g , h , j , k , 100 μM CGP39551 and CPP, competitive antagonists of NMDA receptors, had no effect on I ASICs and cannot block glutamateinduced potentiation of I ASICs . n =9 cells ( g ), 9 cells ( h ), 13 cells ( j ) and 14 cells ( k ). m , n , 100 μM L-AA, an agonist for NMDAR and metabotropic glutamate receptors (mGluRs), had no effect on I ASICs , however, can eliminate glutamate-induced potentiation of I ASICs . n =13 cells ( m ) and 13 cells ( n ). Data are mean±s.e.m.; two-tailed paired t -test ( b , d , g , j , m ); one-way ANOVA with Tukey post hoc correction ( e , h , k , n ). P values are indicated.
    Cnqx, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    a,c,f,i,l, Chemical structure of CNQX, Memantine, CGP39551, CPP and L-Aminoadipic acid (L-AA). b , Summary data showing 10 μM CNQX, an AMPA receptor antagonist, had no effect on I ASICs . n =11 cells. d , e , Memantine, an open channel blocker of NMDA receptors, had no effect on I ASICs . n =15 cells ( d ) and 9 cells ( e ). g , h , j , k , 100 μM CGP39551 and CPP, competitive antagonists of NMDA receptors, had no effect on I ASICs and cannot block glutamateinduced potentiation of I ASICs . n =9 cells ( g ), 9 cells ( h ), 13 cells ( j ) and 14 cells ( k ). m , n , 100 μM L-AA, an agonist for NMDAR and metabotropic glutamate receptors (mGluRs), had no effect on I ASICs , however, can eliminate glutamate-induced potentiation of I ASICs . n =13 cells ( m ) and 13 cells ( n ). Data are mean±s.e.m.; two-tailed paired t -test ( b , d , g , j , m ); one-way ANOVA with Tukey post hoc correction ( e , h , k , n ). P values are indicated.

    Journal: bioRxiv

    Article Title: Glutamate as a co-agonist for acid-sensing ion channels to aggravate ischemic brain damage

    doi: 10.1101/2024.02.17.580727

    Figure Lengend Snippet: a,c,f,i,l, Chemical structure of CNQX, Memantine, CGP39551, CPP and L-Aminoadipic acid (L-AA). b , Summary data showing 10 μM CNQX, an AMPA receptor antagonist, had no effect on I ASICs . n =11 cells. d , e , Memantine, an open channel blocker of NMDA receptors, had no effect on I ASICs . n =15 cells ( d ) and 9 cells ( e ). g , h , j , k , 100 μM CGP39551 and CPP, competitive antagonists of NMDA receptors, had no effect on I ASICs and cannot block glutamateinduced potentiation of I ASICs . n =9 cells ( g ), 9 cells ( h ), 13 cells ( j ) and 14 cells ( k ). m , n , 100 μM L-AA, an agonist for NMDAR and metabotropic glutamate receptors (mGluRs), had no effect on I ASICs , however, can eliminate glutamate-induced potentiation of I ASICs . n =13 cells ( m ) and 13 cells ( n ). Data are mean±s.e.m.; two-tailed paired t -test ( b , d , g , j , m ); one-way ANOVA with Tukey post hoc correction ( e , h , k , n ). P values are indicated.

    Article Snippet: D-AP5, CGS19755, CNQX, Amiloride, PcTX-1 were purchased from Alomone Lab, L-AP5 and CGP39551 were purchased from Tocris, and other chemicals were purchased from Sigma-Aldrich.

    Techniques: Blocking Assay, Two Tailed Test