ω conotoxin  (Alomone Labs)


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    Structured Review

    Alomone Labs ω conotoxin
    Two populations of presynaptic BK Ca channels can be distinguished electrophysiologically at MFBs. A , Outside-out patches drawn from MFBs (steady state at +20 mV) exhibit large single-channel openings that are sensitive to Pax but not to IBTX. Ctrl, Control. B , Long depolarizing voltage steps to 0 mV in the whole-cell recording configuration reveal Pax- and IBTX-sensitive BK Ca channel-mediated currents (green) composed of two kinetically distinct components. C , Summary of Pax ( n = 4), IBTX ( n = 7), and cadmium (Cd 2+ , n = 7) sensitivity for recordings as shown in B (filled bars, first, fast activating/fast inactivating component; open bars, second, slowly activating/persistent component; see also filled dots and open squares in B ). D , ω-Agatoxin, <t>ω-conotoxin,</t> and Ni 2+ sensitivity (each n = 6) of currents as recorded in B (bar code as in C ). E , Voltage dependence of first, fast activating/fast inactivating component (open squares), and of second, slowly activating/persistent component (filled circles; n = 3). F , Left, Comparison of example K v -mediated current kinetics (black trace) and BK Ca -mediated current kinetics (green trace: Cd 2+ -sensitive current); traces scaled to the same peak amplitude. Note the extremely fast inactivation of I BKCa . Right, Same traces at higher temporal resolution. Blue trace represents example Ca v -mediated current recorded in a separate MFB. Vertical scale bar applies to BK Ca - and Ca v -mediated currents.
    ω Conotoxin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ω conotoxin/product/Alomone Labs
    Average 93 stars, based on 7 article reviews
    Price from $9.99 to $1999.99
    ω conotoxin - by Bioz Stars, 2022-08
    93/100 stars

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    1) Product Images from "Sparse But Highly Efficient Kv3 Outpace BKCa Channels in Action Potential Repolarization at Hippocampal Mossy Fiber Boutons"

    Article Title: Sparse But Highly Efficient Kv3 Outpace BKCa Channels in Action Potential Repolarization at Hippocampal Mossy Fiber Boutons

    Journal: The Journal of Neuroscience

    doi: 10.1523/JNEUROSCI.0972-11.2011

    Two populations of presynaptic BK Ca channels can be distinguished electrophysiologically at MFBs. A , Outside-out patches drawn from MFBs (steady state at +20 mV) exhibit large single-channel openings that are sensitive to Pax but not to IBTX. Ctrl, Control. B , Long depolarizing voltage steps to 0 mV in the whole-cell recording configuration reveal Pax- and IBTX-sensitive BK Ca channel-mediated currents (green) composed of two kinetically distinct components. C , Summary of Pax ( n = 4), IBTX ( n = 7), and cadmium (Cd 2+ , n = 7) sensitivity for recordings as shown in B (filled bars, first, fast activating/fast inactivating component; open bars, second, slowly activating/persistent component; see also filled dots and open squares in B ). D , ω-Agatoxin, ω-conotoxin, and Ni 2+ sensitivity (each n = 6) of currents as recorded in B (bar code as in C ). E , Voltage dependence of first, fast activating/fast inactivating component (open squares), and of second, slowly activating/persistent component (filled circles; n = 3). F , Left, Comparison of example K v -mediated current kinetics (black trace) and BK Ca -mediated current kinetics (green trace: Cd 2+ -sensitive current); traces scaled to the same peak amplitude. Note the extremely fast inactivation of I BKCa . Right, Same traces at higher temporal resolution. Blue trace represents example Ca v -mediated current recorded in a separate MFB. Vertical scale bar applies to BK Ca - and Ca v -mediated currents.
    Figure Legend Snippet: Two populations of presynaptic BK Ca channels can be distinguished electrophysiologically at MFBs. A , Outside-out patches drawn from MFBs (steady state at +20 mV) exhibit large single-channel openings that are sensitive to Pax but not to IBTX. Ctrl, Control. B , Long depolarizing voltage steps to 0 mV in the whole-cell recording configuration reveal Pax- and IBTX-sensitive BK Ca channel-mediated currents (green) composed of two kinetically distinct components. C , Summary of Pax ( n = 4), IBTX ( n = 7), and cadmium (Cd 2+ , n = 7) sensitivity for recordings as shown in B (filled bars, first, fast activating/fast inactivating component; open bars, second, slowly activating/persistent component; see also filled dots and open squares in B ). D , ω-Agatoxin, ω-conotoxin, and Ni 2+ sensitivity (each n = 6) of currents as recorded in B (bar code as in C ). E , Voltage dependence of first, fast activating/fast inactivating component (open squares), and of second, slowly activating/persistent component (filled circles; n = 3). F , Left, Comparison of example K v -mediated current kinetics (black trace) and BK Ca -mediated current kinetics (green trace: Cd 2+ -sensitive current); traces scaled to the same peak amplitude. Note the extremely fast inactivation of I BKCa . Right, Same traces at higher temporal resolution. Blue trace represents example Ca v -mediated current recorded in a separate MFB. Vertical scale bar applies to BK Ca - and Ca v -mediated currents.

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    Alomone Labs ω conotoxin
    Two populations of presynaptic BK Ca channels can be distinguished electrophysiologically at MFBs. A , Outside-out patches drawn from MFBs (steady state at +20 mV) exhibit large single-channel openings that are sensitive to Pax but not to IBTX. Ctrl, Control. B , Long depolarizing voltage steps to 0 mV in the whole-cell recording configuration reveal Pax- and IBTX-sensitive BK Ca channel-mediated currents (green) composed of two kinetically distinct components. C , Summary of Pax ( n = 4), IBTX ( n = 7), and cadmium (Cd 2+ , n = 7) sensitivity for recordings as shown in B (filled bars, first, fast activating/fast inactivating component; open bars, second, slowly activating/persistent component; see also filled dots and open squares in B ). D , ω-Agatoxin, <t>ω-conotoxin,</t> and Ni 2+ sensitivity (each n = 6) of currents as recorded in B (bar code as in C ). E , Voltage dependence of first, fast activating/fast inactivating component (open squares), and of second, slowly activating/persistent component (filled circles; n = 3). F , Left, Comparison of example K v -mediated current kinetics (black trace) and BK Ca -mediated current kinetics (green trace: Cd 2+ -sensitive current); traces scaled to the same peak amplitude. Note the extremely fast inactivation of I BKCa . Right, Same traces at higher temporal resolution. Blue trace represents example Ca v -mediated current recorded in a separate MFB. Vertical scale bar applies to BK Ca - and Ca v -mediated currents.
    ω Conotoxin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ω conotoxin/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    ω conotoxin - by Bioz Stars, 2022-08
    93/100 stars
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    Two populations of presynaptic BK Ca channels can be distinguished electrophysiologically at MFBs. A , Outside-out patches drawn from MFBs (steady state at +20 mV) exhibit large single-channel openings that are sensitive to Pax but not to IBTX. Ctrl, Control. B , Long depolarizing voltage steps to 0 mV in the whole-cell recording configuration reveal Pax- and IBTX-sensitive BK Ca channel-mediated currents (green) composed of two kinetically distinct components. C , Summary of Pax ( n = 4), IBTX ( n = 7), and cadmium (Cd 2+ , n = 7) sensitivity for recordings as shown in B (filled bars, first, fast activating/fast inactivating component; open bars, second, slowly activating/persistent component; see also filled dots and open squares in B ). D , ω-Agatoxin, ω-conotoxin, and Ni 2+ sensitivity (each n = 6) of currents as recorded in B (bar code as in C ). E , Voltage dependence of first, fast activating/fast inactivating component (open squares), and of second, slowly activating/persistent component (filled circles; n = 3). F , Left, Comparison of example K v -mediated current kinetics (black trace) and BK Ca -mediated current kinetics (green trace: Cd 2+ -sensitive current); traces scaled to the same peak amplitude. Note the extremely fast inactivation of I BKCa . Right, Same traces at higher temporal resolution. Blue trace represents example Ca v -mediated current recorded in a separate MFB. Vertical scale bar applies to BK Ca - and Ca v -mediated currents.

    Journal: The Journal of Neuroscience

    Article Title: Sparse But Highly Efficient Kv3 Outpace BKCa Channels in Action Potential Repolarization at Hippocampal Mossy Fiber Boutons

    doi: 10.1523/JNEUROSCI.0972-11.2011

    Figure Lengend Snippet: Two populations of presynaptic BK Ca channels can be distinguished electrophysiologically at MFBs. A , Outside-out patches drawn from MFBs (steady state at +20 mV) exhibit large single-channel openings that are sensitive to Pax but not to IBTX. Ctrl, Control. B , Long depolarizing voltage steps to 0 mV in the whole-cell recording configuration reveal Pax- and IBTX-sensitive BK Ca channel-mediated currents (green) composed of two kinetically distinct components. C , Summary of Pax ( n = 4), IBTX ( n = 7), and cadmium (Cd 2+ , n = 7) sensitivity for recordings as shown in B (filled bars, first, fast activating/fast inactivating component; open bars, second, slowly activating/persistent component; see also filled dots and open squares in B ). D , ω-Agatoxin, ω-conotoxin, and Ni 2+ sensitivity (each n = 6) of currents as recorded in B (bar code as in C ). E , Voltage dependence of first, fast activating/fast inactivating component (open squares), and of second, slowly activating/persistent component (filled circles; n = 3). F , Left, Comparison of example K v -mediated current kinetics (black trace) and BK Ca -mediated current kinetics (green trace: Cd 2+ -sensitive current); traces scaled to the same peak amplitude. Note the extremely fast inactivation of I BKCa . Right, Same traces at higher temporal resolution. Blue trace represents example Ca v -mediated current recorded in a separate MFB. Vertical scale bar applies to BK Ca - and Ca v -mediated currents.

    Article Snippet: From stocks made of distilled water, blood-depressing substance I (BDS-I) (final concentration in HEPES–ACSF, 3 μ m ), α-dendrotoxin (DTX) (0.2 or 1 μ m ), iberiotoxin (IBTX) (3 μ m ), ω-agatoxin (1 μ m ), ω-conotoxin (3 μ m ) (all from Alomone Labs), paxilline (Pax) (10 μ m ; Tocris Bioscience), and NiCl2 (200 μ m ) were added to the HEPES–ACSF, and DTX was added to the ACSF in bath-application experiments.

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