bicuculline  (Alomone Labs)


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  • 93

    Structured Review

    Alomone Labs bicuculline
    Bicuculline, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    bicuculline - by Bioz Stars, 2023-02
    93/100 stars

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    nacl  (Alomone Labs)


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  • 86

    Structured Review

    Alomone Labs nacl
    Nacl, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 86 stars, based on 1 article reviews
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    nacl - by Bioz Stars, 2023-02
    86/100 stars

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    bicuculline  (Alomone Labs)


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  • 93

    Structured Review

    Alomone Labs bicuculline
    Bicuculline, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    bicuculline - by Bioz Stars, 2023-02
    93/100 stars

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    bicuculline  (Alomone Labs)


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  • 93

    Structured Review

    Alomone Labs bicuculline
    Bicuculline, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    bicuculline - by Bioz Stars, 2023-02
    93/100 stars

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    bicuculline  (Alomone Labs)


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  • 93

    Structured Review

    Alomone Labs bicuculline
    Bicuculline, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/bicuculline/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    bicuculline - by Bioz Stars, 2023-02
    93/100 stars

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    bicuculline  (Alomone Labs)


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  • 93

    Structured Review

    Alomone Labs bicuculline
    Bicuculline, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    bicuculline - by Bioz Stars, 2023-02
    93/100 stars

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    bicuculline  (Alomone Labs)


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  • 93

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    Alomone Labs bicuculline
    Bicuculline, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 93 stars, based on 1 article reviews
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    bicuculline - by Bioz Stars, 2023-02
    93/100 stars

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    zinc58368839  (Alomone Labs)


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  • 91

    Structured Review

    Alomone Labs zinc58368839
    Use of intersubunit allosteric pocket “signature mutants” to investigate the site of action for brilliant blue G, KN-62, calmidazolium, <t>ZINC58368839,</t> and PPADS. (A) Concentration-dependent inhibition by P2X7 antagonists of response to an EC 90 concentration of ATP for P2X7-2N β (black), F88A (firebrick), T90V (orange), D92A (yellow), F103A (green), and V312A (purple). (B) Top panel: P2X7R overview with “signature mutants” residues shown as spheres; colors as in (A). Other panels: View from the top of the extracellular domains along the central axis perpendicular to the membrane. The P2X7R model is shown as cartoon with the three subunits highlighted in light blue, light pink, and gray with the docked pose of the antagonist shown as spheres. (C) Top panel: Surface representation of entrance to allosteric pocket. Other panels: Zoom into the proposed binding site, one subunit [light blue in (B)] is omitted for clarity. Residues F88, T90, D92, F103, and V312 and the respective antagonist are shown as sticks [colors as in (A) and (B)].
    Zinc58368839, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91/100 stars

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    1) Product Images from "Mapping the Site of Action of Human P2X7 Receptor Antagonists AZ11645373, Brilliant Blue G, KN-62, Calmidazolium, and ZINC58368839 to the Intersubunit Allosteric Pocket "

    Article Title: Mapping the Site of Action of Human P2X7 Receptor Antagonists AZ11645373, Brilliant Blue G, KN-62, Calmidazolium, and ZINC58368839 to the Intersubunit Allosteric Pocket

    Journal: Molecular Pharmacology

    doi: 10.1124/mol.119.116715

    Use of intersubunit allosteric pocket “signature mutants” to investigate the site of action for brilliant blue G, KN-62, calmidazolium, ZINC58368839, and PPADS. (A) Concentration-dependent inhibition by P2X7 antagonists of response to an EC 90 concentration of ATP for P2X7-2N β (black), F88A (firebrick), T90V (orange), D92A (yellow), F103A (green), and V312A (purple). (B) Top panel: P2X7R overview with “signature mutants” residues shown as spheres; colors as in (A). Other panels: View from the top of the extracellular domains along the central axis perpendicular to the membrane. The P2X7R model is shown as cartoon with the three subunits highlighted in light blue, light pink, and gray with the docked pose of the antagonist shown as spheres. (C) Top panel: Surface representation of entrance to allosteric pocket. Other panels: Zoom into the proposed binding site, one subunit [light blue in (B)] is omitted for clarity. Residues F88, T90, D92, F103, and V312 and the respective antagonist are shown as sticks [colors as in (A) and (B)].
    Figure Legend Snippet: Use of intersubunit allosteric pocket “signature mutants” to investigate the site of action for brilliant blue G, KN-62, calmidazolium, ZINC58368839, and PPADS. (A) Concentration-dependent inhibition by P2X7 antagonists of response to an EC 90 concentration of ATP for P2X7-2N β (black), F88A (firebrick), T90V (orange), D92A (yellow), F103A (green), and V312A (purple). (B) Top panel: P2X7R overview with “signature mutants” residues shown as spheres; colors as in (A). Other panels: View from the top of the extracellular domains along the central axis perpendicular to the membrane. The P2X7R model is shown as cartoon with the three subunits highlighted in light blue, light pink, and gray with the docked pose of the antagonist shown as spheres. (C) Top panel: Surface representation of entrance to allosteric pocket. Other panels: Zoom into the proposed binding site, one subunit [light blue in (B)] is omitted for clarity. Residues F88, T90, D92, F103, and V312 and the respective antagonist are shown as sticks [colors as in (A) and (B)].

    Techniques Used: Concentration Assay, Inhibition, Binding Assay

    bicuculline  (Alomone Labs)


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  • 93

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    Alomone Labs bicuculline
    Bicuculline, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    bicuculline - by Bioz Stars, 2023-02
    93/100 stars

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    bicuculline  (Alomone Labs)


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  • 93

    Structured Review

    Alomone Labs bicuculline
    Bicuculline, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    bicuculline - by Bioz Stars, 2023-02
    93/100 stars

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