bq 788  (Millipore)


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    Millipore bq 788
    BQ 788

    https://www.bioz.com/result/bq 788/product/Millipore
    Average 94 stars, based on 7 article reviews
    Price from $9.99 to $1999.99
    bq 788 - by Bioz Stars, 2020-10
    94/100 stars

    Images

    1) Product Images from "Endothelin-1 inhibits sodium reabsorption by ETA and ETB receptors in the mouse cortical collecting duct"

    Article Title: Endothelin-1 inhibits sodium reabsorption by ETA and ETB receptors in the mouse cortical collecting duct

    Journal: American Journal of Physiology - Renal Physiology

    doi: 10.1152/ajprenal.00613.2012

    Effect of benzamil in the presence of ET-1 and the ET A receptor inhibitor BQ-123 ( A ) or ET B receptor inhibitor BQ-788 ( B ) on Na reabsorption in the CCD of male mice. Benzamil significantly inhibited J Na in the presence of ET-1 plus ET A receptor inhibitor
    Figure Legend Snippet: Effect of benzamil in the presence of ET-1 and the ET A receptor inhibitor BQ-123 ( A ) or ET B receptor inhibitor BQ-788 ( B ) on Na reabsorption in the CCD of male mice. Benzamil significantly inhibited J Na in the presence of ET-1 plus ET A receptor inhibitor

    Techniques Used: Mouse Assay

    2) Product Images from "Endothelin-1 stimulates human colonic myofibroblast contraction and migration"

    Article Title: Endothelin-1 stimulates human colonic myofibroblast contraction and migration

    Journal: Gut

    doi:

    Effect of endothelin-1 (ET-1) on migration by colonic myofibroblasts. (A) ET-1 stimulated migration in a dose dependent manner. Migration is presented as the reduction in wound area at 24 hours as a percentage of the maximal wound area (that is, initial quantitation). Each data point represents the mean (SEM) (n=5 for each point). (B) Migration in response to 10 nM sarafotoxin (SFTX) or 10 nM ET-1 was measured at 24 hours in the presence or absence of 10 μM BQ-123 (ETA-R inhib) or 10 μM BQ-788 (ETB-R inhib), as indicated. Each bar represents the mean (SEM) (n=5). ET-1 stimulated migration was significantly (p
    Figure Legend Snippet: Effect of endothelin-1 (ET-1) on migration by colonic myofibroblasts. (A) ET-1 stimulated migration in a dose dependent manner. Migration is presented as the reduction in wound area at 24 hours as a percentage of the maximal wound area (that is, initial quantitation). Each data point represents the mean (SEM) (n=5 for each point). (B) Migration in response to 10 nM sarafotoxin (SFTX) or 10 nM ET-1 was measured at 24 hours in the presence or absence of 10 μM BQ-123 (ETA-R inhib) or 10 μM BQ-788 (ETB-R inhib), as indicated. Each bar represents the mean (SEM) (n=5). ET-1 stimulated migration was significantly (p

    Techniques Used: Migration, Quantitation Assay, Inhibition

    3) Product Images from "Inflammatory Murine Skin Responses to UV-B Light Are Partially Dependent on Endothelin-1 and Mast Cells"

    Article Title: Inflammatory Murine Skin Responses to UV-B Light Are Partially Dependent on Endothelin-1 and Mast Cells

    Journal: The American Journal of Pathology

    doi: 10.2353/ajpath.2006.060037

    ET-1 promotes skin inflammation after UVB irradiation via ET A . A: UVB-induced (250 mJ/cm 2 ) ear swelling in C57BL/6 mice pretreated with the ET receptor antagonists BQ-123 (ET A ,10 −4 M), BQ-788 (ET B ,10 −4 M), or vehicle (0.9% NaCl, 200 μl i.v.) ( n = 11 to 21/group). B: Inflammation-associated neutrophil recruitment into the ears of BQ-123-, BQ-788-, or vehicle-pretreated mice on day 8 after UVB irradiation as assessed by measuring MPO activity. Data are expressed as percentage of MPO in vehicle-treated mice ( n = 16 to 17/group). Data pooled from three independent experiments. All data shown as means ± SEM. ** P =
    Figure Legend Snippet: ET-1 promotes skin inflammation after UVB irradiation via ET A . A: UVB-induced (250 mJ/cm 2 ) ear swelling in C57BL/6 mice pretreated with the ET receptor antagonists BQ-123 (ET A ,10 −4 M), BQ-788 (ET B ,10 −4 M), or vehicle (0.9% NaCl, 200 μl i.v.) ( n = 11 to 21/group). B: Inflammation-associated neutrophil recruitment into the ears of BQ-123-, BQ-788-, or vehicle-pretreated mice on day 8 after UVB irradiation as assessed by measuring MPO activity. Data are expressed as percentage of MPO in vehicle-treated mice ( n = 16 to 17/group). Data pooled from three independent experiments. All data shown as means ± SEM. ** P =

    Techniques Used: Irradiation, Mouse Assay, Activity Assay

    ET-1 induces skin inflammation. A: ET-1 in various concentrations or vehicle was injected intradermally into ears of C57BL/6 mice, and increases in ear swelling were measured as a parameter of inflammation. B: ET-1-induced ear swelling in C57BL/6 mice pretreated with the ET receptor antagonists BQ-123 (ET A , 10 −4 M), BQ-788 (ET B , 10 −4 M), or vehicle (0.9% NaCl, 200 μl i.v.). Ear swelling is shown 1 hour after ET-1 injection (20 pmol in 20 μl). C: Passive cutaneous anaphylaxis was induced in C57BL/6 mice by sensitizing with IgE anti-DNP (100 ng in 20 μl i.d.) and subsequent challenge 24 hours later with DNP-human serum albumin (400 μg in 100 μl i.v.). D: Ears of ET-1-, vehicle-, or IgE+antigen-injected mice were harvested 6 hours after injection and processed for histochemistry. The extent of MC degranulation was then assessed in alkaline Giemsa-stained 1-μm sections by quantitative histomorphometry at ×400. Data pooled from three (A) or two (B) independent experiments. All data shown as means ± SEM. * P =
    Figure Legend Snippet: ET-1 induces skin inflammation. A: ET-1 in various concentrations or vehicle was injected intradermally into ears of C57BL/6 mice, and increases in ear swelling were measured as a parameter of inflammation. B: ET-1-induced ear swelling in C57BL/6 mice pretreated with the ET receptor antagonists BQ-123 (ET A , 10 −4 M), BQ-788 (ET B , 10 −4 M), or vehicle (0.9% NaCl, 200 μl i.v.). Ear swelling is shown 1 hour after ET-1 injection (20 pmol in 20 μl). C: Passive cutaneous anaphylaxis was induced in C57BL/6 mice by sensitizing with IgE anti-DNP (100 ng in 20 μl i.d.) and subsequent challenge 24 hours later with DNP-human serum albumin (400 μg in 100 μl i.v.). D: Ears of ET-1-, vehicle-, or IgE+antigen-injected mice were harvested 6 hours after injection and processed for histochemistry. The extent of MC degranulation was then assessed in alkaline Giemsa-stained 1-μm sections by quantitative histomorphometry at ×400. Data pooled from three (A) or two (B) independent experiments. All data shown as means ± SEM. * P =

    Techniques Used: Injection, Mouse Assay, Staining

    4) Product Images from "Suc-[Glu9, Ala11,15]-endothelin-1 (8-21), IRL 1620, identifies two populations of ETB receptors in guinea-pig bronchus"

    Article Title: Suc-[Glu9, Ala11,15]-endothelin-1 (8-21), IRL 1620, identifies two populations of ETB receptors in guinea-pig bronchus

    Journal: British Journal of Pharmacology

    doi: 10.1038/sj.bjp.0702672

    Contractions of guinea-pig isolated bronchus to IRL 1620 in the presence and absence of increasing concentrations of the ET B -selective antagonist, BQ 788 (A), or the ET A -selective antagonist, BQ 123 (B). Each point represents the mean±s.e.mean of 4–6 experiments. Where no error bar is visible, error falls within the limits of the symbol.
    Figure Legend Snippet: Contractions of guinea-pig isolated bronchus to IRL 1620 in the presence and absence of increasing concentrations of the ET B -selective antagonist, BQ 788 (A), or the ET A -selective antagonist, BQ 123 (B). Each point represents the mean±s.e.mean of 4–6 experiments. Where no error bar is visible, error falls within the limits of the symbol.

    Techniques Used: Isolation

    5) Product Images from "A Novel Bidirectional Interaction between endothelin-3 and Retinoic Acid in Rat Enteric Nervous System Precursors"

    Article Title: A Novel Bidirectional Interaction between endothelin-3 and Retinoic Acid in Rat Enteric Nervous System Precursors

    Journal: PLoS ONE

    doi: 10.1371/journal.pone.0074311

    EDN3 is associated with decreased levels of RA receptor mRNA and RA metabolic enzyme mRNA. p75 NTR + cells were grown for 72 hours in the presence of RA, EDN3, RA with EDN3, or neither compound. When EDN3 was absent, the EDN signaling inhibitor BQ-788 was added to inhibit endogenous EDNRB signaling. Relative Rarb (A), Rarg (B), Raldh2 (C), and Cyp26a1 (D) mRNA levels were measured by quantitative RT-PCR. Levels are normalized to β-actin and the -RA/-EDN3 condition was standardized to a value of 1. Solid lines denote a statistically significant difference (p
    Figure Legend Snippet: EDN3 is associated with decreased levels of RA receptor mRNA and RA metabolic enzyme mRNA. p75 NTR + cells were grown for 72 hours in the presence of RA, EDN3, RA with EDN3, or neither compound. When EDN3 was absent, the EDN signaling inhibitor BQ-788 was added to inhibit endogenous EDNRB signaling. Relative Rarb (A), Rarg (B), Raldh2 (C), and Cyp26a1 (D) mRNA levels were measured by quantitative RT-PCR. Levels are normalized to β-actin and the -RA/-EDN3 condition was standardized to a value of 1. Solid lines denote a statistically significant difference (p

    Techniques Used: Quantitative RT-PCR

    Effects of RA and EDN3 on the terminal culture morphology of ENS precursors. p75 NTR immunoselected cells were grown for 14 days in the presence of RA, EDN3, RA with EDN3, or neither compound. When EDN3 was absent, the EDN signaling inhibitor BQ-788 was added to inhibit endogenous EDNRB signaling. Culture morphology was evaluated by immunofluorescence microscopy. Peripherin expression (red) is consistent with neuronal morphology and myofibroblasts are indicated by expression of α-SMA (green). The third and fourth columns include DAPI staining for nuclei. The first three columns were photographed at 10x (Scale bar = 100 µm) and the fourth column was photographed at 40x (Scale bar = 50 µm). In the absence of EDN3 and RA (EDN3-RA-), SMA+ myofibroblasts predominated, but sparse neurons were also seen. EDN3+RA- treated cultures formed a homogeneous sheet of SMA+ myofibroblasts. In EDN3-RA+ cultures, neurons formed a plexus punctuated by large multicellular ganglia, abundant peripherin+ neurites and cell bodies, and non-myofibroblast-like SMA+ cells. SMA+ myofibroblasts were also present beneath the plexus. With EDN3+RA+ treatment, many peripherin+ neurons and long complex neurites were seen, without forming a plexus. Myofibroblasts, while excluded from neuronal regions, were still present in large number.
    Figure Legend Snippet: Effects of RA and EDN3 on the terminal culture morphology of ENS precursors. p75 NTR immunoselected cells were grown for 14 days in the presence of RA, EDN3, RA with EDN3, or neither compound. When EDN3 was absent, the EDN signaling inhibitor BQ-788 was added to inhibit endogenous EDNRB signaling. Culture morphology was evaluated by immunofluorescence microscopy. Peripherin expression (red) is consistent with neuronal morphology and myofibroblasts are indicated by expression of α-SMA (green). The third and fourth columns include DAPI staining for nuclei. The first three columns were photographed at 10x (Scale bar = 100 µm) and the fourth column was photographed at 40x (Scale bar = 50 µm). In the absence of EDN3 and RA (EDN3-RA-), SMA+ myofibroblasts predominated, but sparse neurons were also seen. EDN3+RA- treated cultures formed a homogeneous sheet of SMA+ myofibroblasts. In EDN3-RA+ cultures, neurons formed a plexus punctuated by large multicellular ganglia, abundant peripherin+ neurites and cell bodies, and non-myofibroblast-like SMA+ cells. SMA+ myofibroblasts were also present beneath the plexus. With EDN3+RA+ treatment, many peripherin+ neurons and long complex neurites were seen, without forming a plexus. Myofibroblasts, while excluded from neuronal regions, were still present in large number.

    Techniques Used: Immunofluorescence, Microscopy, Expressing, Staining

    Culture in the presence of RA increases Sox10 , but EDN3 suppresses this effect. p75 NTR + cells were grown for 72 hours in the presence of RA, EDN3, RA with EDN3, or neither compound. When EDN3 was absent, the EDN signaling inhibitor BQ-788 was added to inhibit endogenous EDNRB signaling. Relative Sox10 (A–B) and Ret (C–D) mRNA levels were measured by quantitative RT-PCR after 3 (A, C) and 14 (B, D) days. Expression is normalized to β-actin and the -RA/-EDN3 condition was standardized to a value of 1. Solid lines denote a statistically significant difference (p
    Figure Legend Snippet: Culture in the presence of RA increases Sox10 , but EDN3 suppresses this effect. p75 NTR + cells were grown for 72 hours in the presence of RA, EDN3, RA with EDN3, or neither compound. When EDN3 was absent, the EDN signaling inhibitor BQ-788 was added to inhibit endogenous EDNRB signaling. Relative Sox10 (A–B) and Ret (C–D) mRNA levels were measured by quantitative RT-PCR after 3 (A, C) and 14 (B, D) days. Expression is normalized to β-actin and the -RA/-EDN3 condition was standardized to a value of 1. Solid lines denote a statistically significant difference (p

    Techniques Used: Quantitative RT-PCR, Expressing

    RA decreases EDN3 and Ece1 mRNA levels, depending on whether exogenous EDN3 is present. p75 NTR + cells were grown for 72 hours in the presence of RA, EDN3, RA with EDN3, or neither compound. When EDN3 was absent, the EDN signaling inhibitor BQ-788 was added to inhibit endogenous EDNRB signaling. Relative EDN3 (A-B) and Ece1 (C-D) mRNA levels were measured by quantitative RT-PCR after 3 (A, C) and 14 (B, D) days. Levels are normalized to β-actin and the -RA/-EDN3 condition was standardized to a value of 1. Solid lines denote a statistically significant difference (p
    Figure Legend Snippet: RA decreases EDN3 and Ece1 mRNA levels, depending on whether exogenous EDN3 is present. p75 NTR + cells were grown for 72 hours in the presence of RA, EDN3, RA with EDN3, or neither compound. When EDN3 was absent, the EDN signaling inhibitor BQ-788 was added to inhibit endogenous EDNRB signaling. Relative EDN3 (A-B) and Ece1 (C-D) mRNA levels were measured by quantitative RT-PCR after 3 (A, C) and 14 (B, D) days. Levels are normalized to β-actin and the -RA/-EDN3 condition was standardized to a value of 1. Solid lines denote a statistically significant difference (p

