zaleplon (Alomone Labs)


Structured Review

Zaleplon, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/zaleplon/product/Alomone Labs
Average 92 stars, based on 1 article reviews
Price from $9.99 to $1999.99
Images
1) Product Images from "The Z-Drugs Zolpidem, Zaleplon, and Eszopiclone Have Varying Actions on Human GABAA Receptors Containing γ1, γ2, and γ3 Subunits"
Article Title: The Z-Drugs Zolpidem, Zaleplon, and Eszopiclone Have Varying Actions on Human GABAA Receptors Containing γ1, γ2, and γ3 Subunits
Journal: Frontiers in Neuroscience
doi: 10.3389/fnins.2020.599812

Figure Legend Snippet: Modulatory actions of (A) zaleplon, (B) indiplon, (C) eszopiclone, (D) diazepam, (E) zolpidem, and (F) alpidem, on GABA evoked Cl – currents measured in human α1β2γ1, α1β2γ2, and α1β2γ3 GABA A receptors expressed in Xenopus laevis oocytes measured via two-electrode voltage-clamp. The data are expressed as a percentage potentiation of GABA EC 10 and are means ± SD ( n = 4–8 from at least 2 separate Xenopus laevis donors). Data points were fitted to the Hill equation with bottom set to 0 and slope constrained to 1.
Techniques Used:

Figure Legend Snippet: Modulatory actions of zaleplon, indiplon, eszopiclone, diazepam, zolpidem, and alpidem, on GABA evoked Cl – currents measured in human (A) α1β2γ1, (B) α1β2γ2, and (C) α1β2γ3 GABA A receptors expressed in Xenopus laevis oocytes measured via two-electrode voltage-clamp. The data are expressed as a percentage potentiation of GABA EC 10 and are means ± SD ( n = 4–8 from at least 2 separate Xenopus laevis donors). Data points were fitted to the Hill equation with bottom set to 0 and slope constrained to 1. (D–F) Representative traces illustrating modulator concentration-response experiments.
Techniques Used: Concentration Assay

Figure Legend Snippet: Modulatory actions of 10 μM (A) zaleplon, (B) indiplon, (C) eszopiclone, (D) diazepam, (E) zolpidem, and (F) alpidem, on GABA evoked Cl – currents measured in human α1β2γ1, α1β2γ2, α1β2γ3, and binary α1β2 GABA A receptors expressed in Xenopus laevis oocytes measured via two-electrode voltage-clamp. Data are expressed as percentage potentiation of GABA EC 10 and are means ± SD ( n = 3–8 from at least 2 separate Xenopus laevis donors). One-way ANOVA with post hoc Sidak multiple comparisons test were calculated between all compounds on γ1 vs. α1β2 and between zolpidem and alpidem on γ3 vs. α1β2; * p
Techniques Used: