bekm 1  (Alomone Labs)


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  • 92
    Name:
    BeKm 1
    Description:
    A Novel ERG1 KV11 1 K Channel Blocker
    Catalog Number:
    STB-470
    Price:
    225.0
    Category:
    Toxin
    Source:
    Synthetic peptide
    Applications:
    0
    Purity:
    >98% (HPLC)
    Size:
    0 1 mg
    Format:
    Lyophilized powder.
    Formula:
    C174H267N51O52S6
    Molecular Weight:
    4092 Da.
    Molecule Name:
    BeKm-1, K+ channel toxin γ-KTx 2.1
    Buy from Supplier


    Structured Review

    Alomone Labs bekm 1
    BeKm 1
    A Novel ERG1 KV11 1 K Channel Blocker
    https://www.bioz.com/result/bekm 1/product/Alomone Labs
    Average 92 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    bekm 1 - by Bioz Stars, 2021-09
    92/100 stars

    Images

    1) Product Images from "Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243)"

    Article Title: Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243)

    Journal:

    doi: 10.1124/mol.108.045591

    BeKm-1 potentiated the activator effect of PD307243 but suppressed the activator effect of NS1643. A, cartoon of hERG pore domain with an extracellular BeKm-1 structure. Three hERG subunits are depicted, with the fourth one closest to viewers removed
    Figure Legend Snippet: BeKm-1 potentiated the activator effect of PD307243 but suppressed the activator effect of NS1643. A, cartoon of hERG pore domain with an extracellular BeKm-1 structure. Three hERG subunits are depicted, with the fourth one closest to viewers removed

    Techniques Used:

    2) Product Images from "Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243) s"

    Article Title: Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243) s

    Journal:

    doi: 10.1124/mol.108.045591

    BeKm-1 potentiated the activator effect of PD307243 but suppressed the activator effect of NS1643. A, cartoon of hERG pore domain with an extracellular BeKm-1 structure. Three hERG subunits are depicted, with the fourth one closest to viewers removed
    Figure Legend Snippet: BeKm-1 potentiated the activator effect of PD307243 but suppressed the activator effect of NS1643. A, cartoon of hERG pore domain with an extracellular BeKm-1 structure. Three hERG subunits are depicted, with the fourth one closest to viewers removed

    Techniques Used:

    3) Product Images from "Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243) s"

    Article Title: Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243) s

    Journal:

    doi: 10.1124/mol.108.045591

    BeKm-1 potentiated the activator effect of PD307243 but suppressed the activator effect of NS1643. A, cartoon of hERG pore domain with an extracellular BeKm-1 structure. Three hERG subunits are depicted, with the fourth one closest to viewers removed
    Figure Legend Snippet: BeKm-1 potentiated the activator effect of PD307243 but suppressed the activator effect of NS1643. A, cartoon of hERG pore domain with an extracellular BeKm-1 structure. Three hERG subunits are depicted, with the fourth one closest to viewers removed

    Techniques Used:

    4) Product Images from "Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243) s"

    Article Title: Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243) s

    Journal:

    doi: 10.1124/mol.108.045591

    BeKm-1 potentiated the activator effect of PD307243 but suppressed the activator effect of NS1643. A, cartoon of hERG pore domain with an extracellular BeKm-1 structure. Three hERG subunits are depicted, with the fourth one closest to viewers removed
    Figure Legend Snippet: BeKm-1 potentiated the activator effect of PD307243 but suppressed the activator effect of NS1643. A, cartoon of hERG pore domain with an extracellular BeKm-1 structure. Three hERG subunits are depicted, with the fourth one closest to viewers removed

    Techniques Used:

    5) Product Images from "Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243) s"

    Article Title: Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243) s

    Journal:

    doi: 10.1124/mol.108.045591

    BeKm-1 potentiated the activator effect of PD307243 but suppressed the activator effect of NS1643. A, cartoon of hERG pore domain with an extracellular BeKm-1 structure. Three hERG subunits are depicted, with the fourth one closest to viewers removed
    Figure Legend Snippet: BeKm-1 potentiated the activator effect of PD307243 but suppressed the activator effect of NS1643. A, cartoon of hERG pore domain with an extracellular BeKm-1 structure. Three hERG subunits are depicted, with the fourth one closest to viewers removed

    Techniques Used:

    6) Product Images from "Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243) s"

    Article Title: Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243) s

    Journal:

    doi: 10.1124/mol.108.045591

    BeKm-1 potentiated the activator effect of PD307243 but suppressed the activator effect of NS1643. A, cartoon of hERG pore domain with an extracellular BeKm-1 structure. Three hERG subunits are depicted, with the fourth one closest to viewers removed
    Figure Legend Snippet: BeKm-1 potentiated the activator effect of PD307243 but suppressed the activator effect of NS1643. A, cartoon of hERG pore domain with an extracellular BeKm-1 structure. Three hERG subunits are depicted, with the fourth one closest to viewers removed

    Techniques Used:

    7) Product Images from "Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243) s"

    Article Title: Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243) s

    Journal:

    doi: 10.1124/mol.108.045591

    BeKm-1 potentiated the activator effect of PD307243 but suppressed the activator effect of NS1643. A, cartoon of hERG pore domain with an extracellular BeKm-1 structure. Three hERG subunits are depicted, with the fourth one closest to viewers removed
    Figure Legend Snippet: BeKm-1 potentiated the activator effect of PD307243 but suppressed the activator effect of NS1643. A, cartoon of hERG pore domain with an extracellular BeKm-1 structure. Three hERG subunits are depicted, with the fourth one closest to viewers removed

    Techniques Used:

    8) Product Images from "Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243) s"

    Article Title: Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243) s

    Journal:

    doi: 10.1124/mol.108.045591

    BeKm-1 potentiated the activator effect of PD307243 but suppressed the activator effect of NS1643. A, cartoon of hERG pore domain with an extracellular BeKm-1 structure. Three hERG subunits are depicted, with the fourth one closest to viewers removed
    Figure Legend Snippet: BeKm-1 potentiated the activator effect of PD307243 but suppressed the activator effect of NS1643. A, cartoon of hERG pore domain with an extracellular BeKm-1 structure. Three hERG subunits are depicted, with the fourth one closest to viewers removed

    Techniques Used:

    Related Articles

    Labeling:

    Article Title: Fluorescent analogues of BeKm-1 with high and specific activity against the hERG channel
    Article Snippet: .. 3.4 Effects of native BeKm-1 and its analogues on the hKv 10.1 and Kv 1.3 currents We then checked whether labeling affected BeKm-1 specificity or whether the grafted chemical groups induce any block of K+ channels insensitive to the BeKm-1 toxin. ..

    Blocking Assay:

    Article Title: Fluorescent analogues of BeKm-1 with high and specific activity against the hERG channel
    Article Snippet: .. 3.4 Effects of native BeKm-1 and its analogues on the hKv 10.1 and Kv 1.3 currents We then checked whether labeling affected BeKm-1 specificity or whether the grafted chemical groups induce any block of K+ channels insensitive to the BeKm-1 toxin. ..

    other:

    Article Title: Fluorescent analogues of BeKm-1 with high and specific activity against the hERG channel
    Article Snippet: When increasing concentrations of native BeKm-1 were perfused in the bathing solution, the outward current was gradually inhibited ( ).

    Mutagenesis:

    Article Title: Fluorescent analogues of BeKm-1 with high and specific activity against the hERG channel
    Article Snippet: .. When exposed to increasing concentrations of native BeKm-1, the hERG mutant channel harboring the S631C mutation was significantly (p < 0.01) less inhibited than the wild type hERG channel (IC50 = 41 ± 4 nM, n = 5, with mutant hERG vs 12 ± 2 nM, with wild type hERG channel) whereas the Hill coefficient was not changed (0.8 ± 0.1, n = 5, vs 0.9 ± 0.1, n = 9) ( ). ..

    Modification:

    Article Title: BeKm-1, a peptide inhibitor of human ether-a-go-go-related gene potassium currents, prolongs QTc intervals in isolated rabbit heart.
    Article Snippet: .. Drug-induced cardiac arrhythmia, specifically Torsades de pointes, is associated with QT/QTc interval prolongation, thus prolongation of the QT interval is considered as a biomarker for Torsades de pointes risk (N Engl J Med 350:1013-1022, 2004).. Specific inhibition of human ether-a-go-go-related gene (hERG) potassium channels has been recognized as the main mechanism for QT prolongation (Cardiovasc Res 58:32-45, 2003). ..

    Inhibition:

    Article Title: Fluorescent analogues of BeKm-1 with high and specific activity against the hERG channel
    Article Snippet: .. We determined the inhibition of the peak outward current measured at 0 mV for hKv10.1 or +70 mV for hKv 1.3, from a holding potential of −80 mV, when 200 nM native BeKm-1 or 500 nM toxin analogues were perfused in the bathing solution ( ). ..

    Article Title: Fluorescent analogues of BeKm-1 with high and specific activity against the hERG channel
    Article Snippet: .. For human EAG (Kv10.1) and Kv1.3, peak current inhibition by native BeKm-1 and its analogues was determined during step depolarization from a holding potential of −80 mV to 0 mV or +70 mV, respectively, and normalized to the current recorded without toxin (ITx/ICt). ..

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  • 92
    Alomone Labs bekm 1
    <t>BeKm-1</t> potentiated the activator effect of PD307243 but suppressed the activator effect of NS1643. A, cartoon of hERG pore domain with an extracellular BeKm-1 structure. Three hERG subunits are depicted, with the fourth one closest to viewers removed
    Bekm 1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/bekm 1/product/Alomone Labs
    Average 92 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    bekm 1 - by Bioz Stars, 2021-09
    92/100 stars
      Buy from Supplier

    Image Search Results


    BeKm-1 potentiated the activator effect of PD307243 but suppressed the activator effect of NS1643. A, cartoon of hERG pore domain with an extracellular BeKm-1 structure. Three hERG subunits are depicted, with the fourth one closest to viewers removed

    Journal:

    Article Title: Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243)

    doi: 10.1124/mol.108.045591

    Figure Lengend Snippet: BeKm-1 potentiated the activator effect of PD307243 but suppressed the activator effect of NS1643. A, cartoon of hERG pore domain with an extracellular BeKm-1 structure. Three hERG subunits are depicted, with the fourth one closest to viewers removed

    Article Snippet: Indeed, , shows that BeKm-1 potentiated PD’s activator effect but suppressed NS’s activator effect.

    Techniques: