Journal: bioRxiv

Article Title: Psilocybin exerts differential effects on social behaviour and inflammation in mice in contexts of activity-based anorexia (ABA)

doi: 10.1101/2025.10.14.682467

Figure Lengend Snippet: (A, B, D-E) No significant differences were observed between RW and ABA mice in the change of mean daily running wheel activity (RWA), overall mean daily RWA, or dark-phase RWA across both habituation and ABA periods. (C) During the light phase, ABA mice exhibited higher RWA than RW controls only during the ABA period (p = 0.0191). (F) During the light phase, RW group did not show a strong correlation between the % body weight loss during the ABA period and Δ Light-phase RWA, whereas a strong positive correlation was seen in the ABA group (Pearson’s r = 0.7251, p = 0.0022). (G) In both the RW and ABA group, no significant correlations between the % body weight loss during the ABA period and Δ dark-phase RWA were observed. Shaded areas represent the dark phase of the light cycle. ABA (Activity-Based Anorexia) and RW (running wheel) groups. Data are presented as mean ± SEM. Analyses were performed using an unpaired t-test as well as a two-way ANOVA or mixed-effects models followed by Šidák’s post hoc comparisons. Pearson correlation analyses were performed for panels F and G. *p < 0.05.

Article Snippet: Mice were acclimated to the running wheel for 7 days (habituation period) to establish baseline levels of running wheel activity (RWA), which was monitored using the Wheel Manager Software (SOF-860, Med Associates Inc, USA).

Techniques: Activity Assay