ana 12  (Alomone Labs)


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    Structured Review

    Alomone Labs ana 12
    Ana 12, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ana 12/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    ana 12 - by Bioz Stars, 2022-09
    93/100 stars

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    Alomone Labs pharmacological trk inhibitor
    Effects of NTs and the inhibitors of <t>Trk</t> <t>(K252a),</t> TrkB (ANA-12) and p75 NTR (anti-p75) on TASMC proliferation in GCA patients and controls. Proliferation assay performed with a BrdU assay on day 1 (A) in serum-starved TASMC incubated with NT or NT receptor inhibitors, or a combination of NT and NT receptor inhibitors, in GCA patients ( n = 6) and controls ( n = 10). In all figures, bars represent the mean of three experiments with their SEMs. K252a: specific Trk receptor <t>inhibitor;</t> ANA-12: a specific TrkB receptor inhibitor; anti-p75: p75 NTR Ab inhibitor; N (NGF) or B (BDNF) + K (K252a) or anti-p75 NTR : NGF or BDNF are added at the same time with the specific inhibitor. (B) Effect of ANA-12 on GCA-derived TASMCs proliferation. Three independent assays were performed and cells were seeded in triplicate for each cell line. BDNF, brain-derived neurotrophic factor; GCA, giant-cell arteritis; NGF, nerve growth factor; NT, neurotrophin; SEM, standard errors of the mean; TASMC, temporal artery VSMC; Trk, tropomyosin receptor kinase; VSMC, vascular smooth muscle cell.
    Pharmacological Trk Inhibitor, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pharmacological trk inhibitor/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    pharmacological trk inhibitor - by Bioz Stars, 2022-09
    93/100 stars
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    Effects of NTs and the inhibitors of Trk (K252a), TrkB (ANA-12) and p75 NTR (anti-p75) on TASMC proliferation in GCA patients and controls. Proliferation assay performed with a BrdU assay on day 1 (A) in serum-starved TASMC incubated with NT or NT receptor inhibitors, or a combination of NT and NT receptor inhibitors, in GCA patients ( n = 6) and controls ( n = 10). In all figures, bars represent the mean of three experiments with their SEMs. K252a: specific Trk receptor inhibitor; ANA-12: a specific TrkB receptor inhibitor; anti-p75: p75 NTR Ab inhibitor; N (NGF) or B (BDNF) + K (K252a) or anti-p75 NTR : NGF or BDNF are added at the same time with the specific inhibitor. (B) Effect of ANA-12 on GCA-derived TASMCs proliferation. Three independent assays were performed and cells were seeded in triplicate for each cell line. BDNF, brain-derived neurotrophic factor; GCA, giant-cell arteritis; NGF, nerve growth factor; NT, neurotrophin; SEM, standard errors of the mean; TASMC, temporal artery VSMC; Trk, tropomyosin receptor kinase; VSMC, vascular smooth muscle cell.

    Journal: Arthritis Research & Therapy

    Article Title: Neurotrophins are expressed in giant cell arteritis lesions and may contribute to vascular remodeling

    doi: 10.1186/s13075-014-0487-z

    Figure Lengend Snippet: Effects of NTs and the inhibitors of Trk (K252a), TrkB (ANA-12) and p75 NTR (anti-p75) on TASMC proliferation in GCA patients and controls. Proliferation assay performed with a BrdU assay on day 1 (A) in serum-starved TASMC incubated with NT or NT receptor inhibitors, or a combination of NT and NT receptor inhibitors, in GCA patients ( n = 6) and controls ( n = 10). In all figures, bars represent the mean of three experiments with their SEMs. K252a: specific Trk receptor inhibitor; ANA-12: a specific TrkB receptor inhibitor; anti-p75: p75 NTR Ab inhibitor; N (NGF) or B (BDNF) + K (K252a) or anti-p75 NTR : NGF or BDNF are added at the same time with the specific inhibitor. (B) Effect of ANA-12 on GCA-derived TASMCs proliferation. Three independent assays were performed and cells were seeded in triplicate for each cell line. BDNF, brain-derived neurotrophic factor; GCA, giant-cell arteritis; NGF, nerve growth factor; NT, neurotrophin; SEM, standard errors of the mean; TASMC, temporal artery VSMC; Trk, tropomyosin receptor kinase; VSMC, vascular smooth muscle cell.

    Article Snippet: Cell viability, proliferation and migration assays were studied using exogenous NGF (Alomone Labs, Jerusalem, Israel), recombinant human BDNF (Promega, Madison, WI, USA), or PDGF-AB (R & D Systems, Minneapolis, Minnesota, USA), alone or both with K252a, a pharmacological Trk inhibitor (Alomone), ANA-12 (100 μM), a specific TrkB inhibitor, acting without altering TrkA and TrkC functions (Tocris, Bristol, UK) [ ] or an anti-p75NTR antagonist Ab (Alomone).

    Techniques: Proliferation Assay, BrdU Staining, Incubation, Derivative Assay

    Immunostaining of NTs and their receptors and T lymphocytes (CD3+) in temporal arteries of patients and controls. (A) Panels are representative examples of immunohistological images (x50 and x200) of temporal arteries from GCA patients ( n = 22) compared to controls ( n = 21). (B) . Panels are measurements of significant NT immunostaining intensities. Results are shown as mean values and standard errors of the mean (SEM). (C) TrkB immunostaining in GCA patients with or without ischaemic complications. Immunoreactivity to TrkB in the media and intima of TAs in GCA patients with ( n = 9) or without ( n = 13) ischaemic complications. GCA, giant cell arteritis; NT, neurotrophin; TA, temporal artery; Trk, tropomyosin receptor kinase.

    Journal: Arthritis Research & Therapy

    Article Title: Neurotrophins are expressed in giant cell arteritis lesions and may contribute to vascular remodeling

    doi: 10.1186/s13075-014-0487-z

    Figure Lengend Snippet: Immunostaining of NTs and their receptors and T lymphocytes (CD3+) in temporal arteries of patients and controls. (A) Panels are representative examples of immunohistological images (x50 and x200) of temporal arteries from GCA patients ( n = 22) compared to controls ( n = 21). (B) . Panels are measurements of significant NT immunostaining intensities. Results are shown as mean values and standard errors of the mean (SEM). (C) TrkB immunostaining in GCA patients with or without ischaemic complications. Immunoreactivity to TrkB in the media and intima of TAs in GCA patients with ( n = 9) or without ( n = 13) ischaemic complications. GCA, giant cell arteritis; NT, neurotrophin; TA, temporal artery; Trk, tropomyosin receptor kinase.

    Article Snippet: Cell viability, proliferation and migration assays were studied using exogenous NGF (Alomone Labs, Jerusalem, Israel), recombinant human BDNF (Promega, Madison, WI, USA), or PDGF-AB (R & D Systems, Minneapolis, Minnesota, USA), alone or both with K252a, a pharmacological Trk inhibitor (Alomone), ANA-12 (100 μM), a specific TrkB inhibitor, acting without altering TrkA and TrkC functions (Tocris, Bristol, UK) [ ] or an anti-p75NTR antagonist Ab (Alomone).

    Techniques: Immunostaining