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Bio-Techne corporation brl 15572 hydrochloride
Brl 15572 Hydrochloride, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/brl 15572 hydrochloride/product/Bio-Techne corporation
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
brl 15572 hydrochloride - by Bioz Stars, 2024-04
86/100 stars

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Structured Review

Bio-Techne corporation brl 15572 hydrochloride
Brl 15572 Hydrochloride, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/brl 15572 hydrochloride/product/Bio-Techne corporation
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
brl 15572 hydrochloride - by Bioz Stars, 2024-04
86/100 stars

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Structured Review

Bio-Techne corporation brl 15572
Brl 15572, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/brl 15572/product/Bio-Techne corporation
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
brl 15572 - by Bioz Stars, 2024-04
86/100 stars

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Structured Review

Bio-Techne corporation brl 15572
Upper panel: Female rats received vehicle (5 μL; black bar), NAS-181 (1 μg; 5-HT1B receptor antagonist; gray bar) or <t>BRL</t> <t>15572</t> (1 μg; 5-HT1D receptor antagonist; white bar) co-injected with sumatriptan [1 pg (A), 1 ng (B) or 10 ng (C)] on the dorsum of the hind paw. The mechanical nociceptive threshold was evaluated 30 min after sumatriptan injection. A. In the group co-injected with BRL 15572, but not with NAS-181, mechanical hyperalgesia induced by sumatriptan (1 pg) was completely prevented (white bar; F = 89.24, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). B. A dose of 1 ng of sumatriptan, injected with vehicle (black bar), was able to induce mechanical hyperalgesia in female rats that was significantly attenuated by NAS-181 (gray bar) and BRL 15572 (white bar; F = 12.32, ** p = 0.0020, when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). C. When the dose of 10 ng of sumatriptan was co-injected with vehicle (black bar) or NAS-181 (gray bar) a robust hyperalgesia was observed; however, when co-injected with BRL 15572 (white bar) the hyperalgesia was completely blocked (F = 91.70, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). (N = 6 paws per group)
Brl 15572, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/brl 15572/product/Bio-Techne corporation
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
brl 15572 - by Bioz Stars, 2024-04
86/100 stars

Images

1) Product Images from "Marked Sexual Dimorphism in 5-HT 1 Receptors Mediating Pronociceptive Effects of Sumatriptan"

Article Title: Marked Sexual Dimorphism in 5-HT 1 Receptors Mediating Pronociceptive Effects of Sumatriptan

Journal: Neuroscience

doi: 10.1016/j.neuroscience.2016.12.031

Upper panel: Female rats received vehicle (5 μL; black bar), NAS-181 (1 μg; 5-HT1B receptor antagonist; gray bar) or BRL 15572 (1 μg; 5-HT1D receptor antagonist; white bar) co-injected with sumatriptan [1 pg (A), 1 ng (B) or 10 ng (C)] on the dorsum of the hind paw. The mechanical nociceptive threshold was evaluated 30 min after sumatriptan injection. A. In the group co-injected with BRL 15572, but not with NAS-181, mechanical hyperalgesia induced by sumatriptan (1 pg) was completely prevented (white bar; F = 89.24, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). B. A dose of 1 ng of sumatriptan, injected with vehicle (black bar), was able to induce mechanical hyperalgesia in female rats that was significantly attenuated by NAS-181 (gray bar) and BRL 15572 (white bar; F = 12.32, ** p = 0.0020, when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). C. When the dose of 10 ng of sumatriptan was co-injected with vehicle (black bar) or NAS-181 (gray bar) a robust hyperalgesia was observed; however, when co-injected with BRL 15572 (white bar) the hyperalgesia was completely blocked (F = 91.70, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). (N = 6 paws per group)
Figure Legend Snippet: Upper panel: Female rats received vehicle (5 μL; black bar), NAS-181 (1 μg; 5-HT1B receptor antagonist; gray bar) or BRL 15572 (1 μg; 5-HT1D receptor antagonist; white bar) co-injected with sumatriptan [1 pg (A), 1 ng (B) or 10 ng (C)] on the dorsum of the hind paw. The mechanical nociceptive threshold was evaluated 30 min after sumatriptan injection. A. In the group co-injected with BRL 15572, but not with NAS-181, mechanical hyperalgesia induced by sumatriptan (1 pg) was completely prevented (white bar; F = 89.24, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). B. A dose of 1 ng of sumatriptan, injected with vehicle (black bar), was able to induce mechanical hyperalgesia in female rats that was significantly attenuated by NAS-181 (gray bar) and BRL 15572 (white bar; F = 12.32, ** p = 0.0020, when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). C. When the dose of 10 ng of sumatriptan was co-injected with vehicle (black bar) or NAS-181 (gray bar) a robust hyperalgesia was observed; however, when co-injected with BRL 15572 (white bar) the hyperalgesia was completely blocked (F = 91.70, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). (N = 6 paws per group)

