anti igm  (Valiant)


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Bioz Manufacturer Symbol Valiant manufactures this product  
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    Structured Review

    Valiant anti igm
    BH3 profiling demonstrates that primary CLL cells stimulated in vitro with <t>anti-IgM</t> or CXCL12 are less primed to undergo apoptosis and that priming can be restored with <t>CAL-101.</t> (A-B) PB-derived CLL cells from 4 individual patients were stimulated with
    Anti Igm, supplied by Valiant, used in various techniques. Bioz Stars score: 88/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/anti igm/product/Valiant
    Average 88 stars, based on 10 article reviews
    Price from $9.99 to $1999.99
    anti igm - by Bioz Stars, 2022-12
    88/100 stars

    Images

    1) Product Images from "Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia"

    Article Title: Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia

    Journal: Blood

    doi: 10.1182/blood-2012-02-414060

    BH3 profiling demonstrates that primary CLL cells stimulated in vitro with anti-IgM or CXCL12 are less primed to undergo apoptosis and that priming can be restored with CAL-101. (A-B) PB-derived CLL cells from 4 individual patients were stimulated with
    Figure Legend Snippet: BH3 profiling demonstrates that primary CLL cells stimulated in vitro with anti-IgM or CXCL12 are less primed to undergo apoptosis and that priming can be restored with CAL-101. (A-B) PB-derived CLL cells from 4 individual patients were stimulated with

    Techniques Used: In Vitro, Derivative Assay

    2) Product Images from "The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo"

    Article Title: The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo

    Journal: Blood

    doi: 10.1182/blood-2011-10-386417

    Abrogation of signaling downstream of the BCRs and of CXCR4 and CXCR5 receptors. Displayed are immunoblots from CLL cells from 1 representative patient of 9 patients, that were either unstimulated or stimulated for 10 minutes with anti-IgM (αIgM,
    Figure Legend Snippet: Abrogation of signaling downstream of the BCRs and of CXCR4 and CXCR5 receptors. Displayed are immunoblots from CLL cells from 1 representative patient of 9 patients, that were either unstimulated or stimulated for 10 minutes with anti-IgM (αIgM,

    Techniques Used: Western Blot

    PCI-32765 inhibits anti-IgM and NLC-mediated prosurvival signals in CLL cells. (A) Contour plots of a representative CLL sample, depicting CLL cell viabilities after 24, 48, and 72 hours of incubation with anti-IgM in the presence or absence of PCI-32765,
    Figure Legend Snippet: PCI-32765 inhibits anti-IgM and NLC-mediated prosurvival signals in CLL cells. (A) Contour plots of a representative CLL sample, depicting CLL cell viabilities after 24, 48, and 72 hours of incubation with anti-IgM in the presence or absence of PCI-32765,

    Techniques Used: Incubation

    3) Product Images from "The phosphoinositide 3′-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia"

    Article Title: The phosphoinositide 3′-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia

    Journal: Blood

    doi: 10.1182/blood-2011-05-352492

    CAL-101 inhibits signaling downstream of the BCR, CXCR4 and CXCR5. In vivo, CAL-101 reduces plasma chemokine levels, impairs AKT activation, and induces lymphocytosis in CLL patients. (A) CLL cells were activated with anti-IgM, or CXCL12, or CXCL13 in
    Figure Legend Snippet: CAL-101 inhibits signaling downstream of the BCR, CXCR4 and CXCR5. In vivo, CAL-101 reduces plasma chemokine levels, impairs AKT activation, and induces lymphocytosis in CLL patients. (A) CLL cells were activated with anti-IgM, or CXCL12, or CXCL13 in

    Techniques Used: In Vivo, Activation Assay

    Specific PI3Kδ inhibition with CAL-101 induces CLL apoptosis and abrogates BCR-derived survival signals. (A) CLL cells were incubated in medium alone (control), medium containing 10 μg/mL of anti-IgM mAbs, or medium with anti-IgM mAbs
    Figure Legend Snippet: Specific PI3Kδ inhibition with CAL-101 induces CLL apoptosis and abrogates BCR-derived survival signals. (A) CLL cells were incubated in medium alone (control), medium containing 10 μg/mL of anti-IgM mAbs, or medium with anti-IgM mAbs

    Techniques Used: Inhibition, Derivative Assay, Incubation

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