gtx1 15  (Alomone Labs)


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    Name:
    GTx1 15
    Description:
    GTx1 15 inhibits rat Nav1 3 and Nav1 7 voltage gated Na channels as well as T type Ca2 channels
    Catalog Number:
    STT-300
    Price:
    242.0
    Category:
    Toxin
    Source:
    Synthetic peptide
    Applications:
    0
    Purity:
    >98% (HPLC)
    Size:
    50 mcg
    Format:
    Lyophilized powder.
    Formula:
    C176H271N53O45S7
    Molecular Weight:
    4075 Da.
    Molecule Name:
    GTx1-15, omega/beta-Theraphotoxin-Ps2a, beta-TRTX-Ps2a, Peptide E
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    Structured Review

    Alomone Labs gtx1 15
    GTx1 15
    GTx1 15 inhibits rat Nav1 3 and Nav1 7 voltage gated Na channels as well as T type Ca2 channels
    https://www.bioz.com/result/gtx1 15/product/Alomone Labs
    Average 91 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    gtx1 15 - by Bioz Stars, 2021-09
    91/100 stars

    Images

    1) Product Images from "Accelerated Development of the First-Order Central Auditory Neurons With Spontaneous Activity"

    Article Title: Accelerated Development of the First-Order Central Auditory Neurons With Spontaneous Activity

    Journal: Frontiers in Molecular Neuroscience

    doi: 10.3389/fnmol.2018.00183

    HCN channels play a dominant role in generating IFs over TTX-resistant sodium channels and T-type calcium channels in P5–10 CN neurons. (A–H) Example traces and time course are shown for control (in the presence of synaptic blockers), subsequent application and washout of HCN blockers CsCl (2 mM), ZD7288 (40 μM), or TTX-resistant sodium channel blocker A-803478 (10 μM) or T-type calcium channel blocker GTX1–15 (0.01 μM). The control solution was applied for 3 min, followed by the bath application of different blockers for 6 min and a washout for another 3 min. Data was collected after 2 min drug application to achieve equilibrium. (I) Summary plot of the inhibition of each antagonist, showing significantly larger effects of HCN channels blockers (CsCl and ZD7288), as compared with other two pacemaker channels. Normalized data were collected by taking the average of spikes for each 1-min bin during 6 min drug application.
    Figure Legend Snippet: HCN channels play a dominant role in generating IFs over TTX-resistant sodium channels and T-type calcium channels in P5–10 CN neurons. (A–H) Example traces and time course are shown for control (in the presence of synaptic blockers), subsequent application and washout of HCN blockers CsCl (2 mM), ZD7288 (40 μM), or TTX-resistant sodium channel blocker A-803478 (10 μM) or T-type calcium channel blocker GTX1–15 (0.01 μM). The control solution was applied for 3 min, followed by the bath application of different blockers for 6 min and a washout for another 3 min. Data was collected after 2 min drug application to achieve equilibrium. (I) Summary plot of the inhibition of each antagonist, showing significantly larger effects of HCN channels blockers (CsCl and ZD7288), as compared with other two pacemaker channels. Normalized data were collected by taking the average of spikes for each 1-min bin during 6 min drug application.

    Techniques Used: Inhibition

    2) Product Images from "High Proteolytic Resistance of Spider-Derived Inhibitor Cystine Knots"

    Article Title: High Proteolytic Resistance of Spider-Derived Inhibitor Cystine Knots

    Journal: International Journal of Peptides

    doi: 10.1155/2015/537508

    Three-dimensional structures of spider-derived ICK peptides. Protein Data Bank ID numbers for NMR structures of (a) ProTx-I [ 31 ] and (b) GsMTx-4 [ 33 ] are 2M9L and 1TYK, respectively. 3D structure models of (c) GTx1-15 were constructed by homology modeling with ICM-PRO (Molsoft, La Jolla, CA) based on NMR structures of HnTx-IV (PDB: 1niy). (d) NMR structure of ProTx-II by Park et al. [ 35 ]. Reprinted with permission from [ 35 ]. Copyright: 2014 American Chemical Society. β -Sheets are indicated as green or black arrows and disulfide bonds are highlighted with yellow. Note: spider-derived ICKs have only two antiparallel β -sheets and three disulfide bonds except for ProTx-II which has only one β -sheet.
    Figure Legend Snippet: Three-dimensional structures of spider-derived ICK peptides. Protein Data Bank ID numbers for NMR structures of (a) ProTx-I [ 31 ] and (b) GsMTx-4 [ 33 ] are 2M9L and 1TYK, respectively. 3D structure models of (c) GTx1-15 were constructed by homology modeling with ICM-PRO (Molsoft, La Jolla, CA) based on NMR structures of HnTx-IV (PDB: 1niy). (d) NMR structure of ProTx-II by Park et al. [ 35 ]. Reprinted with permission from [ 35 ]. Copyright: 2014 American Chemical Society. β -Sheets are indicated as green or black arrows and disulfide bonds are highlighted with yellow. Note: spider-derived ICKs have only two antiparallel β -sheets and three disulfide bonds except for ProTx-II which has only one β -sheet.

    Techniques Used: Derivative Assay, Nuclear Magnetic Resonance, Construct

    Related Articles

    other:

    Article Title: High Proteolytic Resistance of Spider-Derived Inhibitor Cystine Knots
    Article Snippet: GTx1-15 was obtained from Alomone Labs (Jerusalem, Israel).

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  • 91
    Alomone Labs gtx1 15
    HCN channels play a dominant role in generating IFs over TTX-resistant sodium channels and T-type calcium channels in P5–10 CN neurons. (A–H) Example traces and time course are shown for control (in the presence of synaptic blockers), subsequent application and washout of HCN blockers CsCl (2 mM), ZD7288 (40 μM), or TTX-resistant sodium channel blocker A-803478 (10 μM) or T-type calcium channel blocker <t>GTX1–15</t> (0.01 μM). The control solution was applied for 3 min, followed by the bath application of different blockers for 6 min and a washout for another 3 min. Data was collected after 2 min drug application to achieve equilibrium. (I) Summary plot of the inhibition of each antagonist, showing significantly larger effects of HCN channels blockers (CsCl and ZD7288), as compared with other two pacemaker channels. Normalized data were collected by taking the average of spikes for each 1-min bin during 6 min drug application.
    Gtx1 15, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gtx1 15/product/Alomone Labs
    Average 91 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    gtx1 15 - by Bioz Stars, 2021-09
    91/100 stars
      Buy from Supplier

    Image Search Results


    HCN channels play a dominant role in generating IFs over TTX-resistant sodium channels and T-type calcium channels in P5–10 CN neurons. (A–H) Example traces and time course are shown for control (in the presence of synaptic blockers), subsequent application and washout of HCN blockers CsCl (2 mM), ZD7288 (40 μM), or TTX-resistant sodium channel blocker A-803478 (10 μM) or T-type calcium channel blocker GTX1–15 (0.01 μM). The control solution was applied for 3 min, followed by the bath application of different blockers for 6 min and a washout for another 3 min. Data was collected after 2 min drug application to achieve equilibrium. (I) Summary plot of the inhibition of each antagonist, showing significantly larger effects of HCN channels blockers (CsCl and ZD7288), as compared with other two pacemaker channels. Normalized data were collected by taking the average of spikes for each 1-min bin during 6 min drug application.

    Journal: Frontiers in Molecular Neuroscience

    Article Title: Accelerated Development of the First-Order Central Auditory Neurons With Spontaneous Activity

    doi: 10.3389/fnmol.2018.00183

    Figure Lengend Snippet: HCN channels play a dominant role in generating IFs over TTX-resistant sodium channels and T-type calcium channels in P5–10 CN neurons. (A–H) Example traces and time course are shown for control (in the presence of synaptic blockers), subsequent application and washout of HCN blockers CsCl (2 mM), ZD7288 (40 μM), or TTX-resistant sodium channel blocker A-803478 (10 μM) or T-type calcium channel blocker GTX1–15 (0.01 μM). The control solution was applied for 3 min, followed by the bath application of different blockers for 6 min and a washout for another 3 min. Data was collected after 2 min drug application to achieve equilibrium. (I) Summary plot of the inhibition of each antagonist, showing significantly larger effects of HCN channels blockers (CsCl and ZD7288), as compared with other two pacemaker channels. Normalized data were collected by taking the average of spikes for each 1-min bin during 6 min drug application.

    Article Snippet: Chemicals and drugs were purchased from Sigma (St. Louis, MO, USA), except GTX1–15 which was purchased from Alomone Labs (Jerusalem, Israel).

    Techniques: Inhibition

    Three-dimensional structures of spider-derived ICK peptides. Protein Data Bank ID numbers for NMR structures of (a) ProTx-I [ 31 ] and (b) GsMTx-4 [ 33 ] are 2M9L and 1TYK, respectively. 3D structure models of (c) GTx1-15 were constructed by homology modeling with ICM-PRO (Molsoft, La Jolla, CA) based on NMR structures of HnTx-IV (PDB: 1niy). (d) NMR structure of ProTx-II by Park et al. [ 35 ]. Reprinted with permission from [ 35 ]. Copyright: 2014 American Chemical Society. β -Sheets are indicated as green or black arrows and disulfide bonds are highlighted with yellow. Note: spider-derived ICKs have only two antiparallel β -sheets and three disulfide bonds except for ProTx-II which has only one β -sheet.

    Journal: International Journal of Peptides

    Article Title: High Proteolytic Resistance of Spider-Derived Inhibitor Cystine Knots

    doi: 10.1155/2015/537508

    Figure Lengend Snippet: Three-dimensional structures of spider-derived ICK peptides. Protein Data Bank ID numbers for NMR structures of (a) ProTx-I [ 31 ] and (b) GsMTx-4 [ 33 ] are 2M9L and 1TYK, respectively. 3D structure models of (c) GTx1-15 were constructed by homology modeling with ICM-PRO (Molsoft, La Jolla, CA) based on NMR structures of HnTx-IV (PDB: 1niy). (d) NMR structure of ProTx-II by Park et al. [ 35 ]. Reprinted with permission from [ 35 ]. Copyright: 2014 American Chemical Society. β -Sheets are indicated as green or black arrows and disulfide bonds are highlighted with yellow. Note: spider-derived ICKs have only two antiparallel β -sheets and three disulfide bonds except for ProTx-II which has only one β -sheet.

    Article Snippet: GTx1-15 was obtained from Alomone Labs (Jerusalem, Israel).

    Techniques: Derivative Assay, Nuclear Magnetic Resonance, Construct