Structured Review

Santa Cruz Biotechnology brl 15572
Upper panel: Female rats received vehicle (5 μL; black bar), NAS-181 (1 μg; 5-HT1B receptor antagonist; gray bar) or <t>BRL</t> <t>15572</t> (1 μg; 5-HT1D receptor antagonist; white bar) co-injected with sumatriptan [1 pg (A), 1 ng (B) or 10 ng (C)] on the dorsum of the hind paw. The mechanical nociceptive threshold was evaluated 30 min after sumatriptan injection. A. In the group co-injected with BRL 15572, but not with NAS-181, mechanical hyperalgesia induced by sumatriptan (1 pg) was completely prevented (white bar; F = 89.24, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). B. A dose of 1 ng of sumatriptan, injected with vehicle (black bar), was able to induce mechanical hyperalgesia in female rats that was significantly attenuated by NAS-181 (gray bar) and BRL 15572 (white bar; F = 12.32, ** p = 0.0020, when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). C. When the dose of 10 ng of sumatriptan was co-injected with vehicle (black bar) or NAS-181 (gray bar) a robust hyperalgesia was observed; however, when co-injected with BRL 15572 (white bar) the hyperalgesia was completely blocked (F = 91.70, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). (N = 6 paws per group)
Brl 15572, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 86 stars, based on 1 article reviews
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86/100 stars

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1) Product Images from "Marked Sexual Dimorphism in 5-HT 1 Receptors Mediating Pronociceptive Effects of Sumatriptan"

Article Title: Marked Sexual Dimorphism in 5-HT 1 Receptors Mediating Pronociceptive Effects of Sumatriptan

Journal: Neuroscience

doi: 10.1016/j.neuroscience.2016.12.031

Upper panel: Female rats received vehicle (5 μL; black bar), NAS-181 (1 μg; 5-HT1B receptor antagonist; gray bar) or BRL 15572 (1 μg; 5-HT1D receptor antagonist; white bar) co-injected with sumatriptan [1 pg (A), 1 ng (B) or 10 ng (C)] on the dorsum of the hind paw. The mechanical nociceptive threshold was evaluated 30 min after sumatriptan injection. A. In the group co-injected with BRL 15572, but not with NAS-181, mechanical hyperalgesia induced by sumatriptan (1 pg) was completely prevented (white bar; F = 89.24, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). B. A dose of 1 ng of sumatriptan, injected with vehicle (black bar), was able to induce mechanical hyperalgesia in female rats that was significantly attenuated by NAS-181 (gray bar) and BRL 15572 (white bar; F = 12.32, ** p = 0.0020, when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). C. When the dose of 10 ng of sumatriptan was co-injected with vehicle (black bar) or NAS-181 (gray bar) a robust hyperalgesia was observed; however, when co-injected with BRL 15572 (white bar) the hyperalgesia was completely blocked (F = 91.70, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). (N = 6 paws per group)
Figure Legend Snippet: Upper panel: Female rats received vehicle (5 μL; black bar), NAS-181 (1 μg; 5-HT1B receptor antagonist; gray bar) or BRL 15572 (1 μg; 5-HT1D receptor antagonist; white bar) co-injected with sumatriptan [1 pg (A), 1 ng (B) or 10 ng (C)] on the dorsum of the hind paw. The mechanical nociceptive threshold was evaluated 30 min after sumatriptan injection. A. In the group co-injected with BRL 15572, but not with NAS-181, mechanical hyperalgesia induced by sumatriptan (1 pg) was completely prevented (white bar; F = 89.24, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). B. A dose of 1 ng of sumatriptan, injected with vehicle (black bar), was able to induce mechanical hyperalgesia in female rats that was significantly attenuated by NAS-181 (gray bar) and BRL 15572 (white bar; F = 12.32, ** p = 0.0020, when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). C. When the dose of 10 ng of sumatriptan was co-injected with vehicle (black bar) or NAS-181 (gray bar) a robust hyperalgesia was observed; however, when co-injected with BRL 15572 (white bar) the hyperalgesia was completely blocked (F = 91.70, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). (N = 6 paws per group)

Techniques Used: Injection, Comparison


Structured Review

Santa Cruz Biotechnology brl 15572
Upper panel: Female rats received vehicle (5 μL; black bar), NAS-181 (1 μg; 5-HT1B receptor antagonist; gray bar) or <t>BRL</t> <t>15572</t> (1 μg; 5-HT1D receptor antagonist; white bar) co-injected with sumatriptan [1 pg (A), 1 ng (B) or 10 ng (C)] on the dorsum of the hind paw. The mechanical nociceptive threshold was evaluated 30 min after sumatriptan injection. A. In the group co-injected with BRL 15572, but not with NAS-181, mechanical hyperalgesia induced by sumatriptan (1 pg) was completely prevented (white bar; F = 89.24, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). B. A dose of 1 ng of sumatriptan, injected with vehicle (black bar), was able to induce mechanical hyperalgesia in female rats that was significantly attenuated by NAS-181 (gray bar) and BRL 15572 (white bar; F = 12.32, ** p = 0.0020, when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). C. When the dose of 10 ng of sumatriptan was co-injected with vehicle (black bar) or NAS-181 (gray bar) a robust hyperalgesia was observed; however, when co-injected with BRL 15572 (white bar) the hyperalgesia was completely blocked (F = 91.70, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). (N = 6 paws per group)
Brl 15572, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/brl 15572/product/Santa Cruz Biotechnology
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
brl 15572 - by Bioz Stars, 2024-04
86/100 stars

Images

1) Product Images from "Marked Sexual Dimorphism in 5-HT 1 Receptors Mediating Pronociceptive Effects of Sumatriptan"

Article Title: Marked Sexual Dimorphism in 5-HT 1 Receptors Mediating Pronociceptive Effects of Sumatriptan

Journal: Neuroscience

doi: 10.1016/j.neuroscience.2016.12.031

Upper panel: Female rats received vehicle (5 μL; black bar), NAS-181 (1 μg; 5-HT1B receptor antagonist; gray bar) or BRL 15572 (1 μg; 5-HT1D receptor antagonist; white bar) co-injected with sumatriptan [1 pg (A), 1 ng (B) or 10 ng (C)] on the dorsum of the hind paw. The mechanical nociceptive threshold was evaluated 30 min after sumatriptan injection. A. In the group co-injected with BRL 15572, but not with NAS-181, mechanical hyperalgesia induced by sumatriptan (1 pg) was completely prevented (white bar; F = 89.24, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). B. A dose of 1 ng of sumatriptan, injected with vehicle (black bar), was able to induce mechanical hyperalgesia in female rats that was significantly attenuated by NAS-181 (gray bar) and BRL 15572 (white bar; F = 12.32, ** p = 0.0020, when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). C. When the dose of 10 ng of sumatriptan was co-injected with vehicle (black bar) or NAS-181 (gray bar) a robust hyperalgesia was observed; however, when co-injected with BRL 15572 (white bar) the hyperalgesia was completely blocked (F = 91.70, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). (N = 6 paws per group)
Figure Legend Snippet: Upper panel: Female rats received vehicle (5 μL; black bar), NAS-181 (1 μg; 5-HT1B receptor antagonist; gray bar) or BRL 15572 (1 μg; 5-HT1D receptor antagonist; white bar) co-injected with sumatriptan [1 pg (A), 1 ng (B) or 10 ng (C)] on the dorsum of the hind paw. The mechanical nociceptive threshold was evaluated 30 min after sumatriptan injection. A. In the group co-injected with BRL 15572, but not with NAS-181, mechanical hyperalgesia induced by sumatriptan (1 pg) was completely prevented (white bar; F = 89.24, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). B. A dose of 1 ng of sumatriptan, injected with vehicle (black bar), was able to induce mechanical hyperalgesia in female rats that was significantly attenuated by NAS-181 (gray bar) and BRL 15572 (white bar; F = 12.32, ** p = 0.0020, when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). C. When the dose of 10 ng of sumatriptan was co-injected with vehicle (black bar) or NAS-181 (gray bar) a robust hyperalgesia was observed; however, when co-injected with BRL 15572 (white bar) the hyperalgesia was completely blocked (F = 91.70, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). (N = 6 paws per group)

Techniques Used: Injection, Comparison


Structured Review

Santa Cruz Biotechnology brl 15572
Brl 15572, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 88/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/brl 15572/product/Santa Cruz Biotechnology
Average 88 stars, based on 1 article reviews
Price from $9.99 to $1999.99
brl 15572 - by Bioz Stars, 2024-04
88/100 stars

Images


Structured Review

Santa Cruz Biotechnology brl 15572
Brl 15572, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 88/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/brl 15572/product/Santa Cruz Biotechnology
Average 88 stars, based on 1 article reviews
Price from $9.99 to $1999.99
brl 15572 - by Bioz Stars, 2024-04
88/100 stars

