mambalgin 1  (Alomone Labs)


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    Alomone Labs mambalgin 1
    Effect of amiloride, <t>mambalgin-1,</t> APETx2 and PcTx1 on ASIC1b-expressing muscle afferent DRG neurons. (A) Whole-cell patch clamp recording on an ASIC1b-expressing DRG neuron projecting to gastrocnemius muscle labeled by fluorogold. (B) Mambalgin-1 (MB-1) (1 μM) inhibited acid (pH 5.0)-induced currents in 13 of 14 ASIC1b-expressing muscle afferent DRG neurons. (C) APETx2 (1 μM) inhibited acid (pH 5.0)-induced currents in 6 of 13 ASIC1b-expressing muscle afferent DRG neurons. (D) PcTx1 (100 nM) inhibited acid (pH 5.0)-induced currents in 5 of 11 ASIC1b-expressing muscle afferent DRG neurons.
    Mambalgin 1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mambalgin 1/product/Alomone Labs
    Average 91 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    mambalgin 1 - by Bioz Stars, 2022-07
    91/100 stars

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    1) Product Images from "Involvement of Acid-Sensing Ion Channel 1b in the Development of Acid-Induced Chronic Muscle Pain"

    Article Title: Involvement of Acid-Sensing Ion Channel 1b in the Development of Acid-Induced Chronic Muscle Pain

    Journal: Frontiers in Neuroscience

    doi: 10.3389/fnins.2019.01247

    Effect of amiloride, mambalgin-1, APETx2 and PcTx1 on ASIC1b-expressing muscle afferent DRG neurons. (A) Whole-cell patch clamp recording on an ASIC1b-expressing DRG neuron projecting to gastrocnemius muscle labeled by fluorogold. (B) Mambalgin-1 (MB-1) (1 μM) inhibited acid (pH 5.0)-induced currents in 13 of 14 ASIC1b-expressing muscle afferent DRG neurons. (C) APETx2 (1 μM) inhibited acid (pH 5.0)-induced currents in 6 of 13 ASIC1b-expressing muscle afferent DRG neurons. (D) PcTx1 (100 nM) inhibited acid (pH 5.0)-induced currents in 5 of 11 ASIC1b-expressing muscle afferent DRG neurons.
    Figure Legend Snippet: Effect of amiloride, mambalgin-1, APETx2 and PcTx1 on ASIC1b-expressing muscle afferent DRG neurons. (A) Whole-cell patch clamp recording on an ASIC1b-expressing DRG neuron projecting to gastrocnemius muscle labeled by fluorogold. (B) Mambalgin-1 (MB-1) (1 μM) inhibited acid (pH 5.0)-induced currents in 13 of 14 ASIC1b-expressing muscle afferent DRG neurons. (C) APETx2 (1 μM) inhibited acid (pH 5.0)-induced currents in 6 of 13 ASIC1b-expressing muscle afferent DRG neurons. (D) PcTx1 (100 nM) inhibited acid (pH 5.0)-induced currents in 5 of 11 ASIC1b-expressing muscle afferent DRG neurons.

    Techniques Used: Expressing, Patch Clamp, Labeling

    Acid-induced currents in ASIC1b-expressing DRG neurons. (A) Representative current traces of ASIC-like currents in ASIC1b-expressing DRG neurons. Amiloride (100 μM) inhibited the acid-induced transient inward current ( n = 5). (B) Representative current traces of acid-induced sustained currents in ASIC1b-expressing DRG neurons ( n = 5). (C) Representative current traces of acid-induced sustained currents resistant to mambalgin-1 (1 μM). (D) Representative current traces of acid-induced sustained currents sensitive ( n = 1) or resistant ( n = 3) to 10 μM ruthenium red treatment. (E) Histograms of DRG neurons by size and acid-induced current types (biphasic, n = 81; sustained, n = 61). (F) pH sensitivity of DRG neurons with biphasic and sustained currents. Peak amplitudes were normalized to that induced by pH-5 artificial cerebrospinal fluid (ACSF) (biphasic, n = 10; sustained, n = 10). (G) The proportion of three subtypes of ASIC-like currents with different desensitization time constants (rapid,
    Figure Legend Snippet: Acid-induced currents in ASIC1b-expressing DRG neurons. (A) Representative current traces of ASIC-like currents in ASIC1b-expressing DRG neurons. Amiloride (100 μM) inhibited the acid-induced transient inward current ( n = 5). (B) Representative current traces of acid-induced sustained currents in ASIC1b-expressing DRG neurons ( n = 5). (C) Representative current traces of acid-induced sustained currents resistant to mambalgin-1 (1 μM). (D) Representative current traces of acid-induced sustained currents sensitive ( n = 1) or resistant ( n = 3) to 10 μM ruthenium red treatment. (E) Histograms of DRG neurons by size and acid-induced current types (biphasic, n = 81; sustained, n = 61). (F) pH sensitivity of DRG neurons with biphasic and sustained currents. Peak amplitudes were normalized to that induced by pH-5 artificial cerebrospinal fluid (ACSF) (biphasic, n = 10; sustained, n = 10). (G) The proportion of three subtypes of ASIC-like currents with different desensitization time constants (rapid,

