r agonist muscimol  (Alomone Labs)


Bioz Verified Symbol Alomone Labs is a verified supplier
Bioz Manufacturer Symbol Alomone Labs manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 94

    Structured Review

    Alomone Labs r agonist muscimol
    Involvement of impaired LTD in the NAc in depressive-like behaviors. (A – C) Bar graphs show the distance traveled in OFT, and the immobility time in FST and in TST of control mice, NE-100 mice, and mice treated with NAc-injection <t>of</t> <t>quinpirole</t> (quin), PMA, or <t>muscimol</t> (mus). ** p < 0.01 vs. control mice; # p < 0.05 vs. vehicle-treated NE-100 mice ( n = 11 mice of quin-treated group in FST, n = 11 mice of vehicle-treated control group and PMA-treated control group in TST, and n = 12 mice in the other groups; two-way ANOVA).
    R Agonist Muscimol, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/r agonist muscimol/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    r agonist muscimol - by Bioz Stars, 2023-02
    94/100 stars

    Images

    1) Product Images from "Repeated inhibition of sigma-1 receptor suppresses GABA A receptor expression and long-term depression in the nucleus accumbens leading to depressive-like behaviors"

    Article Title: Repeated inhibition of sigma-1 receptor suppresses GABA A receptor expression and long-term depression in the nucleus accumbens leading to depressive-like behaviors

    Journal: Frontiers in Molecular Neuroscience

    doi: 10.3389/fnmol.2022.959224

    Involvement of impaired LTD in the NAc in depressive-like behaviors. (A – C) Bar graphs show the distance traveled in OFT, and the immobility time in FST and in TST of control mice, NE-100 mice, and mice treated with NAc-injection of quinpirole (quin), PMA, or muscimol (mus). ** p < 0.01 vs. control mice; # p < 0.05 vs. vehicle-treated NE-100 mice ( n = 11 mice of quin-treated group in FST, n = 11 mice of vehicle-treated control group and PMA-treated control group in TST, and n = 12 mice in the other groups; two-way ANOVA).
    Figure Legend Snippet: Involvement of impaired LTD in the NAc in depressive-like behaviors. (A – C) Bar graphs show the distance traveled in OFT, and the immobility time in FST and in TST of control mice, NE-100 mice, and mice treated with NAc-injection of quinpirole (quin), PMA, or muscimol (mus). ** p < 0.01 vs. control mice; # p < 0.05 vs. vehicle-treated NE-100 mice ( n = 11 mice of quin-treated group in FST, n = 11 mice of vehicle-treated control group and PMA-treated control group in TST, and n = 12 mice in the other groups; two-way ANOVA).