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    Santa Cruz Biotechnology brl 15572
    Upper panel: Female rats received vehicle (5 μL; black bar), NAS-181 (1 μg; 5-HT1B receptor antagonist; gray bar) or <t>BRL</t> <t>15572</t> (1 μg; 5-HT1D receptor antagonist; white bar) co-injected with sumatriptan [1 pg (A), 1 ng (B) or 10 ng (C)] on the dorsum of the hind paw. The mechanical nociceptive threshold was evaluated 30 min after sumatriptan injection. A. In the group co-injected with BRL 15572, but not with NAS-181, mechanical hyperalgesia induced by sumatriptan (1 pg) was completely prevented (white bar; F = 89.24, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). B. A dose of 1 ng of sumatriptan, injected with vehicle (black bar), was able to induce mechanical hyperalgesia in female rats that was significantly attenuated by NAS-181 (gray bar) and BRL 15572 (white bar; F = 12.32, ** p = 0.0020, when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). C. When the dose of 10 ng of sumatriptan was co-injected with vehicle (black bar) or NAS-181 (gray bar) a robust hyperalgesia was observed; however, when co-injected with BRL 15572 (white bar) the hyperalgesia was completely blocked (F = 91.70, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). (N = 6 paws per group)
    Brl 15572, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/brl 15572/product/Santa Cruz Biotechnology
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    brl 15572 - by Bioz Stars, 2024-04
    86/100 stars
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    Upper panel: Female rats received vehicle (5 μL; black bar), NAS-181 (1 μg; 5-HT1B receptor antagonist; gray bar) or BRL 15572 (1 μg; 5-HT1D receptor antagonist; white bar) co-injected with sumatriptan [1 pg (A), 1 ng (B) or 10 ng (C)] on the dorsum of the hind paw. The mechanical nociceptive threshold was evaluated 30 min after sumatriptan injection. A. In the group co-injected with BRL 15572, but not with NAS-181, mechanical hyperalgesia induced by sumatriptan (1 pg) was completely prevented (white bar; F = 89.24, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). B. A dose of 1 ng of sumatriptan, injected with vehicle (black bar), was able to induce mechanical hyperalgesia in female rats that was significantly attenuated by NAS-181 (gray bar) and BRL 15572 (white bar; F = 12.32, ** p = 0.0020, when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). C. When the dose of 10 ng of sumatriptan was co-injected with vehicle (black bar) or NAS-181 (gray bar) a robust hyperalgesia was observed; however, when co-injected with BRL 15572 (white bar) the hyperalgesia was completely blocked (F = 91.70, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). (N = 6 paws per group)

    Journal: Neuroscience

    Article Title: Marked Sexual Dimorphism in 5-HT 1 Receptors Mediating Pronociceptive Effects of Sumatriptan

    doi: 10.1016/j.neuroscience.2016.12.031

    Figure Lengend Snippet: Upper panel: Female rats received vehicle (5 μL; black bar), NAS-181 (1 μg; 5-HT1B receptor antagonist; gray bar) or BRL 15572 (1 μg; 5-HT1D receptor antagonist; white bar) co-injected with sumatriptan [1 pg (A), 1 ng (B) or 10 ng (C)] on the dorsum of the hind paw. The mechanical nociceptive threshold was evaluated 30 min after sumatriptan injection. A. In the group co-injected with BRL 15572, but not with NAS-181, mechanical hyperalgesia induced by sumatriptan (1 pg) was completely prevented (white bar; F = 89.24, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). B. A dose of 1 ng of sumatriptan, injected with vehicle (black bar), was able to induce mechanical hyperalgesia in female rats that was significantly attenuated by NAS-181 (gray bar) and BRL 15572 (white bar; F = 12.32, ** p = 0.0020, when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). C. When the dose of 10 ng of sumatriptan was co-injected with vehicle (black bar) or NAS-181 (gray bar) a robust hyperalgesia was observed; however, when co-injected with BRL 15572 (white bar) the hyperalgesia was completely blocked (F = 91.70, *** p < 0.0001; when vehicle, NAS-181, and BRL 15572 groups were compared; one-way repeated-measures ANOVA followed Dunnett’s multiple comparison test). (N = 6 paws per group)

    Article Snippet: Drugs and their administration The following drugs were used: sumatriptan succinate (prototypical 5-HT 1B and 5-HT 1D receptor agonist), CP-93129 dihydrochloride hydrate [a selective 5-HT 1B receptor agonist; ( Araldi et al., 2016b )] and pertussis toxin [PTX; Gi-protein inhibitor; ( Araldi et al., 2015 , 2016b , a )] from Sigma-Aldrich (St. Louis, MO, USA); H-89 dihydrochloride [inhibitor of protein kinase A (PKA); ( Araldi et al., 2015 , 2016a , b )] from Santa Cruz Biotechnology (Dallas, TX, USA); BRL 15572 [5-HT 1D receptor antagonist; ( Araldi et al., 2016b )], L-694,247 [a selective 5-HT 1D receptor agonist; ( Araldi et al., 2016b )] and NAS-181 [5-HT 1B receptor antagonist; ( Araldi et al., 2016b )] from Tocris Bioscience (Avonmouth, Bristol, UK); and G-36 [GPR30 receptor antagonist; ( Alvarez et al., 2014 )] from Azano Pharmaceuticals (Albuquerque, NM, USA).

    Techniques: Injection, Comparison