Techniques Used: Injection, Comparison


Structured Review

Bio-Techne corporation brl 15572
Upper panel: Female rats received vehicle (5 μL; black bar), NAS-181 (1 μg; 5-HT1B receptor antagonist; gray bar) or <t>BRL</t> <t>15572</t> (1 μg; 5-HT1D receptor antagonist; white bar) co-injected with sumatriptan [1 pg (A), 1 ng (B) or 10 ng (C)] on the dorsum of the hind paw. The mechanical nociceptive threshold was evaluated 30 min after sumatriptan injection. A. In the group co-injected with BRL 15572, but not with NAS-181, mechanical hyperalgesia induced by sumatriptan (1 pg) was completely prevented (white bar; F = 89.24, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). B. A dose of 1 ng of sumatriptan, injected with vehicle (black bar), was able to induce mechanical hyperalgesia in female rats that was significantly attenuated by NAS-181 (gray bar) and BRL 15572 (white bar; F = 12.32, ** p = 0.0020, when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). C. When the dose of 10 ng of sumatriptan was co-injected with vehicle (black bar) or NAS-181 (gray bar) a robust hyperalgesia was observed; however, when co-injected with BRL 15572 (white bar) the hyperalgesia was completely blocked (F = 91.70, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). (N = 6 paws per group)
Brl 15572, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/brl 15572/product/Bio-Techne corporation
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
brl 15572 - by Bioz Stars, 2024-04
86/100 stars

Images

1) Product Images from "Marked Sexual Dimorphism in 5-HT 1 Receptors Mediating Pronociceptive Effects of Sumatriptan"

Article Title: Marked Sexual Dimorphism in 5-HT 1 Receptors Mediating Pronociceptive Effects of Sumatriptan

Journal: Neuroscience

doi: 10.1016/j.neuroscience.2016.12.031

Upper panel: Female rats received vehicle (5 μL; black bar), NAS-181 (1 μg; 5-HT1B receptor antagonist; gray bar) or BRL 15572 (1 μg; 5-HT1D receptor antagonist; white bar) co-injected with sumatriptan [1 pg (A), 1 ng (B) or 10 ng (C)] on the dorsum of the hind paw. The mechanical nociceptive threshold was evaluated 30 min after sumatriptan injection. A. In the group co-injected with BRL 15572, but not with NAS-181, mechanical hyperalgesia induced by sumatriptan (1 pg) was completely prevented (white bar; F = 89.24, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). B. A dose of 1 ng of sumatriptan, injected with vehicle (black bar), was able to induce mechanical hyperalgesia in female rats that was significantly attenuated by NAS-181 (gray bar) and BRL 15572 (white bar; F = 12.32, ** p = 0.0020, when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). C. When the dose of 10 ng of sumatriptan was co-injected with vehicle (black bar) or NAS-181 (gray bar) a robust hyperalgesia was observed; however, when co-injected with BRL 15572 (white bar) the hyperalgesia was completely blocked (F = 91.70, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). (N = 6 paws per group)
Figure Legend Snippet: Upper panel: Female rats received vehicle (5 μL; black bar), NAS-181 (1 μg; 5-HT1B receptor antagonist; gray bar) or BRL 15572 (1 μg; 5-HT1D receptor antagonist; white bar) co-injected with sumatriptan [1 pg (A), 1 ng (B) or 10 ng (C)] on the dorsum of the hind paw. The mechanical nociceptive threshold was evaluated 30 min after sumatriptan injection. A. In the group co-injected with BRL 15572, but not with NAS-181, mechanical hyperalgesia induced by sumatriptan (1 pg) was completely prevented (white bar; F = 89.24, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). B. A dose of 1 ng of sumatriptan, injected with vehicle (black bar), was able to induce mechanical hyperalgesia in female rats that was significantly attenuated by NAS-181 (gray bar) and BRL 15572 (white bar; F = 12.32, ** p = 0.0020, when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). C. When the dose of 10 ng of sumatriptan was co-injected with vehicle (black bar) or NAS-181 (gray bar) a robust hyperalgesia was observed; however, when co-injected with BRL 15572 (white bar) the hyperalgesia was completely blocked (F = 91.70, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). (N = 6 paws per group)

Techniques Used: Injection, Comparison


Structured Review

Bio-Techne corporation brl 15572 hydrochloride
Brl 15572 Hydrochloride, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/brl 15572 hydrochloride/product/Bio-Techne corporation
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
brl 15572 hydrochloride - by Bioz Stars, 2024-04
86/100 stars

Images


Structured Review

Bio-Techne corporation brl 15572
Effect of prazosin, RX 821002, rauwolscine, JP 1302, ketanserin, methiothepin, SB 224289, and <t>BRL</t> <t>15572</t> on the contractions of rat thoracic aorta induced by lerimazoline
Brl 15572, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/brl 15572/product/Bio-Techne corporation
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
brl 15572 - by Bioz Stars, 2024-04
86/100 stars

Images

1) Product Images from "Atypical sympathomimetic drug lerimazoline mediates contractile effects in rat aorta predominantly by 5-HT2A receptors"

Article Title: Atypical sympathomimetic drug lerimazoline mediates contractile effects in rat aorta predominantly by 5-HT2A receptors

Journal: Bosnian Journal of Basic Medical Sciences

doi: 10.17305/bjbms.2017.2071

Effect of prazosin, RX 821002, rauwolscine, JP 1302, ketanserin, methiothepin, SB 224289, and BRL 15572 on the contractions of rat thoracic aorta induced by lerimazoline
Figure Legend Snippet: Effect of prazosin, RX 821002, rauwolscine, JP 1302, ketanserin, methiothepin, SB 224289, and BRL 15572 on the contractions of rat thoracic aorta induced by lerimazoline

Techniques Used:

Effects of selective serotonergic antagonists: (A) 5-HT1D antagonist BRL 15572 (1 μM, n=8), (B) 5-HT1B antagonist SB 224289 (1 μM, n=10), and (C and D) 5HT2A antagonist ketanserin (1 μM, n=9; 10 nM, n=9) on the lerimazoline-induced contractions in the rat aorta. The points represent mean±standard error of the mean (SEM). The strength of constriction is expressed as a percentage of the maximum tension induced by lerimazoline to that induced by 10-4 M phenylephrine. The effects of the antagonist on the lerimazoline-induced constrictions were compared with the control (*p<0.05, **p<0.01; Student’s t-test.
Figure Legend Snippet: Effects of selective serotonergic antagonists: (A) 5-HT1D antagonist BRL 15572 (1 μM, n=8), (B) 5-HT1B antagonist SB 224289 (1 μM, n=10), and (C and D) 5HT2A antagonist ketanserin (1 μM, n=9; 10 nM, n=9) on the lerimazoline-induced contractions in the rat aorta. The points represent mean±standard error of the mean (SEM). The strength of constriction is expressed as a percentage of the maximum tension induced by lerimazoline to that induced by 10-4 M phenylephrine. The effects of the antagonist on the lerimazoline-induced constrictions were compared with the control (*p<0.05, **p<0.01; Student’s t-test.

Techniques Used:


Structured Review

Bio-Techne corporation brl 15572
Effect of prazosin, RX 821002, rauwolscine, JP 1302, ketanserin, methiothepin, SB 224289, and <t>BRL</t> <t>15572</t> on the contractions of rat thoracic aorta induced by lerimazoline
Brl 15572, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/brl 15572/product/Bio-Techne corporation
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
brl 15572 - by Bioz Stars, 2024-04
86/100 stars

Images

1) Product Images from "Atypical sympathomimetic drug lerimazoline mediates contractile effects in rat aorta predominantly by 5-HT2A receptors"

Article Title: Atypical sympathomimetic drug lerimazoline mediates contractile effects in rat aorta predominantly by 5-HT2A receptors

Journal: Bosnian Journal of Basic Medical Sciences

doi: 10.17305/bjbms.2017.2071

Effect of prazosin, RX 821002, rauwolscine, JP 1302, ketanserin, methiothepin, SB 224289, and BRL 15572 on the contractions of rat thoracic aorta induced by lerimazoline
Figure Legend Snippet: Effect of prazosin, RX 821002, rauwolscine, JP 1302, ketanserin, methiothepin, SB 224289, and BRL 15572 on the contractions of rat thoracic aorta induced by lerimazoline

Techniques Used:

Effects of selective serotonergic antagonists: (A) 5-HT1D antagonist BRL 15572 (1 μM, n=8), (B) 5-HT1B antagonist SB 224289 (1 μM, n=10), and (C and D) 5HT2A antagonist ketanserin (1 μM, n=9; 10 nM, n=9) on the lerimazoline-induced contractions in the rat aorta. The points represent mean±standard error of the mean (SEM). The strength of constriction is expressed as a percentage of the maximum tension induced by lerimazoline to that induced by 10-4 M phenylephrine. The effects of the antagonist on the lerimazoline-induced constrictions were compared with the control (*p<0.05, **p<0.01; Student’s t-test.
Figure Legend Snippet: Effects of selective serotonergic antagonists: (A) 5-HT1D antagonist BRL 15572 (1 μM, n=8), (B) 5-HT1B antagonist SB 224289 (1 μM, n=10), and (C and D) 5HT2A antagonist ketanserin (1 μM, n=9; 10 nM, n=9) on the lerimazoline-induced contractions in the rat aorta. The points represent mean±standard error of the mean (SEM). The strength of constriction is expressed as a percentage of the maximum tension induced by lerimazoline to that induced by 10-4 M phenylephrine. The effects of the antagonist on the lerimazoline-induced constrictions were compared with the control (*p<0.05, **p<0.01; Student’s t-test.

Techniques Used:


Structured Review

Bio-Techne corporation brl 15572
Brl 15572, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/brl 15572/product/Bio-Techne corporation
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
brl 15572 - by Bioz Stars, 2024-04
86/100 stars

Images


Structured Review

Bio-Techne corporation brl 15572
Brl 15572, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/brl 15572/product/Bio-Techne corporation
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
brl 15572 - by Bioz Stars, 2024-04
86/100 stars

Images

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    Bio-Techne corporation brl 15572 hydrochloride
    Brl 15572 Hydrochloride, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/brl 15572 hydrochloride/product/Bio-Techne corporation
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    brl 15572 hydrochloride - by Bioz Stars, 2024-04
    86/100 stars
      Buy from Supplier

    86
    Bio-Techne corporation brl 15572
    Brl 15572, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/brl 15572/product/Bio-Techne corporation
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    brl 15572 - by Bioz Stars, 2024-04
    86/100 stars
      Buy from Supplier

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