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A ) Loss of IRF3 expression in IRF3 -/- RAW cells generated via CRISPR-Cas9 was confirmed by Western blot analysis. B) The release of IFN-β in response to LPS is inhibited in IRF3 -/- RAW cells. C ) MitAP activation by LPS is not affected by the loss of IRF3. D ) Western blot analysis shows inhibition of phosphorylated IRF3 (P-IRF3), confirming the efficacy of the TBK1 inhibitor <t>BX795.</t> E ) BX795-mediated inhibition of TBK1 suppresses MitAP activation.
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A ) Loss of IRF3 expression in IRF3 -/- RAW cells generated via CRISPR-Cas9 was confirmed by Western blot analysis. B) The release of IFN-β in response to LPS is inhibited in IRF3 -/- RAW cells. C ) MitAP activation by LPS is not affected by the loss of IRF3. D ) Western blot analysis shows inhibition of phosphorylated IRF3 (P-IRF3), confirming the efficacy of the TBK1 inhibitor <t>BX795.</t> E ) BX795-mediated inhibition of TBK1 suppresses MitAP activation.
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A ) Loss of IRF3 expression in IRF3 -/- RAW cells generated via CRISPR-Cas9 was confirmed by Western blot analysis. B) The release of IFN-β in response to LPS is inhibited in IRF3 -/- RAW cells. C ) MitAP activation by LPS is not affected by the loss of IRF3. D ) Western blot analysis shows inhibition of phosphorylated IRF3 (P-IRF3), confirming the efficacy of the TBK1 inhibitor <t>BX795.</t> E ) BX795-mediated inhibition of TBK1 suppresses MitAP activation.
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A ) Loss of IRF3 expression in IRF3 -/- RAW cells generated via CRISPR-Cas9 was confirmed by Western blot analysis. B) The release of IFN-β in response to LPS is inhibited in IRF3 -/- RAW cells. C ) MitAP activation by LPS is not affected by the loss of IRF3. D ) Western blot analysis shows inhibition of phosphorylated IRF3 (P-IRF3), confirming the efficacy of the TBK1 inhibitor <t>BX795.</t> E ) BX795-mediated inhibition of TBK1 suppresses MitAP activation.
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A ) Loss of IRF3 expression in IRF3 -/- RAW cells generated via CRISPR-Cas9 was confirmed by Western blot analysis. B) The release of IFN-β in response to LPS is inhibited in IRF3 -/- RAW cells. C ) MitAP activation by LPS is not affected by the loss of IRF3. D ) Western blot analysis shows inhibition of phosphorylated IRF3 (P-IRF3), confirming the efficacy of the TBK1 inhibitor BX795. E ) BX795-mediated inhibition of TBK1 suppresses MitAP activation.

Journal: bioRxiv

Article Title: STING dampens the unfolded protein response to enable the presentation of self-antigens on MHC-I during inflammation

doi: 10.64898/2026.05.25.727656

Figure Lengend Snippet: A ) Loss of IRF3 expression in IRF3 -/- RAW cells generated via CRISPR-Cas9 was confirmed by Western blot analysis. B) The release of IFN-β in response to LPS is inhibited in IRF3 -/- RAW cells. C ) MitAP activation by LPS is not affected by the loss of IRF3. D ) Western blot analysis shows inhibition of phosphorylated IRF3 (P-IRF3), confirming the efficacy of the TBK1 inhibitor BX795. E ) BX795-mediated inhibition of TBK1 suppresses MitAP activation.

Article Snippet: BAY11-7082 (tlrl-b82), LPS-EB Ultrapure (TLRL-3PELPS), 2’3’-cGAMP (TLRL-NACGA23-5), PGN-EB (tlrl-pgneb), Fla-st (TLRL-STFLA), and BX795 (tlrl-bx7) were from InvivoGen.

Techniques: Expressing, Generated, CRISPR, Western Blot, Activation Assay, Inhibition

A ) LPS treatment induced a strong induction of MitAP. (B) LPS stimulation induces translocation of STING RRAA to the Golgi, as assessed by anti-GFP staining and GM130 labeling, by 60 min, followed by exit from the Golgi by 240 min. Scale bar, 5 µm. (C) Neither LPS nor DMXAA treatment induces translocation of STING RRDD to the Golgi up to 120 min. Scale bar, 5 µm. D) Pre-treatment of WT RAW cells with DMXAA, which induces STING translocation to the Golgi, attenuates LPS-induced MitAP. E ) Pre-treatment of WT RAW cells with the TBK1 inhibitor (BX795) inhibits LPS-induced UPR.

Journal: bioRxiv

Article Title: STING dampens the unfolded protein response to enable the presentation of self-antigens on MHC-I during inflammation

doi: 10.64898/2026.05.25.727656

Figure Lengend Snippet: A ) LPS treatment induced a strong induction of MitAP. (B) LPS stimulation induces translocation of STING RRAA to the Golgi, as assessed by anti-GFP staining and GM130 labeling, by 60 min, followed by exit from the Golgi by 240 min. Scale bar, 5 µm. (C) Neither LPS nor DMXAA treatment induces translocation of STING RRDD to the Golgi up to 120 min. Scale bar, 5 µm. D) Pre-treatment of WT RAW cells with DMXAA, which induces STING translocation to the Golgi, attenuates LPS-induced MitAP. E ) Pre-treatment of WT RAW cells with the TBK1 inhibitor (BX795) inhibits LPS-induced UPR.

Article Snippet: BAY11-7082 (tlrl-b82), LPS-EB Ultrapure (TLRL-3PELPS), 2’3’-cGAMP (TLRL-NACGA23-5), PGN-EB (tlrl-pgneb), Fla-st (TLRL-STFLA), and BX795 (tlrl-bx7) were from InvivoGen.

Techniques: Translocation Assay, Staining, Labeling