kt5823  (Alomone Labs)


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    Name:
    KT5823
    Description:
    KT5823 is a selective and potent inhibitor of PKG IC50 234 nM
    Catalog Number:
    K-250
    Price:
    300.0
    Category:
    Small Molecule
    Source:
    Nocardiopsis sp. (soil fungi).
    Applications:
    0
    Purity:
    >98%
    Size:
    1 Vials containing 50 mcg each
    Format:
    Lyophilized/solid.
    Formula:
    C29H25N3O5
    Molecular Weight:
    495
    Molecule Name:
    (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-di methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-k l]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester.
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    Structured Review

    Alomone Labs kt5823
    KT5823
    KT5823 is a selective and potent inhibitor of PKG IC50 234 nM
    https://www.bioz.com/result/kt5823/product/Alomone Labs
    Average 85 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    kt5823 - by Bioz Stars, 2021-09
    85/100 stars

    Images

    1) Product Images from "Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5"

    Article Title: Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5

    Journal: Stem Cells International

    doi: 10.1155/2014/878397

    Inhibition of PKG prevented the proliferation of SVZ cells stimulated by PDE5 inhibitors. Cell proliferation following treatment with 1 μ M KT5823 and 1 μ M T0156 (a, d), 1 μ M sildenafil (b, e), or 10 μ M zaprinast (c, f) was assessed by incorporation of EdU and evaluated by flow cytometry, following 6 h or 24 h of treatment. Data are expressed as means ± SEM of at least 4 independent experiments. One-way ANOVA (Bonferroni's post-test), * P
    Figure Legend Snippet: Inhibition of PKG prevented the proliferation of SVZ cells stimulated by PDE5 inhibitors. Cell proliferation following treatment with 1 μ M KT5823 and 1 μ M T0156 (a, d), 1 μ M sildenafil (b, e), or 10 μ M zaprinast (c, f) was assessed by incorporation of EdU and evaluated by flow cytometry, following 6 h or 24 h of treatment. Data are expressed as means ± SEM of at least 4 independent experiments. One-way ANOVA (Bonferroni's post-test), * P

    Techniques Used: Inhibition, Flow Cytometry, Cytometry

    Activation of sGC stimulates proliferation of NSC, increases ERK1/2 phosphorylation, and decreases p27 Kip1 levels. Cell proliferation following treatment with 20 μ M YC-1 (a) for 24 h was assessed by the incorporation of EdU and analyzed by flow cytometry. Levels of phospho-ERK1/2 following treatment with 20 μ M YC-1 (b) or YC-1 plus 1 μ M KT5823 (c) and p27 Kip1 levels following treatment with YC-1 (d) or YC-1 plus 1 μ M U0126 (e) or KT5823 (f) for 2 h were assessed by Western blot. Representative images are shown. Data are expressed as means ± SEM of at least 4 independent experiments. (a), (b), and (d) two-tailed t -test, * P
    Figure Legend Snippet: Activation of sGC stimulates proliferation of NSC, increases ERK1/2 phosphorylation, and decreases p27 Kip1 levels. Cell proliferation following treatment with 20 μ M YC-1 (a) for 24 h was assessed by the incorporation of EdU and analyzed by flow cytometry. Levels of phospho-ERK1/2 following treatment with 20 μ M YC-1 (b) or YC-1 plus 1 μ M KT5823 (c) and p27 Kip1 levels following treatment with YC-1 (d) or YC-1 plus 1 μ M U0126 (e) or KT5823 (f) for 2 h were assessed by Western blot. Representative images are shown. Data are expressed as means ± SEM of at least 4 independent experiments. (a), (b), and (d) two-tailed t -test, * P

    Techniques Used: Activation Assay, Flow Cytometry, Cytometry, Western Blot, Two Tailed Test

    Inhibition of PKG did not prevent the decrease of p27 Kip1 levels by T0156. p27 Kip1 levels following treatment with 1 μ M KT5823 and 1 μ M T0156 (a), 1 μ M sildenafil (b), or 10 μ M zaprinast (c) for 2 h were assessed by Western blot. Representative images are shown. Data are expressed as means ± SEM of at least 4 independent experiments. One-way ANOVA (Bonferroni's post-test), * P
    Figure Legend Snippet: Inhibition of PKG did not prevent the decrease of p27 Kip1 levels by T0156. p27 Kip1 levels following treatment with 1 μ M KT5823 and 1 μ M T0156 (a), 1 μ M sildenafil (b), or 10 μ M zaprinast (c) for 2 h were assessed by Western blot. Representative images are shown. Data are expressed as means ± SEM of at least 4 independent experiments. One-way ANOVA (Bonferroni's post-test), * P

    Techniques Used: Inhibition, Western Blot

    Inhibition of PKG prevented the phosphorylation of ERK1/2 by treatment with T0156 or zaprinast. Levels of phospho-ERK1/2 following treatment with 1 μ M KT5823 and 1 μ M T0156 (a), 1 μ M sildenafil (b), and 10 μ M zaprinast (c) for 2 h were assessed by Western blot. Representative images are shown. Data are expressed as means ± SEM of at least 4 independent experiments. One-way ANOVA (Bonferroni's post-test), * P
    Figure Legend Snippet: Inhibition of PKG prevented the phosphorylation of ERK1/2 by treatment with T0156 or zaprinast. Levels of phospho-ERK1/2 following treatment with 1 μ M KT5823 and 1 μ M T0156 (a), 1 μ M sildenafil (b), and 10 μ M zaprinast (c) for 2 h were assessed by Western blot. Representative images are shown. Data are expressed as means ± SEM of at least 4 independent experiments. One-way ANOVA (Bonferroni's post-test), * P

    Techniques Used: Inhibition, Western Blot

    Related Articles

    other:

    Article Title: Expression of olfactory-type cyclic nucleotide-gated channels in rat cortical astrocytes.
    Article Snippet: Cyclic nucleotide-gated (CNG) channels are nonselective cation channels activated by cyclic AMP (cAMP) or cyclic GMP (cGMP).. They were originally identified in retinal and olfactory receptors, but evidence has also emerged for their expression in several mammalian brain areas.

    Article Title: Low Doses of Bisphenol A and Diethylstilbestrol Impair Ca2+ Signals in Pancreatic ?-Cells through a Nonclassical Membrane Estrogen Receptor within Intact Islets of Langerhans
    Article Snippet: Materials.We obtained Fluo-3 AM from Molecular Probes Inc. (Leiden, the Netherlands); ICI182,780 and 1H-[1,2,4] oxadiazolo[4,3-a] quinoxalin-1-one (ODQ) from Tocris Cookson Ltd. (Avonmouth, UK); and KT-5823 from Alomone Labs (Jerusalem, Israel).

    Article Title: Staurosporine induces lamellipodial widening in locomoting fish keratocytes by abolishing the gradient from radial extension of leading edge
    Article Snippet: Protein-serine/threonine kinase inhibitorsStaurosporine, KT5720, and KT5823 were products of Aromone Labs (Jerusalem, Israel), and Ro 31-8220, SB-415286, KN-93, K-252a, and K-252b were purchased from Biomol Research Laboratories Inc. (Plymouth Meeting, PA, USA), while ML-7 and Y-27632 were from EMD Biosciences, Inc (Merck KGaA, Darmstadt, Germany).

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  • 85
    Alomone Labs kt5823
    Inhibition of PKG prevented the proliferation of SVZ cells stimulated by PDE5 inhibitors. Cell proliferation following treatment with 1 μ M <t>KT5823</t> and 1 μ M T0156 (a, d), 1 μ M sildenafil (b, e), or 10 μ M zaprinast (c, f) was assessed by incorporation of EdU and evaluated by flow cytometry, following 6 h or 24 h of treatment. Data are expressed as means ± SEM of at least 4 independent experiments. One-way ANOVA (Bonferroni's post-test), * P
    Kt5823, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/kt5823/product/Alomone Labs
    Average 85 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    kt5823 - by Bioz Stars, 2021-09
    85/100 stars
      Buy from Supplier

    Image Search Results


    Inhibition of PKG prevented the proliferation of SVZ cells stimulated by PDE5 inhibitors. Cell proliferation following treatment with 1 μ M KT5823 and 1 μ M T0156 (a, d), 1 μ M sildenafil (b, e), or 10 μ M zaprinast (c, f) was assessed by incorporation of EdU and evaluated by flow cytometry, following 6 h or 24 h of treatment. Data are expressed as means ± SEM of at least 4 independent experiments. One-way ANOVA (Bonferroni's post-test), * P

    Journal: Stem Cells International

    Article Title: Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5

    doi: 10.1155/2014/878397

    Figure Lengend Snippet: Inhibition of PKG prevented the proliferation of SVZ cells stimulated by PDE5 inhibitors. Cell proliferation following treatment with 1 μ M KT5823 and 1 μ M T0156 (a, d), 1 μ M sildenafil (b, e), or 10 μ M zaprinast (c, f) was assessed by incorporation of EdU and evaluated by flow cytometry, following 6 h or 24 h of treatment. Data are expressed as means ± SEM of at least 4 independent experiments. One-way ANOVA (Bonferroni's post-test), * P

    Article Snippet: KT5823 was obtained from Alomone Labs (Jerusalem, Israel) and 3-(5′-Hydroxymethyl-2′-furyl)-1-benzylindazole (YC-1) from Santa Cruz Biotechnology (Santa Cruz, CA, USA).

    Techniques: Inhibition, Flow Cytometry, Cytometry

    Activation of sGC stimulates proliferation of NSC, increases ERK1/2 phosphorylation, and decreases p27 Kip1 levels. Cell proliferation following treatment with 20 μ M YC-1 (a) for 24 h was assessed by the incorporation of EdU and analyzed by flow cytometry. Levels of phospho-ERK1/2 following treatment with 20 μ M YC-1 (b) or YC-1 plus 1 μ M KT5823 (c) and p27 Kip1 levels following treatment with YC-1 (d) or YC-1 plus 1 μ M U0126 (e) or KT5823 (f) for 2 h were assessed by Western blot. Representative images are shown. Data are expressed as means ± SEM of at least 4 independent experiments. (a), (b), and (d) two-tailed t -test, * P

    Journal: Stem Cells International

    Article Title: Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5

    doi: 10.1155/2014/878397

    Figure Lengend Snippet: Activation of sGC stimulates proliferation of NSC, increases ERK1/2 phosphorylation, and decreases p27 Kip1 levels. Cell proliferation following treatment with 20 μ M YC-1 (a) for 24 h was assessed by the incorporation of EdU and analyzed by flow cytometry. Levels of phospho-ERK1/2 following treatment with 20 μ M YC-1 (b) or YC-1 plus 1 μ M KT5823 (c) and p27 Kip1 levels following treatment with YC-1 (d) or YC-1 plus 1 μ M U0126 (e) or KT5823 (f) for 2 h were assessed by Western blot. Representative images are shown. Data are expressed as means ± SEM of at least 4 independent experiments. (a), (b), and (d) two-tailed t -test, * P

    Article Snippet: KT5823 was obtained from Alomone Labs (Jerusalem, Israel) and 3-(5′-Hydroxymethyl-2′-furyl)-1-benzylindazole (YC-1) from Santa Cruz Biotechnology (Santa Cruz, CA, USA).

    Techniques: Activation Assay, Flow Cytometry, Cytometry, Western Blot, Two Tailed Test

    Inhibition of PKG did not prevent the decrease of p27 Kip1 levels by T0156. p27 Kip1 levels following treatment with 1 μ M KT5823 and 1 μ M T0156 (a), 1 μ M sildenafil (b), or 10 μ M zaprinast (c) for 2 h were assessed by Western blot. Representative images are shown. Data are expressed as means ± SEM of at least 4 independent experiments. One-way ANOVA (Bonferroni's post-test), * P

    Journal: Stem Cells International

    Article Title: Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5

    doi: 10.1155/2014/878397

    Figure Lengend Snippet: Inhibition of PKG did not prevent the decrease of p27 Kip1 levels by T0156. p27 Kip1 levels following treatment with 1 μ M KT5823 and 1 μ M T0156 (a), 1 μ M sildenafil (b), or 10 μ M zaprinast (c) for 2 h were assessed by Western blot. Representative images are shown. Data are expressed as means ± SEM of at least 4 independent experiments. One-way ANOVA (Bonferroni's post-test), * P

    Article Snippet: KT5823 was obtained from Alomone Labs (Jerusalem, Israel) and 3-(5′-Hydroxymethyl-2′-furyl)-1-benzylindazole (YC-1) from Santa Cruz Biotechnology (Santa Cruz, CA, USA).

    Techniques: Inhibition, Western Blot

    Inhibition of PKG prevented the phosphorylation of ERK1/2 by treatment with T0156 or zaprinast. Levels of phospho-ERK1/2 following treatment with 1 μ M KT5823 and 1 μ M T0156 (a), 1 μ M sildenafil (b), and 10 μ M zaprinast (c) for 2 h were assessed by Western blot. Representative images are shown. Data are expressed as means ± SEM of at least 4 independent experiments. One-way ANOVA (Bonferroni's post-test), * P

    Journal: Stem Cells International

    Article Title: Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5

    doi: 10.1155/2014/878397

    Figure Lengend Snippet: Inhibition of PKG prevented the phosphorylation of ERK1/2 by treatment with T0156 or zaprinast. Levels of phospho-ERK1/2 following treatment with 1 μ M KT5823 and 1 μ M T0156 (a), 1 μ M sildenafil (b), and 10 μ M zaprinast (c) for 2 h were assessed by Western blot. Representative images are shown. Data are expressed as means ± SEM of at least 4 independent experiments. One-way ANOVA (Bonferroni's post-test), * P

    Article Snippet: KT5823 was obtained from Alomone Labs (Jerusalem, Israel) and 3-(5′-Hydroxymethyl-2′-furyl)-1-benzylindazole (YC-1) from Santa Cruz Biotechnology (Santa Cruz, CA, USA).

    Techniques: Inhibition, Western Blot