beta hexaclorocyclohexane β hch  (Millipore)

 
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    Name:
    beta HCH
    Description:
    β Hexachlorocyclohexane is an isomer of hexachlorocyclohexane It is an organochlorine pesticide with carcinogenic effects on both humans and animals
    Catalog Number:
    33376
    Price:
    None
    Applications:
    β-Hexachlorocyclohexane may be used as a reference standard for the determination of β-hexachlorocyclohexane in marine sediments by pressurized liquid extraction (PLE) and stir-bar sorptive extraction (SBSE) coupled with thermal desorption and gas chromatography-triple quadrupole mass spectrometry (TD-GC-MS/MS QqQ).
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    Structured Review

    Millipore beta hexaclorocyclohexane β hch
    beta HCH
    β Hexachlorocyclohexane is an isomer of hexachlorocyclohexane It is an organochlorine pesticide with carcinogenic effects on both humans and animals
    https://www.bioz.com/result/beta hexaclorocyclohexane β hch/product/Millipore
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    beta hexaclorocyclohexane β hch - by Bioz Stars, 2021-07
    94/100 stars

    Images

    1) Product Images from "STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by β-Hexaclorocyclohexane"

    Article Title: STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by β-Hexaclorocyclohexane

    Journal: International Journal of Molecular Sciences

    doi: 10.3390/ijms19072108

    Evaluation of the signaling pathways triggered by β-hexaclorocyclohexane (β-HCH). Immunoblot analysis of the time-course assay performed on human prostate cancer (LNCaP), human breast cancer (MCF-7 and MDA-MB 468), and human hepatoma (HepG2) cells treated with 10 μM β-HCH. Samples were analyzed for signal transducer and activator of transcription 3 (STAT3) and each cell line for a specific membrane or membrane associated tyrosine kinase receptor: EGFR in MDA-MB 468 cells, JAK2 in HepG2 cells, SRC in LNCaP cells and HER2 in MCF-7 cells. Both unmodified and the corresponding phosphorylated form were detected for each protein using specific antibodies.
    Figure Legend Snippet: Evaluation of the signaling pathways triggered by β-hexaclorocyclohexane (β-HCH). Immunoblot analysis of the time-course assay performed on human prostate cancer (LNCaP), human breast cancer (MCF-7 and MDA-MB 468), and human hepatoma (HepG2) cells treated with 10 μM β-HCH. Samples were analyzed for signal transducer and activator of transcription 3 (STAT3) and each cell line for a specific membrane or membrane associated tyrosine kinase receptor: EGFR in MDA-MB 468 cells, JAK2 in HepG2 cells, SRC in LNCaP cells and HER2 in MCF-7 cells. Both unmodified and the corresponding phosphorylated form were detected for each protein using specific antibodies.

    Techniques Used: Multiple Displacement Amplification

    2) Product Images from "STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by β-Hexaclorocyclohexane"

    Article Title: STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by β-Hexaclorocyclohexane

    Journal: International Journal of Molecular Sciences

    doi: 10.3390/ijms19072108

    Evaluation of the signaling pathways triggered by β-hexaclorocyclohexane (β-HCH). Immunoblot analysis of the time-course assay performed on human prostate cancer (LNCaP), human breast cancer (MCF-7 and MDA-MB 468), and human hepatoma (HepG2) cells treated with 10 μM β-HCH. Samples were analyzed for signal transducer and activator of transcription 3 (STAT3) and each cell line for a specific membrane or membrane associated tyrosine kinase receptor: EGFR in MDA-MB 468 cells, JAK2 in HepG2 cells, SRC in LNCaP cells and HER2 in MCF-7 cells. Both unmodified and the corresponding phosphorylated form were detected for each protein using specific antibodies.
    Figure Legend Snippet: Evaluation of the signaling pathways triggered by β-hexaclorocyclohexane (β-HCH). Immunoblot analysis of the time-course assay performed on human prostate cancer (LNCaP), human breast cancer (MCF-7 and MDA-MB 468), and human hepatoma (HepG2) cells treated with 10 μM β-HCH. Samples were analyzed for signal transducer and activator of transcription 3 (STAT3) and each cell line for a specific membrane or membrane associated tyrosine kinase receptor: EGFR in MDA-MB 468 cells, JAK2 in HepG2 cells, SRC in LNCaP cells and HER2 in MCF-7 cells. Both unmodified and the corresponding phosphorylated form were detected for each protein using specific antibodies.

    Techniques Used: Multiple Displacement Amplification

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    Article Snippet: Chemicals 17β-Estradiol (E2 ; 99% purity), estrone (99%), estriol (98%), dienestrol (98%), hexestrol (98%), aldrin (98.6%), dieldrin (99.8%), α-endosulfan (I; 99.5%), β-endosulfan (II; 99.2%), methoxychlor (99.5%), kepone (99%), 1,1,1-trichloro-2-(o -chlorophenyl)-2-(p -chlorophenyl)-ethane (o,p ′-DDT; 97.5%),o,p ’-dichlorodiphenyl-dichloroethane (o,p ′-DDD; 99%), 1,1,1-trichloro-2,2-bis(p -chlorophenyl)-ethane (p,p ′-DDT; 99.1%), 1,1-dichloro-2,2-bis(p -chlorophenyl)-ethylene (p,p ′-DDE; 99.5%), β-hexachlorocyclohexane (HCH; 98.1%), coumesterol (98%) butyl paraben, propyl paraben, and bisphenol A ( > 99%) were purchased from Sigma-Aldrich Co. (Dorset, UK).

    Article Title: Extending the Applicability of the Dose Addition Model to the Assessment of Chemical Mixtures of Partial Agonists by Using a Novel Toxic Unit Extrapolation Method
    Article Snippet: Chemicals 17β-Estradiol (E2, 99% purity), estrone (99%), aldrin (98.6%), dieldrin (99.8%), endosulfan α (I, 99.5%), endosulfan β (II, 99.2%), methoxychlor (99.5%), o,p '-DDT (97.5%), o,p '-DDD (99%), p,p '-DDT (99.1%), p,p '-DDE (99.5%), β-hexachlorocyclohexane (β-HCH, 98.1%), n-butylparaben, n-propylparaben, and bisphenol A ( > 99%) were purchased from Sigma-Aldrich Company (Dorset, UK).

    Concentration Assay:

    Article Title: STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by β-Hexaclorocyclohexane
    Article Snippet: Cells were grown to 80% confluence at 37 °C in 5% CO2 in the appropriate culture medium, RPMI 1640 (Sigma-Aldrich, Milano, Italy) or DMEM-LG (Sigma-Aldrich), supplemented with 1% sodium pyruvate, 10% fetal bovine serum, 2 mM glutamine, 100 μg/mL streptomycin, and 100 U/mL penicillin. .. Beta-hexaclorocyclohexane (β-HCH) (Sigma-Aldrich, 33376), at a final concentration of 10 μM, was tested on each cell line pre-treated or not with specific inhibitors: 6 μM AZD1480 (Sigma-Aldrich, SML1505), 100 μM S3I-201 (Sigma-Aldrich, SML0330), 70 nM Dasatinib (Selleckchem, Roma, Italy, Cat. No. S1021), 0.8 μM Lapatinib (Sigma-Aldrich, CDS022971), and 15 μM Gefitinib (Sigma-Aldrich, SLM1657). .. The β-HCH cytotoxicity was evaluated by seeding cells in 96-well plates and measuring cell viability after 24 and 48 h incubation in the presence of different concentrations of β-HCH (5, 10, 25, 50, 75, 100, 125, 150, 175, and 200 μM).

    Article Title: β-Hexachlorocyclohexane Drives Carcinogenesis in the Human Normal Bronchial Epithelium Cell Line BEAS-2B
    Article Snippet: Cells were grown to 80% confluence at 37 °C in 5% CO2 in the appropriate culture medium, RPMI 1640 (Sigma-Aldrich, cat. R0883) supplemented with 1% sodium pyruvate (Sigma Aldrich, Milano, Italy, cat. S8636), 10% fetal bovine serum (Sigma Aldrich, cat. F7524), 2 mM glutamine, 100 μg/mL streptomycin, and 100 U/mL penicillin (Sigma Aldrich, cat. P4333). .. Beta-hexachlorocyclohexane (β-HCH) (Sigma-Aldrich, 33376) was tested on each cell line at a final concentration of 10 μM. .. Cell Viability The impact of β-HCH on cell viability was evaluated by seeding 1.2 × 104 cells/well in 96-well plates and determining cell viability after 24, 48, or 72 h of incubation with different concentrations of β-HCH (2, 10, 25, 50, and 100 μM).

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  • 94
    Millipore beta hexaclorocyclohexane β hch
    Evaluation of the signaling pathways triggered by <t>β-hexaclorocyclohexane</t> <t>(β-HCH).</t> Immunoblot analysis of the time-course assay performed on human prostate cancer (LNCaP), human breast cancer (MCF-7 and MDA-MB 468), and human hepatoma (HepG2) cells treated with 10 μM β-HCH. Samples were analyzed for signal transducer and activator of transcription 3 (STAT3) and each cell line for a specific membrane or membrane associated tyrosine kinase receptor: EGFR in MDA-MB 468 cells, JAK2 in HepG2 cells, SRC in LNCaP cells and HER2 in MCF-7 cells. Both unmodified and the corresponding phosphorylated form were detected for each protein using specific antibodies.
    Beta Hexaclorocyclohexane β Hch, supplied by Millipore, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/beta hexaclorocyclohexane β hch/product/Millipore
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    beta hexaclorocyclohexane β hch - by Bioz Stars, 2021-07
    94/100 stars
      Buy from Supplier

