kv7 2 (Alomone Labs)


Structured Review

Kv7 2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/kv7 2/product/Alomone Labs
Average 93 stars, based on 1 article reviews
Price from $9.99 to $1999.99
Images
1) Product Images from "Kv7 Channels in the Nucleus Accumbens are altered by Chronic Drinking and are Targets for Reducing Alcohol Consumption"
Article Title: Kv7 Channels in the Nucleus Accumbens are altered by Chronic Drinking and are Targets for Reducing Alcohol Consumption
Journal: Addiction biology
doi: 10.1111/adb.12279

Figure Legend Snippet: Long-term drinking reduced SUMOylation levels of Kv7.2 in the NAc. (a) Schematic depicting locations of the SUMOylation consensus sequences in rat Kv7.2 (orange circle and arrow indicate point of SUMO attachment). (b) Representative western blot images showing the expression of SUMOylated Kv7.2 in fractionated NAc tissue. (c) 72 hr withdrawal from alcohol decreased expression of SUMOylated Kv7.2 in the DSM but not the DRM fraction. (d) However, IAA exposure reduced the ratio of SUMOylated Kv7.2 to total Kv7.2 in the DRM fraction (* p
Techniques Used: Western Blot, Expressing

Figure Legend Snippet: Long-term drinking altered Kv7.2 surface trafficking in the NAc. (a) Representative western blot images showing the relative expression patterns of Kv7.2, AKAP150, and SGK1 in the DRM, IC, and DSM fractions in tissue targeting the NAc core. (b) Representative western blot images of Kv7.2, AKAP150, and SGK1 expression in the NAc of alcohol naïve and IAA rats after 72 hr withdrawal from alcohol. (c) Kv7.2 expression is increased in the DRM of IAA rats and decreased in the DSM. There is no effect of alcohol exposure on the expression of (d) AKAP150 in the DRM or (e) SGK1 in the IC fraction (* p
Techniques Used: Western Blot, Expressing
2) Product Images from "G9a Is Essential for Epigenetic Silencing of K+ Channel Genes in Acute-to-Chronic Pain Transition"
Article Title: G9a Is Essential for Epigenetic Silencing of K+ Channel Genes in Acute-to-Chronic Pain Transition
Journal: Nature neuroscience
doi: 10.1038/nn.4165

Figure Legend Snippet: Inhibition of G9a activity normalizes K + channel gene expression in the DRG diminished by nerve injury ( a-d) Effects of intrathecal treatments with vehicle (n = 10), SAHA (50 μg, n = 9), UNC0638 (10 μg, n = 8), GSK503 (5 μg, n = 10), SAHA plus GSK503 (n = 8), SAHA plus UNC0638 (n = 9) or UNC0638 plus GSK503 (n = 8) on the mRNA levels of Kcna4 ( a ), Kcnd2 ( b ), Kcnq2 ( c ), and Kcnma1 ( d ) in the DRG obtained from SNL rats 28 days after surgery. Data from sham control rats were plotted as the control (n = 6 rats). ( e,f ) Effects of nerve injury and UNC0638 on the protein levels of Kv1.4, Kv4.2, Kv7.2 and BKα1 in the L5 and L6 DRG (n = 6 rats in each group). ( g,h ) Effect of G9a-specific siRNA on the G9a and H3K9me2 protein levels in the DRG obtained from SNL rats 24 h after the last injection (n = 5 in each group). ( i,j ) Effects of G9a-specific siRNA on the mRNA levels of G9a, Ezh2, Kcna4, Kcnd2, Kcnq2 and Kcnma1 in the DRG obtained from SNL ( i ) and sham control ( j ) rats 24 h after the last injection (n = 10 in each group). Data are presented as mean ± s.e.m. Statistical analysis was performed using two-way ANOVA followed by Bonferroni’s post hoc tests ( a-d ), one-way ANOVA ( f,h,i ), or Mann-Whitney test ( j ). * P
Techniques Used: Inhibition, Activity Assay, Expressing, Injection, MANN-WHITNEY