    Techniques Used: Quantitative RT-PCR

    RA increases S100β+ and decreases peripherin+ cell prevalence while EDN3 decreases S100β+ cell prevalence. p75 NTR + cells were grown for 72 hours in the presence of RA, EDN3, RA with EDN3, or neither compound. When EDN3 was absent, the EDN signaling inhibitor BQ-788 was added to inhibit endogenous EDNRB signaling. The proportion (A and C) and proliferating fraction (B and D) of peripherin- and S100β-immunoreactive cells were quantified. Solid lines denote a statistically significant difference (p
    Figure Legend Snippet: RA increases S100β+ and decreases peripherin+ cell prevalence while EDN3 decreases S100β+ cell prevalence. p75 NTR + cells were grown for 72 hours in the presence of RA, EDN3, RA with EDN3, or neither compound. When EDN3 was absent, the EDN signaling inhibitor BQ-788 was added to inhibit endogenous EDNRB signaling. The proportion (A and C) and proliferating fraction (B and D) of peripherin- and S100β-immunoreactive cells were quantified. Solid lines denote a statistically significant difference (p

    Techniques Used:

    Effects of RA and EDN3 on the terminal culture morphology of ENS precursors. p75 NTR immunoselected cells were grown for 14 days in the presence of RA, EDN3, RA with EDN3, or neither compound. When EDN3 was absent, the EDN signaling inhibitor BQ-788 was added to inhibit endogenous EDNRB signaling. Culture morphology was evaluated by immunofluorescence microscopy. Peripherin expression (red) is consistent with neuronal morphology and glia are indicated by expression of S100β (green). The third and fourth columns include DAPI staining for nuclei. The first three columns were photographed at 10x (Scale bar = 100 µm) and the fourth column was photographed at 40x (Scale bar = 50 µm). Without EDN3 and RA (EDN3-RA-) sparse neurons developed, but S100β+ glia were more numerous and more brightly staining. EDN3+RA- cultures did not contain glia or neurons. EDN3-RA+ cultures formed discrete heterocellular ganglia with abundant peripherin+ cell bodies and S100β+ glia, linked by thick peripherin+ neurites in a plexus pattern. EDN3+RA+ treatment also contained many peripherin+ neurons and long complex neurites, but these neurons were disorganized, and did not form a plexus. Weakly staining S100β+ cells with glial cell morphology were also found amidst the neurons. The glia in these cultures were more fusiform and were mainly associated with neurons.
    Figure Legend Snippet: Effects of RA and EDN3 on the terminal culture morphology of ENS precursors. p75 NTR immunoselected cells were grown for 14 days in the presence of RA, EDN3, RA with EDN3, or neither compound. When EDN3 was absent, the EDN signaling inhibitor BQ-788 was added to inhibit endogenous EDNRB signaling. Culture morphology was evaluated by immunofluorescence microscopy. Peripherin expression (red) is consistent with neuronal morphology and glia are indicated by expression of S100β (green). The third and fourth columns include DAPI staining for nuclei. The first three columns were photographed at 10x (Scale bar = 100 µm) and the fourth column was photographed at 40x (Scale bar = 50 µm). Without EDN3 and RA (EDN3-RA-) sparse neurons developed, but S100β+ glia were more numerous and more brightly staining. EDN3+RA- cultures did not contain glia or neurons. EDN3-RA+ cultures formed discrete heterocellular ganglia with abundant peripherin+ cell bodies and S100β+ glia, linked by thick peripherin+ neurites in a plexus pattern. EDN3+RA+ treatment also contained many peripherin+ neurons and long complex neurites, but these neurons were disorganized, and did not form a plexus. Weakly staining S100β+ cells with glial cell morphology were also found amidst the neurons. The glia in these cultures were more fusiform and were mainly associated with neurons.

