Journal: Alcohol and Alcoholism (Oxford, Oxfordshire)
Article Title: Selective Blockade of T-Type Ca2+ Channels is Protective Against Alcohol-Withdrawal Induced Seizure and Mortality
Figure Lengend Snippet: Pretreatment TTA-P2 reduces latency to seizure during alcohol withdrawal. Animals in alcohol withdrawal were treated with 10, 20, 40 mg/kg TTA-P2 or saline. Thirty minutes later, all animals were injected with a high dose of PTZ. Pretreatment with 40 mg/kg TTA-P2 significantly increased the latency to seizure.
Article Snippet: Approximately 6 h into the 4th WD period, mice were treated with the T-channel antagonist TTA-P2 (10, 20 or 40 mg/kg intraperitoneal; Alomone Labs, Jerusalem, Israel) or saline.