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Proteintech anti human coro1c rabbit polyclonal antibody
Associations between <t>CORO1C,</t> TROP2, and CRC metastasis. Overexpression of Trop2 in 293T cells was confirmed by (A) qRT-PCR, (B) Western blotting, and (C) Immunofluorescence. (D) Trop2 immunocomplex by Co-IP; (E) Heatmap of proteins interacting with Trop2 in PC and MC. The RNA-seq data were obtained from GSE28702. Red and green colors represent high and low gene expression, respectively. PC: primary CRC; MC: metastatic CRC, **p < 0.01.
Anti Human Coro1c Rabbit Polyclonal Antibody, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/anti human coro1c rabbit polyclonal antibody/product/Proteintech
Average 93 stars, based on 1 article reviews
Price from $9.99 to $1999.99
anti human coro1c rabbit polyclonal antibody - by Bioz Stars, 2024-07
93/100 stars

Images

1) Product Images from "CORO1C is Associated With Poor Prognosis and Promotes Metastasis Through PI3K/AKT Pathway in Colorectal Cancer"

Article Title: CORO1C is Associated With Poor Prognosis and Promotes Metastasis Through PI3K/AKT Pathway in Colorectal Cancer

Journal: Frontiers in Molecular Biosciences

doi: 10.3389/fmolb.2021.682594

Associations between CORO1C, TROP2, and CRC metastasis. Overexpression of Trop2 in 293T cells was confirmed by (A) qRT-PCR, (B) Western blotting, and (C) Immunofluorescence. (D) Trop2 immunocomplex by Co-IP; (E) Heatmap of proteins interacting with Trop2 in PC and MC. The RNA-seq data were obtained from GSE28702. Red and green colors represent high and low gene expression, respectively. PC: primary CRC; MC: metastatic CRC, **p < 0.01.
Figure Legend Snippet: Associations between CORO1C, TROP2, and CRC metastasis. Overexpression of Trop2 in 293T cells was confirmed by (A) qRT-PCR, (B) Western blotting, and (C) Immunofluorescence. (D) Trop2 immunocomplex by Co-IP; (E) Heatmap of proteins interacting with Trop2 in PC and MC. The RNA-seq data were obtained from GSE28702. Red and green colors represent high and low gene expression, respectively. PC: primary CRC; MC: metastatic CRC, **p < 0.01.

Techniques Used: Over Expression, Quantitative RT-PCR, Western Blot, Immunofluorescence, Co-Immunoprecipitation Assay, RNA Sequencing Assay, Expressing

Expression of CORO1C in CRC patients. (A) CORO1C mRNA levels in the 35 CRC tissues. (B) Representative images of CORO1C protein expression in colorectal tissues: a. Negative expression of CORO1C in normal colorectal tissues; b. Positive expression of CORO1C in moderately differentiated tubular adenocarcinoma tissues; c. Positive expression of CORO1C in mucinous adenocarcinoma tissues; d. Positive expression of CORO1C in highly differentiated tubular adenocarcinoma tissues. (C) Positive rate of high CORO1C in CRC tissues was higher than in normal tissues, *p < 0.05.
Figure Legend Snippet: Expression of CORO1C in CRC patients. (A) CORO1C mRNA levels in the 35 CRC tissues. (B) Representative images of CORO1C protein expression in colorectal tissues: a. Negative expression of CORO1C in normal colorectal tissues; b. Positive expression of CORO1C in moderately differentiated tubular adenocarcinoma tissues; c. Positive expression of CORO1C in mucinous adenocarcinoma tissues; d. Positive expression of CORO1C in highly differentiated tubular adenocarcinoma tissues. (C) Positive rate of high CORO1C in CRC tissues was higher than in normal tissues, *p < 0.05.

Techniques Used: Expressing

Association between  CORO1C  expression and clinicopathological characteristics in CRC patients.
Figure Legend Snippet: Association between CORO1C expression and clinicopathological characteristics in CRC patients.

Techniques Used: Expressing

Univariate and multivariate analysis of prognostic factors for overall survival in CRC.
Figure Legend Snippet: Univariate and multivariate analysis of prognostic factors for overall survival in CRC.

Techniques Used:

Survival curves of CRC patients using the Kaplan-Meier method and the log-rank test. (A) OS curves for patients with low CORO1C expression (blue line) and patients with high CORO1C expression (green line). (B) OS curves for distant metastases, M0 (blue line), and M1 (green line). (C) OS curves by TNM stage, TNM 0 and I (blue line), TNM II (green line), TNM III (gray line), and TNM IV (purple line).
Figure Legend Snippet: Survival curves of CRC patients using the Kaplan-Meier method and the log-rank test. (A) OS curves for patients with low CORO1C expression (blue line) and patients with high CORO1C expression (green line). (B) OS curves for distant metastases, M0 (blue line), and M1 (green line). (C) OS curves by TNM stage, TNM 0 and I (blue line), TNM II (green line), TNM III (gray line), and TNM IV (purple line).