    Techniques Used: Injection

    Repeated injection of NE-100 leads to synaptic dysfunction. (A) The timecourse of the experimental procedure. (B) Schematic illustrating sites of stimulating electrode (Stim) and recording electrode (Rec) in the shell of NAc (left panel). The right panel shows a typical trace. The dark mark of the initial descending phase indicates the 10% to 90% data points of the slope, and the two-way arrow indicates the duration. (C) Input-output (I-O) curve in the NAc. Each point represents the group mean value of fEPSP slopes against stimulus intensity from 0.1 mA to 1.1 mA in control mice and NE-100 mice. Representative traces of fEPSP evoked at 0.5 mA stimulus intensity in control mice and NE-100 mice ( n = 8 slices/4 mice per group; repeated-measures ANOVA). (D) Bar graphs show the duration (ms) of fEPSP in control mice and NE-100 mice. ** p < 0.01 vs. control mice ( n = 8 slices/4 mice per group; Student’s- t test). (E) PPR (%) of fEPSP slopes was plotted against interpulse intervals (IPIs) ranging from 15 ms to 100 ms. Traces represent fEPSPs evoked by stimulation pulses delivered with a 25 ms IPI. * p < 0.05 vs. control mice ( n = 8 slices/4 mice per group; repeated-measures ANOVA). (F) LTD induction by delivering low-frequency stimulation (LFS) in control mice and NE-100 mice. A solid line indicates when LFS was given. Traces show fEPSPs pre- and post-LFS. ** p < 0.01 vs. control mice ( n = 8 slices/4 mice per group; Mann-Whitney U test). (Gi,Gii) Bar graphs show the duration (ms) of fEPSP and the PPR value (25 ms IPI) in vehicle-treated and bicuculline (bicu)-treated control mice. ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Student’s t -test). (H) LTD induction by LFS in slices of control mice treated with bicuculline (bicu). ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Mann-Whitney U test). (Ii,Iii) Bar graphs show the duration (ms) of fEPSP and the PPR value (25 ms IPI) in vehicle-treated and muscimol (mus)-treated NE-100 mice. ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Student’s t -test). (J) LTD induction in slices of NE-100 mice treated with muscimol (mus). ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Mann-Whitney U test).
    Figure Legend Snippet: Repeated injection of NE-100 leads to synaptic dysfunction. (A) The timecourse of the experimental procedure. (B) Schematic illustrating sites of stimulating electrode (Stim) and recording electrode (Rec) in the shell of NAc (left panel). The right panel shows a typical trace. The dark mark of the initial descending phase indicates the 10% to 90% data points of the slope, and the two-way arrow indicates the duration. (C) Input-output (I-O) curve in the NAc. Each point represents the group mean value of fEPSP slopes against stimulus intensity from 0.1 mA to 1.1 mA in control mice and NE-100 mice. Representative traces of fEPSP evoked at 0.5 mA stimulus intensity in control mice and NE-100 mice ( n = 8 slices/4 mice per group; repeated-measures ANOVA). (D) Bar graphs show the duration (ms) of fEPSP in control mice and NE-100 mice. ** p < 0.01 vs. control mice ( n = 8 slices/4 mice per group; Student’s- t test). (E) PPR (%) of fEPSP slopes was plotted against interpulse intervals (IPIs) ranging from 15 ms to 100 ms. Traces represent fEPSPs evoked by stimulation pulses delivered with a 25 ms IPI. * p < 0.05 vs. control mice ( n = 8 slices/4 mice per group; repeated-measures ANOVA). (F) LTD induction by delivering low-frequency stimulation (LFS) in control mice and NE-100 mice. A solid line indicates when LFS was given. Traces show fEPSPs pre- and post-LFS. ** p < 0.01 vs. control mice ( n = 8 slices/4 mice per group; Mann-Whitney U test). (Gi,Gii) Bar graphs show the duration (ms) of fEPSP and the PPR value (25 ms IPI) in vehicle-treated and bicuculline (bicu)-treated control mice. ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Student’s t -test). (H) LTD induction by LFS in slices of control mice treated with bicuculline (bicu). ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Mann-Whitney U test). (Ii,Iii) Bar graphs show the duration (ms) of fEPSP and the PPR value (25 ms IPI) in vehicle-treated and muscimol (mus)-treated NE-100 mice. ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Student’s t -test). (J) LTD induction in slices of NE-100 mice treated with muscimol (mus). ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Mann-Whitney U test).

    Techniques Used: Injection, MANN-WHITNEY

    r agonist muscimol  (Alomone Labs)


    Bioz Verified Symbol Alomone Labs is a verified supplier
    Bioz Manufacturer Symbol Alomone Labs manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 94

    Structured Review

    Alomone Labs r agonist muscimol
    Involvement of impaired LTD in the NAc in depressive-like behaviors. (A – C) Bar graphs show the distance traveled in OFT, and the immobility time in FST and in TST of control mice, NE-100 mice, and mice treated with NAc-injection <t>of</t> <t>quinpirole</t> (quin), PMA, or <t>muscimol</t> (mus). ** p < 0.01 vs. control mice; # p < 0.05 vs. vehicle-treated NE-100 mice ( n = 11 mice of quin-treated group in FST, n = 11 mice of vehicle-treated control group and PMA-treated control group in TST, and n = 12 mice in the other groups; two-way ANOVA).
    R Agonist Muscimol, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/r agonist muscimol/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    r agonist muscimol - by Bioz Stars, 2023-02
    94/100 stars

    Images

    1) Product Images from "Repeated inhibition of sigma-1 receptor suppresses GABA A receptor expression and long-term depression in the nucleus accumbens leading to depressive-like behaviors"

    Article Title: Repeated inhibition of sigma-1 receptor suppresses GABA A receptor expression and long-term depression in the nucleus accumbens leading to depressive-like behaviors

    Journal: Frontiers in Molecular Neuroscience

    doi: 10.3389/fnmol.2022.959224

    Involvement of impaired LTD in the NAc in depressive-like behaviors. (A – C) Bar graphs show the distance traveled in OFT, and the immobility time in FST and in TST of control mice, NE-100 mice, and mice treated with NAc-injection of quinpirole (quin), PMA, or muscimol (mus). ** p < 0.01 vs. control mice; # p < 0.05 vs. vehicle-treated NE-100 mice ( n = 11 mice of quin-treated group in FST, n = 11 mice of vehicle-treated control group and PMA-treated control group in TST, and n = 12 mice in the other groups; two-way ANOVA).
    Figure Legend Snippet: Involvement of impaired LTD in the NAc in depressive-like behaviors. (A – C) Bar graphs show the distance traveled in OFT, and the immobility time in FST and in TST of control mice, NE-100 mice, and mice treated with NAc-injection of quinpirole (quin), PMA, or muscimol (mus). ** p < 0.01 vs. control mice; # p < 0.05 vs. vehicle-treated NE-100 mice ( n = 11 mice of quin-treated group in FST, n = 11 mice of vehicle-treated control group and PMA-treated control group in TST, and n = 12 mice in the other groups; two-way ANOVA).

    Techniques Used: Injection

    Repeated injection of NE-100 leads to synaptic dysfunction. (A) The timecourse of the experimental procedure. (B) Schematic illustrating sites of stimulating electrode (Stim) and recording electrode (Rec) in the shell of NAc (left panel). The right panel shows a typical trace. The dark mark of the initial descending phase indicates the 10% to 90% data points of the slope, and the two-way arrow indicates the duration. (C) Input-output (I-O) curve in the NAc. Each point represents the group mean value of fEPSP slopes against stimulus intensity from 0.1 mA to 1.1 mA in control mice and NE-100 mice. Representative traces of fEPSP evoked at 0.5 mA stimulus intensity in control mice and NE-100 mice ( n = 8 slices/4 mice per group; repeated-measures ANOVA). (D) Bar graphs show the duration (ms) of fEPSP in control mice and NE-100 mice. ** p < 0.01 vs. control mice ( n = 8 slices/4 mice per group; Student’s- t test). (E) PPR (%) of fEPSP slopes was plotted against interpulse intervals (IPIs) ranging from 15 ms to 100 ms. Traces represent fEPSPs evoked by stimulation pulses delivered with a 25 ms IPI. * p < 0.05 vs. control mice ( n = 8 slices/4 mice per group; repeated-measures ANOVA). (F) LTD induction by delivering low-frequency stimulation (LFS) in control mice and NE-100 mice. A solid line indicates when LFS was given. Traces show fEPSPs pre- and post-LFS. ** p < 0.01 vs. control mice ( n = 8 slices/4 mice per group; Mann-Whitney U test). (Gi,Gii) Bar graphs show the duration (ms) of fEPSP and the PPR value (25 ms IPI) in vehicle-treated and bicuculline (bicu)-treated control mice. ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Student’s t -test). (H) LTD induction by LFS in slices of control mice treated with bicuculline (bicu). ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Mann-Whitney U test). (Ii,Iii) Bar graphs show the duration (ms) of fEPSP and the PPR value (25 ms IPI) in vehicle-treated and muscimol (mus)-treated NE-100 mice. ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Student’s t -test). (J) LTD induction in slices of NE-100 mice treated with muscimol (mus). ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Mann-Whitney U test).
    Figure Legend Snippet: Repeated injection of NE-100 leads to synaptic dysfunction. (A) The timecourse of the experimental procedure. (B) Schematic illustrating sites of stimulating electrode (Stim) and recording electrode (Rec) in the shell of NAc (left panel). The right panel shows a typical trace. The dark mark of the initial descending phase indicates the 10% to 90% data points of the slope, and the two-way arrow indicates the duration. (C) Input-output (I-O) curve in the NAc. Each point represents the group mean value of fEPSP slopes against stimulus intensity from 0.1 mA to 1.1 mA in control mice and NE-100 mice. Representative traces of fEPSP evoked at 0.5 mA stimulus intensity in control mice and NE-100 mice ( n = 8 slices/4 mice per group; repeated-measures ANOVA). (D) Bar graphs show the duration (ms) of fEPSP in control mice and NE-100 mice. ** p < 0.01 vs. control mice ( n = 8 slices/4 mice per group; Student’s- t test). (E) PPR (%) of fEPSP slopes was plotted against interpulse intervals (IPIs) ranging from 15 ms to 100 ms. Traces represent fEPSPs evoked by stimulation pulses delivered with a 25 ms IPI. * p < 0.05 vs. control mice ( n = 8 slices/4 mice per group; repeated-measures ANOVA). (F) LTD induction by delivering low-frequency stimulation (LFS) in control mice and NE-100 mice. A solid line indicates when LFS was given. Traces show fEPSPs pre- and post-LFS. ** p < 0.01 vs. control mice ( n = 8 slices/4 mice per group; Mann-Whitney U test). (Gi,Gii) Bar graphs show the duration (ms) of fEPSP and the PPR value (25 ms IPI) in vehicle-treated and bicuculline (bicu)-treated control mice. ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Student’s t -test). (H) LTD induction by LFS in slices of control mice treated with bicuculline (bicu). ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Mann-Whitney U test). (Ii,Iii) Bar graphs show the duration (ms) of fEPSP and the PPR value (25 ms IPI) in vehicle-treated and muscimol (mus)-treated NE-100 mice. ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Student’s t -test). (J) LTD induction in slices of NE-100 mice treated with muscimol (mus). ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Mann-Whitney U test).

    Techniques Used: Injection, MANN-WHITNEY

    muscimol bromide  (Alomone Labs)


    Bioz Verified Symbol Alomone Labs is a verified supplier
    Bioz Manufacturer Symbol Alomone Labs manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 94

    Structured Review

    Alomone Labs muscimol bromide
    Muscimol Bromide, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/muscimol bromide/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    muscimol bromide - by Bioz Stars, 2023-02
    94/100 stars

    Images

    Similar Products

  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 94
    Alomone Labs r agonist muscimol
    Involvement of impaired LTD in the NAc in depressive-like behaviors. (A – C) Bar graphs show the distance traveled in OFT, and the immobility time in FST and in TST of control mice, NE-100 mice, and mice treated with NAc-injection <t>of</t> <t>quinpirole</t> (quin), PMA, or <t>muscimol</t> (mus). ** p < 0.01 vs. control mice; # p < 0.05 vs. vehicle-treated NE-100 mice ( n = 11 mice of quin-treated group in FST, n = 11 mice of vehicle-treated control group and PMA-treated control group in TST, and n = 12 mice in the other groups; two-way ANOVA).
    R Agonist Muscimol, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/r agonist muscimol/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    r agonist muscimol - by Bioz Stars, 2023-02
    94/100 stars
      Buy from Supplier

    94
    Alomone Labs muscimol bromide
    Involvement of impaired LTD in the NAc in depressive-like behaviors. (A – C) Bar graphs show the distance traveled in OFT, and the immobility time in FST and in TST of control mice, NE-100 mice, and mice treated with NAc-injection <t>of</t> <t>quinpirole</t> (quin), PMA, or <t>muscimol</t> (mus). ** p < 0.01 vs. control mice; # p < 0.05 vs. vehicle-treated NE-100 mice ( n = 11 mice of quin-treated group in FST, n = 11 mice of vehicle-treated control group and PMA-treated control group in TST, and n = 12 mice in the other groups; two-way ANOVA).
    Muscimol Bromide, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/muscimol bromide/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    muscimol bromide - by Bioz Stars, 2023-02
    94/100 stars
      Buy from Supplier

    Image Search Results


    Involvement of impaired LTD in the NAc in depressive-like behaviors. (A – C) Bar graphs show the distance traveled in OFT, and the immobility time in FST and in TST of control mice, NE-100 mice, and mice treated with NAc-injection of quinpirole (quin), PMA, or muscimol (mus). ** p < 0.01 vs. control mice; # p < 0.05 vs. vehicle-treated NE-100 mice ( n = 11 mice of quin-treated group in FST, n = 11 mice of vehicle-treated control group and PMA-treated control group in TST, and n = 12 mice in the other groups; two-way ANOVA).

    Journal: Frontiers in Molecular Neuroscience

    Article Title: Repeated inhibition of sigma-1 receptor suppresses GABA A receptor expression and long-term depression in the nucleus accumbens leading to depressive-like behaviors

    doi: 10.3389/fnmol.2022.959224

    Figure Lengend Snippet: Involvement of impaired LTD in the NAc in depressive-like behaviors. (A – C) Bar graphs show the distance traveled in OFT, and the immobility time in FST and in TST of control mice, NE-100 mice, and mice treated with NAc-injection of quinpirole (quin), PMA, or muscimol (mus). ** p < 0.01 vs. control mice; # p < 0.05 vs. vehicle-treated NE-100 mice ( n = 11 mice of quin-treated group in FST, n = 11 mice of vehicle-treated control group and PMA-treated control group in TST, and n = 12 mice in the other groups; two-way ANOVA).

    Article Snippet: σ 1 R antagonist NE-100 (Tocris Cat#3133), PKC activator phorbol 12-myristate 13-acetate (PMA; Sigma-Aldrich Cat#P1585), PKC inhibitor GF109302X (Tocris Cat#0741), D2R antagonist L-sulpiride (Sigma-Aldrich Cat#S7771), D2R agonist quinpirole (Sigma-Aldrich Cat#Q102), GABA A R agonist muscimol (Alomone Labs Cat#M-240), GABA A R antagonist bicuculline(Sigma-Aldrich Cat#14340), D1R agonist SKF38393 (Sigma-Aldrich Cat#S101), D1R antagonist SCH23390 (TocrisCat#No.

    Techniques: Injection

    Repeated injection of NE-100 leads to synaptic dysfunction. (A) The timecourse of the experimental procedure. (B) Schematic illustrating sites of stimulating electrode (Stim) and recording electrode (Rec) in the shell of NAc (left panel). The right panel shows a typical trace. The dark mark of the initial descending phase indicates the 10% to 90% data points of the slope, and the two-way arrow indicates the duration. (C) Input-output (I-O) curve in the NAc. Each point represents the group mean value of fEPSP slopes against stimulus intensity from 0.1 mA to 1.1 mA in control mice and NE-100 mice. Representative traces of fEPSP evoked at 0.5 mA stimulus intensity in control mice and NE-100 mice ( n = 8 slices/4 mice per group; repeated-measures ANOVA). (D) Bar graphs show the duration (ms) of fEPSP in control mice and NE-100 mice. ** p < 0.01 vs. control mice ( n = 8 slices/4 mice per group; Student’s- t test). (E) PPR (%) of fEPSP slopes was plotted against interpulse intervals (IPIs) ranging from 15 ms to 100 ms. Traces represent fEPSPs evoked by stimulation pulses delivered with a 25 ms IPI. * p < 0.05 vs. control mice ( n = 8 slices/4 mice per group; repeated-measures ANOVA). (F) LTD induction by delivering low-frequency stimulation (LFS) in control mice and NE-100 mice. A solid line indicates when LFS was given. Traces show fEPSPs pre- and post-LFS. ** p < 0.01 vs. control mice ( n = 8 slices/4 mice per group; Mann-Whitney U test). (Gi,Gii) Bar graphs show the duration (ms) of fEPSP and the PPR value (25 ms IPI) in vehicle-treated and bicuculline (bicu)-treated control mice. ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Student’s t -test). (H) LTD induction by LFS in slices of control mice treated with bicuculline (bicu). ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Mann-Whitney U test). (Ii,Iii) Bar graphs show the duration (ms) of fEPSP and the PPR value (25 ms IPI) in vehicle-treated and muscimol (mus)-treated NE-100 mice. ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Student’s t -test). (J) LTD induction in slices of NE-100 mice treated with muscimol (mus). ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Mann-Whitney U test).

