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MAMs redox is responsible for ROS production: Ca 2+ flux from the ER to MT through the IP3R/VADC Ca 2+ channels, which generates redox nanodomain.

Journal: Aging and Disease

Article Title: Mitochondria-Associated Membranes in Aging and Senescence

doi: 10.14336/AD.2024.0652

Figure Lengend Snippet: MAMs redox is responsible for ROS production: Ca 2+ flux from the ER to MT through the IP3R/VADC Ca 2+ channels, which generates redox nanodomain.

Article Snippet: In multiple cell systems, including breast cancer cells, Bcl-xl inhibits Ca 2+ release from the ER to the cytoplasm, thereby providing protection against IP3R-mediated apoptosis [ ].

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