    Techniques Used: Immunofluorescence, Microscopy, Expressing, Staining

    6) Product Images from "Endothelial overexpression of endothelin-1 modulates aortic, carotid, iliac and renal arterial responses in obese mice"

    Article Title: Endothelial overexpression of endothelin-1 modulates aortic, carotid, iliac and renal arterial responses in obese mice

    Journal: Acta Pharmacologica Sinica

    doi: 10.1038/aps.2016.138

    Contractions to endothelin-1 (ET-1) in iliac arterial rings from lean (A and B) and obese (C and D) wild-type (WT) mice and mice with heterozygous endothelial overexpression of the prepro-ET-1 gene (TET het ). All the experiments were performed in the presence of L- NAME (3×10 −4 mol/L) and BQ-123, BQ-788, or bosentan (all 10 −6 mol/L). The data are expressed as the percentage of reference contractions to a 60 mmol/L high potassium solution, and the negative logarithms of the calculated concentrations that cause a half maximal responses (pD 2 values in brackets where calculation possible) are given as the mean±SEM; n =6–9. ** P
    Figure Legend Snippet: Contractions to endothelin-1 (ET-1) in iliac arterial rings from lean (A and B) and obese (C and D) wild-type (WT) mice and mice with heterozygous endothelial overexpression of the prepro-ET-1 gene (TET het ). All the experiments were performed in the presence of L- NAME (3×10 −4 mol/L) and BQ-123, BQ-788, or bosentan (all 10 −6 mol/L). The data are expressed as the percentage of reference contractions to a 60 mmol/L high potassium solution, and the negative logarithms of the calculated concentrations that cause a half maximal responses (pD 2 values in brackets where calculation possible) are given as the mean±SEM; n =6–9. ** P

    Techniques Used: Mouse Assay, Over Expression

    7) Product Images from "Endothelin-1 Regulates Cardiac L-Type Calcium Channels via NAD(P)H Oxidase-Derived Superoxide"

    Article Title: Endothelin-1 Regulates Cardiac L-Type Calcium Channels via NAD(P)H Oxidase-Derived Superoxide

    Journal: The Journal of pharmacology and experimental therapeutics

    doi: 10.1124/jpet.108.140301

    Role of ET A receptor, ET B receptor, and superoxide in ET-1-induced increases in I CaL in isolated cardiomyocytes. A, bar graphs showing the effect of an ET A receptor antagonist, BQ-123 (BQ123, 1 μM), and an ET B receptor antagonist, BQ-788 (BQ788,
    Figure Legend Snippet: Role of ET A receptor, ET B receptor, and superoxide in ET-1-induced increases in I CaL in isolated cardiomyocytes. A, bar graphs showing the effect of an ET A receptor antagonist, BQ-123 (BQ123, 1 μM), and an ET B receptor antagonist, BQ-788 (BQ788,

    Techniques Used: Isolation

    8) Product Images from "Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect"

    Article Title: Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect

    Journal: The Journal of Venomous Animals and Toxins Including Tropical Diseases

    doi: 10.1186/s40409-017-0104-0

    Involvement of endothelin on MT-II-induced articular hyperalgesia. MT-II (10 μg/joint) or PBS (vehicle) was injected in tibio-tarsal articulation (25 μL). Pain threshold was determined using a modified electronic pressure-meter test 8 h after MT-II injection, and represented as force (in g ). a BQ-123 or ( b ) BQ-788 (10 and 20 nmol/joint, selective antagonists of ET-A and ET-B endothelin receptors, respectively) were injected 30 min before MT-II. Each point represents the mean ± SEM of six animals. ** p
    Figure Legend Snippet: Involvement of endothelin on MT-II-induced articular hyperalgesia. MT-II (10 μg/joint) or PBS (vehicle) was injected in tibio-tarsal articulation (25 μL). Pain threshold was determined using a modified electronic pressure-meter test 8 h after MT-II injection, and represented as force (in g ). a BQ-123 or ( b ) BQ-788 (10 and 20 nmol/joint, selective antagonists of ET-A and ET-B endothelin receptors, respectively) were injected 30 min before MT-II. Each point represents the mean ± SEM of six animals. ** p

    Techniques Used: Injection, Modification

    9) Product Images from "Evaluation of Arteriolar Smooth Muscle Cell Function in an Ex Vivo Microvascular Network Model"

    Article Title: Evaluation of Arteriolar Smooth Muscle Cell Function in an Ex Vivo Microvascular Network Model

    Journal: Scientific Reports

    doi: 10.1038/s41598-017-02272-4

    Evaluation of endothelin-1 sub-type receptors (ET A and ET B ) in the rat mesentery culture model. Comparison of arteriole constriction responses to 20 nM ET-1 in the presence of BQ-123 and BQ-788 antagonists. The statistically significant difference between Control and BQ-123 + BQ-788 for Day 0 (pre-culture) and Day 3 (cultured) groups suggests the endothelin-1 sub-type receptors (ET A and ET B ) remain functional in the rat mesentery culture model after three days in culture. Black and white bars represent the Control and BQ-123 + BQ-788 groups respectively. * and ** indicates a significant difference of p
    Figure Legend Snippet: Evaluation of endothelin-1 sub-type receptors (ET A and ET B ) in the rat mesentery culture model. Comparison of arteriole constriction responses to 20 nM ET-1 in the presence of BQ-123 and BQ-788 antagonists. The statistically significant difference between Control and BQ-123 + BQ-788 for Day 0 (pre-culture) and Day 3 (cultured) groups suggests the endothelin-1 sub-type receptors (ET A and ET B ) remain functional in the rat mesentery culture model after three days in culture. Black and white bars represent the Control and BQ-123 + BQ-788 groups respectively. * and ** indicates a significant difference of p

    Techniques Used: Cell Culture, Functional Assay

    Related Articles

    Concentration Assay:

    Article Title: An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo
    Article Snippet: .. Thus, the effects of BQ788 at high concentration are not mediated through ETRA. .. To examine further the effect of BQ788, we used the highly selective ETRB agonist, sarafotoxin 6c (S6c) ( ).

    In Vivo:

    Article Title: An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo
    Article Snippet: .. Although it remains to be seen whether BQ788 is the most effective ETRB antagonist for stopping melanoma growth in vivo , there is evidence that such drugs can be well tolerated. .. In an animal model of hypertension, BQ788 reduced renal blood flow without affecting urine formation or causing toxic side effects ( ).

    other:

    Article Title: An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo
    Article Snippet: Therefore, we asked whether systemic administration of BQ788 also inhibits tumor growth.

    Article Title: Endothelin‐1 and its receptors on haemorrhoidal tissue: a potential site for therapeutic intervention) Endothelin‐1 and its receptors on haemorrhoidal tissue: a potential site for therapeutic intervention
    Article Snippet: PD156707 and BQ788 were dissolved in DMSO (Sigma‐Aldrich, UK).

    Article Title: An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo
    Article Snippet: As shown in Fig. , all seven melanoma lines show a significant loss in the number of viable cells upon treatment with 100 μM BQ788, although some lines are more sensitive than others.

    Mouse Assay:

    Article Title: An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo
    Article Snippet: .. This graph, however, does mask an important heterogeneity in the response of the mice to BQ788. ..

    Activation Assay:

    Article Title: Endothelin-1, the Unfolded Protein Response, and Persistent Inflammation
    Article Snippet: .. BQ123, but not BQ788, prevented activation of the ATF6 reporter. ..

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    Millipore bq788
    TUNEL staining of A375 cell tumors grown in nude mice reveals evidence for <t>BQ788-stimulated</t> apoptosis. Representative sections are illustrated from four tumors from BQ788-injected (i.p.) mice and three tumors from vehicle-injected mice. TUNEL-positive cells are in most cases much more frequent in tumors from the drug-treated animals, suggesting enhanced apoptosis. ( A – D ) BQ788-treated mice. ( A and B ) Less-affected tumors. ( C and D ) Strongly affected tumors. ( E – G ) Vehicle-treated mice. Pictures were taken at ×20 magnification.
    Bq788, supplied by Millipore, used in various techniques. Bioz Stars score: 94/100, based on 40 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    TUNEL staining of A375 cell tumors grown in nude mice reveals evidence for BQ788-stimulated apoptosis. Representative sections are illustrated from four tumors from BQ788-injected (i.p.) mice and three tumors from vehicle-injected mice. TUNEL-positive cells are in most cases much more frequent in tumors from the drug-treated animals, suggesting enhanced apoptosis. ( A – D ) BQ788-treated mice. ( A and B ) Less-affected tumors. ( C and D ) Strongly affected tumors. ( E – G ) Vehicle-treated mice. Pictures were taken at ×20 magnification.

    Journal: Proceedings of the National Academy of Sciences of the United States of America

    Article Title: An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo

    doi:

    Figure Lengend Snippet: TUNEL staining of A375 cell tumors grown in nude mice reveals evidence for BQ788-stimulated apoptosis. Representative sections are illustrated from four tumors from BQ788-injected (i.p.) mice and three tumors from vehicle-injected mice. TUNEL-positive cells are in most cases much more frequent in tumors from the drug-treated animals, suggesting enhanced apoptosis. ( A – D ) BQ788-treated mice. ( A and B ) Less-affected tumors. ( C and D ) Strongly affected tumors. ( E – G ) Vehicle-treated mice. Pictures were taken at ×20 magnification.

    Article Snippet: As shown in Fig. , all seven melanoma lines show a significant loss in the number of viable cells upon treatment with 100 μM BQ788, although some lines are more sensitive than others.

    Techniques: TUNEL Assay, Staining, Mouse Assay, Injection

    Intratumor injection of BQ788 inhibits melanoma tumor growth in nude mice. Nude mice (nu/nu, BALB/c background) were implanted with grafts of A375 cells s.c. in the flank. After the tumors had reached approximately 4 mm in diameter they were injected daily with BQ788 for 9 days. Perpendicular tumor diameters were measured daily to estimate tumor volume. Controls were injected on the same schedule with vehicle. Data from three experiments using 10 BQ788-treated mice and 8 vehicle-treated mice are pooled. P values were calculated by using the Student’s t test and are indicated by ∗ when significantly different from controls ( P

    Journal: Proceedings of the National Academy of Sciences of the United States of America

    Article Title: An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo

    doi:

    Figure Lengend Snippet: Intratumor injection of BQ788 inhibits melanoma tumor growth in nude mice. Nude mice (nu/nu, BALB/c background) were implanted with grafts of A375 cells s.c. in the flank. After the tumors had reached approximately 4 mm in diameter they were injected daily with BQ788 for 9 days. Perpendicular tumor diameters were measured daily to estimate tumor volume. Controls were injected on the same schedule with vehicle. Data from three experiments using 10 BQ788-treated mice and 8 vehicle-treated mice are pooled. P values were calculated by using the Student’s t test and are indicated by ∗ when significantly different from controls ( P

    Article Snippet: As shown in Fig. , all seven melanoma lines show a significant loss in the number of viable cells upon treatment with 100 μM BQ788, although some lines are more sensitive than others.

    Techniques: Injection, Mouse Assay

    The ETRB antagonist BQ788 induces morphological changes in cultured melanoma cells. Cells were cultured for 4 days with 100 μM BQ788 ( A and C ) or with vehicle ( B and D ). The cell lines were melanoma line SK-MEL 28 ( A and B ) and melanoma line SK-MEL 5 ( C and D ). Note the different shape of the drug-treated melanoma cells and their accumulation of black pigment. Pictures were taken with bright-field optics at ×40 magnification.

    Journal: Proceedings of the National Academy of Sciences of the United States of America

    Article Title: An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo

    doi:

    Figure Lengend Snippet: The ETRB antagonist BQ788 induces morphological changes in cultured melanoma cells. Cells were cultured for 4 days with 100 μM BQ788 ( A and C ) or with vehicle ( B and D ). The cell lines were melanoma line SK-MEL 28 ( A and B ) and melanoma line SK-MEL 5 ( C and D ). Note the different shape of the drug-treated melanoma cells and their accumulation of black pigment. Pictures were taken with bright-field optics at ×40 magnification.

    Article Snippet: As shown in Fig. , all seven melanoma lines show a significant loss in the number of viable cells upon treatment with 100 μM BQ788, although some lines are more sensitive than others.

    Techniques: Cell Culture