β pompilidotoxin  (Alomone Labs)


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    Structured Review

    Alomone Labs β pompilidotoxin
    Pompilidotoxins inhibit Nav channel fast inactivation. <t>β-pompilidotoxin</t> from Batozonellus maculifrons (silhouette of related wasp Vespula germanica on the left —peptide sequence in the middle ) inhibits rNav1.2a fast inactivation when currents
    β Pompilidotoxin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/β pompilidotoxin/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    β pompilidotoxin - by Bioz Stars, 2022-07
    93/100 stars

    Images

    1) Product Images from "Animal Toxins Influence Voltage-Gated Sodium Channel Function"

    Article Title: Animal Toxins Influence Voltage-Gated Sodium Channel Function

    Journal: Handbook of experimental pharmacology

    doi: 10.1007/978-3-642-41588-3_10

    Pompilidotoxins inhibit Nav channel fast inactivation. β-pompilidotoxin from Batozonellus maculifrons (silhouette of related wasp Vespula germanica on the left —peptide sequence in the middle ) inhibits rNav1.2a fast inactivation when currents
    Figure Legend Snippet: Pompilidotoxins inhibit Nav channel fast inactivation. β-pompilidotoxin from Batozonellus maculifrons (silhouette of related wasp Vespula germanica on the left —peptide sequence in the middle ) inhibits rNav1.2a fast inactivation when currents

    Techniques Used: Sequencing

    2) Product Images from "Animal Toxins Influence Voltage-Gated Sodium Channel Function"

    Article Title: Animal Toxins Influence Voltage-Gated Sodium Channel Function

    Journal: Handbook of experimental pharmacology

    doi: 10.1007/978-3-642-41588-3_10

    Pompilidotoxins inhibit Nav channel fast inactivation. β-pompilidotoxin from Batozonellus maculifrons (silhouette of related wasp Vespula germanica on the left —peptide sequence in the middle ) inhibits rNav1.2a fast inactivation when currents
    Figure Legend Snippet: Pompilidotoxins inhibit Nav channel fast inactivation. β-pompilidotoxin from Batozonellus maculifrons (silhouette of related wasp Vespula germanica on the left —peptide sequence in the middle ) inhibits rNav1.2a fast inactivation when currents

    Techniques Used: Sequencing

    3) Product Images from "The Evidence for Sparsentan-Mediated Inhibition of INa and IK(erg): Possibly Unlinked to Its Antagonism of Angiotensin II or Endothelin Type a Receptor"

    Article Title: The Evidence for Sparsentan-Mediated Inhibition of INa and IK(erg): Possibly Unlinked to Its Antagonism of Angiotensin II or Endothelin Type a Receptor

    Journal: Biomedicines

    doi: 10.3390/biomedicines10010086

    Effect of tefluthin, β-pompilidoxin, tefluthrin plus sparsentan, β-pompilidotoxin plus sparsentan on I Na in GH 3 cells. The voltage-clamp experiments were undertaken, as cells were voltage-clamped at −80 mV and the depolarizing pulse to −10 mV was imposed to them. ( A ) Representative current traces obtained in the control period (a, sparsentan was not present), and during exposure to 3 μM sparsentan (b) or to 3 μM sparsentan plus 3 μM tefluthrin (c). The top panel indicates the voltage-clamp protocol applied. Of note, the deactivating I Na was additionally detected as membrane potential was returned to −50 mV with a duration of 40 ms. ( B ) Summary bar graph demonstrating effect of 3 μM tefluthrin, 3 μM β-pompilidotoxn, 3 μM tefluthrin plus 3 μM sparsentan and 3 μM β-pompilidotoxin plus 3 μM sparsentan on the peak amplitude of I Na (mean ± SEM; n = 8 for each bar). The peak amplitude was measured at the start of 40 ms depolarizing command voltage from −80 to −10 mV. Tef: tefluthrin; Pomp: β-pompilidotoxin; Spar, sparsentan. Statistical analysis was performed by one-way ANOVA ( p
    Figure Legend Snippet: Effect of tefluthin, β-pompilidoxin, tefluthrin plus sparsentan, β-pompilidotoxin plus sparsentan on I Na in GH 3 cells. The voltage-clamp experiments were undertaken, as cells were voltage-clamped at −80 mV and the depolarizing pulse to −10 mV was imposed to them. ( A ) Representative current traces obtained in the control period (a, sparsentan was not present), and during exposure to 3 μM sparsentan (b) or to 3 μM sparsentan plus 3 μM tefluthrin (c). The top panel indicates the voltage-clamp protocol applied. Of note, the deactivating I Na was additionally detected as membrane potential was returned to −50 mV with a duration of 40 ms. ( B ) Summary bar graph demonstrating effect of 3 μM tefluthrin, 3 μM β-pompilidotoxn, 3 μM tefluthrin plus 3 μM sparsentan and 3 μM β-pompilidotoxin plus 3 μM sparsentan on the peak amplitude of I Na (mean ± SEM; n = 8 for each bar). The peak amplitude was measured at the start of 40 ms depolarizing command voltage from −80 to −10 mV. Tef: tefluthrin; Pomp: β-pompilidotoxin; Spar, sparsentan. Statistical analysis was performed by one-way ANOVA ( p

