zaleplon  (Alomone Labs)


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    Alomone Labs zaleplon
    Modulatory actions of (A) <t>zaleplon,</t> (B) indiplon, (C) eszopiclone, (D) diazepam, (E) zolpidem, and (F) alpidem, on GABA evoked Cl – currents measured in human α1β2γ1, α1β2γ2, and α1β2γ3 GABA A receptors expressed in Xenopus laevis oocytes measured via two-electrode voltage-clamp. The data are expressed as a percentage potentiation of GABA EC 10 and are means ± SD ( n = 4–8 from at least 2 separate Xenopus laevis donors). Data points were fitted to the Hill equation with bottom set to 0 and slope constrained to 1.
    Zaleplon, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/zaleplon/product/Alomone Labs
    Average 92 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    zaleplon - by Bioz Stars, 2022-06
    92/100 stars

    Images

    1) Product Images from "The Z-Drugs Zolpidem, Zaleplon, and Eszopiclone Have Varying Actions on Human GABAA Receptors Containing γ1, γ2, and γ3 Subunits"

    Article Title: The Z-Drugs Zolpidem, Zaleplon, and Eszopiclone Have Varying Actions on Human GABAA Receptors Containing γ1, γ2, and γ3 Subunits

    Journal: Frontiers in Neuroscience

    doi: 10.3389/fnins.2020.599812

    Modulatory actions of (A) zaleplon, (B) indiplon, (C) eszopiclone, (D) diazepam, (E) zolpidem, and (F) alpidem, on GABA evoked Cl – currents measured in human α1β2γ1, α1β2γ2, and α1β2γ3 GABA A receptors expressed in Xenopus laevis oocytes measured via two-electrode voltage-clamp. The data are expressed as a percentage potentiation of GABA EC 10 and are means ± SD ( n = 4–8 from at least 2 separate Xenopus laevis donors). Data points were fitted to the Hill equation with bottom set to 0 and slope constrained to 1.
    Figure Legend Snippet: Modulatory actions of (A) zaleplon, (B) indiplon, (C) eszopiclone, (D) diazepam, (E) zolpidem, and (F) alpidem, on GABA evoked Cl – currents measured in human α1β2γ1, α1β2γ2, and α1β2γ3 GABA A receptors expressed in Xenopus laevis oocytes measured via two-electrode voltage-clamp. The data are expressed as a percentage potentiation of GABA EC 10 and are means ± SD ( n = 4–8 from at least 2 separate Xenopus laevis donors). Data points were fitted to the Hill equation with bottom set to 0 and slope constrained to 1.

    Techniques Used:

    Modulatory actions of zaleplon, indiplon, eszopiclone, diazepam, zolpidem, and alpidem, on GABA evoked Cl – currents measured in human (A) α1β2γ1, (B) α1β2γ2, and (C) α1β2γ3 GABA A receptors expressed in Xenopus laevis oocytes measured via two-electrode voltage-clamp. The data are expressed as a percentage potentiation of GABA EC 10 and are means ± SD ( n = 4–8 from at least 2 separate Xenopus laevis donors). Data points were fitted to the Hill equation with bottom set to 0 and slope constrained to 1. (D–F) Representative traces illustrating modulator concentration-response experiments.
    Figure Legend Snippet: Modulatory actions of zaleplon, indiplon, eszopiclone, diazepam, zolpidem, and alpidem, on GABA evoked Cl – currents measured in human (A) α1β2γ1, (B) α1β2γ2, and (C) α1β2γ3 GABA A receptors expressed in Xenopus laevis oocytes measured via two-electrode voltage-clamp. The data are expressed as a percentage potentiation of GABA EC 10 and are means ± SD ( n = 4–8 from at least 2 separate Xenopus laevis donors). Data points were fitted to the Hill equation with bottom set to 0 and slope constrained to 1. (D–F) Representative traces illustrating modulator concentration-response experiments.