    Journal: Frontiers in Molecular Neuroscience

    Article Title: Repeated inhibition of sigma-1 receptor suppresses GABA A receptor expression and long-term depression in the nucleus accumbens leading to depressive-like behaviors

    doi: 10.3389/fnmol.2022.959224

    Figure Lengend Snippet: Repeated injection of NE-100 leads to synaptic dysfunction. (A) The timecourse of the experimental procedure. (B) Schematic illustrating sites of stimulating electrode (Stim) and recording electrode (Rec) in the shell of NAc (left panel). The right panel shows a typical trace. The dark mark of the initial descending phase indicates the 10% to 90% data points of the slope, and the two-way arrow indicates the duration. (C) Input-output (I-O) curve in the NAc. Each point represents the group mean value of fEPSP slopes against stimulus intensity from 0.1 mA to 1.1 mA in control mice and NE-100 mice. Representative traces of fEPSP evoked at 0.5 mA stimulus intensity in control mice and NE-100 mice ( n = 8 slices/4 mice per group; repeated-measures ANOVA). (D) Bar graphs show the duration (ms) of fEPSP in control mice and NE-100 mice. ** p < 0.01 vs. control mice ( n = 8 slices/4 mice per group; Student’s- t test). (E) PPR (%) of fEPSP slopes was plotted against interpulse intervals (IPIs) ranging from 15 ms to 100 ms. Traces represent fEPSPs evoked by stimulation pulses delivered with a 25 ms IPI. * p < 0.05 vs. control mice ( n = 8 slices/4 mice per group; repeated-measures ANOVA). (F) LTD induction by delivering low-frequency stimulation (LFS) in control mice and NE-100 mice. A solid line indicates when LFS was given. Traces show fEPSPs pre- and post-LFS. ** p < 0.01 vs. control mice ( n = 8 slices/4 mice per group; Mann-Whitney U test). (Gi,Gii) Bar graphs show the duration (ms) of fEPSP and the PPR value (25 ms IPI) in vehicle-treated and bicuculline (bicu)-treated control mice. ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Student’s t -test). (H) LTD induction by LFS in slices of control mice treated with bicuculline (bicu). ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Mann-Whitney U test). (Ii,Iii) Bar graphs show the duration (ms) of fEPSP and the PPR value (25 ms IPI) in vehicle-treated and muscimol (mus)-treated NE-100 mice. ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Student’s t -test). (J) LTD induction in slices of NE-100 mice treated with muscimol (mus). ** p < 0.01 vs. vehicle-treated mice ( n = 8 slices/4 mice per group; Mann-Whitney U test).

    Article Snippet: σ 1 R antagonist NE-100 (Tocris Cat#3133), PKC activator phorbol 12-myristate 13-acetate (PMA; Sigma-Aldrich Cat#P1585), PKC inhibitor GF109302X (Tocris Cat#0741), D2R antagonist L-sulpiride (Sigma-Aldrich Cat#S7771), D2R agonist quinpirole (Sigma-Aldrich Cat#Q102), GABA A R agonist muscimol (Alomone Labs Cat#M-240), GABA A R antagonist bicuculline(Sigma-Aldrich Cat#14340), D1R agonist SKF38393 (Sigma-Aldrich Cat#S101), D1R antagonist SCH23390 (TocrisCat#No.

    Techniques: Injection, MANN-WHITNEY