trichostatin a  (Alomone Labs)


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    Name:
    Trichostatin A
    Description:
    Trichostatin A an antifungal antibiotic irreversibly inhibits histone deacetylase It could also promote apoptosis and in some cases even inhibits the proliferation of some cancer cells
    Catalog Number:
    T-300
    Price:
    554.0
    Category:
    Small Molecule
    Source:
    Streptomyces platensis.
    Applications:
    0
    Purity:
    >98%
    Size:
    1 Vials containing 1 mg each
    Format:
    Lyophilized/solid.
    Formula:
    C17H22N2O3
    Molecular Weight:
    302.4
    Molecule Name:
    (2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6- di methyl-7-oxo-2,4-heptadienamide.
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    Structured Review

    Alomone Labs trichostatin a
    Trichostatin A
    Trichostatin A an antifungal antibiotic irreversibly inhibits histone deacetylase It could also promote apoptosis and in some cases even inhibits the proliferation of some cancer cells
    https://www.bioz.com/result/trichostatin a/product/Alomone Labs
    Average 85 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    trichostatin a - by Bioz Stars, 2021-09
    85/100 stars

    Images

    1) Product Images from "IL12-Mediated Liver Inflammation Reduces the Formation of AAV Transcriptionally Active Forms but Has No Effect over Preexisting AAV Transgene Expression"

    Article Title: IL12-Mediated Liver Inflammation Reduces the Formation of AAV Transcriptionally Active Forms but Has No Effect over Preexisting AAV Transgene Expression

    Journal: PLoS ONE

    doi: 10.1371/journal.pone.0067748

    DNA demethylating agents but not histone acetylation inhibition revert the IFN-γ inhibitory effect. C57BL/6 mice received 2.5 × 1011 vg/kg of AAV8-luc vector alone or in combination with 1.5 × 109 vg/kg of AAV8-IL12 vector. One group of 5 mice treated with AAV8-luc or AAV8-luc in combination with AAV8-IL12 received 5′-Azacytidine (AZA) intraperitoneally at a dose of 1 mg/kg every 24 hours starting the day of vector injection. A second group of 5 mice treated with AAV8-luc or AAV8-luc in combination with AAV8-IL12 received 2 mg/kg of trichostatin A (TSA) were injected IP every 48 hours starting the day of vector injection. A third group of animals received only vector injection. Luciferase expression levels were analyzed in both groups of animals at days 1, 4, and 7 using a Xenogen in vivo luminometer, experiments could not be performed at longer time points due to the toxicity of 5-AZA long term treatment. Luciferase expression was quantified and represented as photons/second. The data are shown as mean ± standard deviation (SD). The differences in luciferase expression were statistically evaluated by Student t test (**p
    Figure Legend Snippet: DNA demethylating agents but not histone acetylation inhibition revert the IFN-γ inhibitory effect. C57BL/6 mice received 2.5 × 1011 vg/kg of AAV8-luc vector alone or in combination with 1.5 × 109 vg/kg of AAV8-IL12 vector. One group of 5 mice treated with AAV8-luc or AAV8-luc in combination with AAV8-IL12 received 5′-Azacytidine (AZA) intraperitoneally at a dose of 1 mg/kg every 24 hours starting the day of vector injection. A second group of 5 mice treated with AAV8-luc or AAV8-luc in combination with AAV8-IL12 received 2 mg/kg of trichostatin A (TSA) were injected IP every 48 hours starting the day of vector injection. A third group of animals received only vector injection. Luciferase expression levels were analyzed in both groups of animals at days 1, 4, and 7 using a Xenogen in vivo luminometer, experiments could not be performed at longer time points due to the toxicity of 5-AZA long term treatment. Luciferase expression was quantified and represented as photons/second. The data are shown as mean ± standard deviation (SD). The differences in luciferase expression were statistically evaluated by Student t test (**p

    Techniques Used: Inhibition, Mouse Assay, Plasmid Preparation, Injection, Luciferase, Expressing, In Vivo, Standard Deviation

    Related Articles

    Inhibition:

    Article Title: IL12-Mediated Liver Inflammation Reduces the Formation of AAV Transcriptionally Active Forms but Has No Effect over Preexisting AAV Transgene Expression
    Article Snippet: .. For the inhibition of histone deacetylation, 2 mg/kg of trichostatin A (Alomon Laboratories) were injected IP every 48 hours. ..

