beta hexaclorocyclohexane β hch  (Millipore)


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    Name:
    beta HCH
    Description:
    β Hexachlorocyclohexane is an isomer of hexachlorocyclohexane It is an organochlorine pesticide with carcinogenic effects on both humans and animals
    Catalog Number:
    33376
    Price:
    None
    Applications:
    β-Hexachlorocyclohexane may be used as a reference standard for the determination of β-hexachlorocyclohexane in marine sediments by pressurized liquid extraction (PLE) and stir-bar sorptive extraction (SBSE) coupled with thermal desorption and gas chromatography-triple quadrupole mass spectrometry (TD-GC-MS/MS QqQ).
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    Structured Review

    Millipore beta hexaclorocyclohexane β hch
    beta HCH
    β Hexachlorocyclohexane is an isomer of hexachlorocyclohexane It is an organochlorine pesticide with carcinogenic effects on both humans and animals
    https://www.bioz.com/result/beta hexaclorocyclohexane β hch/product/Millipore
    Average 93 stars, based on 2 article reviews
    Price from $9.99 to $1999.99
    beta hexaclorocyclohexane β hch - by Bioz Stars, 2020-07
    93/100 stars

    Images

    1) Product Images from "STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by β-Hexaclorocyclohexane"

    Article Title: STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by β-Hexaclorocyclohexane

    Journal: International Journal of Molecular Sciences

    doi: 10.3390/ijms19072108

    Evaluation of the signaling pathways triggered by β-hexaclorocyclohexane (β-HCH). Immunoblot analysis of the time-course assay performed on human prostate cancer (LNCaP), human breast cancer (MCF-7 and MDA-MB 468), and human hepatoma (HepG2) cells treated with 10 μM β-HCH. Samples were analyzed for signal transducer and activator of transcription 3 (STAT3) and each cell line for a specific membrane or membrane associated tyrosine kinase receptor: EGFR in MDA-MB 468 cells, JAK2 in HepG2 cells, SRC in LNCaP cells and HER2 in MCF-7 cells. Both unmodified and the corresponding phosphorylated form were detected for each protein using specific antibodies.
    Figure Legend Snippet: Evaluation of the signaling pathways triggered by β-hexaclorocyclohexane (β-HCH). Immunoblot analysis of the time-course assay performed on human prostate cancer (LNCaP), human breast cancer (MCF-7 and MDA-MB 468), and human hepatoma (HepG2) cells treated with 10 μM β-HCH. Samples were analyzed for signal transducer and activator of transcription 3 (STAT3) and each cell line for a specific membrane or membrane associated tyrosine kinase receptor: EGFR in MDA-MB 468 cells, JAK2 in HepG2 cells, SRC in LNCaP cells and HER2 in MCF-7 cells. Both unmodified and the corresponding phosphorylated form were detected for each protein using specific antibodies.

    Techniques Used: Multiple Displacement Amplification

    2) Product Images from "STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by β-Hexaclorocyclohexane"

    Article Title: STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by β-Hexaclorocyclohexane

    Journal: International Journal of Molecular Sciences

    doi: 10.3390/ijms19072108

    Evaluation of the signaling pathways triggered by β-hexaclorocyclohexane (β-HCH). Immunoblot analysis of the time-course assay performed on human prostate cancer (LNCaP), human breast cancer (MCF-7 and MDA-MB 468), and human hepatoma (HepG2) cells treated with 10 μM β-HCH. Samples were analyzed for signal transducer and activator of transcription 3 (STAT3) and each cell line for a specific membrane or membrane associated tyrosine kinase receptor: EGFR in MDA-MB 468 cells, JAK2 in HepG2 cells, SRC in LNCaP cells and HER2 in MCF-7 cells. Both unmodified and the corresponding phosphorylated form were detected for each protein using specific antibodies.
    Figure Legend Snippet: Evaluation of the signaling pathways triggered by β-hexaclorocyclohexane (β-HCH). Immunoblot analysis of the time-course assay performed on human prostate cancer (LNCaP), human breast cancer (MCF-7 and MDA-MB 468), and human hepatoma (HepG2) cells treated with 10 μM β-HCH. Samples were analyzed for signal transducer and activator of transcription 3 (STAT3) and each cell line for a specific membrane or membrane associated tyrosine kinase receptor: EGFR in MDA-MB 468 cells, JAK2 in HepG2 cells, SRC in LNCaP cells and HER2 in MCF-7 cells. Both unmodified and the corresponding phosphorylated form were detected for each protein using specific antibodies.

    Techniques Used: Multiple Displacement Amplification

    Related Articles

    Modification:

    Article Title: Estrogenic Evaluation and Organochlorine Identification in Blubber of North Sea Harbour Porpoise (Phocoena phocoena) Stranded on the North Sea Coast
    Article Snippet: .. Equipment, Chemicals, and Reagents The following equipment and materials have been used in this study: carbon dioxide (Air Liquide, Liège, Belgium); helium (Air Products, Brussels, Belgium); acetonitrile (Biosolve, Valkenswaard, Netherlands); luminometer Orion II (BRS, Drogenbos, Belgium); adenosine triphosphate (ATP), Dulbecco's modified Eagle's medium (DMEM), DMEM without red phenol, and fetal bovine serum and trypsin (Fisher Bioblock Scientific, Tournai, Belgium); Focus gas chromatograph and Polaris Q mass spectrometer (Interscience, Louvain-la-Neuve, Belgium); charcoal, dextran, o ,p ′-DDD, p ,p ′-DDD, p ,p ′-DDE, o ,p ′-DDT, p ,p ′-DDT, 17β -estradiol, HCB, α -HCH, β -HCH, γ -HCH, δ -HCH, nonane, PCB 80 13 C, PCB 138 (2,2′,3,4,4′,5′-hexachlorobiphenyl), PCB 153 (2,2′,4,4′,5,5′-hexachlorobiphenyl), and PCB 180 (2,2′,3,4,4′,5,5′-heptachlorobiphenyl) (Sigma-Aldrich, Bornem, Belgium); D-luciferin (potassium salt) (Synchem OHG, Kassel, Germany); HT8 column (VWR, Leuven, Belgium). .. Stable Reporter Cell Lines and Culture To obtain an estrogen-responsive cell line, MCF-7 human mammary tumour cells were stably transformed with a reporter vector containing the firefly luciferase gene under control of the vitellogenin promoter [ , ].

    Concentration Assay:

    Article Title: STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by β-Hexaclorocyclohexane
    Article Snippet: .. Beta-hexaclorocyclohexane (β-HCH) (Sigma-Aldrich, 33376), at a final concentration of 10 μM, was tested on each cell line pre-treated or not with specific inhibitors: 6 μM AZD1480 (Sigma-Aldrich, SML1505), 100 μM S3I-201 (Sigma-Aldrich, SML0330), 70 nM Dasatinib (Selleckchem, Roma, Italy, Cat. No. S1021), 0.8 μM Lapatinib (Sigma-Aldrich, CDS022971), and 15 μM Gefitinib (Sigma-Aldrich, SLM1657). .. The β-HCH cytotoxicity was evaluated by seeding cells in 96-well plates and measuring cell viability after 24 and 48 h incubation in the presence of different concentrations of β-HCH (5, 10, 25, 50, 75, 100, 125, 150, 175, and 200 μM).

    other:

    Article Title: Extending the Applicability of the Dose Addition Model to the Assessment of Chemical Mixtures of Partial Agonists by Using a Novel Toxic Unit Extrapolation Method
    Article Snippet: Chemicals 17β-Estradiol (E2, 99% purity), estrone (99%), aldrin (98.6%), dieldrin (99.8%), endosulfan α (I, 99.5%), endosulfan β (II, 99.2%), methoxychlor (99.5%), o,p '-DDT (97.5%), o,p '-DDD (99%), p,p '-DDT (99.1%), p,p '-DDE (99.5%), β-hexachlorocyclohexane (β-HCH, 98.1%), n-butylparaben, n-propylparaben, and bisphenol A ( > 99%) were purchased from Sigma-Aldrich Company (Dorset, UK).

    Mass Spectrometry:

    Article Title: Estrogenic Evaluation and Organochlorine Identification in Blubber of North Sea Harbour Porpoise (Phocoena phocoena) Stranded on the North Sea Coast
    Article Snippet: .. Equipment, Chemicals, and Reagents The following equipment and materials have been used in this study: carbon dioxide (Air Liquide, Liège, Belgium); helium (Air Products, Brussels, Belgium); acetonitrile (Biosolve, Valkenswaard, Netherlands); luminometer Orion II (BRS, Drogenbos, Belgium); adenosine triphosphate (ATP), Dulbecco's modified Eagle's medium (DMEM), DMEM without red phenol, and fetal bovine serum and trypsin (Fisher Bioblock Scientific, Tournai, Belgium); Focus gas chromatograph and Polaris Q mass spectrometer (Interscience, Louvain-la-Neuve, Belgium); charcoal, dextran, o ,p ′-DDD, p ,p ′-DDD, p ,p ′-DDE, o ,p ′-DDT, p ,p ′-DDT, 17β -estradiol, HCB, α -HCH, β -HCH, γ -HCH, δ -HCH, nonane, PCB 80 13 C, PCB 138 (2,2′,3,4,4′,5′-hexachlorobiphenyl), PCB 153 (2,2′,4,4′,5,5′-hexachlorobiphenyl), and PCB 180 (2,2′,3,4,4′,5,5′-heptachlorobiphenyl) (Sigma-Aldrich, Bornem, Belgium); D-luciferin (potassium salt) (Synchem OHG, Kassel, Germany); HT8 column (VWR, Leuven, Belgium). .. Stable Reporter Cell Lines and Culture To obtain an estrogen-responsive cell line, MCF-7 human mammary tumour cells were stably transformed with a reporter vector containing the firefly luciferase gene under control of the vitellogenin promoter [ , ].