apamin apa  (Alomone Labs)


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    Structured Review

    Alomone Labs apamin apa
    <t>Apamin</t> prolongs action potentials in TAB rat VMs and TAB rat whole heart A , representative current clamp traces in TAB rat VMs under baseline (left) or ISO (100 nmol L –1 for 3 min) (right) before and after treatment with apamin (100 nmol L –1 for 3 min). Pooled mean ± SD APD 90 . n = 5–9, N = 4–7, * P = 0.04, # P = 0.03, Student's t test. B , representative APD maps before and after APA (10 nmol L –1 ) recorded under basal conditions and in the presence of β‐adrenergic agonist ISO (50 nmol L –1 ) and the corresponding APD profile. Right, Pooled data for APD 75 . * P
    Apamin Apa, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/apamin apa/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    apamin apa - by Bioz Stars, 2022-07
    93/100 stars

    Images

    1) Product Images from "PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts"

    Article Title: PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts

    Journal: The Journal of Physiology

    doi: 10.1113/JP277618

    Apamin prolongs action potentials in TAB rat VMs and TAB rat whole heart A , representative current clamp traces in TAB rat VMs under baseline (left) or ISO (100 nmol L –1 for 3 min) (right) before and after treatment with apamin (100 nmol L –1 for 3 min). Pooled mean ± SD APD 90 . n = 5–9, N = 4–7, * P = 0.04, # P = 0.03, Student's t test. B , representative APD maps before and after APA (10 nmol L –1 ) recorded under basal conditions and in the presence of β‐adrenergic agonist ISO (50 nmol L –1 ) and the corresponding APD profile. Right, Pooled data for APD 75 . * P
    Figure Legend Snippet: Apamin prolongs action potentials in TAB rat VMs and TAB rat whole heart A , representative current clamp traces in TAB rat VMs under baseline (left) or ISO (100 nmol L –1 for 3 min) (right) before and after treatment with apamin (100 nmol L –1 for 3 min). Pooled mean ± SD APD 90 . n = 5–9, N = 4–7, * P = 0.04, # P = 0.03, Student's t test. B , representative APD maps before and after APA (10 nmol L –1 ) recorded under basal conditions and in the presence of β‐adrenergic agonist ISO (50 nmol L –1 ) and the corresponding APD profile. Right, Pooled data for APD 75 . * P

    Techniques Used:

    SK current in Sham rat VMs with application of ISO A , representative superimposed traces of I SK (blue), I Ca (black) and [Ca 2+ ] i transient (red) recorded in Sham VMs depolarized to −20 mV (left). I SK was obtained by application of 1 nmol L –1 APA. Pooled I – V and peak [Ca 2+ ]/ V relationships. B , representative inward current traces recorded in Sham VMs at 3, 6 and 8 min following application of 100 nmol L –1 ISO at −10 mV (HP −40 mV). Right: plot of normalized inward current amplitude vs . time after application of ISO. Mean ± SD, n = 5, N = 2. The normalized inward current after 6 min of ISO and 3 min of 100 nmol L –1 apamin is plotted in red. Mean ± SD, n = 8, N = 7, * P = 0.04 vs . ISO only, Student's t test.
    Figure Legend Snippet: SK current in Sham rat VMs with application of ISO A , representative superimposed traces of I SK (blue), I Ca (black) and [Ca 2+ ] i transient (red) recorded in Sham VMs depolarized to −20 mV (left). I SK was obtained by application of 1 nmol L –1 APA. Pooled I – V and peak [Ca 2+ ]/ V relationships. B , representative inward current traces recorded in Sham VMs at 3, 6 and 8 min following application of 100 nmol L –1 ISO at −10 mV (HP −40 mV). Right: plot of normalized inward current amplitude vs . time after application of ISO. Mean ± SD, n = 5, N = 2. The normalized inward current after 6 min of ISO and 3 min of 100 nmol L –1 apamin is plotted in red. Mean ± SD, n = 8, N = 7, * P = 0.04 vs . ISO only, Student's t test.

    Techniques Used:

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  • 93
    Alomone Labs apamin apa
    <t>Apamin</t> prolongs action potentials in TAB rat VMs and TAB rat whole heart A , representative current clamp traces in TAB rat VMs under baseline (left) or ISO (100 nmol L –1 for 3 min) (right) before and after treatment with apamin (100 nmol L –1 for 3 min). Pooled mean ± SD APD 90 . n = 5–9, N = 4–7, * P = 0.04, # P = 0.03, Student's t test. B , representative APD maps before and after APA (10 nmol L –1 ) recorded under basal conditions and in the presence of β‐adrenergic agonist ISO (50 nmol L –1 ) and the corresponding APD profile. Right, Pooled data for APD 75 . * P
    Apamin Apa, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/apamin apa/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    apamin apa - by Bioz Stars, 2022-07
    93/100 stars
      Buy from Supplier

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    Apamin prolongs action potentials in TAB rat VMs and TAB rat whole heart A , representative current clamp traces in TAB rat VMs under baseline (left) or ISO (100 nmol L –1 for 3 min) (right) before and after treatment with apamin (100 nmol L –1 for 3 min). Pooled mean ± SD APD 90 . n = 5–9, N = 4–7, * P = 0.04, # P = 0.03, Student's t test. B , representative APD maps before and after APA (10 nmol L –1 ) recorded under basal conditions and in the presence of β‐adrenergic agonist ISO (50 nmol L –1 ) and the corresponding APD profile. Right, Pooled data for APD 75 . * P

    Journal: The Journal of Physiology

    Article Title: PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts

    doi: 10.1113/JP277618

    Figure Lengend Snippet: Apamin prolongs action potentials in TAB rat VMs and TAB rat whole heart A , representative current clamp traces in TAB rat VMs under baseline (left) or ISO (100 nmol L –1 for 3 min) (right) before and after treatment with apamin (100 nmol L –1 for 3 min). Pooled mean ± SD APD 90 . n = 5–9, N = 4–7, * P = 0.04, # P = 0.03, Student's t test. B , representative APD maps before and after APA (10 nmol L –1 ) recorded under basal conditions and in the presence of β‐adrenergic agonist ISO (50 nmol L –1 ) and the corresponding APD profile. Right, Pooled data for APD 75 . * P

    Article Snippet: Apamin (APA), a selective SK1, 2 and 3 polypeptide inhibitor (IC50 < 10 nmol L–1 ; Alomone Labs) was used to identify SK currents.

    Techniques:

    SK current in Sham rat VMs with application of ISO A , representative superimposed traces of I SK (blue), I Ca (black) and [Ca 2+ ] i transient (red) recorded in Sham VMs depolarized to −20 mV (left). I SK was obtained by application of 1 nmol L –1 APA. Pooled I – V and peak [Ca 2+ ]/ V relationships. B , representative inward current traces recorded in Sham VMs at 3, 6 and 8 min following application of 100 nmol L –1 ISO at −10 mV (HP −40 mV). Right: plot of normalized inward current amplitude vs . time after application of ISO. Mean ± SD, n = 5, N = 2. The normalized inward current after 6 min of ISO and 3 min of 100 nmol L –1 apamin is plotted in red. Mean ± SD, n = 8, N = 7, * P = 0.04 vs . ISO only, Student's t test.

    Journal: The Journal of Physiology

    Article Title: PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts

    doi: 10.1113/JP277618

    Figure Lengend Snippet: SK current in Sham rat VMs with application of ISO A , representative superimposed traces of I SK (blue), I Ca (black) and [Ca 2+ ] i transient (red) recorded in Sham VMs depolarized to −20 mV (left). I SK was obtained by application of 1 nmol L –1 APA. Pooled I – V and peak [Ca 2+ ]/ V relationships. B , representative inward current traces recorded in Sham VMs at 3, 6 and 8 min following application of 100 nmol L –1 ISO at −10 mV (HP −40 mV). Right: plot of normalized inward current amplitude vs . time after application of ISO. Mean ± SD, n = 5, N = 2. The normalized inward current after 6 min of ISO and 3 min of 100 nmol L –1 apamin is plotted in red. Mean ± SD, n = 8, N = 7, * P = 0.04 vs . ISO only, Student's t test.

    Article Snippet: Apamin (APA), a selective SK1, 2 and 3 polypeptide inhibitor (IC50 < 10 nmol L–1 ; Alomone Labs) was used to identify SK currents.

    Techniques: