philanthotoxin 74  (Alomone Labs)


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    Structured Review

    Alomone Labs philanthotoxin 74
    CP-AMPARs are present in SPNs and LPS selectively decreases AMPA-stimulated [Ca 2+ ] i through CP-AMPARs in D2 SPNs Corticostriatal coronal sections were treated with 125 ng/ml LPS or vehicle for two hours. D2 or D1 SPNs were pretreated via y-tube application with <t>philanthotoxin-74</t> (300 µM), TTX, and CdCl 2 , before exposure to the AMPA cocktail + philanthotoxin, TTX, and CdCl 2 . A) Peak amplitude of fluorescence response in D2 SPNs (****P
    Philanthotoxin 74, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 88/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/philanthotoxin 74/product/Alomone Labs
    Average 88 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    philanthotoxin 74 - by Bioz Stars, 2022-12
    88/100 stars

    Images

    1) Product Images from "Inflammation alters AMPA-stimulated calcium responses in dorsal striatal D2 but not D1 spiny projection neurons"

    Article Title: Inflammation alters AMPA-stimulated calcium responses in dorsal striatal D2 but not D1 spiny projection neurons

    Journal: The European journal of neuroscience

    doi: 10.1111/ejn.13711

    CP-AMPARs are present in SPNs and LPS selectively decreases AMPA-stimulated [Ca 2+ ] i through CP-AMPARs in D2 SPNs Corticostriatal coronal sections were treated with 125 ng/ml LPS or vehicle for two hours. D2 or D1 SPNs were pretreated via y-tube application with philanthotoxin-74 (300 µM), TTX, and CdCl 2 , before exposure to the AMPA cocktail + philanthotoxin, TTX, and CdCl 2 . A) Peak amplitude of fluorescence response in D2 SPNs (****P
    Figure Legend Snippet: CP-AMPARs are present in SPNs and LPS selectively decreases AMPA-stimulated [Ca 2+ ] i through CP-AMPARs in D2 SPNs Corticostriatal coronal sections were treated with 125 ng/ml LPS or vehicle for two hours. D2 or D1 SPNs were pretreated via y-tube application with philanthotoxin-74 (300 µM), TTX, and CdCl 2 , before exposure to the AMPA cocktail + philanthotoxin, TTX, and CdCl 2 . A) Peak amplitude of fluorescence response in D2 SPNs (****P

    Techniques Used: Fluorescence

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    Alomone Labs selective kca3 1 channel blocker tram 34
    BrdU incorporation and αSM-actin expression in collaterals. ( a , b ) Bar graphs represent the results of quantitative analyses of BrdU + ECs (left panels) and SMCs (right panels) in solvent (control), ( a ) PAP-1 or ( b ) <t>TRAM-34-treated</t> mice at day 7 after induction of arteriogenesis. Data are means ± SEM, n = 3 mice per group. * p
    Selective Kca3 1 Channel Blocker Tram 34, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/selective kca3 1 channel blocker tram 34/product/Alomone Labs
    Average 92 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    selective kca3 1 channel blocker tram 34 - by Bioz Stars, 2022-12
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    88
    Alomone Labs philanthotoxin 74
    CP-AMPARs are present in SPNs and LPS selectively decreases AMPA-stimulated [Ca 2+ ] i through CP-AMPARs in D2 SPNs Corticostriatal coronal sections were treated with 125 ng/ml LPS or vehicle for two hours. D2 or D1 SPNs were pretreated via y-tube application with <t>philanthotoxin-74</t> (300 µM), TTX, and CdCl 2 , before exposure to the AMPA cocktail + philanthotoxin, TTX, and CdCl 2 . A) Peak amplitude of fluorescence response in D2 SPNs (****P
    Philanthotoxin 74, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 88/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/philanthotoxin 74/product/Alomone Labs
    Average 88 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    philanthotoxin 74 - by Bioz Stars, 2022-12
    88/100 stars
      Buy from Supplier

    Image Search Results


    BrdU incorporation and αSM-actin expression in collaterals. ( a , b ) Bar graphs represent the results of quantitative analyses of BrdU + ECs (left panels) and SMCs (right panels) in solvent (control), ( a ) PAP-1 or ( b ) TRAM-34-treated mice at day 7 after induction of arteriogenesis. Data are means ± SEM, n = 3 mice per group. * p

    Journal: Cells

    Article Title: Contribution of the Potassium Channels KV1.3 and KCa3.1 to Smooth Muscle Cell Proliferation in Growing Collateral Arteries

    doi: 10.3390/cells9040913

    Figure Lengend Snippet: BrdU incorporation and αSM-actin expression in collaterals. ( a , b ) Bar graphs represent the results of quantitative analyses of BrdU + ECs (left panels) and SMCs (right panels) in solvent (control), ( a ) PAP-1 or ( b ) TRAM-34-treated mice at day 7 after induction of arteriogenesis. Data are means ± SEM, n = 3 mice per group. * p

    Article Snippet: To block potassium channels, mice were treated either with the selective KV 1.3 channel blocker (5-(4-phenoxybutoxy)psoralen (PAP-1, 40 mg/kg/d, intraperitoneally (i.p), Sigma-Aldrich) [ ], or the selective KCa3.1 channel blocker TRAM-34 (120 mg/kg/d, i.p., Alomone Labs) [ ], dissolved in peanut oil, at doses previously described [ , ].

    Techniques: BrdU Incorporation Assay, Expressing, Mouse Assay

    Laser Doppler perfusion measurements. Line plot (left panel) along with corresponding flux images (right panel) of laser Doppler perfusion measurements. Mice were treated with solvent (control), PAP-1, or TRAM-34, respectively, and the perfusion was calculated by right to left (occlusion (occ) to sham) ratio before, immediately after, and at day 3 and 7 after the surgical procedure (left panel). Data are means ± SEM, n = 6 per group. * p

    Journal: Cells

    Article Title: Contribution of the Potassium Channels KV1.3 and KCa3.1 to Smooth Muscle Cell Proliferation in Growing Collateral Arteries

    doi: 10.3390/cells9040913

    Figure Lengend Snippet: Laser Doppler perfusion measurements. Line plot (left panel) along with corresponding flux images (right panel) of laser Doppler perfusion measurements. Mice were treated with solvent (control), PAP-1, or TRAM-34, respectively, and the perfusion was calculated by right to left (occlusion (occ) to sham) ratio before, immediately after, and at day 3 and 7 after the surgical procedure (left panel). Data are means ± SEM, n = 6 per group. * p

    Article Snippet: To block potassium channels, mice were treated either with the selective KV 1.3 channel blocker (5-(4-phenoxybutoxy)psoralen (PAP-1, 40 mg/kg/d, intraperitoneally (i.p), Sigma-Aldrich) [ ], or the selective KCa3.1 channel blocker TRAM-34 (120 mg/kg/d, i.p., Alomone Labs) [ ], dissolved in peanut oil, at doses previously described [ , ].

    Techniques: Mouse Assay

    Proliferation assay of mouse primary artery SMCs. Mouse primary artery SMCs were cultured with 10% FCS with or without treatment of different concentrations of the K V 1.3 blocker PAP-1 or the K Ca 3.1 blocker TRAM-34. Cell proliferation was investigated by means of BrdU incorporation. Values are expressed as percentages of the positive control (+), i.e., mouse primary artery SMCs stimulated with 10% FCS. For the negative control (–), mouse primary artery SMCs cultured with 2% FCS. Data are means ± SEM, n > 6 per group. * p

    Journal: Cells

    Article Title: Contribution of the Potassium Channels KV1.3 and KCa3.1 to Smooth Muscle Cell Proliferation in Growing Collateral Arteries

    doi: 10.3390/cells9040913

    Figure Lengend Snippet: Proliferation assay of mouse primary artery SMCs. Mouse primary artery SMCs were cultured with 10% FCS with or without treatment of different concentrations of the K V 1.3 blocker PAP-1 or the K Ca 3.1 blocker TRAM-34. Cell proliferation was investigated by means of BrdU incorporation. Values are expressed as percentages of the positive control (+), i.e., mouse primary artery SMCs stimulated with 10% FCS. For the negative control (–), mouse primary artery SMCs cultured with 2% FCS. Data are means ± SEM, n > 6 per group. * p

    Article Snippet: To block potassium channels, mice were treated either with the selective KV 1.3 channel blocker (5-(4-phenoxybutoxy)psoralen (PAP-1, 40 mg/kg/d, intraperitoneally (i.p), Sigma-Aldrich) [ ], or the selective KCa3.1 channel blocker TRAM-34 (120 mg/kg/d, i.p., Alomone Labs) [ ], dissolved in peanut oil, at doses previously described [ , ].

