ifenprodil (Alomone Labs)

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Alomone Labs ifenprodil
$a . Representative micrograph of a hippocampal neuron overexpressing a GluN2B-variant and YFP (for visualization); recording pipette is highlighted by dashed white lines. b . Whole cell recordings of NMDAR-dependent currents from non-transfected (dark blue trace), GluN2B-G689C-transfected neuron (cyan) or GluN2B-G689S-transfected neurons (red) in response to 100 μM NMDA (+50 μM glycine) and 100 μM PS. The GluN2B-dependent fraction of the current was determined by application of 2.5 μM <t>ifenprodil</t> in the presence of the agonists. Note the strong and significant reduction in the maximal steady-state NMDAR-dependent currents between control and transfected neurons (dashed grey line and asterisks). c . Summary of the maximal currents (I max ), before and after application of PS. Each bullet represents an individual neuron, with means (and SEM) depicted by blue (non-transfected), cyan (GluN2B-G689C) or red (GluN2B-G689S). d . Summary of the extant (fold change) of current potentiation by PS. e . Fraction of GluN2B-dependent current is unchanged between groups (% inhibition by ifenprodil). **, p < 0.01; n.s., not significant.$
Ifenprodil, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ifenprodil/product/Alomone Labs
Average 93 stars, based on 1 article reviews
Price from $9.99 to $1999.99

ifenprodil - by Bioz Stars, 2023-06

93/100 stars

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1) Product Images from "Two extreme Loss-of-Function GRIN2B -mutations are detrimental to tri-heteromeric NMDAR-function, but rescued by pregnanolone-sulfate"

Article Title: Two extreme Loss-of-Function GRIN2B -mutations are detrimental to tri-heteromeric NMDAR-function, but rescued by pregnanolone-sulfate

Journal: bioRxiv

doi: 10.1101/2022.12.13.520218

$a . Representative micrograph of a hippocampal neuron overexpressing a GluN2B-variant and YFP (for visualization); recording pipette is highlighted by dashed white lines. b . Whole cell recordings of NMDAR-dependent currents from non-transfected (dark blue trace), GluN2B-G689C-transfected neuron (cyan) or GluN2B-G689S-transfected neurons (red) in response to 100 μM NMDA (+50 μM glycine) and 100 μM PS. The GluN2B-dependent fraction of the current was determined by application of 2.5 μM ifenprodil in the presence of the agonists. Note the strong and significant reduction in the maximal steady-state NMDAR-dependent currents between control and transfected neurons (dashed grey line and asterisks). c . Summary of the maximal currents (I max ), before and after application of PS. Each bullet represents an individual neuron, with means (and SEM) depicted by blue (non-transfected), cyan (GluN2B-G689C) or red (GluN2B-G689S). d . Summary of the extant (fold change) of current potentiation by PS. e . Fraction of GluN2B-dependent current is unchanged between groups (% inhibition by ifenprodil). **, p < 0.01; n.s., not significant.$
Figure Legend Snippet: a . Representative micrograph of a hippocampal neuron overexpressing a GluN2B-variant and YFP (for visualization); recording pipette is highlighted by dashed white lines. b . Whole cell recordings of NMDAR-dependent currents from non-transfected (dark blue trace), GluN2B-G689C-transfected neuron (cyan) or GluN2B-G689S-transfected neurons (red) in response to 100 μM NMDA (+50 μM glycine) and 100 μM PS. The GluN2B-dependent fraction of the current was determined by application of 2.5 μM ifenprodil in the presence of the agonists. Note the strong and significant reduction in the maximal steady-state NMDAR-dependent currents between control and transfected neurons (dashed grey line and asterisks). c . Summary of the maximal currents (I max ), before and after application of PS. Each bullet represents an individual neuron, with means (and SEM) depicted by blue (non-transfected), cyan (GluN2B-G689C) or red (GluN2B-G689S). d . Summary of the extant (fold change) of current potentiation by PS. e . Fraction of GluN2B-dependent current is unchanged between groups (% inhibition by ifenprodil). **, p < 0.01; n.s., not significant.

Techniques Used: Variant Assay, Transferring, Transfection, Inhibition

ifenprodil (Alomone Labs)

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1) Product Images from "Two extreme Loss-of-Function GRIN2B -mutations are detrimental to tri-heteromeric NMDAR-function, but rescued by pregnanolone-sulfate"

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