diazepam  (Alomone Labs)


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    Alomone Labs diazepam
    Diazepam, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/diazepam/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    diazepam - by Bioz Stars, 2022-12
    94/100 stars

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    Alomone Labs diazepam
    Diazepam, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/diazepam/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    diazepam - by Bioz Stars, 2022-12
    94/100 stars
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    93
    Alomone Labs ml297
    Rescue of GIRK channel activity by VU0529331 and <t>ML297</t> in the presence of LoF mutants I80N and I80T Oocytes expressed GIRK2 (2 ng RNA) or GIRK1/3 (3 ng) channels, with or without Gβ WT (5 ng), I80N and I80T (10 ng), and Gγ (1/5 of Gβ). (A) Representative records of GIRK2 currents and their activation by 40 μM of VU0529331 in oocytes expressing Gβγ. (B and C) Summary of GIRK2 currents with and without Gβγ before (B) and after (C) the application of 40 μM VU0529331. (D) Fold activation of GIRK2 by 40 μM of VU0529331. (E) GIRK1/3 currents and their activation by 10 μM of ML297 in the presence of Gβγ. (F and G) Summary of GIRK1/3 currents with and without Gβγ before (F) and after (G) the application of 10 μM ML297. (H) Fold activation of GIRK1/3 by 10 μM of ML297 (N = 1).
    Ml297, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Rescue of GIRK channel activity by VU0529331 and ML297 in the presence of LoF mutants I80N and I80T Oocytes expressed GIRK2 (2 ng RNA) or GIRK1/3 (3 ng) channels, with or without Gβ WT (5 ng), I80N and I80T (10 ng), and Gγ (1/5 of Gβ). (A) Representative records of GIRK2 currents and their activation by 40 μM of VU0529331 in oocytes expressing Gβγ. (B and C) Summary of GIRK2 currents with and without Gβγ before (B) and after (C) the application of 40 μM VU0529331. (D) Fold activation of GIRK2 by 40 μM of VU0529331. (E) GIRK1/3 currents and their activation by 10 μM of ML297 in the presence of Gβγ. (F and G) Summary of GIRK1/3 currents with and without Gβγ before (F) and after (G) the application of 10 μM ML297. (H) Fold activation of GIRK1/3 by 10 μM of ML297 (N = 1).

    Journal: iScience

    Article Title: Encephalopathy-causing mutations in Gβ1 (GNB1) alter regulation of neuronal GIRK channels

    doi: 10.1016/j.isci.2021.103018

    Figure Lengend Snippet: Rescue of GIRK channel activity by VU0529331 and ML297 in the presence of LoF mutants I80N and I80T Oocytes expressed GIRK2 (2 ng RNA) or GIRK1/3 (3 ng) channels, with or without Gβ WT (5 ng), I80N and I80T (10 ng), and Gγ (1/5 of Gβ). (A) Representative records of GIRK2 currents and their activation by 40 μM of VU0529331 in oocytes expressing Gβγ. (B and C) Summary of GIRK2 currents with and without Gβγ before (B) and after (C) the application of 40 μM VU0529331. (D) Fold activation of GIRK2 by 40 μM of VU0529331. (E) GIRK1/3 currents and their activation by 10 μM of ML297 in the presence of Gβγ. (F and G) Summary of GIRK1/3 currents with and without Gβγ before (F) and after (G) the application of 10 μM ML297. (H) Fold activation of GIRK1/3 by 10 μM of ML297 (N = 1).

    Article Snippet: To measure GIRK1/3 response to ML297, the drug was diluted into HK24 solution to 2.5, 10 and 40 μM concentrations.

    Techniques: Activity Assay, Activation Assay, Expressing