    Techniques Used: Expressing

    2) Product Images from "Involvement of Acid-Sensing Ion Channel 1b in the Development of Acid-Induced Chronic Muscle Pain"

    Article Title: Involvement of Acid-Sensing Ion Channel 1b in the Development of Acid-Induced Chronic Muscle Pain

    Journal: Frontiers in Neuroscience

    doi: 10.3389/fnins.2019.01247

    Effect of amiloride, mambalgin-1, APETx2 and PcTx1 on ASIC1b-expressing muscle afferent DRG neurons. (A) Whole-cell patch clamp recording on an ASIC1b-expressing DRG neuron projecting to gastrocnemius muscle labeled by fluorogold. (B) Mambalgin-1 (MB-1) (1 μM) inhibited acid (pH 5.0)-induced currents in 13 of 14 ASIC1b-expressing muscle afferent DRG neurons. (C) APETx2 (1 μM) inhibited acid (pH 5.0)-induced currents in 6 of 13 ASIC1b-expressing muscle afferent DRG neurons. (D) PcTx1 (100 nM) inhibited acid (pH 5.0)-induced currents in 5 of 11 ASIC1b-expressing muscle afferent DRG neurons.
    Figure Legend Snippet: Effect of amiloride, mambalgin-1, APETx2 and PcTx1 on ASIC1b-expressing muscle afferent DRG neurons. (A) Whole-cell patch clamp recording on an ASIC1b-expressing DRG neuron projecting to gastrocnemius muscle labeled by fluorogold. (B) Mambalgin-1 (MB-1) (1 μM) inhibited acid (pH 5.0)-induced currents in 13 of 14 ASIC1b-expressing muscle afferent DRG neurons. (C) APETx2 (1 μM) inhibited acid (pH 5.0)-induced currents in 6 of 13 ASIC1b-expressing muscle afferent DRG neurons. (D) PcTx1 (100 nM) inhibited acid (pH 5.0)-induced currents in 5 of 11 ASIC1b-expressing muscle afferent DRG neurons.

    Techniques Used: Expressing, Patch Clamp, Labeling

    Acid-induced currents in ASIC1b-expressing DRG neurons. (A) Representative current traces of ASIC-like currents in ASIC1b-expressing DRG neurons. Amiloride (100 μM) inhibited the acid-induced transient inward current ( n = 5). (B) Representative current traces of acid-induced sustained currents in ASIC1b-expressing DRG neurons ( n = 5). (C) Representative current traces of acid-induced sustained currents resistant to mambalgin-1 (1 μM). (D) Representative current traces of acid-induced sustained currents sensitive ( n = 1) or resistant ( n = 3) to 10 μM ruthenium red treatment. (E) Histograms of DRG neurons by size and acid-induced current types (biphasic, n = 81; sustained, n = 61). (F) pH sensitivity of DRG neurons with biphasic and sustained currents. Peak amplitudes were normalized to that induced by pH-5 artificial cerebrospinal fluid (ACSF) (biphasic, n = 10; sustained, n = 10). (G) The proportion of three subtypes of ASIC-like currents with different desensitization time constants (rapid,
    Figure Legend Snippet: Acid-induced currents in ASIC1b-expressing DRG neurons. (A) Representative current traces of ASIC-like currents in ASIC1b-expressing DRG neurons. Amiloride (100 μM) inhibited the acid-induced transient inward current ( n = 5). (B) Representative current traces of acid-induced sustained currents in ASIC1b-expressing DRG neurons ( n = 5). (C) Representative current traces of acid-induced sustained currents resistant to mambalgin-1 (1 μM). (D) Representative current traces of acid-induced sustained currents sensitive ( n = 1) or resistant ( n = 3) to 10 μM ruthenium red treatment. (E) Histograms of DRG neurons by size and acid-induced current types (biphasic, n = 81; sustained, n = 61). (F) pH sensitivity of DRG neurons with biphasic and sustained currents. Peak amplitudes were normalized to that induced by pH-5 artificial cerebrospinal fluid (ACSF) (biphasic, n = 10; sustained, n = 10). (G) The proportion of three subtypes of ASIC-like currents with different desensitization time constants (rapid,

    Techniques Used: Expressing

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    Alomone Labs mambalgin 1
    Effect of amiloride, <t>mambalgin-1,</t> APETx2 and PcTx1 on ASIC1b-expressing muscle afferent DRG neurons. (A) Whole-cell patch clamp recording on an ASIC1b-expressing DRG neuron projecting to gastrocnemius muscle labeled by fluorogold. (B) Mambalgin-1 (MB-1) (1 μM) inhibited acid (pH 5.0)-induced currents in 13 of 14 ASIC1b-expressing muscle afferent DRG neurons. (C) APETx2 (1 μM) inhibited acid (pH 5.0)-induced currents in 6 of 13 ASIC1b-expressing muscle afferent DRG neurons. (D) PcTx1 (100 nM) inhibited acid (pH 5.0)-induced currents in 5 of 11 ASIC1b-expressing muscle afferent DRG neurons.
    Mambalgin 1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mambalgin 1/product/Alomone Labs
    Average 91 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    mambalgin 1 - by Bioz Stars, 2022-07
    91/100 stars
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    Effect of amiloride, mambalgin-1, APETx2 and PcTx1 on ASIC1b-expressing muscle afferent DRG neurons. (A) Whole-cell patch clamp recording on an ASIC1b-expressing DRG neuron projecting to gastrocnemius muscle labeled by fluorogold. (B) Mambalgin-1 (MB-1) (1 μM) inhibited acid (pH 5.0)-induced currents in 13 of 14 ASIC1b-expressing muscle afferent DRG neurons. (C) APETx2 (1 μM) inhibited acid (pH 5.0)-induced currents in 6 of 13 ASIC1b-expressing muscle afferent DRG neurons. (D) PcTx1 (100 nM) inhibited acid (pH 5.0)-induced currents in 5 of 11 ASIC1b-expressing muscle afferent DRG neurons.

    Journal: Frontiers in Neuroscience

    Article Title: Involvement of Acid-Sensing Ion Channel 1b in the Development of Acid-Induced Chronic Muscle Pain

    doi: 10.3389/fnins.2019.01247

    Figure Lengend Snippet: Effect of amiloride, mambalgin-1, APETx2 and PcTx1 on ASIC1b-expressing muscle afferent DRG neurons. (A) Whole-cell patch clamp recording on an ASIC1b-expressing DRG neuron projecting to gastrocnemius muscle labeled by fluorogold. (B) Mambalgin-1 (MB-1) (1 μM) inhibited acid (pH 5.0)-induced currents in 13 of 14 ASIC1b-expressing muscle afferent DRG neurons. (C) APETx2 (1 μM) inhibited acid (pH 5.0)-induced currents in 6 of 13 ASIC1b-expressing muscle afferent DRG neurons. (D) PcTx1 (100 nM) inhibited acid (pH 5.0)-induced currents in 5 of 11 ASIC1b-expressing muscle afferent DRG neurons.

    Article Snippet: Mambalgin-1, APETx2, and psalmotoxin 1 (PcTx1) were purchased from Alomone Labs and prepared by autoclaved water in stock solutions of 200 μM, 1 mM, and 200 μM respectively.

    Techniques: Expressing, Patch Clamp, Labeling

    Acid-induced currents in ASIC1b-expressing DRG neurons. (A) Representative current traces of ASIC-like currents in ASIC1b-expressing DRG neurons. Amiloride (100 μM) inhibited the acid-induced transient inward current ( n = 5). (B) Representative current traces of acid-induced sustained currents in ASIC1b-expressing DRG neurons ( n = 5). (C) Representative current traces of acid-induced sustained currents resistant to mambalgin-1 (1 μM). (D) Representative current traces of acid-induced sustained currents sensitive ( n = 1) or resistant ( n = 3) to 10 μM ruthenium red treatment. (E) Histograms of DRG neurons by size and acid-induced current types (biphasic, n = 81; sustained, n = 61). (F) pH sensitivity of DRG neurons with biphasic and sustained currents. Peak amplitudes were normalized to that induced by pH-5 artificial cerebrospinal fluid (ACSF) (biphasic, n = 10; sustained, n = 10). (G) The proportion of three subtypes of ASIC-like currents with different desensitization time constants (rapid,

    Journal: Frontiers in Neuroscience

    Article Title: Involvement of Acid-Sensing Ion Channel 1b in the Development of Acid-Induced Chronic Muscle Pain

    doi: 10.3389/fnins.2019.01247

    Figure Lengend Snippet: Acid-induced currents in ASIC1b-expressing DRG neurons. (A) Representative current traces of ASIC-like currents in ASIC1b-expressing DRG neurons. Amiloride (100 μM) inhibited the acid-induced transient inward current ( n = 5). (B) Representative current traces of acid-induced sustained currents in ASIC1b-expressing DRG neurons ( n = 5). (C) Representative current traces of acid-induced sustained currents resistant to mambalgin-1 (1 μM). (D) Representative current traces of acid-induced sustained currents sensitive ( n = 1) or resistant ( n = 3) to 10 μM ruthenium red treatment. (E) Histograms of DRG neurons by size and acid-induced current types (biphasic, n = 81; sustained, n = 61). (F) pH sensitivity of DRG neurons with biphasic and sustained currents. Peak amplitudes were normalized to that induced by pH-5 artificial cerebrospinal fluid (ACSF) (biphasic, n = 10; sustained, n = 10). (G) The proportion of three subtypes of ASIC-like currents with different desensitization time constants (rapid,

    Article Snippet: Mambalgin-1, APETx2, and psalmotoxin 1 (PcTx1) were purchased from Alomone Labs and prepared by autoclaved water in stock solutions of 200 μM, 1 mM, and 200 μM respectively.

    Techniques: Expressing