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( A ) Survival rate of the mice in each group at the 5th day after the last DOX injection ( n = 10–20). ( B ) Representative <t>ECG</t> results that show several kinds of ECG changes including arrhythmia, T wave flat, and ST-segment depression in DOX-treated mice. ( C ) LDH activities among different groups of mice. ( D ) Histopathological changes (×100), showing myofibrillar disarrangement and vacuolization of the cytoplasm in the heart of DOX-treated mice.
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( A ) Survival rate of the mice in each group at the 5th day after the last DOX injection ( n = 10–20). ( B ) Representative <t>ECG</t> results that show several kinds of ECG changes including arrhythmia, T wave flat, and ST-segment depression in DOX-treated mice. ( C ) LDH activities among different groups of mice. ( D ) Histopathological changes (×100), showing myofibrillar disarrangement and vacuolization of the cytoplasm in the heart of DOX-treated mice.
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( A ) Survival rate of the mice in each group at the 5th day after the last DOX injection ( n = 10–20). ( B ) Representative ECG results that show several kinds of ECG changes including arrhythmia, T wave flat, and ST-segment depression in DOX-treated mice. ( C ) LDH activities among different groups of mice. ( D ) Histopathological changes (×100), showing myofibrillar disarrangement and vacuolization of the cytoplasm in the heart of DOX-treated mice.

Journal: Oncotarget

Article Title: Low dose radiation prevents doxorubicin-induced cardiotoxicity

doi: 10.18632/oncotarget.23013

Figure Lengend Snippet: ( A ) Survival rate of the mice in each group at the 5th day after the last DOX injection ( n = 10–20). ( B ) Representative ECG results that show several kinds of ECG changes including arrhythmia, T wave flat, and ST-segment depression in DOX-treated mice. ( C ) LDH activities among different groups of mice. ( D ) Histopathological changes (×100), showing myofibrillar disarrangement and vacuolization of the cytoplasm in the heart of DOX-treated mice.

Article Snippet: Five days after DOX injection, mice were anesthetized with sodium pentobarbital and subjected to ECG recording with Lab Chart7 Analysis Software (AD Instruments Inc., Australia) to measure arrhythmia.

Techniques: Injection