Techniques Used: Expressing

The effects of CORO1C knockdown on CRC growth and metastasis in vitro and in vivo . (A) Levels of CORO1C1 protein expression in CRC cell lines and normal colorectal epithelial cells (NCM460) determined by western blotting. (B) COCA2 and HCT116 cells showed a significant decrease in protein level after shCORO1C transfection. (C) CORO1C downregulation significantly inhibited the proliferation of both cell lines. (D) A significant decrease in cell anchorage-dependent growth was detected after CORO1C knockdown. (E, F) Decreased CORO1C expression impaired abilities of migration (E) and invasion (F) of CRC cells (scale bar, 150 μm). All quantitative data of in vitro assays were generated from three replicates (G) . The effects of CORO1C downregulation on the tumor growth in the xenograft mouse model ( n = 6 mice/per group). *p < 0.05, **p < 0.01, ***p < 0.001.
Figure Legend Snippet: The effects of CORO1C knockdown on CRC growth and metastasis in vitro and in vivo . (A) Levels of CORO1C1 protein expression in CRC cell lines and normal colorectal epithelial cells (NCM460) determined by western blotting. (B) COCA2 and HCT116 cells showed a significant decrease in protein level after shCORO1C transfection. (C) CORO1C downregulation significantly inhibited the proliferation of both cell lines. (D) A significant decrease in cell anchorage-dependent growth was detected after CORO1C knockdown. (E, F) Decreased CORO1C expression impaired abilities of migration (E) and invasion (F) of CRC cells (scale bar, 150 μm). All quantitative data of in vitro assays were generated from three replicates (G) . The effects of CORO1C downregulation on the tumor growth in the xenograft mouse model ( n = 6 mice/per group). *p < 0.05, **p < 0.01, ***p < 0.001.

Techniques Used: In Vitro, In Vivo, Expressing, Western Blot, Transfection, Migration, Generated

Underlying mechanism of CORO1C in CRC. (A) GO analysis of CORO1C-related genes in CRC. (B) GSEA of CORO1C-related genes in CRC. (C) Expression changes of EMT-related proteins and PI3K/AKT signaling pathway after CORO1C knockdown. (D, E) The effects of AKT inhibitor (Miltefosine) on the abilities of migration (D) and invasion (E) of CRC cells (scale bar, 150 μm). All quantitative data were generated from three replicates. *p < 0.05, **p < 0.01, ***p < 0.001 vs. OE-Control group, #p < 0.05, ## p < 0.01 vs. OE-CORO1C group.
Figure Legend Snippet: Underlying mechanism of CORO1C in CRC. (A) GO analysis of CORO1C-related genes in CRC. (B) GSEA of CORO1C-related genes in CRC. (C) Expression changes of EMT-related proteins and PI3K/AKT signaling pathway after CORO1C knockdown. (D, E) The effects of AKT inhibitor (Miltefosine) on the abilities of migration (D) and invasion (E) of CRC cells (scale bar, 150 μm). All quantitative data were generated from three replicates. *p < 0.05, **p < 0.01, ***p < 0.001 vs. OE-Control group, #p < 0.05, ## p < 0.01 vs. OE-CORO1C group.

Techniques Used: Expressing, Migration, Generated

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    Proteintech anti human coro1c rabbit polyclonal antibody
    Associations between <t>CORO1C,</t> TROP2, and CRC metastasis. Overexpression of Trop2 in 293T cells was confirmed by (A) qRT-PCR, (B) Western blotting, and (C) Immunofluorescence. (D) Trop2 immunocomplex by Co-IP; (E) Heatmap of proteins interacting with Trop2 in PC and MC. The RNA-seq data were obtained from GSE28702. Red and green colors represent high and low gene expression, respectively. PC: primary CRC; MC: metastatic CRC, **p < 0.01.
    Anti Human Coro1c Rabbit Polyclonal Antibody, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/anti human coro1c rabbit polyclonal antibody/product/Proteintech
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    anti human coro1c rabbit polyclonal antibody - by Bioz Stars, 2024-07
    93/100 stars
      Buy from Supplier

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    Associations between CORO1C, TROP2, and CRC metastasis. Overexpression of Trop2 in 293T cells was confirmed by (A) qRT-PCR, (B) Western blotting, and (C) Immunofluorescence. (D) Trop2 immunocomplex by Co-IP; (E) Heatmap of proteins interacting with Trop2 in PC and MC. The RNA-seq data were obtained from GSE28702. Red and green colors represent high and low gene expression, respectively. PC: primary CRC; MC: metastatic CRC, **p < 0.01.

    Journal: Frontiers in Molecular Biosciences

    Article Title: CORO1C is Associated With Poor Prognosis and Promotes Metastasis Through PI3K/AKT Pathway in Colorectal Cancer

    doi: 10.3389/fmolb.2021.682594

    Figure Lengend Snippet: Associations between CORO1C, TROP2, and CRC metastasis. Overexpression of Trop2 in 293T cells was confirmed by (A) qRT-PCR, (B) Western blotting, and (C) Immunofluorescence. (D) Trop2 immunocomplex by Co-IP; (E) Heatmap of proteins interacting with Trop2 in PC and MC. The RNA-seq data were obtained from GSE28702. Red and green colors represent high and low gene expression, respectively. PC: primary CRC; MC: metastatic CRC, **p < 0.01.

    Article Snippet: CORO1C was detected by a anti-human CORO1C rabbit polyclonal antibody (dilution 1:200) (#14749-1-AP, Proteintech, United States).

    Techniques: Over Expression, Quantitative RT-PCR, Western Blot, Immunofluorescence, Co-Immunoprecipitation Assay, RNA Sequencing Assay, Expressing

    Expression of CORO1C in CRC patients. (A) CORO1C mRNA levels in the 35 CRC tissues. (B) Representative images of CORO1C protein expression in colorectal tissues: a. Negative expression of CORO1C in normal colorectal tissues; b. Positive expression of CORO1C in moderately differentiated tubular adenocarcinoma tissues; c. Positive expression of CORO1C in mucinous adenocarcinoma tissues; d. Positive expression of CORO1C in highly differentiated tubular adenocarcinoma tissues. (C) Positive rate of high CORO1C in CRC tissues was higher than in normal tissues, *p < 0.05.

    Journal: Frontiers in Molecular Biosciences

    Article Title: CORO1C is Associated With Poor Prognosis and Promotes Metastasis Through PI3K/AKT Pathway in Colorectal Cancer

    doi: 10.3389/fmolb.2021.682594

    Figure Lengend Snippet: Expression of CORO1C in CRC patients. (A) CORO1C mRNA levels in the 35 CRC tissues. (B) Representative images of CORO1C protein expression in colorectal tissues: a. Negative expression of CORO1C in normal colorectal tissues; b. Positive expression of CORO1C in moderately differentiated tubular adenocarcinoma tissues; c. Positive expression of CORO1C in mucinous adenocarcinoma tissues; d. Positive expression of CORO1C in highly differentiated tubular adenocarcinoma tissues. (C) Positive rate of high CORO1C in CRC tissues was higher than in normal tissues, *p < 0.05.

    Article Snippet: CORO1C was detected by a anti-human CORO1C rabbit polyclonal antibody (dilution 1:200) (#14749-1-AP, Proteintech, United States).

    Techniques: Expressing

    Association between  CORO1C  expression and clinicopathological characteristics in CRC patients.

    Journal: Frontiers in Molecular Biosciences

    Article Title: CORO1C is Associated With Poor Prognosis and Promotes Metastasis Through PI3K/AKT Pathway in Colorectal Cancer

    doi: 10.3389/fmolb.2021.682594

    Figure Lengend Snippet: Association between CORO1C expression and clinicopathological characteristics in CRC patients.

    Article Snippet: CORO1C was detected by a anti-human CORO1C rabbit polyclonal antibody (dilution 1:200) (#14749-1-AP, Proteintech, United States).

    Techniques: Expressing

    Univariate and multivariate analysis of prognostic factors for overall survival in CRC.

    Journal: Frontiers in Molecular Biosciences

    Article Title: CORO1C is Associated With Poor Prognosis and Promotes Metastasis Through PI3K/AKT Pathway in Colorectal Cancer

    doi: 10.3389/fmolb.2021.682594

    Figure Lengend Snippet: Univariate and multivariate analysis of prognostic factors for overall survival in CRC.

    Article Snippet: CORO1C was detected by a anti-human CORO1C rabbit polyclonal antibody (dilution 1:200) (#14749-1-AP, Proteintech, United States).

    Techniques:

    Survival curves of CRC patients using the Kaplan-Meier method and the log-rank test. (A) OS curves for patients with low CORO1C expression (blue line) and patients with high CORO1C expression (green line). (B) OS curves for distant metastases, M0 (blue line), and M1 (green line). (C) OS curves by TNM stage, TNM 0 and I (blue line), TNM II (green line), TNM III (gray line), and TNM IV (purple line).

    Journal: Frontiers in Molecular Biosciences

    Article Title: CORO1C is Associated With Poor Prognosis and Promotes Metastasis Through PI3K/AKT Pathway in Colorectal Cancer

    doi: 10.3389/fmolb.2021.682594

    Figure Lengend Snippet: Survival curves of CRC patients using the Kaplan-Meier method and the log-rank test. (A) OS curves for patients with low CORO1C expression (blue line) and patients with high CORO1C expression (green line). (B) OS curves for distant metastases, M0 (blue line), and M1 (green line). (C) OS curves by TNM stage, TNM 0 and I (blue line), TNM II (green line), TNM III (gray line), and TNM IV (purple line).

    Article Snippet: CORO1C was detected by a anti-human CORO1C rabbit polyclonal antibody (dilution 1:200) (#14749-1-AP, Proteintech, United States).

    Techniques: Expressing

    The effects of CORO1C knockdown on CRC growth and metastasis in vitro and in vivo . (A) Levels of CORO1C1 protein expression in CRC cell lines and normal colorectal epithelial cells (NCM460) determined by western blotting. (B) COCA2 and HCT116 cells showed a significant decrease in protein level after shCORO1C transfection. (C) CORO1C downregulation significantly inhibited the proliferation of both cell lines. (D) A significant decrease in cell anchorage-dependent growth was detected after CORO1C knockdown. (E, F) Decreased CORO1C expression impaired abilities of migration (E) and invasion (F) of CRC cells (scale bar, 150 μm). All quantitative data of in vitro assays were generated from three replicates (G) . The effects of CORO1C downregulation on the tumor growth in the xenograft mouse model ( n = 6 mice/per group). *p < 0.05, **p < 0.01, ***p < 0.001.

    Journal: Frontiers in Molecular Biosciences

    Article Title: CORO1C is Associated With Poor Prognosis and Promotes Metastasis Through PI3K/AKT Pathway in Colorectal Cancer

    doi: 10.3389/fmolb.2021.682594

    Figure Lengend Snippet: The effects of CORO1C knockdown on CRC growth and metastasis in vitro and in vivo . (A) Levels of CORO1C1 protein expression in CRC cell lines and normal colorectal epithelial cells (NCM460) determined by western blotting. (B) COCA2 and HCT116 cells showed a significant decrease in protein level after shCORO1C transfection. (C) CORO1C downregulation significantly inhibited the proliferation of both cell lines. (D) A significant decrease in cell anchorage-dependent growth was detected after CORO1C knockdown. (E, F) Decreased CORO1C expression impaired abilities of migration (E) and invasion (F) of CRC cells (scale bar, 150 μm). All quantitative data of in vitro assays were generated from three replicates (G) . The effects of CORO1C downregulation on the tumor growth in the xenograft mouse model ( n = 6 mice/per group). *p < 0.05, **p < 0.01, ***p < 0.001.

    Article Snippet: CORO1C was detected by a anti-human CORO1C rabbit polyclonal antibody (dilution 1:200) (#14749-1-AP, Proteintech, United States).

    Techniques: In Vitro, In Vivo, Expressing, Western Blot, Transfection, Migration, Generated

    Underlying mechanism of CORO1C in CRC. (A) GO analysis of CORO1C-related genes in CRC. (B) GSEA of CORO1C-related genes in CRC. (C) Expression changes of EMT-related proteins and PI3K/AKT signaling pathway after CORO1C knockdown. (D, E) The effects of AKT inhibitor (Miltefosine) on the abilities of migration (D) and invasion (E) of CRC cells (scale bar, 150 μm). All quantitative data were generated from three replicates. *p < 0.05, **p < 0.01, ***p < 0.001 vs. OE-Control group, #p < 0.05, ## p < 0.01 vs. OE-CORO1C group.

    Journal: Frontiers in Molecular Biosciences

    Article Title: CORO1C is Associated With Poor Prognosis and Promotes Metastasis Through PI3K/AKT Pathway in Colorectal Cancer

    doi: 10.3389/fmolb.2021.682594

    Figure Lengend Snippet: Underlying mechanism of CORO1C in CRC. (A) GO analysis of CORO1C-related genes in CRC. (B) GSEA of CORO1C-related genes in CRC. (C) Expression changes of EMT-related proteins and PI3K/AKT signaling pathway after CORO1C knockdown. (D, E) The effects of AKT inhibitor (Miltefosine) on the abilities of migration (D) and invasion (E) of CRC cells (scale bar, 150 μm). All quantitative data were generated from three replicates. *p < 0.05, **p < 0.01, ***p < 0.001 vs. OE-Control group, #p < 0.05, ## p < 0.01 vs. OE-CORO1C group.

    Article Snippet: CORO1C was detected by a anti-human CORO1C rabbit polyclonal antibody (dilution 1:200) (#14749-1-AP, Proteintech, United States).

    Techniques: Expressing, Migration, Generated