    Techniques: Proliferation Assay, Cell Culture, BrdU Incorporation Assay, Positive Control, Negative Control

    The qRT-PCR results of the expression levels of Fgfr1 , Pdgfrb, and Egr1 in vitro and during arteriogenesis in vivo. ( a , c ) Bar graphs represent the mRNA expression levels of Fgfr1, Pdgfrb, or Egr1 in vitro and ( b , d ) in vivo. In vitro mouse primary artery SMCs were cultured without (control) or with 1 μM PAP-1 or 100 nM TRAM-34, respectively. In vivo the expression level of Fgfr1 , Pdgfrb, and Egr1 were investigated 12 h after induction of arteriogenesis in collateral arteries and are expressed as occlusion (occ) to sham ratio. All qRT-PCR results were normalized to the expression level of the corresponding 18S rRNA. Data are means ± SEM, n = 3 per group. * p

    Journal: Cells

    Article Title: Contribution of the Potassium Channels KV1.3 and KCa3.1 to Smooth Muscle Cell Proliferation in Growing Collateral Arteries

    doi: 10.3390/cells9040913

    Figure Lengend Snippet: The qRT-PCR results of the expression levels of Fgfr1 , Pdgfrb, and Egr1 in vitro and during arteriogenesis in vivo. ( a , c ) Bar graphs represent the mRNA expression levels of Fgfr1, Pdgfrb, or Egr1 in vitro and ( b , d ) in vivo. In vitro mouse primary artery SMCs were cultured without (control) or with 1 μM PAP-1 or 100 nM TRAM-34, respectively. In vivo the expression level of Fgfr1 , Pdgfrb, and Egr1 were investigated 12 h after induction of arteriogenesis in collateral arteries and are expressed as occlusion (occ) to sham ratio. All qRT-PCR results were normalized to the expression level of the corresponding 18S rRNA. Data are means ± SEM, n = 3 per group. * p

    Article Snippet: To block potassium channels, mice were treated either with the selective KV 1.3 channel blocker (5-(4-phenoxybutoxy)psoralen (PAP-1, 40 mg/kg/d, intraperitoneally (i.p), Sigma-Aldrich) [ ], or the selective KCa3.1 channel blocker TRAM-34 (120 mg/kg/d, i.p., Alomone Labs) [ ], dissolved in peanut oil, at doses previously described [ , ].

    Techniques: Quantitative RT-PCR, Expressing, In Vitro, In Vivo, Cell Culture

    CP-AMPARs are present in SPNs and LPS selectively decreases AMPA-stimulated [Ca 2+ ] i through CP-AMPARs in D2 SPNs Corticostriatal coronal sections were treated with 125 ng/ml LPS or vehicle for two hours. D2 or D1 SPNs were pretreated via y-tube application with philanthotoxin-74 (300 µM), TTX, and CdCl 2 , before exposure to the AMPA cocktail + philanthotoxin, TTX, and CdCl 2 . A) Peak amplitude of fluorescence response in D2 SPNs (****P

    Journal: The European journal of neuroscience

    Article Title: Inflammation alters AMPA-stimulated calcium responses in dorsal striatal D2 but not D1 spiny projection neurons

    doi: 10.1111/ejn.13711

    Figure Lengend Snippet: CP-AMPARs are present in SPNs and LPS selectively decreases AMPA-stimulated [Ca 2+ ] i through CP-AMPARs in D2 SPNs Corticostriatal coronal sections were treated with 125 ng/ml LPS or vehicle for two hours. D2 or D1 SPNs were pretreated via y-tube application with philanthotoxin-74 (300 µM), TTX, and CdCl 2 , before exposure to the AMPA cocktail + philanthotoxin, TTX, and CdCl 2 . A) Peak amplitude of fluorescence response in D2 SPNs (****P

    Article Snippet: Studies employed commercially available chemicals as follows: S-AMPA (Abcam, # ), cyclothiazide (Abcam, # ), (R-)CPP (Abcam, # ), TTX (Abcam, # ), philanthotoxin-74 (Alomone Labs, #P-120), and isradipine (Tocris, #2004).

    Techniques: Fluorescence