cav 1 2  (Alomone Labs)


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    Structured Review

    Alomone Labs cav 1 2
    Cav 1 2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 95/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cav 1 2/product/Alomone Labs
    Average 95 stars, based on 2 article reviews
    Price from $9.99 to $1999.99
    cav 1 2 - by Bioz Stars, 2022-10
    95/100 stars

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    Alomone Labs anti cacna1a cav2 1 antibody
    a Representative confocal image of a nerve terminal arborization. Singly, dually, and innervated by three or more axons NMJs from YFP muscles and also images of the morphologic maturation (S1, the most inmature, and S4, almost fully differentiated, stages) of the postsynaptic clusters from P9 mice. The bar indicates 10 μm. b Confocal immunofluorescence location of α 1D L-, N-, and P/Q-type voltage-dependent calcium channels (VDCCs) at the NMJ. Triple labeling of VDCCs (green fluorescence) with syntaxin (blue fluorescence) and nAChR-α-bungarotoxin (red fluorescence) in merge images. Figure shows the presence of α 1D L-, <t>N-,</t> <t>and</t> <t>P/Q-type-VDCC</t> (in green) in the nerve terminal of P9 Levator auris longus (LAL) muscle endplates. The bar indicates 10 μm
    Anti Cacna1a Cav2 1 Antibody, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/anti cacna1a cav2 1 antibody/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    anti cacna1a cav2 1 antibody - by Bioz Stars, 2022-10
    94/100 stars
      Buy from Supplier

    85
    Alomone Labs anti cav 2 1
    AβOs bind to axons and colocalize with presynaptic voltage-gated calcium channels. (A) Representative images of immunocytochemistry with an AβO-specific antibody (NU-4) show that AβOs bind along the entire length of the axon in cultured neurons. (B) Immunohistochemistry on coronal sections from 12-mo-old transgenic AD mouse brain (LaFerla 3xTg) reveal a punctate distribution of AβOs along axons in the cortex. Axons are distinguished by the absence of MAP2 staining (inset). AβOs were not detected in age-matched wild-type control mice. (C) Representative images of AβO and CaV 2.1 (P/Q-type VGCC) immunocytochemistry. Of axonal AβOs, 83.5% colocalize with P/Q-type VGCCs. A minimum of 15 cells from three independent cultures were analyzed. Arrows indicate axons, arrowheads indicate dendrites, and asterisks indicate regions of overlapping puncta. Scale bar, 100 μm.
    Anti Cav 2 1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/anti cav 2 1/product/Alomone Labs
    Average 85 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    anti cav 2 1 - by Bioz Stars, 2022-10
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    95
    Alomone Labs rabbit anti cav 1 2
    AβOs bind to axons and colocalize with presynaptic voltage-gated calcium channels. (A) Representative images of immunocytochemistry with an AβO-specific antibody (NU-4) show that AβOs bind along the entire length of the axon in cultured neurons. (B) Immunohistochemistry on coronal sections from 12-mo-old transgenic AD mouse brain (LaFerla 3xTg) reveal a punctate distribution of AβOs along axons in the cortex. Axons are distinguished by the absence of MAP2 staining (inset). AβOs were not detected in age-matched wild-type control mice. (C) Representative images of AβO and CaV 2.1 (P/Q-type VGCC) immunocytochemistry. Of axonal AβOs, 83.5% colocalize with P/Q-type VGCCs. A minimum of 15 cells from three independent cultures were analyzed. Arrows indicate axons, arrowheads indicate dendrites, and asterisks indicate regions of overlapping puncta. Scale bar, 100 μm.
    Rabbit Anti Cav 1 2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rabbit anti cav 1 2/product/Alomone Labs
    Average 95 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    rabbit anti cav 1 2 - by Bioz Stars, 2022-10
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    Image Search Results


    a Representative confocal image of a nerve terminal arborization. Singly, dually, and innervated by three or more axons NMJs from YFP muscles and also images of the morphologic maturation (S1, the most inmature, and S4, almost fully differentiated, stages) of the postsynaptic clusters from P9 mice. The bar indicates 10 μm. b Confocal immunofluorescence location of α 1D L-, N-, and P/Q-type voltage-dependent calcium channels (VDCCs) at the NMJ. Triple labeling of VDCCs (green fluorescence) with syntaxin (blue fluorescence) and nAChR-α-bungarotoxin (red fluorescence) in merge images. Figure shows the presence of α 1D L-, N-, and P/Q-type-VDCC (in green) in the nerve terminal of P9 Levator auris longus (LAL) muscle endplates. The bar indicates 10 μm

    Journal: Molecular Neurobiology

    Article Title: Involvement of the Voltage-Gated Calcium Channels L- P/Q- and N-Types in Synapse Elimination During Neuromuscular Junction Development

    doi: 10.1007/s12035-022-02818-2

    Figure Lengend Snippet: a Representative confocal image of a nerve terminal arborization. Singly, dually, and innervated by three or more axons NMJs from YFP muscles and also images of the morphologic maturation (S1, the most inmature, and S4, almost fully differentiated, stages) of the postsynaptic clusters from P9 mice. The bar indicates 10 μm. b Confocal immunofluorescence location of α 1D L-, N-, and P/Q-type voltage-dependent calcium channels (VDCCs) at the NMJ. Triple labeling of VDCCs (green fluorescence) with syntaxin (blue fluorescence) and nAChR-α-bungarotoxin (red fluorescence) in merge images. Figure shows the presence of α 1D L-, N-, and P/Q-type-VDCC (in green) in the nerve terminal of P9 Levator auris longus (LAL) muscle endplates. The bar indicates 10 μm

    Article Snippet: Muscles were incubated overnight at 4 °C with anti-CaV 1.3 (CACNA1D) antibody voltage-dependent L-type calcium channel subunit α1D (1/100; ACC-005, Alomone Labs, Jerusalem, Israel); anti-CaV 2.1 (CACNA1A) antibody voltage-dependent P/Q-type calcium channel subunit α1A (1/100; ACC-001, Alomone Labs, Jerusalem, Israel); anti-CaV 2.2 (CACNA1B) antibody voltage-dependent N-type calcium channel subunit α1B (1/100; ACC1-002, Alomone Labs, Jerusalem, Israel), and anti-mouse syntaxin (1/1000, S066, Sigma, St Louis, MO, USA).

    Techniques: Mouse Assay, Immunofluorescence, Labeling, Fluorescence

    AβOs bind to axons and colocalize with presynaptic voltage-gated calcium channels. (A) Representative images of immunocytochemistry with an AβO-specific antibody (NU-4) show that AβOs bind along the entire length of the axon in cultured neurons. (B) Immunohistochemistry on coronal sections from 12-mo-old transgenic AD mouse brain (LaFerla 3xTg) reveal a punctate distribution of AβOs along axons in the cortex. Axons are distinguished by the absence of MAP2 staining (inset). AβOs were not detected in age-matched wild-type control mice. (C) Representative images of AβO and CaV 2.1 (P/Q-type VGCC) immunocytochemistry. Of axonal AβOs, 83.5% colocalize with P/Q-type VGCCs. A minimum of 15 cells from three independent cultures were analyzed. Arrows indicate axons, arrowheads indicate dendrites, and asterisks indicate regions of overlapping puncta. Scale bar, 100 μm.

    Journal: Molecular Biology of the Cell

    Article Title: Dendritic and axonal mechanisms of Ca2+ elevation impair BDNF transport in Aβ oligomer–treated hippocampal neurons

    doi: 10.1091/mbc.E14-12-1612

    Figure Lengend Snippet: AβOs bind to axons and colocalize with presynaptic voltage-gated calcium channels. (A) Representative images of immunocytochemistry with an AβO-specific antibody (NU-4) show that AβOs bind along the entire length of the axon in cultured neurons. (B) Immunohistochemistry on coronal sections from 12-mo-old transgenic AD mouse brain (LaFerla 3xTg) reveal a punctate distribution of AβOs along axons in the cortex. Axons are distinguished by the absence of MAP2 staining (inset). AβOs were not detected in age-matched wild-type control mice. (C) Representative images of AβO and CaV 2.1 (P/Q-type VGCC) immunocytochemistry. Of axonal AβOs, 83.5% colocalize with P/Q-type VGCCs. A minimum of 15 cells from three independent cultures were analyzed. Arrows indicate axons, arrowheads indicate dendrites, and asterisks indicate regions of overlapping puncta. Scale bar, 100 μm.

    Article Snippet: To determine AβO colocalization with VGCCs, AβO-treated cells were stained with anti-CaV 2.1, anti-CaV 2.2, and anti-CaV 2.3 (1:100; Alomone Labs).

    Techniques: Immunocytochemistry, Cell Culture, Immunohistochemistry, Transgenic Assay, Staining, Mouse Assay