ω agatoxin iva  (Alomone Labs)


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    Alomone Labs ω agatoxin iva
    Cav2.1 and α1ACT functions in SCA6 neurons. ( A) Cultured human neurons of all genotypes express functional VGCCs. Ba 2+ I/V curves in SCA6 and control 5w neurons. Currents are normalized to cell capacitance (pA/pF). (B) Cultured human neurons of all genotypes express functional P/Q type channels. Representative traces (300 ms depolarization from −70 to 0 mV) of Ba 2+ currents before and after application of 400 nM <t>ω-Agatoxin</t> <t>IVA,</t> specific blocker of P/Q type currents in SCA6 and control 5w neurons. Traces represent normalized to I max without ω-Agatoxin IVA currents ( I / I max ), showing current amplitude reduction on toxin perfusion, demonstrating the expression of ω-Agatoxin IVA-sensitive Cav2.1 channels. (C) mRNA expression levels of the α1ACT target genes GRN , BTG1 , and TAF1 in SCA6 and control 5w neuronal cultures. Expression levels are normalized to control. GRN gene transcripts are significantly reduced in cultures of SCA6 neurons compared with the control. Each bar represents mean ± s.e.m. from three independent experiments. One-way ANOVA test, Tukey's multiple-comparisons test: * P
    ω Agatoxin Iva, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 95/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ω agatoxin iva/product/Alomone Labs
    Average 95 stars, based on 2 article reviews
    Price from $9.99 to $1999.99
    ω agatoxin iva - by Bioz Stars, 2022-08
    95/100 stars

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    1) Product Images from "Bicistronic CACNA1A Gene Expression in Neurons Derived from Spinocerebellar Ataxia Type 6 Patient-Induced Pluripotent Stem Cells"

    Article Title: Bicistronic CACNA1A Gene Expression in Neurons Derived from Spinocerebellar Ataxia Type 6 Patient-Induced Pluripotent Stem Cells

    Journal: Stem Cells and Development

    doi: 10.1089/scd.2017.0085

    Cav2.1 and α1ACT functions in SCA6 neurons. ( A) Cultured human neurons of all genotypes express functional VGCCs. Ba 2+ I/V curves in SCA6 and control 5w neurons. Currents are normalized to cell capacitance (pA/pF). (B) Cultured human neurons of all genotypes express functional P/Q type channels. Representative traces (300 ms depolarization from −70 to 0 mV) of Ba 2+ currents before and after application of 400 nM ω-Agatoxin IVA, specific blocker of P/Q type currents in SCA6 and control 5w neurons. Traces represent normalized to I max without ω-Agatoxin IVA currents ( I / I max ), showing current amplitude reduction on toxin perfusion, demonstrating the expression of ω-Agatoxin IVA-sensitive Cav2.1 channels. (C) mRNA expression levels of the α1ACT target genes GRN , BTG1 , and TAF1 in SCA6 and control 5w neuronal cultures. Expression levels are normalized to control. GRN gene transcripts are significantly reduced in cultures of SCA6 neurons compared with the control. Each bar represents mean ± s.e.m. from three independent experiments. One-way ANOVA test, Tukey's multiple-comparisons test: * P
    Figure Legend Snippet: Cav2.1 and α1ACT functions in SCA6 neurons. ( A) Cultured human neurons of all genotypes express functional VGCCs. Ba 2+ I/V curves in SCA6 and control 5w neurons. Currents are normalized to cell capacitance (pA/pF). (B) Cultured human neurons of all genotypes express functional P/Q type channels. Representative traces (300 ms depolarization from −70 to 0 mV) of Ba 2+ currents before and after application of 400 nM ω-Agatoxin IVA, specific blocker of P/Q type currents in SCA6 and control 5w neurons. Traces represent normalized to I max without ω-Agatoxin IVA currents ( I / I max ), showing current amplitude reduction on toxin perfusion, demonstrating the expression of ω-Agatoxin IVA-sensitive Cav2.1 channels. (C) mRNA expression levels of the α1ACT target genes GRN , BTG1 , and TAF1 in SCA6 and control 5w neuronal cultures. Expression levels are normalized to control. GRN gene transcripts are significantly reduced in cultures of SCA6 neurons compared with the control. Each bar represents mean ± s.e.m. from three independent experiments. One-way ANOVA test, Tukey's multiple-comparisons test: * P

