bone marrow derived mscs bmscs  (Dawley Inc)

Journal: Neural Regeneration Research

Article Title: Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury: state of the art and future perspectives

doi: 10.4103/NRR.NRR-D-24-00235

Figure Lengend Snippet: Typical examples of preclinical investigations on the application of various types of mesenchymal stem cells in peripheral nerve injury using different delivery methods

Article Snippet: One study showed that a model of PNI in Sprague–Dawley rats exhibited greater improvements in the restoration rate of gastrocnemius-muscle wet weight, sciatic function index (SFI), nerve conduction velocity (NCV), and myelin-sheath thickness after IM injection of bone marrow-derived MSCs (BMSCs), compared with IV delivery of BMSCs or phosphate-buffered solution (Wang et al., 2015a).

Techniques: Injection, IV Injection, Saline, Microinjection, Functional Assay, In Vitro, In Vivo, Transplantation Assay, Expressing

Journal: Neural Regeneration Research

Article Title: Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury: state of the art and future perspectives

doi: 10.4103/NRR.NRR-D-24-00235

Figure Lengend Snippet: Historical milestones in preclinical investigations applying various types of MSCs in peripheral nerve injury. Created with BioRender.com. MSC: Mesenchymal stem cell.

Article Snippet: One study showed that a model of PNI in Sprague–Dawley rats exhibited greater improvements in the restoration rate of gastrocnemius-muscle wet weight, sciatic function index (SFI), nerve conduction velocity (NCV), and myelin-sheath thickness after IM injection of bone marrow-derived MSCs (BMSCs), compared with IV delivery of BMSCs or phosphate-buffered solution (Wang et al., 2015a).

Techniques:

Journal: Neural Regeneration Research

Article Title: Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury: state of the art and future perspectives

doi: 10.4103/NRR.NRR-D-24-00235

Figure Lengend Snippet: Mechanisms underlying MSC therapy for peripheral nerve injury. (A) MSCs can differentiate into Schwann cell–like cells that produce growth factors, secrete neurotrophic factors, clear debris, and promote vascularization and myelination. (B) MSCs enhance nerve regeneration through their paracrine effects, which facilitate the transition of pro-inflammatory T helper 1 (Th1) cells to anti-inflammatory Th2 cells, recruit macrophages, promote M2-type polarization, and support vascularization. (C) Direct cell-to-cell contact between MSCs and other cells, such as pro-inflammatory macrophages, inhibits T-cell proliferation, and facilitates the transition of M1 macrophages to the M2 type, thereby alleviating excessive inflammation. Cell-to-cell contacts also provide approaches for the transport of molecules and organelles such as mitochondria between cells. (D) MSCs enhance the expression of transcription factors such as Krox-20/EGR2, which increase myelin proteins and promote myelination. Created with Adobe Illustrator TM 2019, with elements sourced from Servier Medical Art. Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/). MSC: Mesenchymal stem cell.

Article Snippet: One study showed that a model of PNI in Sprague–Dawley rats exhibited greater improvements in the restoration rate of gastrocnemius-muscle wet weight, sciatic function index (SFI), nerve conduction velocity (NCV), and myelin-sheath thickness after IM injection of bone marrow-derived MSCs (BMSCs), compared with IV delivery of BMSCs or phosphate-buffered solution (Wang et al., 2015a).

Techniques: Expressing

Journal: Neural Regeneration Research

Article Title: Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury: state of the art and future perspectives

doi: 10.4103/NRR.NRR-D-24-00235

Figure Lengend Snippet: Mechanisms of mesenchymal stem cells and their exosomes for treating peripheral nerve injury. Created using Adobe Illustrator™ 2019, with elements sourced from Servier Medical Art. Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/). MSCs: Mesenchymal stem cells; M1: M1-polarized macrophage; M2: M2-polarized macrophage; Th1: T helper 1 cell; Th2: T helper 2 cell.

Article Snippet: One study showed that a model of PNI in Sprague–Dawley rats exhibited greater improvements in the restoration rate of gastrocnemius-muscle wet weight, sciatic function index (SFI), nerve conduction velocity (NCV), and myelin-sheath thickness after IM injection of bone marrow-derived MSCs (BMSCs), compared with IV delivery of BMSCs or phosphate-buffered solution (Wang et al., 2015a).

Techniques: