chlorotoxin  (Alomone Labs)


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    Structured Review

    Alomone Labs chlorotoxin
    1 H NMR spectra showing characteristic peaks of the <t>chlorotoxin</t> peptide (CTX) at 2.60–3.10 and 3.65–3.80 ppm, SIAX-functionalized P-PEG polymer (P-PEG-SIAX) at 3.60–3.65 for the -O-CH2-CH2- repeating unit of PEG and at 2.50–3.10
    Chlorotoxin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 11 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/chlorotoxin/product/Alomone Labs
    Average 93 stars, based on 11 article reviews
    Price from $9.99 to $1999.99
    chlorotoxin - by Bioz Stars, 2022-09
    93/100 stars

    Images

    1) Product Images from "A ligand-mediated nanovector for targeted gene delivery and transfection in cancer cells"

    Article Title: A ligand-mediated nanovector for targeted gene delivery and transfection in cancer cells

    Journal: Biomaterials

    doi: 10.1016/j.biomaterials.2008.10.003

    1 H NMR spectra showing characteristic peaks of the chlorotoxin peptide (CTX) at 2.60–3.10 and 3.65–3.80 ppm, SIAX-functionalized P-PEG polymer (P-PEG-SIAX) at 3.60–3.65 for the -O-CH2-CH2- repeating unit of PEG and at 2.50–3.10
    Figure Legend Snippet: 1 H NMR spectra showing characteristic peaks of the chlorotoxin peptide (CTX) at 2.60–3.10 and 3.65–3.80 ppm, SIAX-functionalized P-PEG polymer (P-PEG-SIAX) at 3.60–3.65 for the -O-CH2-CH2- repeating unit of PEG and at 2.50–3.10

    Techniques Used: Nuclear Magnetic Resonance

    Nanovector preparation scheme. (a) PEGylation of PEI polymer and modification with Alexa Fluor 647 fluorophores (AF). (b) P-PEG-AF modification with SIAX, modification of chlorotoxin (CTX) with traut’s reagent to produce free thiols on peptide
    Figure Legend Snippet: Nanovector preparation scheme. (a) PEGylation of PEI polymer and modification with Alexa Fluor 647 fluorophores (AF). (b) P-PEG-AF modification with SIAX, modification of chlorotoxin (CTX) with traut’s reagent to produce free thiols on peptide

    Techniques Used: Modification

    2) Product Images from "Chlorotoxin Labeled Magnetic Nanovectors for Targeted Gene Delivery to Glioma"

    Article Title: Chlorotoxin Labeled Magnetic Nanovectors for Targeted Gene Delivery to Glioma

    Journal: ACS nano

    doi: 10.1021/nn1008512

    Enhanced delivery of GFP encoding DNA to C6 glioma cells in vivo using chlorotoxin labeled NPs. a) Xenogen images of tumors, livers, kidneys, and spleens from C6 xenograft tumor bearing mice, harvested 48 hrs after treatment, indicating GFP fluorescence
    Figure Legend Snippet: Enhanced delivery of GFP encoding DNA to C6 glioma cells in vivo using chlorotoxin labeled NPs. a) Xenogen images of tumors, livers, kidneys, and spleens from C6 xenograft tumor bearing mice, harvested 48 hrs after treatment, indicating GFP fluorescence

    Techniques Used: In Vivo, Labeling, Mouse Assay, Fluorescence

    3) Product Images from "Properties of single-channel and whole cell Cl− currents in guinea pig detrusor smooth muscle cells"

    Article Title: Properties of single-channel and whole cell Cl− currents in guinea pig detrusor smooth muscle cells

    Journal: American Journal of Physiology - Cell Physiology

    doi: 10.1152/ajpcell.00327.2018

    Niflumic acid and DIDS inhibit outwardly rectifying Cl − current in detrusor smooth muscle (DSM) cells while chlorotoxin does not. A – C : normalized leak-unsubtracted time courses of Cl − currents measured at +100 mV caused by repetitive 1 s voltage ramps from −100 mM to +100 mV. Data were normalized to the first data point value. Arrow indicates the beginning of local perfusion (also marked as “Flow”). Isochronic drug applications show inhibitory effects of niflumic acid (NA, n = 5, N = 3) ( A ) and DIDS ( n = 4, N = 3) ( B ), and no effect of chlorotoxin (CTX, n = 5, N = 3) ( C ) on Cl − current.
    Figure Legend Snippet: Niflumic acid and DIDS inhibit outwardly rectifying Cl − current in detrusor smooth muscle (DSM) cells while chlorotoxin does not. A – C : normalized leak-unsubtracted time courses of Cl − currents measured at +100 mV caused by repetitive 1 s voltage ramps from −100 mM to +100 mV. Data were normalized to the first data point value. Arrow indicates the beginning of local perfusion (also marked as “Flow”). Isochronic drug applications show inhibitory effects of niflumic acid (NA, n = 5, N = 3) ( A ) and DIDS ( n = 4, N = 3) ( B ), and no effect of chlorotoxin (CTX, n = 5, N = 3) ( C ) on Cl − current.

    Techniques Used:

    4) Product Images from "Properties of single-channel and whole cell Cl− currents in guinea pig detrusor smooth muscle cells"

    Article Title: Properties of single-channel and whole cell Cl− currents in guinea pig detrusor smooth muscle cells

    Journal: American Journal of Physiology - Cell Physiology

    doi: 10.1152/ajpcell.00327.2018

    Niflumic acid and DIDS inhibit outwardly rectifying Cl − current in detrusor smooth muscle (DSM) cells while chlorotoxin does not. A – C : normalized leak-unsubtracted time courses of Cl − currents measured at +100 mV caused by repetitive 1 s voltage ramps from −100 mM to +100 mV. Data were normalized to the first data point value. Arrow indicates the beginning of local perfusion (also marked as “Flow”). Isochronic drug applications show inhibitory effects of niflumic acid (NA, n = 5, N = 3) ( A ) and DIDS ( n = 4, N = 3) ( B ), and no effect of chlorotoxin (CTX, n = 5, N = 3) ( C ) on Cl − current.
    Figure Legend Snippet: Niflumic acid and DIDS inhibit outwardly rectifying Cl − current in detrusor smooth muscle (DSM) cells while chlorotoxin does not. A – C : normalized leak-unsubtracted time courses of Cl − currents measured at +100 mV caused by repetitive 1 s voltage ramps from −100 mM to +100 mV. Data were normalized to the first data point value. Arrow indicates the beginning of local perfusion (also marked as “Flow”). Isochronic drug applications show inhibitory effects of niflumic acid (NA, n = 5, N = 3) ( A ) and DIDS ( n = 4, N = 3) ( B ), and no effect of chlorotoxin (CTX, n = 5, N = 3) ( C ) on Cl − current.

    Techniques Used:

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    Alomone Labs chlorotoxin chtx
    Effect of SOL, SOL plus acetylcholine (ACh), SOL plus iberiotoxin (Iber), SOL plus apamin (Apa), SOL plus tolbutamide (TLB), SOL plus <t>chlorotoxin</t> <t>(ChTx),</t> SOL plus Lino, or SOL plus TRH on the amplitude of I K(M) . In these experiments, we bathed GH 3 cells in high-K + , Ca 2+ -free solution and the recording electrode was filled with K + -enriched (145 mM) solution. Current amplitude was measured at the end of the depolarizing step from −50 to −10 mV. Each bar represents the mean ± SEM ( n = 7). * Significantly different from controls ( p
    Chlorotoxin Chtx, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/chlorotoxin chtx/product/Alomone Labs
    Average 93 stars, based on 2 article reviews
    Price from $9.99 to $1999.99
    chlorotoxin chtx - by Bioz Stars, 2022-09
    93/100 stars
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    Effect of SOL, SOL plus acetylcholine (ACh), SOL plus iberiotoxin (Iber), SOL plus apamin (Apa), SOL plus tolbutamide (TLB), SOL plus chlorotoxin (ChTx), SOL plus Lino, or SOL plus TRH on the amplitude of I K(M) . In these experiments, we bathed GH 3 cells in high-K + , Ca 2+ -free solution and the recording electrode was filled with K + -enriched (145 mM) solution. Current amplitude was measured at the end of the depolarizing step from −50 to −10 mV. Each bar represents the mean ± SEM ( n = 7). * Significantly different from controls ( p

    Journal: International Journal of Molecular Sciences

    Article Title: The Effectiveness in Activating M-Type K+ Current Produced by Solifenacin ([(3R)-1-azabicyclo[2.2.2]octan-3-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate): Independent of Its Antimuscarinic Action

    doi: 10.3390/ijms222212399

    Figure Lengend Snippet: Effect of SOL, SOL plus acetylcholine (ACh), SOL plus iberiotoxin (Iber), SOL plus apamin (Apa), SOL plus tolbutamide (TLB), SOL plus chlorotoxin (ChTx), SOL plus Lino, or SOL plus TRH on the amplitude of I K(M) . In these experiments, we bathed GH 3 cells in high-K + , Ca 2+ -free solution and the recording electrode was filled with K + -enriched (145 mM) solution. Current amplitude was measured at the end of the depolarizing step from −50 to −10 mV. Each bar represents the mean ± SEM ( n = 7). * Significantly different from controls ( p

    Article Snippet: Chlorotoxin (ChTx) was kindly provided by Professor Dr. Woei-Jer Chuang (Department of Biochemistry, National Cheng Kung University Medical College, Tainan, Taiwan).

    Techniques:

    1 H NMR spectra showing characteristic peaks of the chlorotoxin peptide (CTX) at 2.60–3.10 and 3.65–3.80 ppm, SIAX-functionalized P-PEG polymer (P-PEG-SIAX) at 3.60–3.65 for the -O-CH2-CH2- repeating unit of PEG and at 2.50–3.10

    Journal: Biomaterials

    Article Title: A ligand-mediated nanovector for targeted gene delivery and transfection in cancer cells

    doi: 10.1016/j.biomaterials.2008.10.003

    Figure Lengend Snippet: 1 H NMR spectra showing characteristic peaks of the chlorotoxin peptide (CTX) at 2.60–3.10 and 3.65–3.80 ppm, SIAX-functionalized P-PEG polymer (P-PEG-SIAX) at 3.60–3.65 for the -O-CH2-CH2- repeating unit of PEG and at 2.50–3.10

    Article Snippet: Chlorotoxin (Alomone Labs, Ltd. Jerusalem, Israel) is a peptide derived from vemon of the Giant Israeli scorpion Leiurus q. hebraeus .

    Techniques: Nuclear Magnetic Resonance

    Nanovector preparation scheme. (a) PEGylation of PEI polymer and modification with Alexa Fluor 647 fluorophores (AF). (b) P-PEG-AF modification with SIAX, modification of chlorotoxin (CTX) with traut’s reagent to produce free thiols on peptide

    Journal: Biomaterials

    Article Title: A ligand-mediated nanovector for targeted gene delivery and transfection in cancer cells

    doi: 10.1016/j.biomaterials.2008.10.003

    Figure Lengend Snippet: Nanovector preparation scheme. (a) PEGylation of PEI polymer and modification with Alexa Fluor 647 fluorophores (AF). (b) P-PEG-AF modification with SIAX, modification of chlorotoxin (CTX) with traut’s reagent to produce free thiols on peptide

    Article Snippet: Chlorotoxin (Alomone Labs, Ltd. Jerusalem, Israel) is a peptide derived from vemon of the Giant Israeli scorpion Leiurus q. hebraeus .

    Techniques: Modification

    Enhanced delivery of GFP encoding DNA to C6 glioma cells in vivo using chlorotoxin labeled NPs. a) Xenogen images of tumors, livers, kidneys, and spleens from C6 xenograft tumor bearing mice, harvested 48 hrs after treatment, indicating GFP fluorescence

    Journal: ACS nano

    Article Title: Chlorotoxin Labeled Magnetic Nanovectors for Targeted Gene Delivery to Glioma

    doi: 10.1021/nn1008512

    Figure Lengend Snippet: Enhanced delivery of GFP encoding DNA to C6 glioma cells in vivo using chlorotoxin labeled NPs. a) Xenogen images of tumors, livers, kidneys, and spleens from C6 xenograft tumor bearing mice, harvested 48 hrs after treatment, indicating GFP fluorescence

    Article Snippet: NP-CP-PEI (herein called NP) were complexed with pEGFP-CS2 at a weight ratio of 10:1 (Fe equivalent of NP:DNA) in reaction buffer (20 mM HEPES, 5 mM EDTA, pH 7.2) for 30 min. Chlorotoxin (CTX, Alamone Labs, Jerusalem, Israel) was conjugated to DNA loaded NPs using a heterobifunctional PEG linker.

    Techniques: In Vivo, Labeling, Mouse Assay, Fluorescence

    In vivo NIRF imaging of autochthonous medulloblastoma tumors in genetically engineered ND2:SmoA1 mice. ( a and b ) Fluorescence imaging of medulloblastoma tumors in ND2:SmoA1 mice injected with either NPCP-Cy5.5-CTX or NPCP-Cy5.5, or receiving no injection

    Journal:

    Article Title: Specific targeting of brain tumors with an optical/MR imaging nanoprobe across the blood brain barrier

    doi: 10.1158/0008-5472.CAN-09-1157

    Figure Lengend Snippet: In vivo NIRF imaging of autochthonous medulloblastoma tumors in genetically engineered ND2:SmoA1 mice. ( a and b ) Fluorescence imaging of medulloblastoma tumors in ND2:SmoA1 mice injected with either NPCP-Cy5.5-CTX or NPCP-Cy5.5, or receiving no injection

    Article Snippet: CTX (Alamone Labs, Jerusalem, Israel) and Cy5.5 (GE Healthcare, Piscataway, NJ) were conjugated to the NPCP through the chemical scheme outlined in .

    Techniques: In Vivo, Imaging, Mouse Assay, Fluorescence, Injection

    Histological examination of mouse cerebellum 5 days post injection of NPCP-Cy5.5-CTX or NPCP-Cy5.5. ( a ) The H E stained cerebellum section of symptomatic ND2:SmoA1 mice confirming presence of medulloblastoma, and ( b ) for comparison, the cerebellum

    Journal:

    Article Title: Specific targeting of brain tumors with an optical/MR imaging nanoprobe across the blood brain barrier

    doi: 10.1158/0008-5472.CAN-09-1157

    Figure Lengend Snippet: Histological examination of mouse cerebellum 5 days post injection of NPCP-Cy5.5-CTX or NPCP-Cy5.5. ( a ) The H E stained cerebellum section of symptomatic ND2:SmoA1 mice confirming presence of medulloblastoma, and ( b ) for comparison, the cerebellum

    Article Snippet: CTX (Alamone Labs, Jerusalem, Israel) and Cy5.5 (GE Healthcare, Piscataway, NJ) were conjugated to the NPCP through the chemical scheme outlined in .

    Techniques: Injection, Staining, Mouse Assay

    Biodistribution of nanoprobes. Accumulation of nanoprobes in various tissues assessed by NIRF signal measurements of tissues/organs excised from ND2:SmoA1 mice receiving no injection and 120 hours after receiving injection of either targeting NPCP-Cy5.5-CTX

    Journal:

    Article Title: Specific targeting of brain tumors with an optical/MR imaging nanoprobe across the blood brain barrier

    doi: 10.1158/0008-5472.CAN-09-1157

    Figure Lengend Snippet: Biodistribution of nanoprobes. Accumulation of nanoprobes in various tissues assessed by NIRF signal measurements of tissues/organs excised from ND2:SmoA1 mice receiving no injection and 120 hours after receiving injection of either targeting NPCP-Cy5.5-CTX

    Article Snippet: CTX (Alamone Labs, Jerusalem, Israel) and Cy5.5 (GE Healthcare, Piscataway, NJ) were conjugated to the NPCP through the chemical scheme outlined in .

    Techniques: Mouse Assay, Injection

    Synthesis and characterization of NPCP-Cy5.5-CTX nanoprobes. Chemical reaction schematic for the syntheses of ( a ) PEG-grafted chitosan, ( b ) sulfhydryl functionalization of chlorotoxin (CTX), and ( c ) chlorotoxin and Cy5.5 conjugation to NPCP. ( d ) Summary

    Journal:

    Article Title: Specific targeting of brain tumors with an optical/MR imaging nanoprobe across the blood brain barrier

    doi: 10.1158/0008-5472.CAN-09-1157

    Figure Lengend Snippet: Synthesis and characterization of NPCP-Cy5.5-CTX nanoprobes. Chemical reaction schematic for the syntheses of ( a ) PEG-grafted chitosan, ( b ) sulfhydryl functionalization of chlorotoxin (CTX), and ( c ) chlorotoxin and Cy5.5 conjugation to NPCP. ( d ) Summary

    Article Snippet: CTX (Alamone Labs, Jerusalem, Israel) and Cy5.5 (GE Healthcare, Piscataway, NJ) were conjugated to the NPCP through the chemical scheme outlined in .

    Techniques: Conjugation Assay