    Techniques Used: Cell Culture, Functional Assay, Mass Spectrometry, Expressing

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  • 95
    Alomone Labs ω agatoxin iva
    Cav2.1 and α1ACT functions in SCA6 neurons. ( A) Cultured human neurons of all genotypes express functional VGCCs. Ba 2+ I/V curves in SCA6 and control 5w neurons. Currents are normalized to cell capacitance (pA/pF). (B) Cultured human neurons of all genotypes express functional P/Q type channels. Representative traces (300 ms depolarization from −70 to 0 mV) of Ba 2+ currents before and after application of 400 nM <t>ω-Agatoxin</t> <t>IVA,</t> specific blocker of P/Q type currents in SCA6 and control 5w neurons. Traces represent normalized to I max without ω-Agatoxin IVA currents ( I / I max ), showing current amplitude reduction on toxin perfusion, demonstrating the expression of ω-Agatoxin IVA-sensitive Cav2.1 channels. (C) mRNA expression levels of the α1ACT target genes GRN , BTG1 , and TAF1 in SCA6 and control 5w neuronal cultures. Expression levels are normalized to control. GRN gene transcripts are significantly reduced in cultures of SCA6 neurons compared with the control. Each bar represents mean ± s.e.m. from three independent experiments. One-way ANOVA test, Tukey's multiple-comparisons test: * P
    ω Agatoxin Iva, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ω agatoxin iva/product/Alomone Labs
    Average 95 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    ω agatoxin iva - by Bioz Stars, 2022-08
    95/100 stars
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    Cav2.1 and α1ACT functions in SCA6 neurons. ( A) Cultured human neurons of all genotypes express functional VGCCs. Ba 2+ I/V curves in SCA6 and control 5w neurons. Currents are normalized to cell capacitance (pA/pF). (B) Cultured human neurons of all genotypes express functional P/Q type channels. Representative traces (300 ms depolarization from −70 to 0 mV) of Ba 2+ currents before and after application of 400 nM ω-Agatoxin IVA, specific blocker of P/Q type currents in SCA6 and control 5w neurons. Traces represent normalized to I max without ω-Agatoxin IVA currents ( I / I max ), showing current amplitude reduction on toxin perfusion, demonstrating the expression of ω-Agatoxin IVA-sensitive Cav2.1 channels. (C) mRNA expression levels of the α1ACT target genes GRN , BTG1 , and TAF1 in SCA6 and control 5w neuronal cultures. Expression levels are normalized to control. GRN gene transcripts are significantly reduced in cultures of SCA6 neurons compared with the control. Each bar represents mean ± s.e.m. from three independent experiments. One-way ANOVA test, Tukey's multiple-comparisons test: * P

    Journal: Stem Cells and Development

    Article Title: Bicistronic CACNA1A Gene Expression in Neurons Derived from Spinocerebellar Ataxia Type 6 Patient-Induced Pluripotent Stem Cells

    doi: 10.1089/scd.2017.0085

    Figure Lengend Snippet: Cav2.1 and α1ACT functions in SCA6 neurons. ( A) Cultured human neurons of all genotypes express functional VGCCs. Ba 2+ I/V curves in SCA6 and control 5w neurons. Currents are normalized to cell capacitance (pA/pF). (B) Cultured human neurons of all genotypes express functional P/Q type channels. Representative traces (300 ms depolarization from −70 to 0 mV) of Ba 2+ currents before and after application of 400 nM ω-Agatoxin IVA, specific blocker of P/Q type currents in SCA6 and control 5w neurons. Traces represent normalized to I max without ω-Agatoxin IVA currents ( I / I max ), showing current amplitude reduction on toxin perfusion, demonstrating the expression of ω-Agatoxin IVA-sensitive Cav2.1 channels. (C) mRNA expression levels of the α1ACT target genes GRN , BTG1 , and TAF1 in SCA6 and control 5w neuronal cultures. Expression levels are normalized to control. GRN gene transcripts are significantly reduced in cultures of SCA6 neurons compared with the control. Each bar represents mean ± s.e.m. from three independent experiments. One-way ANOVA test, Tukey's multiple-comparisons test: * P

    Article Snippet: CaV 2.1 channels were blocked with 400 nM ω-Agatoxin IVA (Alomone Labs, Israel).

    Techniques: Cell Culture, Functional Assay, Mass Spectrometry, Expressing