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    Evaluation of the signaling pathways triggered by β-hexaclorocyclohexane (β-HCH). Immunoblot analysis of the time-course assay performed on human prostate cancer (LNCaP), human breast cancer (MCF-7 and MDA-MB 468), and human hepatoma (HepG2) cells treated with 10 μM β-HCH. Samples were analyzed for signal transducer and activator of transcription 3 (STAT3) and each cell line for a specific membrane or membrane associated tyrosine kinase receptor: EGFR in MDA-MB 468 cells, JAK2 in HepG2 cells, SRC in LNCaP cells and HER2 in MCF-7 cells. Both unmodified and the corresponding phosphorylated form were detected for each protein using specific antibodies.

    Journal: International Journal of Molecular Sciences

    Article Title: STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by β-Hexaclorocyclohexane

    doi: 10.3390/ijms19072108

    Figure Lengend Snippet: Evaluation of the signaling pathways triggered by β-hexaclorocyclohexane (β-HCH). Immunoblot analysis of the time-course assay performed on human prostate cancer (LNCaP), human breast cancer (MCF-7 and MDA-MB 468), and human hepatoma (HepG2) cells treated with 10 μM β-HCH. Samples were analyzed for signal transducer and activator of transcription 3 (STAT3) and each cell line for a specific membrane or membrane associated tyrosine kinase receptor: EGFR in MDA-MB 468 cells, JAK2 in HepG2 cells, SRC in LNCaP cells and HER2 in MCF-7 cells. Both unmodified and the corresponding phosphorylated form were detected for each protein using specific antibodies.

    Article Snippet: Beta-hexaclorocyclohexane (β-HCH) (Sigma-Aldrich, 33376), at a final concentration of 10 μM, was tested on each cell line pre-treated or not with specific inhibitors: 6 μM AZD1480 (Sigma-Aldrich, SML1505), 100 μM S3I-201 (Sigma-Aldrich, SML0330), 70 nM Dasatinib (Selleckchem, Roma, Italy, Cat. No. S1021), 0.8 μM Lapatinib (Sigma-Aldrich, CDS022971), and 15 μM Gefitinib (Sigma-Aldrich, SLM1657).

    Techniques: Multiple Displacement Amplification

    Evaluation of the signaling pathways triggered by β-hexaclorocyclohexane (β-HCH). Immunoblot analysis of the time-course assay performed on human prostate cancer (LNCaP), human breast cancer (MCF-7 and MDA-MB 468), and human hepatoma (HepG2) cells treated with 10 μM β-HCH. Samples were analyzed for signal transducer and activator of transcription 3 (STAT3) and each cell line for a specific membrane or membrane associated tyrosine kinase receptor: EGFR in MDA-MB 468 cells, JAK2 in HepG2 cells, SRC in LNCaP cells and HER2 in MCF-7 cells. Both unmodified and the corresponding phosphorylated form were detected for each protein using specific antibodies.

    Journal: International Journal of Molecular Sciences

    Article Title: STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by β-Hexaclorocyclohexane

    doi: 10.3390/ijms19072108

    Figure Lengend Snippet: Evaluation of the signaling pathways triggered by β-hexaclorocyclohexane (β-HCH). Immunoblot analysis of the time-course assay performed on human prostate cancer (LNCaP), human breast cancer (MCF-7 and MDA-MB 468), and human hepatoma (HepG2) cells treated with 10 μM β-HCH. Samples were analyzed for signal transducer and activator of transcription 3 (STAT3) and each cell line for a specific membrane or membrane associated tyrosine kinase receptor: EGFR in MDA-MB 468 cells, JAK2 in HepG2 cells, SRC in LNCaP cells and HER2 in MCF-7 cells. Both unmodified and the corresponding phosphorylated form were detected for each protein using specific antibodies.

    Article Snippet: Beta-hexaclorocyclohexane (β-HCH) (Sigma-Aldrich, 33376), at a final concentration of 10 μM, was tested on each cell line pre-treated or not with specific inhibitors: 6 μM AZD1480 (Sigma-Aldrich, SML1505), 100 μM S3I-201 (Sigma-Aldrich, SML0330), 70 nM Dasatinib (Selleckchem, Roma, Italy, Cat. No. S1021), 0.8 μM Lapatinib (Sigma-Aldrich, CDS022971), and 15 μM Gefitinib (Sigma-Aldrich, SLM1657).

    Techniques: Multiple Displacement Amplification