agitoxin 2  (Alomone Labs)


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    Alomone Labs agitoxin 2
    Delayed rectifier currents in the hESC-RPE. ( A ) An example of the delayed rectifier currents as responses to 50 ms voltage pulses from −45 mV to 45 mV in 10 mV increments and ( B ) the averaged and normalized IV-curve (mean ± SEM, n = 47). The effects of K + channel inhibitors on the outward currents were studied at 45 mV with IV-curves showing the averaged and normalized values (mean ± SEM) using the following modulators: ( C , D ) 5 mM Ba 2+ ( n = 5), ( E , F ) 20 mM TEA ( n = 7) and ( G , H ) 10 nM <t>Agitoxin-2</t> ( n = 4). Data has been pooled from the cell lines 08/023 and 08/017.
    Agitoxin 2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 17 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/agitoxin 2/product/Alomone Labs
    Average 94 stars, based on 17 article reviews
    Price from $9.99 to $1999.99
    agitoxin 2 - by Bioz Stars, 2022-10
    94/100 stars

    Images

    1) Product Images from "Heterogeneity of Potassium Channels in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium"

    Article Title: Heterogeneity of Potassium Channels in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium

    Journal: Stem Cells Translational Medicine

    doi: 10.1093/stcltm/szac029

    Delayed rectifier currents in the hESC-RPE. ( A ) An example of the delayed rectifier currents as responses to 50 ms voltage pulses from −45 mV to 45 mV in 10 mV increments and ( B ) the averaged and normalized IV-curve (mean ± SEM, n = 47). The effects of K + channel inhibitors on the outward currents were studied at 45 mV with IV-curves showing the averaged and normalized values (mean ± SEM) using the following modulators: ( C , D ) 5 mM Ba 2+ ( n = 5), ( E , F ) 20 mM TEA ( n = 7) and ( G , H ) 10 nM Agitoxin-2 ( n = 4). Data has been pooled from the cell lines 08/023 and 08/017.
    Figure Legend Snippet: Delayed rectifier currents in the hESC-RPE. ( A ) An example of the delayed rectifier currents as responses to 50 ms voltage pulses from −45 mV to 45 mV in 10 mV increments and ( B ) the averaged and normalized IV-curve (mean ± SEM, n = 47). The effects of K + channel inhibitors on the outward currents were studied at 45 mV with IV-curves showing the averaged and normalized values (mean ± SEM) using the following modulators: ( C , D ) 5 mM Ba 2+ ( n = 5), ( E , F ) 20 mM TEA ( n = 7) and ( G , H ) 10 nM Agitoxin-2 ( n = 4). Data has been pooled from the cell lines 08/023 and 08/017.

    Techniques Used:

    2) Product Images from "Heterogeneity of Potassium Channels in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium"

    Article Title: Heterogeneity of Potassium Channels in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium

    Journal: Stem Cells Translational Medicine

    doi: 10.1093/stcltm/szac029

    Delayed rectifier currents in the hESC-RPE. ( A ) An example of the delayed rectifier currents as responses to 50 ms voltage pulses from −45 mV to 45 mV in 10 mV increments and ( B ) the averaged and normalized IV-curve (mean ± SEM, n = 47). The effects of K + channel inhibitors on the outward currents were studied at 45 mV with IV-curves showing the averaged and normalized values (mean ± SEM) using the following modulators: ( C , D ) 5 mM Ba 2+ ( n = 5), ( E , F ) 20 mM TEA ( n = 7) and ( G , H ) 10 nM Agitoxin-2 ( n = 4). Data has been pooled from the cell lines 08/023 and 08/017.
    Figure Legend Snippet: Delayed rectifier currents in the hESC-RPE. ( A ) An example of the delayed rectifier currents as responses to 50 ms voltage pulses from −45 mV to 45 mV in 10 mV increments and ( B ) the averaged and normalized IV-curve (mean ± SEM, n = 47). The effects of K + channel inhibitors on the outward currents were studied at 45 mV with IV-curves showing the averaged and normalized values (mean ± SEM) using the following modulators: ( C , D ) 5 mM Ba 2+ ( n = 5), ( E , F ) 20 mM TEA ( n = 7) and ( G , H ) 10 nM Agitoxin-2 ( n = 4). Data has been pooled from the cell lines 08/023 and 08/017.

    Techniques Used:

    3) Product Images from "Predominant Functional Expression of Kv1.3 by Activated Microglia of the Hippocampus after Status epilepticus"

    Article Title: Predominant Functional Expression of Kv1.3 by Activated Microglia of the Hippocampus after Status epilepticus

    Journal: PLoS ONE

    doi: 10.1371/journal.pone.0006770

    Effects of α-dendrotoxin (A, 50 nM), agitoxin-2 (B, 10 and 50 nM) and margatoxin (C, 1 and 10 nM) on the leak subtracted current induced by a voltage step from −70 to +40 mV (black traces recorded in control, red traces after drug application). The leak conductances of the cells in A, B and C were 338, 862 and 332 pS, respectively. The graphs on the right represent the conductance, normalized to its maximum value, as a function of the membrane potential and its inhibition by α-dendrotoxin (A, n = 4, Dtx), agitoxin-2 (B, AgTx, n = 14 for 10 nM, n = 6 for 50 nM) and margatoxin (C, MgTX, n = 8 for 1 nM, n = 11 for 10 nM).
    Figure Legend Snippet: Effects of α-dendrotoxin (A, 50 nM), agitoxin-2 (B, 10 and 50 nM) and margatoxin (C, 1 and 10 nM) on the leak subtracted current induced by a voltage step from −70 to +40 mV (black traces recorded in control, red traces after drug application). The leak conductances of the cells in A, B and C were 338, 862 and 332 pS, respectively. The graphs on the right represent the conductance, normalized to its maximum value, as a function of the membrane potential and its inhibition by α-dendrotoxin (A, n = 4, Dtx), agitoxin-2 (B, AgTx, n = 14 for 10 nM, n = 6 for 50 nM) and margatoxin (C, MgTX, n = 8 for 1 nM, n = 11 for 10 nM).

    Techniques Used: Inhibition

    4) Product Images from "Heterogeneity of Potassium Channels in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium"

    Article Title: Heterogeneity of Potassium Channels in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium

    Journal: Stem Cells Translational Medicine

    doi: 10.1093/stcltm/szac029

    Delayed rectifier currents in the hESC-RPE. ( A ) An example of the delayed rectifier currents as responses to 50 ms voltage pulses from −45 mV to 45 mV in 10 mV increments and ( B ) the averaged and normalized IV-curve (mean ± SEM, n = 47). The effects of K + channel inhibitors on the outward currents were studied at 45 mV with IV-curves showing the averaged and normalized values (mean ± SEM) using the following modulators: ( C , D ) 5 mM Ba 2+ ( n = 5), ( E , F ) 20 mM TEA ( n = 7) and ( G , H ) 10 nM Agitoxin-2 ( n = 4). Data has been pooled from the cell lines 08/023 and 08/017.
    Figure Legend Snippet: Delayed rectifier currents in the hESC-RPE. ( A ) An example of the delayed rectifier currents as responses to 50 ms voltage pulses from −45 mV to 45 mV in 10 mV increments and ( B ) the averaged and normalized IV-curve (mean ± SEM, n = 47). The effects of K + channel inhibitors on the outward currents were studied at 45 mV with IV-curves showing the averaged and normalized values (mean ± SEM) using the following modulators: ( C , D ) 5 mM Ba 2+ ( n = 5), ( E , F ) 20 mM TEA ( n = 7) and ( G , H ) 10 nM Agitoxin-2 ( n = 4). Data has been pooled from the cell lines 08/023 and 08/017.

    Techniques Used:

    5) Product Images from "Heterogeneity of Potassium Channels in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium"

    Article Title: Heterogeneity of Potassium Channels in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium

    Journal: Stem Cells Translational Medicine

    doi: 10.1093/stcltm/szac029

    Delayed rectifier currents in the hESC-RPE. ( A ) An example of the delayed rectifier currents as responses to 50 ms voltage pulses from −45 mV to 45 mV in 10 mV increments and ( B ) the averaged and normalized IV-curve (mean ± SEM, n = 47). The effects of K + channel inhibitors on the outward currents were studied at 45 mV with IV-curves showing the averaged and normalized values (mean ± SEM) using the following modulators: ( C , D ) 5 mM Ba 2+ ( n = 5), ( E , F ) 20 mM TEA ( n = 7) and ( G , H ) 10 nM Agitoxin-2 ( n = 4). Data has been pooled from the cell lines 08/023 and 08/017.
    Figure Legend Snippet: Delayed rectifier currents in the hESC-RPE. ( A ) An example of the delayed rectifier currents as responses to 50 ms voltage pulses from −45 mV to 45 mV in 10 mV increments and ( B ) the averaged and normalized IV-curve (mean ± SEM, n = 47). The effects of K + channel inhibitors on the outward currents were studied at 45 mV with IV-curves showing the averaged and normalized values (mean ± SEM) using the following modulators: ( C , D ) 5 mM Ba 2+ ( n = 5), ( E , F ) 20 mM TEA ( n = 7) and ( G , H ) 10 nM Agitoxin-2 ( n = 4). Data has been pooled from the cell lines 08/023 and 08/017.

    Techniques Used:

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    • agitoxin 2  (Alomone Labs)
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    Alomone Labs agitoxin 2
    Delayed rectifier currents in the hESC-RPE. ( A ) An example of the delayed rectifier currents as responses to 50 ms voltage pulses from −45 mV to 45 mV in 10 mV increments and ( B ) the averaged and normalized IV-curve (mean ± SEM, n = 47). The effects of K + channel inhibitors on the outward currents were studied at 45 mV with IV-curves showing the averaged and normalized values (mean ± SEM) using the following modulators: ( C , D ) 5 mM Ba 2+ ( n = 5), ( E , F ) 20 mM TEA ( n = 7) and ( G , H ) 10 nM <t>Agitoxin-2</t> ( n = 4). Data has been pooled from the cell lines 08/023 and 08/017.
    Agitoxin 2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/agitoxin 2/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    agitoxin 2 - by Bioz Stars, 2022-10
    94/100 stars
    		  Buy from Supplier

    Image Search Results


    Delayed rectifier currents in the hESC-RPE. ( A ) An example of the delayed rectifier currents as responses to 50 ms voltage pulses from −45 mV to 45 mV in 10 mV increments and ( B ) the averaged and normalized IV-curve (mean ± SEM, n = 47). The effects of K + channel inhibitors on the outward currents were studied at 45 mV with IV-curves showing the averaged and normalized values (mean ± SEM) using the following modulators: ( C , D ) 5 mM Ba 2+ ( n = 5), ( E , F ) 20 mM TEA ( n = 7) and ( G , H ) 10 nM Agitoxin-2 ( n = 4). Data has been pooled from the cell lines 08/023 and 08/017.

    Journal: Stem Cells Translational Medicine

    Article Title: Heterogeneity of Potassium Channels in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium

    doi: 10.1093/stcltm/szac029

    Figure Lengend Snippet: Delayed rectifier currents in the hESC-RPE. ( A ) An example of the delayed rectifier currents as responses to 50 ms voltage pulses from −45 mV to 45 mV in 10 mV increments and ( B ) the averaged and normalized IV-curve (mean ± SEM, n = 47). The effects of K + channel inhibitors on the outward currents were studied at 45 mV with IV-curves showing the averaged and normalized values (mean ± SEM) using the following modulators: ( C , D ) 5 mM Ba 2+ ( n = 5), ( E , F ) 20 mM TEA ( n = 7) and ( G , H ) 10 nM Agitoxin-2 ( n = 4). Data has been pooled from the cell lines 08/023 and 08/017.

    Article Snippet: In the pharmacological experiments, the bath solution contained general K+ channel blockers 5 mM Ba2+ or 20 mM tetraethylammonium chloride (TEA), or the following specific K+ channel modulators delayed rectifier KV1.3 inhibitor 10 nM Agitoxin-2 (RTA-420, Alomone) or KCNQ channel blocker 300 nM linopirdine (L134, Sigma-Aldrich).

    Techniques:

    Effects of α-dendrotoxin (A, 50 nM), agitoxin-2 (B, 10 and 50 nM) and margatoxin (C, 1 and 10 nM) on the leak subtracted current induced by a voltage step from −70 to +40 mV (black traces recorded in control, red traces after drug application). The leak conductances of the cells in A, B and C were 338, 862 and 332 pS, respectively. The graphs on the right represent the conductance, normalized to its maximum value, as a function of the membrane potential and its inhibition by α-dendrotoxin (A, n = 4, Dtx), agitoxin-2 (B, AgTx, n = 14 for 10 nM, n = 6 for 50 nM) and margatoxin (C, MgTX, n = 8 for 1 nM, n = 11 for 10 nM).

    Journal: PLoS ONE

    Article Title: Predominant Functional Expression of Kv1.3 by Activated Microglia of the Hippocampus after Status epilepticus

    doi: 10.1371/journal.pone.0006770

    Figure Lengend Snippet: Effects of α-dendrotoxin (A, 50 nM), agitoxin-2 (B, 10 and 50 nM) and margatoxin (C, 1 and 10 nM) on the leak subtracted current induced by a voltage step from −70 to +40 mV (black traces recorded in control, red traces after drug application). The leak conductances of the cells in A, B and C were 338, 862 and 332 pS, respectively. The graphs on the right represent the conductance, normalized to its maximum value, as a function of the membrane potential and its inhibition by α-dendrotoxin (A, n = 4, Dtx), agitoxin-2 (B, AgTx, n = 14 for 10 nM, n = 6 for 50 nM) and margatoxin (C, MgTX, n = 8 for 1 nM, n = 11 for 10 nM).

    Article Snippet: Reagents Alpha-dendrotoxin, recombinant agitoxin-2 and recombinant margatoxin were purchased from Alomone labs (Jerusalem, Israel).

    Techniques: Inhibition