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Shimadzu Corporation chromatographic conditions tramadol
MS/MS chromatograms of human drug-free plasma ( a ), human drug-free plasma spiked with 200 ng/mL <t>tramadol,</t> 40 ng/mL O -desmethylate, 40 ng/mL N -desmethylate, and 40 ng/mL N,O -didesmethylate, ( b ) a plasma specimen at 8 h after evening dosing in cancer pain ( c ) and non-cancer pain ( d ) patients treated with oral tramadol. (1) Tramadol, (2) O -desmethylate, (3) N -desmethylate, (4) N,O -didesmethylate, and (5) tramadol- d6 as internal standard
Chromatographic Conditions Tramadol, supplied by Shimadzu Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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chromatographic conditions tramadol - by Bioz Stars, 2020-08
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Article Title: Validated determination method of tramadol and its desmethylates in human plasma using an isocratic LC-MS/MS and its clinical application to patients with cancer pain or non-cancer pain

Journal: Journal of Pharmaceutical Health Care and Sciences

doi: 10.1186/s40780-016-0059-2

MS/MS chromatograms of human drug-free plasma ( a ), human drug-free plasma spiked with 200 ng/mL tramadol, 40 ng/mL O -desmethylate, 40 ng/mL N -desmethylate, and 40 ng/mL N,O -didesmethylate, ( b ) a plasma specimen at 8 h after evening dosing in cancer pain ( c ) and non-cancer pain ( d ) patients treated with oral tramadol. (1) Tramadol, (2) O -desmethylate, (3) N -desmethylate, (4) N,O -didesmethylate, and (5) tramadol- d6 as internal standard
Figure Legend Snippet: MS/MS chromatograms of human drug-free plasma ( a ), human drug-free plasma spiked with 200 ng/mL tramadol, 40 ng/mL O -desmethylate, 40 ng/mL N -desmethylate, and 40 ng/mL N,O -didesmethylate, ( b ) a plasma specimen at 8 h after evening dosing in cancer pain ( c ) and non-cancer pain ( d ) patients treated with oral tramadol. (1) Tramadol, (2) O -desmethylate, (3) N -desmethylate, (4) N,O -didesmethylate, and (5) tramadol- d6 as internal standard

Techniques Used: Mass Spectrometry

Plasma concentrations of tramadol, O -desmethylate, N -desmethylate, and N,O -didesmethylate obtained from patients with cancer pain ( a ) or non-cancer pain ( b ) just before treatment of oral tramadol on day 4 or later. (1) Tramadol, (2) O -desmethylate, (3) N -desmethylate, and (4) N,O -didesmethylate
Figure Legend Snippet: Plasma concentrations of tramadol, O -desmethylate, N -desmethylate, and N,O -didesmethylate obtained from patients with cancer pain ( a ) or non-cancer pain ( b ) just before treatment of oral tramadol on day 4 or later. (1) Tramadol, (2) O -desmethylate, (3) N -desmethylate, and (4) N,O -didesmethylate

Techniques Used:

Mass spectra of tramadol ( a ), O -desmethylate ( b ), N -desmethylate ( c ), and N,O -didesmethylate ( d ). A mass-to-charge ( m/z ) of 264.2/58.2 was monitored for tramadol, 250.2/58.2 for O -desmethylate, 250.2/232.2 for N -desmethylate, and 236.1/218.4 for N,O -didesmethylate
Figure Legend Snippet: Mass spectra of tramadol ( a ), O -desmethylate ( b ), N -desmethylate ( c ), and N,O -didesmethylate ( d ). A mass-to-charge ( m/z ) of 264.2/58.2 was monitored for tramadol, 250.2/58.2 for O -desmethylate, 250.2/232.2 for N -desmethylate, and 236.1/218.4 for N,O -didesmethylate

Techniques Used:

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Article Title: Validated determination method of tramadol and its desmethylates in human plasma using an isocratic LC-MS/MS and its clinical application to patients with cancer pain or non-cancer pain
Article Snippet: Chromatographic conditions Tramadol, ODT, NDT, NODT, and IS in human plasma were separated using a validated LC system (UFLCXR , Shimadzu Corporation, Kyoto, Japan).

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    Shimadzu Corporation chromatographic conditions tramadol
    MS/MS chromatograms of human drug-free plasma ( a ), human drug-free plasma spiked with 200 ng/mL <t>tramadol,</t> 40 ng/mL O -desmethylate, 40 ng/mL N -desmethylate, and 40 ng/mL N,O -didesmethylate, ( b ) a plasma specimen at 8 h after evening dosing in cancer pain ( c ) and non-cancer pain ( d ) patients treated with oral tramadol. (1) Tramadol, (2) O -desmethylate, (3) N -desmethylate, (4) N,O -didesmethylate, and (5) tramadol- d6 as internal standard
    Chromatographic Conditions Tramadol, supplied by Shimadzu Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/chromatographic conditions tramadol/product/Shimadzu Corporation
    Average 90 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    chromatographic conditions tramadol - by Bioz Stars, 2020-08
    90/100 stars
      Buy from Supplier

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    MS/MS chromatograms of human drug-free plasma ( a ), human drug-free plasma spiked with 200 ng/mL tramadol, 40 ng/mL O -desmethylate, 40 ng/mL N -desmethylate, and 40 ng/mL N,O -didesmethylate, ( b ) a plasma specimen at 8 h after evening dosing in cancer pain ( c ) and non-cancer pain ( d ) patients treated with oral tramadol. (1) Tramadol, (2) O -desmethylate, (3) N -desmethylate, (4) N,O -didesmethylate, and (5) tramadol- d6 as internal standard

    Journal: Journal of Pharmaceutical Health Care and Sciences

    Article Title: Validated determination method of tramadol and its desmethylates in human plasma using an isocratic LC-MS/MS and its clinical application to patients with cancer pain or non-cancer pain

    doi: 10.1186/s40780-016-0059-2

    Figure Lengend Snippet: MS/MS chromatograms of human drug-free plasma ( a ), human drug-free plasma spiked with 200 ng/mL tramadol, 40 ng/mL O -desmethylate, 40 ng/mL N -desmethylate, and 40 ng/mL N,O -didesmethylate, ( b ) a plasma specimen at 8 h after evening dosing in cancer pain ( c ) and non-cancer pain ( d ) patients treated with oral tramadol. (1) Tramadol, (2) O -desmethylate, (3) N -desmethylate, (4) N,O -didesmethylate, and (5) tramadol- d6 as internal standard

    Article Snippet: Chromatographic conditions Tramadol, ODT, NDT, NODT, and IS in human plasma were separated using a validated LC system (UFLCXR , Shimadzu Corporation, Kyoto, Japan).

    Techniques: Mass Spectrometry

    Plasma concentrations of tramadol, O -desmethylate, N -desmethylate, and N,O -didesmethylate obtained from patients with cancer pain ( a ) or non-cancer pain ( b ) just before treatment of oral tramadol on day 4 or later. (1) Tramadol, (2) O -desmethylate, (3) N -desmethylate, and (4) N,O -didesmethylate

    Journal: Journal of Pharmaceutical Health Care and Sciences

    Article Title: Validated determination method of tramadol and its desmethylates in human plasma using an isocratic LC-MS/MS and its clinical application to patients with cancer pain or non-cancer pain

    doi: 10.1186/s40780-016-0059-2

    Figure Lengend Snippet: Plasma concentrations of tramadol, O -desmethylate, N -desmethylate, and N,O -didesmethylate obtained from patients with cancer pain ( a ) or non-cancer pain ( b ) just before treatment of oral tramadol on day 4 or later. (1) Tramadol, (2) O -desmethylate, (3) N -desmethylate, and (4) N,O -didesmethylate

    Article Snippet: Chromatographic conditions Tramadol, ODT, NDT, NODT, and IS in human plasma were separated using a validated LC system (UFLCXR , Shimadzu Corporation, Kyoto, Japan).

    Techniques:

    Mass spectra of tramadol ( a ), O -desmethylate ( b ), N -desmethylate ( c ), and N,O -didesmethylate ( d ). A mass-to-charge ( m/z ) of 264.2/58.2 was monitored for tramadol, 250.2/58.2 for O -desmethylate, 250.2/232.2 for N -desmethylate, and 236.1/218.4 for N,O -didesmethylate

    Journal: Journal of Pharmaceutical Health Care and Sciences

    Article Title: Validated determination method of tramadol and its desmethylates in human plasma using an isocratic LC-MS/MS and its clinical application to patients with cancer pain or non-cancer pain

    doi: 10.1186/s40780-016-0059-2

    Figure Lengend Snippet: Mass spectra of tramadol ( a ), O -desmethylate ( b ), N -desmethylate ( c ), and N,O -didesmethylate ( d ). A mass-to-charge ( m/z ) of 264.2/58.2 was monitored for tramadol, 250.2/58.2 for O -desmethylate, 250.2/232.2 for N -desmethylate, and 236.1/218.4 for N,O -didesmethylate

    Article Snippet: Chromatographic conditions Tramadol, ODT, NDT, NODT, and IS in human plasma were separated using a validated LC system (UFLCXR , Shimadzu Corporation, Kyoto, Japan).

    Techniques: