B6 Pl, supplied by The Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1) Product Images from "Activation of diverse repertoires of autoreactive T cells enhances the loss of anti-dsDNA B cell tolerance"
Article Title: Activation of diverse repertoires of autoreactive T cells enhances the loss of anti-dsDNA B cell tolerance
Journal: Journal of Clinical Investigation
Figure Legend Snippet: Limited T cell repertoires are activated but fail to enter the B cell follicle. ( a ) Donor Thy1.2 + CD4 cells were identified 7 days after induction of cGVHD in B6.PL/3H9.KI mice by staining with Thy1.2 and CD4. Gated populations of the contour plots represent the expansion in percentage of transferred CD4 + T cells for the indicated cell population. The total number of recovered Thy1.2 + CD4 + splenocytes is indicated above the plot. Representative results from four experiments are shown. ( b ) Donor CD4 + cells were localized by staining spleen sections with Ab’s against Thy1.2 (brown) and B220 (blue). The few B6 CD4 + T cells detected by IHC were scattered throughout the T cell area. Activation of the class II–reactive T cell repertoires resulted in the majority of the cells migrating to T-B interface. The diverse T cell repertoires (K14 and bm12) contained T cells that were also evident in the B cell follicle; however, activation of the limited T cell repertoires (2-2-3/K14 and H2-DM –/– ) did not result in the presence of transferred Thy1.2 + T cells in the follicle. Representative results of four experiments are shown.
Techniques Used: Mouse Assay, Staining, Immunohistochemistry, Activation Assay
Figure Legend Snippet: Loss of B cell tolerance is associated with B7.2 expression on anti-dsDNA B cells. Seven days after cGVHD induction in B6.PL/3H9.KI mice, spleen cells were stained for expression of B7.2, B220, and λ1. Histograms show B7.2 expression on gated B220 + λ1 + cells for mice receiving B6 (thin lines) or I-A b –reactive CD4 + T cells (thick lines). Representative results of four experiments are shown.
Techniques Used: Expressing, Mouse Assay, Staining
2) Product Images from "IL-1?-Mediated Signals Preferentially Drive Conversion of Regulatory T Cells but Not Conventional T Cells into IL-17-Producing Cells"
Article Title: IL-1?-Mediated Signals Preferentially Drive Conversion of Regulatory T Cells but Not Conventional T Cells into IL-17-Producing Cells
Journal: Journal of immunology (Baltimore, Md. : 1950)
Figure Legend Snippet: Tregs are capable of producing IL-17A in vivo after immunization. IL-1R1 −/− or B6.PL congenic (Thy1.1 + ) Tregs were transferred to IL-1R1 −/− mice that were subsequently immunized with KLH in IFA. A and B , Three days later,
Techniques Used: In Vivo, Mouse Assay, Immunofluorescence