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Epitopes of anti-complement factor H autoantibodies targeting domains on factor H. SCRs, short consensus repeats. Recombinant factor H fragments are displayed above. Below are shown the epitope mapping results for FHAAs in 9 adult patients with CM-TMA.

Journal: Kidney Diseases

Article Title: Immunological Characteristics of Chinese Adult Patients with Anti-Complement Factor H Autoantibodies-Associated Complement-Mediated Thrombotic Microangiopathy

doi: 10.1159/000551284

Figure Lengend Snippet: Epitopes of anti-complement factor H autoantibodies targeting domains on factor H. SCRs, short consensus repeats. Recombinant factor H fragments are displayed above. Below are shown the epitope mapping results for FHAAs in 9 adult patients with CM-TMA.

Article Snippet: The generation and expression of the various CFH SCRs were performed by the Novo Nordisk Corporation (Beijing, China).

Techniques: Recombinant

Titers of anti-complement factor H autoantibodies ( a ), anti-SCRs 15–20 autoantibodies ( b ), and anti-SCRs 19–20 autoantibodies ( c ) in patient No. 9 at the active and remission phases. Patient No. 9 visited Peking University First Hospital at first onset in May 2019, then relapsed twice in March 2021 and June 2021, respectively. The cut-off values were marked by dotted lines. The titers of anti-SCRs 1-4, anti-SCR 7, and anti-SCRs 11-14 autoantibodies were not listed above due to negative results at all time (shown in online suppl. Fig. 3).

Journal: Kidney Diseases

Article Title: Immunological Characteristics of Chinese Adult Patients with Anti-Complement Factor H Autoantibodies-Associated Complement-Mediated Thrombotic Microangiopathy

doi: 10.1159/000551284

Figure Lengend Snippet: Titers of anti-complement factor H autoantibodies ( a ), anti-SCRs 15–20 autoantibodies ( b ), and anti-SCRs 19–20 autoantibodies ( c ) in patient No. 9 at the active and remission phases. Patient No. 9 visited Peking University First Hospital at first onset in May 2019, then relapsed twice in March 2021 and June 2021, respectively. The cut-off values were marked by dotted lines. The titers of anti-SCRs 1-4, anti-SCR 7, and anti-SCRs 11-14 autoantibodies were not listed above due to negative results at all time (shown in online suppl. Fig. 3).

Article Snippet: The generation and expression of the various CFH SCRs were performed by the Novo Nordisk Corporation (Beijing, China).

Techniques: