kcnq antagonist xe991 dihydrochloride  (Alomone Labs)


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    Structured Review

    Alomone Labs kcnq antagonist xe991 dihydrochloride
    Kv7.4 is a regulation target of 5-HT 1A auto-inhibition. (A1) 5-HT 1A receptor agonist 8-OH-DPAT increased the Kv7 current in DRN 5-HT neurons of WT mice and the effect was reversed by <t>XE991.</t> (A2) Voltage clamping protocol and the corresponding traces recorded from (A1) . (A3) Summarized data for experiments shown in (A1) (paired samples test, ** P
    Kcnq Antagonist Xe991 Dihydrochloride, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/kcnq antagonist xe991 dihydrochloride/product/Alomone Labs
    Average 93 stars, based on 2 article reviews
    Price from $9.99 to $1999.99
    kcnq antagonist xe991 dihydrochloride - by Bioz Stars, 2022-11
    93/100 stars

    Images

    1) Product Images from "Selective Modulation of K+ Channel Kv7.4 Significantly Affects the Excitability of DRN 5-HT Neurons"

    Article Title: Selective Modulation of K+ Channel Kv7.4 Significantly Affects the Excitability of DRN 5-HT Neurons

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2017.00405

    Kv7.4 is a regulation target of 5-HT 1A auto-inhibition. (A1) 5-HT 1A receptor agonist 8-OH-DPAT increased the Kv7 current in DRN 5-HT neurons of WT mice and the effect was reversed by XE991. (A2) Voltage clamping protocol and the corresponding traces recorded from (A1) . (A3) Summarized data for experiments shown in (A1) (paired samples test, ** P
    Figure Legend Snippet: Kv7.4 is a regulation target of 5-HT 1A auto-inhibition. (A1) 5-HT 1A receptor agonist 8-OH-DPAT increased the Kv7 current in DRN 5-HT neurons of WT mice and the effect was reversed by XE991. (A2) Voltage clamping protocol and the corresponding traces recorded from (A1) . (A3) Summarized data for experiments shown in (A1) (paired samples test, ** P

    Techniques Used: Inhibition, Mouse Assay

    Fasudil potently augments Kv7.4 currents in DRN 5-HT neurons. (A1) Sample time course shows that fasudil (30 μM) augments Kv7 current, which is completely blocked by XE991 (3 μM) in neurons from WT mice. (A2) Voltage clamping protocol and the corresponding current traces recorded from (A1) . (A3) Summarized data for the experiment shown in (A1) (Wilcoxon Singed Ranks Test, * P
    Figure Legend Snippet: Fasudil potently augments Kv7.4 currents in DRN 5-HT neurons. (A1) Sample time course shows that fasudil (30 μM) augments Kv7 current, which is completely blocked by XE991 (3 μM) in neurons from WT mice. (A2) Voltage clamping protocol and the corresponding current traces recorded from (A1) . (A3) Summarized data for the experiment shown in (A1) (Wilcoxon Singed Ranks Test, * P

    Techniques Used: Mouse Assay

    Kv7.4 activity modulates the excitability of the DRN 5-HT neurons. (A,B) Effects of fasudil on the elicited firing activity of DRN 5-HT neurons from WT mice and Kv7.4 −/− mice. (A1) Fasudil (30 μM) significantly hyperpolarized resting membrane potential (RMP) and the effect completely reversed by XE991 (3 μM) in WT mice. (A2) Typical traces with firing activity elicited by depolarizing 250 pA current injection, recorded from a neuron of WT mice. (A3) Summary of RMP in response to fasudil (30 μM) in WT DRN 5-HT neurons (paired samples test, *** P
    Figure Legend Snippet: Kv7.4 activity modulates the excitability of the DRN 5-HT neurons. (A,B) Effects of fasudil on the elicited firing activity of DRN 5-HT neurons from WT mice and Kv7.4 −/− mice. (A1) Fasudil (30 μM) significantly hyperpolarized resting membrane potential (RMP) and the effect completely reversed by XE991 (3 μM) in WT mice. (A2) Typical traces with firing activity elicited by depolarizing 250 pA current injection, recorded from a neuron of WT mice. (A3) Summary of RMP in response to fasudil (30 μM) in WT DRN 5-HT neurons (paired samples test, *** P

    Techniques Used: Activity Assay, Mouse Assay, Injection

    5-HT augments Kv7.4 currents in DRN 5-HT neurons. (A1) Sample time course shows that 5-HT (30 μM) induced a sharp augmentation of Kv7 current and the augmentation was completely reversed by XE991 (3 μM) in DRN 5-HT neurons of WT mice. (A2) Voltage clamping protocol and representative current traces recorded from (A1) . (A3) Summarized data for experiments shown in (A1) (Wilcoxon Signed Ranks Test, *** P
    Figure Legend Snippet: 5-HT augments Kv7.4 currents in DRN 5-HT neurons. (A1) Sample time course shows that 5-HT (30 μM) induced a sharp augmentation of Kv7 current and the augmentation was completely reversed by XE991 (3 μM) in DRN 5-HT neurons of WT mice. (A2) Voltage clamping protocol and representative current traces recorded from (A1) . (A3) Summarized data for experiments shown in (A1) (Wilcoxon Signed Ranks Test, *** P

    Techniques Used: Mouse Assay

    2) Product Images from "Selective Modulation of K+ Channel Kv7.4 Significantly Affects the Excitability of DRN 5-HT Neurons"

    Article Title: Selective Modulation of K+ Channel Kv7.4 Significantly Affects the Excitability of DRN 5-HT Neurons

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2017.00405

    Kv7.4 is a regulation target of 5-HT 1A auto-inhibition. (A1) 5-HT 1A receptor agonist 8-OH-DPAT increased the Kv7 current in DRN 5-HT neurons of WT mice and the effect was reversed by XE991. (A2) Voltage clamping protocol and the corresponding traces recorded from (A1) . (A3) Summarized data for experiments shown in (A1) (paired samples test, ** P
    Figure Legend Snippet: Kv7.4 is a regulation target of 5-HT 1A auto-inhibition. (A1) 5-HT 1A receptor agonist 8-OH-DPAT increased the Kv7 current in DRN 5-HT neurons of WT mice and the effect was reversed by XE991. (A2) Voltage clamping protocol and the corresponding traces recorded from (A1) . (A3) Summarized data for experiments shown in (A1) (paired samples test, ** P

    Techniques Used: Inhibition, Mouse Assay

    Fasudil potently augments Kv7.4 currents in DRN 5-HT neurons. (A1) Sample time course shows that fasudil (30 μM) augments Kv7 current, which is completely blocked by XE991 (3 μM) in neurons from WT mice. (A2) Voltage clamping protocol and the corresponding current traces recorded from (A1) . (A3) Summarized data for the experiment shown in (A1) (Wilcoxon Singed Ranks Test, * P
    Figure Legend Snippet: Fasudil potently augments Kv7.4 currents in DRN 5-HT neurons. (A1) Sample time course shows that fasudil (30 μM) augments Kv7 current, which is completely blocked by XE991 (3 μM) in neurons from WT mice. (A2) Voltage clamping protocol and the corresponding current traces recorded from (A1) . (A3) Summarized data for the experiment shown in (A1) (Wilcoxon Singed Ranks Test, * P

    Techniques Used: Mouse Assay

    Kv7.4 activity modulates the excitability of the DRN 5-HT neurons. (A,B) Effects of fasudil on the elicited firing activity of DRN 5-HT neurons from WT mice and Kv7.4 −/− mice. (A1) Fasudil (30 μM) significantly hyperpolarized resting membrane potential (RMP) and the effect completely reversed by XE991 (3 μM) in WT mice. (A2) Typical traces with firing activity elicited by depolarizing 250 pA current injection, recorded from a neuron of WT mice. (A3) Summary of RMP in response to fasudil (30 μM) in WT DRN 5-HT neurons (paired samples test, *** P
    Figure Legend Snippet: Kv7.4 activity modulates the excitability of the DRN 5-HT neurons. (A,B) Effects of fasudil on the elicited firing activity of DRN 5-HT neurons from WT mice and Kv7.4 −/− mice. (A1) Fasudil (30 μM) significantly hyperpolarized resting membrane potential (RMP) and the effect completely reversed by XE991 (3 μM) in WT mice. (A2) Typical traces with firing activity elicited by depolarizing 250 pA current injection, recorded from a neuron of WT mice. (A3) Summary of RMP in response to fasudil (30 μM) in WT DRN 5-HT neurons (paired samples test, *** P

    Techniques Used: Activity Assay, Mouse Assay, Injection

    5-HT augments Kv7.4 currents in DRN 5-HT neurons. (A1) Sample time course shows that 5-HT (30 μM) induced a sharp augmentation of Kv7 current and the augmentation was completely reversed by XE991 (3 μM) in DRN 5-HT neurons of WT mice. (A2) Voltage clamping protocol and representative current traces recorded from (A1) . (A3) Summarized data for experiments shown in (A1) (Wilcoxon Signed Ranks Test, *** P
    Figure Legend Snippet: 5-HT augments Kv7.4 currents in DRN 5-HT neurons. (A1) Sample time course shows that 5-HT (30 μM) induced a sharp augmentation of Kv7 current and the augmentation was completely reversed by XE991 (3 μM) in DRN 5-HT neurons of WT mice. (A2) Voltage clamping protocol and representative current traces recorded from (A1) . (A3) Summarized data for experiments shown in (A1) (Wilcoxon Signed Ranks Test, *** P

    Techniques Used: Mouse Assay

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  • 93
    Alomone Labs kcnq antagonist xe991 dihydrochloride
    Kv7.4 is a regulation target of 5-HT 1A auto-inhibition. (A1) 5-HT 1A receptor agonist 8-OH-DPAT increased the Kv7 current in DRN 5-HT neurons of WT mice and the effect was reversed by <t>XE991.</t> (A2) Voltage clamping protocol and the corresponding traces recorded from (A1) . (A3) Summarized data for experiments shown in (A1) (paired samples test, ** P
    Kcnq Antagonist Xe991 Dihydrochloride, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/kcnq antagonist xe991 dihydrochloride/product/Alomone Labs
    Average 93 stars, based on 2 article reviews
    Price from $9.99 to $1999.99
    kcnq antagonist xe991 dihydrochloride - by Bioz Stars, 2022-11
    93/100 stars
      Buy from Supplier

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    Kv7.4 is a regulation target of 5-HT 1A auto-inhibition. (A1) 5-HT 1A receptor agonist 8-OH-DPAT increased the Kv7 current in DRN 5-HT neurons of WT mice and the effect was reversed by XE991. (A2) Voltage clamping protocol and the corresponding traces recorded from (A1) . (A3) Summarized data for experiments shown in (A1) (paired samples test, ** P

    Journal: Frontiers in Cellular Neuroscience

    Article Title: Selective Modulation of K+ Channel Kv7.4 Significantly Affects the Excitability of DRN 5-HT Neurons

    doi: 10.3389/fncel.2017.00405

    Figure Lengend Snippet: Kv7.4 is a regulation target of 5-HT 1A auto-inhibition. (A1) 5-HT 1A receptor agonist 8-OH-DPAT increased the Kv7 current in DRN 5-HT neurons of WT mice and the effect was reversed by XE991. (A2) Voltage clamping protocol and the corresponding traces recorded from (A1) . (A3) Summarized data for experiments shown in (A1) (paired samples test, ** P

    Article Snippet: XE991 dihydrochloride was from the Alomone Labs (Jerusalem, Israel).

    Techniques: Inhibition, Mouse Assay

    Fasudil potently augments Kv7.4 currents in DRN 5-HT neurons. (A1) Sample time course shows that fasudil (30 μM) augments Kv7 current, which is completely blocked by XE991 (3 μM) in neurons from WT mice. (A2) Voltage clamping protocol and the corresponding current traces recorded from (A1) . (A3) Summarized data for the experiment shown in (A1) (Wilcoxon Singed Ranks Test, * P

    Journal: Frontiers in Cellular Neuroscience

    Article Title: Selective Modulation of K+ Channel Kv7.4 Significantly Affects the Excitability of DRN 5-HT Neurons

    doi: 10.3389/fncel.2017.00405

    Figure Lengend Snippet: Fasudil potently augments Kv7.4 currents in DRN 5-HT neurons. (A1) Sample time course shows that fasudil (30 μM) augments Kv7 current, which is completely blocked by XE991 (3 μM) in neurons from WT mice. (A2) Voltage clamping protocol and the corresponding current traces recorded from (A1) . (A3) Summarized data for the experiment shown in (A1) (Wilcoxon Singed Ranks Test, * P

    Article Snippet: XE991 dihydrochloride was from the Alomone Labs (Jerusalem, Israel).

    Techniques: Mouse Assay

    Kv7.4 activity modulates the excitability of the DRN 5-HT neurons. (A,B) Effects of fasudil on the elicited firing activity of DRN 5-HT neurons from WT mice and Kv7.4 −/− mice. (A1) Fasudil (30 μM) significantly hyperpolarized resting membrane potential (RMP) and the effect completely reversed by XE991 (3 μM) in WT mice. (A2) Typical traces with firing activity elicited by depolarizing 250 pA current injection, recorded from a neuron of WT mice. (A3) Summary of RMP in response to fasudil (30 μM) in WT DRN 5-HT neurons (paired samples test, *** P

    Journal: Frontiers in Cellular Neuroscience

    Article Title: Selective Modulation of K+ Channel Kv7.4 Significantly Affects the Excitability of DRN 5-HT Neurons

    doi: 10.3389/fncel.2017.00405

    Figure Lengend Snippet: Kv7.4 activity modulates the excitability of the DRN 5-HT neurons. (A,B) Effects of fasudil on the elicited firing activity of DRN 5-HT neurons from WT mice and Kv7.4 −/− mice. (A1) Fasudil (30 μM) significantly hyperpolarized resting membrane potential (RMP) and the effect completely reversed by XE991 (3 μM) in WT mice. (A2) Typical traces with firing activity elicited by depolarizing 250 pA current injection, recorded from a neuron of WT mice. (A3) Summary of RMP in response to fasudil (30 μM) in WT DRN 5-HT neurons (paired samples test, *** P

    Article Snippet: XE991 dihydrochloride was from the Alomone Labs (Jerusalem, Israel).

    Techniques: Activity Assay, Mouse Assay, Injection

    5-HT augments Kv7.4 currents in DRN 5-HT neurons. (A1) Sample time course shows that 5-HT (30 μM) induced a sharp augmentation of Kv7 current and the augmentation was completely reversed by XE991 (3 μM) in DRN 5-HT neurons of WT mice. (A2) Voltage clamping protocol and representative current traces recorded from (A1) . (A3) Summarized data for experiments shown in (A1) (Wilcoxon Signed Ranks Test, *** P

    Journal: Frontiers in Cellular Neuroscience

    Article Title: Selective Modulation of K+ Channel Kv7.4 Significantly Affects the Excitability of DRN 5-HT Neurons

    doi: 10.3389/fncel.2017.00405

    Figure Lengend Snippet: 5-HT augments Kv7.4 currents in DRN 5-HT neurons. (A1) Sample time course shows that 5-HT (30 μM) induced a sharp augmentation of Kv7 current and the augmentation was completely reversed by XE991 (3 μM) in DRN 5-HT neurons of WT mice. (A2) Voltage clamping protocol and representative current traces recorded from (A1) . (A3) Summarized data for experiments shown in (A1) (Wilcoxon Signed Ranks Test, *** P

    Article Snippet: XE991 dihydrochloride was from the Alomone Labs (Jerusalem, Israel).

    Techniques: Mouse Assay