    Injection:

    Article Title: IL12-Mediated Liver Inflammation Reduces the Formation of AAV Transcriptionally Active Forms but Has No Effect over Preexisting AAV Transgene Expression
    Article Snippet: .. For the inhibition of histone deacetylation, 2 mg/kg of trichostatin A (Alomon Laboratories) were injected IP every 48 hours. ..

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  • 85
    Alomone Labs trichostatin a
    DNA demethylating agents but not histone acetylation inhibition revert the IFN-γ inhibitory effect. C57BL/6 mice received 2.5 × 1011 vg/kg of AAV8-luc vector alone or in combination with 1.5 × 109 vg/kg of AAV8-IL12 vector. One group of 5 mice treated with AAV8-luc or AAV8-luc in combination with AAV8-IL12 received 5′-Azacytidine (AZA) intraperitoneally at a dose of 1 mg/kg every 24 hours starting the day of vector injection. A second group of 5 mice treated with AAV8-luc or AAV8-luc in combination with AAV8-IL12 received 2 mg/kg of <t>trichostatin</t> A (TSA) were injected IP every 48 hours starting the day of vector injection. A third group of animals received only vector injection. Luciferase expression levels were analyzed in both groups of animals at days 1, 4, and 7 using a Xenogen in vivo luminometer, experiments could not be performed at longer time points due to the toxicity of 5-AZA long term treatment. Luciferase expression was quantified and represented as photons/second. The data are shown as mean ± standard deviation (SD). The differences in luciferase expression were statistically evaluated by Student t test (**p
    Trichostatin A, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/trichostatin a/product/Alomone Labs
    Average 85 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    trichostatin a - by Bioz Stars, 2021-09
    85/100 stars
      Buy from Supplier

    93
    Alomone Labs 4 9 anhydrotetrodotoxin
    DNA demethylating agents but not histone acetylation inhibition revert the IFN-γ inhibitory effect. C57BL/6 mice received 2.5 × 1011 vg/kg of AAV8-luc vector alone or in combination with 1.5 × 109 vg/kg of AAV8-IL12 vector. One group of 5 mice treated with AAV8-luc or AAV8-luc in combination with AAV8-IL12 received 5′-Azacytidine (AZA) intraperitoneally at a dose of 1 mg/kg every 24 hours starting the day of vector injection. A second group of 5 mice treated with AAV8-luc or AAV8-luc in combination with AAV8-IL12 received 2 mg/kg of <t>trichostatin</t> A (TSA) were injected IP every 48 hours starting the day of vector injection. A third group of animals received only vector injection. Luciferase expression levels were analyzed in both groups of animals at days 1, 4, and 7 using a Xenogen in vivo luminometer, experiments could not be performed at longer time points due to the toxicity of 5-AZA long term treatment. Luciferase expression was quantified and represented as photons/second. The data are shown as mean ± standard deviation (SD). The differences in luciferase expression were statistically evaluated by Student t test (**p
    4 9 Anhydrotetrodotoxin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/4 9 anhydrotetrodotoxin/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    4 9 anhydrotetrodotoxin - by Bioz Stars, 2021-09
    93/100 stars
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    97
    Alomone Labs tetrodotoxin
    DNA demethylating agents but not histone acetylation inhibition revert the IFN-γ inhibitory effect. C57BL/6 mice received 2.5 × 1011 vg/kg of AAV8-luc vector alone or in combination with 1.5 × 109 vg/kg of AAV8-IL12 vector. One group of 5 mice treated with AAV8-luc or AAV8-luc in combination with AAV8-IL12 received 5′-Azacytidine (AZA) intraperitoneally at a dose of 1 mg/kg every 24 hours starting the day of vector injection. A second group of 5 mice treated with AAV8-luc or AAV8-luc in combination with AAV8-IL12 received 2 mg/kg of <t>trichostatin</t> A (TSA) were injected IP every 48 hours starting the day of vector injection. A third group of animals received only vector injection. Luciferase expression levels were analyzed in both groups of animals at days 1, 4, and 7 using a Xenogen in vivo luminometer, experiments could not be performed at longer time points due to the toxicity of 5-AZA long term treatment. Luciferase expression was quantified and represented as photons/second. The data are shown as mean ± standard deviation (SD). The differences in luciferase expression were statistically evaluated by Student t test (**p
    Tetrodotoxin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tetrodotoxin/product/Alomone Labs
    Average 97 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    tetrodotoxin - by Bioz Stars, 2021-09
    97/100 stars
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    Image Search Results


    DNA demethylating agents but not histone acetylation inhibition revert the IFN-γ inhibitory effect. C57BL/6 mice received 2.5 × 1011 vg/kg of AAV8-luc vector alone or in combination with 1.5 × 109 vg/kg of AAV8-IL12 vector. One group of 5 mice treated with AAV8-luc or AAV8-luc in combination with AAV8-IL12 received 5′-Azacytidine (AZA) intraperitoneally at a dose of 1 mg/kg every 24 hours starting the day of vector injection. A second group of 5 mice treated with AAV8-luc or AAV8-luc in combination with AAV8-IL12 received 2 mg/kg of trichostatin A (TSA) were injected IP every 48 hours starting the day of vector injection. A third group of animals received only vector injection. Luciferase expression levels were analyzed in both groups of animals at days 1, 4, and 7 using a Xenogen in vivo luminometer, experiments could not be performed at longer time points due to the toxicity of 5-AZA long term treatment. Luciferase expression was quantified and represented as photons/second. The data are shown as mean ± standard deviation (SD). The differences in luciferase expression were statistically evaluated by Student t test (**p

    Journal: PLoS ONE

    Article Title: IL12-Mediated Liver Inflammation Reduces the Formation of AAV Transcriptionally Active Forms but Has No Effect over Preexisting AAV Transgene Expression

    doi: 10.1371/journal.pone.0067748

    Figure Lengend Snippet: DNA demethylating agents but not histone acetylation inhibition revert the IFN-γ inhibitory effect. C57BL/6 mice received 2.5 × 1011 vg/kg of AAV8-luc vector alone or in combination with 1.5 × 109 vg/kg of AAV8-IL12 vector. One group of 5 mice treated with AAV8-luc or AAV8-luc in combination with AAV8-IL12 received 5′-Azacytidine (AZA) intraperitoneally at a dose of 1 mg/kg every 24 hours starting the day of vector injection. A second group of 5 mice treated with AAV8-luc or AAV8-luc in combination with AAV8-IL12 received 2 mg/kg of trichostatin A (TSA) were injected IP every 48 hours starting the day of vector injection. A third group of animals received only vector injection. Luciferase expression levels were analyzed in both groups of animals at days 1, 4, and 7 using a Xenogen in vivo luminometer, experiments could not be performed at longer time points due to the toxicity of 5-AZA long term treatment. Luciferase expression was quantified and represented as photons/second. The data are shown as mean ± standard deviation (SD). The differences in luciferase expression were statistically evaluated by Student t test (**p

    Article Snippet: For the inhibition of histone deacetylation, 2 mg/kg of trichostatin A (Alomon Laboratories) were injected IP every 48 hours.

    Techniques: Inhibition, Mouse Assay, Plasmid Preparation, Injection, Luciferase, Expressing, In Vivo, Standard Deviation