    Techniques Used: Concentration Assay

    Modulatory actions of 10 μM (A) zaleplon, (B) indiplon, (C) eszopiclone, (D) diazepam, (E) zolpidem, and (F) alpidem, on GABA evoked Cl – currents measured in human α1β2γ1, α1β2γ2, α1β2γ3, and binary α1β2 GABA A receptors expressed in Xenopus laevis oocytes measured via two-electrode voltage-clamp. Data are expressed as percentage potentiation of GABA EC 10 and are means ± SD ( n = 3–8 from at least 2 separate Xenopus laevis donors). One-way ANOVA with post hoc Sidak multiple comparisons test were calculated between all compounds on γ1 vs. α1β2 and between zolpidem and alpidem on γ3 vs. α1β2; * p
    Figure Legend Snippet: Modulatory actions of 10 μM (A) zaleplon, (B) indiplon, (C) eszopiclone, (D) diazepam, (E) zolpidem, and (F) alpidem, on GABA evoked Cl – currents measured in human α1β2γ1, α1β2γ2, α1β2γ3, and binary α1β2 GABA A receptors expressed in Xenopus laevis oocytes measured via two-electrode voltage-clamp. Data are expressed as percentage potentiation of GABA EC 10 and are means ± SD ( n = 3–8 from at least 2 separate Xenopus laevis donors). One-way ANOVA with post hoc Sidak multiple comparisons test were calculated between all compounds on γ1 vs. α1β2 and between zolpidem and alpidem on γ3 vs. α1β2; * p

    Techniques Used:

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    Alomone Labs zaleplon
    Modulatory actions of (A) <t>zaleplon,</t> (B) indiplon, (C) eszopiclone, (D) diazepam, (E) zolpidem, and (F) alpidem, on GABA evoked Cl – currents measured in human α1β2γ1, α1β2γ2, and α1β2γ3 GABA A receptors expressed in Xenopus laevis oocytes measured via two-electrode voltage-clamp. The data are expressed as a percentage potentiation of GABA EC 10 and are means ± SD ( n = 4–8 from at least 2 separate Xenopus laevis donors). Data points were fitted to the Hill equation with bottom set to 0 and slope constrained to 1.
    Zaleplon, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/zaleplon/product/Alomone Labs
    Average 92 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    zaleplon - by Bioz Stars, 2022-06
    92/100 stars
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    Modulatory actions of (A) zaleplon, (B) indiplon, (C) eszopiclone, (D) diazepam, (E) zolpidem, and (F) alpidem, on GABA evoked Cl – currents measured in human α1β2γ1, α1β2γ2, and α1β2γ3 GABA A receptors expressed in Xenopus laevis oocytes measured via two-electrode voltage-clamp. The data are expressed as a percentage potentiation of GABA EC 10 and are means ± SD ( n = 4–8 from at least 2 separate Xenopus laevis donors). Data points were fitted to the Hill equation with bottom set to 0 and slope constrained to 1.

    Journal: Frontiers in Neuroscience

    Article Title: The Z-Drugs Zolpidem, Zaleplon, and Eszopiclone Have Varying Actions on Human GABAA Receptors Containing γ1, γ2, and γ3 Subunits

    doi: 10.3389/fnins.2020.599812

    Figure Lengend Snippet: Modulatory actions of (A) zaleplon, (B) indiplon, (C) eszopiclone, (D) diazepam, (E) zolpidem, and (F) alpidem, on GABA evoked Cl – currents measured in human α1β2γ1, α1β2γ2, and α1β2γ3 GABA A receptors expressed in Xenopus laevis oocytes measured via two-electrode voltage-clamp. The data are expressed as a percentage potentiation of GABA EC 10 and are means ± SD ( n = 4–8 from at least 2 separate Xenopus laevis donors). Data points were fitted to the Hill equation with bottom set to 0 and slope constrained to 1.

    Article Snippet: Zolpidem was purchased from Chemieliva (Yubei District, Chongqing, China), zaleplon was purchased from Alomone Labs (Jerusalem, Israel), eszopiclone was purchased from Clearsynth (NJ, United States), and indiplon was purchased from Tocris (VIC, Australia).

    Techniques:

    Modulatory actions of zaleplon, indiplon, eszopiclone, diazepam, zolpidem, and alpidem, on GABA evoked Cl – currents measured in human (A) α1β2γ1, (B) α1β2γ2, and (C) α1β2γ3 GABA A receptors expressed in Xenopus laevis oocytes measured via two-electrode voltage-clamp. The data are expressed as a percentage potentiation of GABA EC 10 and are means ± SD ( n = 4–8 from at least 2 separate Xenopus laevis donors). Data points were fitted to the Hill equation with bottom set to 0 and slope constrained to 1. (D–F) Representative traces illustrating modulator concentration-response experiments.

    Journal: Frontiers in Neuroscience

    Article Title: The Z-Drugs Zolpidem, Zaleplon, and Eszopiclone Have Varying Actions on Human GABAA Receptors Containing γ1, γ2, and γ3 Subunits

    doi: 10.3389/fnins.2020.599812

    Figure Lengend Snippet: Modulatory actions of zaleplon, indiplon, eszopiclone, diazepam, zolpidem, and alpidem, on GABA evoked Cl – currents measured in human (A) α1β2γ1, (B) α1β2γ2, and (C) α1β2γ3 GABA A receptors expressed in Xenopus laevis oocytes measured via two-electrode voltage-clamp. The data are expressed as a percentage potentiation of GABA EC 10 and are means ± SD ( n = 4–8 from at least 2 separate Xenopus laevis donors). Data points were fitted to the Hill equation with bottom set to 0 and slope constrained to 1. (D–F) Representative traces illustrating modulator concentration-response experiments.

    Article Snippet: Zolpidem was purchased from Chemieliva (Yubei District, Chongqing, China), zaleplon was purchased from Alomone Labs (Jerusalem, Israel), eszopiclone was purchased from Clearsynth (NJ, United States), and indiplon was purchased from Tocris (VIC, Australia).

    Techniques: Concentration Assay

    Modulatory actions of 10 μM (A) zaleplon, (B) indiplon, (C) eszopiclone, (D) diazepam, (E) zolpidem, and (F) alpidem, on GABA evoked Cl – currents measured in human α1β2γ1, α1β2γ2, α1β2γ3, and binary α1β2 GABA A receptors expressed in Xenopus laevis oocytes measured via two-electrode voltage-clamp. Data are expressed as percentage potentiation of GABA EC 10 and are means ± SD ( n = 3–8 from at least 2 separate Xenopus laevis donors). One-way ANOVA with post hoc Sidak multiple comparisons test were calculated between all compounds on γ1 vs. α1β2 and between zolpidem and alpidem on γ3 vs. α1β2; * p

    Journal: Frontiers in Neuroscience

    Article Title: The Z-Drugs Zolpidem, Zaleplon, and Eszopiclone Have Varying Actions on Human GABAA Receptors Containing γ1, γ2, and γ3 Subunits

    doi: 10.3389/fnins.2020.599812

    Figure Lengend Snippet: Modulatory actions of 10 μM (A) zaleplon, (B) indiplon, (C) eszopiclone, (D) diazepam, (E) zolpidem, and (F) alpidem, on GABA evoked Cl – currents measured in human α1β2γ1, α1β2γ2, α1β2γ3, and binary α1β2 GABA A receptors expressed in Xenopus laevis oocytes measured via two-electrode voltage-clamp. Data are expressed as percentage potentiation of GABA EC 10 and are means ± SD ( n = 3–8 from at least 2 separate Xenopus laevis donors). One-way ANOVA with post hoc Sidak multiple comparisons test were calculated between all compounds on γ1 vs. α1β2 and between zolpidem and alpidem on γ3 vs. α1β2; * p

    Article Snippet: Zolpidem was purchased from Chemieliva (Yubei District, Chongqing, China), zaleplon was purchased from Alomone Labs (Jerusalem, Israel), eszopiclone was purchased from Clearsynth (NJ, United States), and indiplon was purchased from Tocris (VIC, Australia).

    Techniques: