agtx2  (Alomone Labs)


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    • 85
    Name:
    Agitoxin 2
    Description:
    A Potent Blocker of KV1 3 K Channels
    Catalog Number:
    STA-420
    Price:
    171.0
    Category:
    Toxin
    Source:
    Synthetic peptide
    Applications:
    0
    Purity:
    >98% (HPLC)
    Size:
    50 mcg
    Format:
    Lyophilized powder.
    Formula:
    C169H278N54O48S8
    Molecular Weight:
    4091 Da.
    Molecule Name:
    Agitoxin-2, Potassium channel toxin alpha-KTx 3.2, AgTx-2, AgTx2
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    Structured Review

    Alomone Labs agtx2
    Agitoxin 2
    A Potent Blocker of KV1 3 K Channels
    https://www.bioz.com/result/agtx2/product/Alomone Labs
    Average 85 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    agtx2 - by Bioz Stars, 2021-09
    85/100 stars

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    Related Articles

    other:

    Article Title: Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels
    Article Snippet: TEA (St. Louis, MO) and agitoxin-II (Alomone Labs, Jerusalem, Israel) were dissolved in Ringers and stored at −20°C until use.

    Article Title: Integration of K+ and Cl– currents regulate steady-state and dynamic membrane potentials in cultured rat microglia
    Article Snippet: Agitoxin-2 (AgTx-2) was obtained from Alomone Laboratories (Jerusalem, Israel).

    Article Title: Slow Inactivation in Shaker K Channels Is Delayed by Intracellular Tetraethylammonium
    Article Snippet: Agitoxin II was purchased from Alomone Laboratories, and type 2 collagenase was from Worthington Biochemical Corporation.

    Article Title: Evidence for Inhibitory Effects of Flupirtine, a Centrally Acting Analgesic, on Delayed Rectifier K+ Currents in Motor Neuron-Like Cells
    Article Snippet: Agitoxin-2, apamin, iberiotoxin, and margatoxin were obtained from Alomone Labs (Jerusalem, Israel).

    Blocking Assay:

    Article Title: A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a
    Article Snippet: .. Leak and background conductances, identified by blocking the channel with agitoxin-2 (Alomone labs) or tetrodotoxin (TTX), were subtracted for most of the Kv or BgNav 1 currents shown. ..

    Recombinant:

    Article Title: Predominant Functional Expression of Kv1.3 by Activated Microglia of the Hippocampus after Status epilepticus
    Article Snippet: .. Reagents Alpha-dendrotoxin, recombinant agitoxin-2 and recombinant margatoxin were purchased from Alomone labs (Jerusalem, Israel). ..

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    • recombinant agitoxin 2  (Alomone Labs)
    85
    Alomone Labs recombinant agitoxin 2
    Effects of α-dendrotoxin (A, 50 nM), <t>agitoxin-2</t> (B, 10 and 50 nM) and margatoxin (C, 1 and 10 nM) on the leak subtracted current induced by a voltage step from −70 to +40 mV (black traces recorded in control, red traces after drug application). The leak conductances of the cells in A, B and C were 338, 862 and 332 pS, respectively. The graphs on the right represent the conductance, normalized to its maximum value, as a function of the membrane potential and its inhibition by α-dendrotoxin (A, n = 4, Dtx), agitoxin-2 (B, AgTx, n = 14 for 10 nM, n = 6 for 50 nM) and margatoxin (C, MgTX, n = 8 for 1 nM, n = 11 for 10 nM).
    Recombinant Agitoxin 2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/recombinant agitoxin 2/product/Alomone Labs
    Average 85 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    recombinant agitoxin 2 - by Bioz Stars, 2021-09
    85/100 stars
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    Effects of α-dendrotoxin (A, 50 nM), agitoxin-2 (B, 10 and 50 nM) and margatoxin (C, 1 and 10 nM) on the leak subtracted current induced by a voltage step from −70 to +40 mV (black traces recorded in control, red traces after drug application). The leak conductances of the cells in A, B and C were 338, 862 and 332 pS, respectively. The graphs on the right represent the conductance, normalized to its maximum value, as a function of the membrane potential and its inhibition by α-dendrotoxin (A, n = 4, Dtx), agitoxin-2 (B, AgTx, n = 14 for 10 nM, n = 6 for 50 nM) and margatoxin (C, MgTX, n = 8 for 1 nM, n = 11 for 10 nM).

    Journal: PLoS ONE

    Article Title: Predominant Functional Expression of Kv1.3 by Activated Microglia of the Hippocampus after Status epilepticus

    doi: 10.1371/journal.pone.0006770

    Figure Lengend Snippet: Effects of α-dendrotoxin (A, 50 nM), agitoxin-2 (B, 10 and 50 nM) and margatoxin (C, 1 and 10 nM) on the leak subtracted current induced by a voltage step from −70 to +40 mV (black traces recorded in control, red traces after drug application). The leak conductances of the cells in A, B and C were 338, 862 and 332 pS, respectively. The graphs on the right represent the conductance, normalized to its maximum value, as a function of the membrane potential and its inhibition by α-dendrotoxin (A, n = 4, Dtx), agitoxin-2 (B, AgTx, n = 14 for 10 nM, n = 6 for 50 nM) and margatoxin (C, MgTX, n = 8 for 1 nM, n = 11 for 10 nM).

    Article Snippet: Reagents Alpha-dendrotoxin, recombinant agitoxin-2 and recombinant margatoxin were purchased from Alomone labs (Jerusalem, Israel).

    Techniques: Inhibition