Journal: Scientific Reports

Article Title: Effect of a weight loss diet with or without Spirulina supplementation on serum lipids and antioxidant capacity of overweight dogs

doi: 10.1038/s41598-024-80843-y

Figure Lengend Snippet: Change in BAP (plasma antioxidant capacity) values from baseline at T1 and T2 in the Spirulina and placebo groups. The dashed line shows the threshold above which BAP values are considered optimal. * indicates p ≤ 0.05.

Article Snippet: The plasma’s biological antioxidant potential (BAP) was determined using a commercial kit (Diacron, Grosseto, Italy) following the manufacturer’s instructions.

Techniques:

Journal: Biomarker Research

Article Title: GDF15 propeptide promotes bone metastasis of castration-resistant prostate cancer by augmenting the bone microenvironment

doi: 10.1186/s40364-024-00695-6

Figure Lengend Snippet: Real-world data on GDPP in CRPC patients with BM. ( A ) A comparison of GDPP, PSA, TRACP 5b, BAP, mGDF15, PINP, OC, ALP, and LDH levels in healthy donors ( n = 30) versus CRPC patients with and without BM ( n = 80 and 75, respectively). The data show significantly elevated levels of GDPP, PSA, BAP, mGDF15 and LDH in patients with BM. GDPP: Growth differentiation factor 15 propeptide, Data are expressed as the mean ± standard deviation (SD), and statistical analyses were performed using the Tukey‒Kramer method (* p < 0.05, ** p < 0.01; n.s., not significant). ( B ) GDPP had the best AUC when comparing the diagnostic performance of each blood biomarker for BM in CRPC patients in each of the two randomized cohorts. ( C ) Comparison of blood GDPP levels by site of metastasis in PC (Local only: n = 60, Lymph node metastatic CRPC only: n = 12, Bone metastatic CRPC only: n = 31). ( D ) The analysis of the relationship between the BSI and GDPP, PSA, TRACP 5b, BAP, mGDF15, PINP, OC, ALP, or LDH in CRPC patients with BM is shown, together with the comparison of the strength of the correlation between each biomarker and the BSI ( n = 80). Statistical analyses were performed using Spearman’s rank correlation coefficient. ( E ) The relationships between the change in BSI (ΔBSI) and the changes in many blood biomarkers during systemic treatment in CRPC patients with BM showed that the change in GDPP (ΔGDPP) correlated best with the change in the BSI ( n = 22). Statistical analyses were performed using Spearman’s rank correlation coefficient. ( F ) This panel shows data from a representative patient who underwent longitudinal monitoring. During the clinical course of the patients, the plasma GDPP levels, rather than PSA levels, reflected the volume of BM revealed by PSMA PET. Red arrow indicates the solitary BM location from PCa. ( G ) Kaplan‒Meier analysis of the OS of CRPC patients with BM stratified by GDPP value; statistical analyses were performed using the log-rank test (** p < 0.01)

Article Snippet: Serum PSA (Beckman Coulter), ALP (Shino-Test Corporation), BAP (IDS, Inc.), TRACP 5b (Nittobo Medical), LDH (FUJIFILM Wako Pure Chemical Corporation), OC (Tosoh), mGDF15 (R&D Systems) and PINP (USCN) levels were measured in the same blood samples.

Techniques: Comparison, Standard Deviation, Diagnostic Assay, Biomarker Assay

Journal: Biomarker Research

Article Title: GDF15 propeptide promotes bone metastasis of castration-resistant prostate cancer by augmenting the bone microenvironment

doi: 10.1186/s40364-024-00695-6

Figure Lengend Snippet: Univariate and multivariate logistic regression analysis of OS in CRPC patients with BM ( n = 80)

Article Snippet: Serum PSA (Beckman Coulter), ALP (Shino-Test Corporation), BAP (IDS, Inc.), TRACP 5b (Nittobo Medical), LDH (FUJIFILM Wako Pure Chemical Corporation), OC (Tosoh), mGDF15 (R&D Systems) and PINP (USCN) levels were measured in the same blood samples.

Techniques:

Journal: Biomarker Research

Article Title: GDF15 propeptide promotes bone metastasis of castration-resistant prostate cancer by augmenting the bone microenvironment

doi: 10.1186/s40364-024-00695-6

Figure Lengend Snippet: Patient baseline characteristics and blood biomarker levels. All continuous data use median and range

Article Snippet: Serum PSA (Beckman Coulter), ALP (Shino-Test Corporation), BAP (IDS, Inc.), TRACP 5b (Nittobo Medical), LDH (FUJIFILM Wako Pure Chemical Corporation), OC (Tosoh), mGDF15 (R&D Systems) and PINP (USCN) levels were measured in the same blood samples.

Techniques: Biomarker Assay