    Techniques Used:

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    Alomone Labs β pompilidotoxin
    Pompilidotoxins inhibit Nav channel fast inactivation. <t>β-pompilidotoxin</t> from Batozonellus maculifrons (silhouette of related wasp Vespula germanica on the left —peptide sequence in the middle ) inhibits rNav1.2a fast inactivation when currents
    β Pompilidotoxin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/β pompilidotoxin/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    β pompilidotoxin - by Bioz Stars, 2022-07
    93/100 stars
      Buy from Supplier

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    Pompilidotoxins inhibit Nav channel fast inactivation. β-pompilidotoxin from Batozonellus maculifrons (silhouette of related wasp Vespula germanica on the left —peptide sequence in the middle ) inhibits rNav1.2a fast inactivation when currents

    Journal: Handbook of experimental pharmacology

    Article Title: Animal Toxins Influence Voltage-Gated Sodium Channel Function

    doi: 10.1007/978-3-642-41588-3_10

    Figure Lengend Snippet: Pompilidotoxins inhibit Nav channel fast inactivation. β-pompilidotoxin from Batozonellus maculifrons (silhouette of related wasp Vespula germanica on the left —peptide sequence in the middle ) inhibits rNav1.2a fast inactivation when currents

    Article Snippet: TTX and β-pompilidotoxin were acquired from Alomone labs, ATX-II from Sigma Aldrich, and BTX was obtained from Latoxan through Fisher Scientific.

    Techniques: Sequencing

    Effect of tefluthin, β-pompilidoxin, tefluthrin plus sparsentan, β-pompilidotoxin plus sparsentan on I Na in GH 3 cells. The voltage-clamp experiments were undertaken, as cells were voltage-clamped at −80 mV and the depolarizing pulse to −10 mV was imposed to them. ( A ) Representative current traces obtained in the control period (a, sparsentan was not present), and during exposure to 3 μM sparsentan (b) or to 3 μM sparsentan plus 3 μM tefluthrin (c). The top panel indicates the voltage-clamp protocol applied. Of note, the deactivating I Na was additionally detected as membrane potential was returned to −50 mV with a duration of 40 ms. ( B ) Summary bar graph demonstrating effect of 3 μM tefluthrin, 3 μM β-pompilidotoxn, 3 μM tefluthrin plus 3 μM sparsentan and 3 μM β-pompilidotoxin plus 3 μM sparsentan on the peak amplitude of I Na (mean ± SEM; n = 8 for each bar). The peak amplitude was measured at the start of 40 ms depolarizing command voltage from −80 to −10 mV. Tef: tefluthrin; Pomp: β-pompilidotoxin; Spar, sparsentan. Statistical analysis was performed by one-way ANOVA ( p

    Journal: Biomedicines

    Article Title: The Evidence for Sparsentan-Mediated Inhibition of INa and IK(erg): Possibly Unlinked to Its Antagonism of Angiotensin II or Endothelin Type a Receptor

    doi: 10.3390/biomedicines10010086

    Figure Lengend Snippet: Effect of tefluthin, β-pompilidoxin, tefluthrin plus sparsentan, β-pompilidotoxin plus sparsentan on I Na in GH 3 cells. The voltage-clamp experiments were undertaken, as cells were voltage-clamped at −80 mV and the depolarizing pulse to −10 mV was imposed to them. ( A ) Representative current traces obtained in the control period (a, sparsentan was not present), and during exposure to 3 μM sparsentan (b) or to 3 μM sparsentan plus 3 μM tefluthrin (c). The top panel indicates the voltage-clamp protocol applied. Of note, the deactivating I Na was additionally detected as membrane potential was returned to −50 mV with a duration of 40 ms. ( B ) Summary bar graph demonstrating effect of 3 μM tefluthrin, 3 μM β-pompilidotoxn, 3 μM tefluthrin plus 3 μM sparsentan and 3 μM β-pompilidotoxin plus 3 μM sparsentan on the peak amplitude of I Na (mean ± SEM; n = 8 for each bar). The peak amplitude was measured at the start of 40 ms depolarizing command voltage from −80 to −10 mV. Tef: tefluthrin; Pomp: β-pompilidotoxin; Spar, sparsentan. Statistical analysis was performed by one-way ANOVA ( p

    Article Snippet: Angiotensin II (AngII), endothelin 1, tefluthrin (Tef), tetraethylammonium chloride (TEA) were supplied by Sigma-Aldrich (Merck, Taipei, Taiwan) and β-pompilidotoxin (Pomp) and tetrodotoxin (TTX) were by Alomone (Jerusalem, Israel).

    Techniques: