k252a  (Alomone Labs)


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    Alomone Labs k252a
    K252a, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/k252a/product/Alomone Labs
    Average 93 stars, based on 3 article reviews
    Price from $9.99 to $1999.99
    k252a - by Bioz Stars, 2022-12
    93/100 stars

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  • 93
    Alomone Labs l type ca2 channel inhibitor nimodipine
    <t>Nimodipine-sensitive</t> Ca 2+ currents from Ca V 1.3 WT and Ca V 1.3 KO SCN during the day and night. Macroscopic Ca 2+ currents were elicited from a holding potential of −90 mV by 150-ms voltage steps from −90 to +50 mV in +10-mV increments. Nimodipine-sensitive LTCC currents were isolated by subtracting currents obtained in 10 μM nimodipine from the total cell current. (A,E) Representative nimodipine-sensitive (Nim-sens) current traces from Ca V 1.3 WT (A) and Ca V 1.3 KO (E) neurons during the day (top current traces) and night (bottom). (B,C) Current-voltage plot for Ca V 1.3 WT Ca 2+ currents before nimodipine (total) and the nimodipine-sensitive (Nim-sens) current from day (B) and night (C) neurons. (D) Comparison of Ca V 1.3 WT nimodipine-sensitive normalized current density between day and night. Ca V 1.3 WT nimodipine-sensitive currents were larger during the day (at −10 mV) compared to night (at 0 mV) ( P = 0.01). (E) Representative nimodipine-sensitive currents from Ca V 1.3 KO neurons during the day (top current traces) and night (bottom). (F,G) Current-voltage plot of Ca V 1.3 KO total and nimodipine-sensitive currents from day (F) and night (G) neurons. (H) Comparison of Ca V 1.3 KO nimodipine-sensitive normalized current density between day and night. Ca V 1.3 KO nimodipine-sensitive currents were not different between day (at 0 mV) and night (at −10 mV) ( P = 0.2). (I,J) Comparisons of nimodipine-sensitive current densities from Ca V 1.3 WT and Ca V 1.3 KO SCN during the day (I) and night (J) . Ca V 1.3 KO nimodipine-sensitive currents were smaller than Ca V 1.3 WT currents during the day ( P = 0.009) but not at night ( P = 0.5). P
    L Type Ca2 Channel Inhibitor Nimodipine, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/l type ca2 channel inhibitor nimodipine/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
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    l type ca2 channel inhibitor nimodipine - by Bioz Stars, 2022-12
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    93
    Alomone Labs l ap4
    <t>Nimodipine-sensitive</t> Ca 2+ currents from Ca V 1.3 WT and Ca V 1.3 KO SCN during the day and night. Macroscopic Ca 2+ currents were elicited from a holding potential of −90 mV by 150-ms voltage steps from −90 to +50 mV in +10-mV increments. Nimodipine-sensitive LTCC currents were isolated by subtracting currents obtained in 10 μM nimodipine from the total cell current. (A,E) Representative nimodipine-sensitive (Nim-sens) current traces from Ca V 1.3 WT (A) and Ca V 1.3 KO (E) neurons during the day (top current traces) and night (bottom). (B,C) Current-voltage plot for Ca V 1.3 WT Ca 2+ currents before nimodipine (total) and the nimodipine-sensitive (Nim-sens) current from day (B) and night (C) neurons. (D) Comparison of Ca V 1.3 WT nimodipine-sensitive normalized current density between day and night. Ca V 1.3 WT nimodipine-sensitive currents were larger during the day (at −10 mV) compared to night (at 0 mV) ( P = 0.01). (E) Representative nimodipine-sensitive currents from Ca V 1.3 KO neurons during the day (top current traces) and night (bottom). (F,G) Current-voltage plot of Ca V 1.3 KO total and nimodipine-sensitive currents from day (F) and night (G) neurons. (H) Comparison of Ca V 1.3 KO nimodipine-sensitive normalized current density between day and night. Ca V 1.3 KO nimodipine-sensitive currents were not different between day (at 0 mV) and night (at −10 mV) ( P = 0.2). (I,J) Comparisons of nimodipine-sensitive current densities from Ca V 1.3 WT and Ca V 1.3 KO SCN during the day (I) and night (J) . Ca V 1.3 KO nimodipine-sensitive currents were smaller than Ca V 1.3 WT currents during the day ( P = 0.009) but not at night ( P = 0.5). P
    L Ap4, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    94
    Alomone Labs conotoxin mviic
    <t>Nimodipine-sensitive</t> Ca 2+ currents from Ca V 1.3 WT and Ca V 1.3 KO SCN during the day and night. Macroscopic Ca 2+ currents were elicited from a holding potential of −90 mV by 150-ms voltage steps from −90 to +50 mV in +10-mV increments. Nimodipine-sensitive LTCC currents were isolated by subtracting currents obtained in 10 μM nimodipine from the total cell current. (A,E) Representative nimodipine-sensitive (Nim-sens) current traces from Ca V 1.3 WT (A) and Ca V 1.3 KO (E) neurons during the day (top current traces) and night (bottom). (B,C) Current-voltage plot for Ca V 1.3 WT Ca 2+ currents before nimodipine (total) and the nimodipine-sensitive (Nim-sens) current from day (B) and night (C) neurons. (D) Comparison of Ca V 1.3 WT nimodipine-sensitive normalized current density between day and night. Ca V 1.3 WT nimodipine-sensitive currents were larger during the day (at −10 mV) compared to night (at 0 mV) ( P = 0.01). (E) Representative nimodipine-sensitive currents from Ca V 1.3 KO neurons during the day (top current traces) and night (bottom). (F,G) Current-voltage plot of Ca V 1.3 KO total and nimodipine-sensitive currents from day (F) and night (G) neurons. (H) Comparison of Ca V 1.3 KO nimodipine-sensitive normalized current density between day and night. Ca V 1.3 KO nimodipine-sensitive currents were not different between day (at 0 mV) and night (at −10 mV) ( P = 0.2). (I,J) Comparisons of nimodipine-sensitive current densities from Ca V 1.3 WT and Ca V 1.3 KO SCN during the day (I) and night (J) . Ca V 1.3 KO nimodipine-sensitive currents were smaller than Ca V 1.3 WT currents during the day ( P = 0.009) but not at night ( P = 0.5). P
    Conotoxin Mviic, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/conotoxin mviic/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    conotoxin mviic - by Bioz Stars, 2022-12
    94/100 stars
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    Nimodipine-sensitive Ca 2+ currents from Ca V 1.3 WT and Ca V 1.3 KO SCN during the day and night. Macroscopic Ca 2+ currents were elicited from a holding potential of −90 mV by 150-ms voltage steps from −90 to +50 mV in +10-mV increments. Nimodipine-sensitive LTCC currents were isolated by subtracting currents obtained in 10 μM nimodipine from the total cell current. (A,E) Representative nimodipine-sensitive (Nim-sens) current traces from Ca V 1.3 WT (A) and Ca V 1.3 KO (E) neurons during the day (top current traces) and night (bottom). (B,C) Current-voltage plot for Ca V 1.3 WT Ca 2+ currents before nimodipine (total) and the nimodipine-sensitive (Nim-sens) current from day (B) and night (C) neurons. (D) Comparison of Ca V 1.3 WT nimodipine-sensitive normalized current density between day and night. Ca V 1.3 WT nimodipine-sensitive currents were larger during the day (at −10 mV) compared to night (at 0 mV) ( P = 0.01). (E) Representative nimodipine-sensitive currents from Ca V 1.3 KO neurons during the day (top current traces) and night (bottom). (F,G) Current-voltage plot of Ca V 1.3 KO total and nimodipine-sensitive currents from day (F) and night (G) neurons. (H) Comparison of Ca V 1.3 KO nimodipine-sensitive normalized current density between day and night. Ca V 1.3 KO nimodipine-sensitive currents were not different between day (at 0 mV) and night (at −10 mV) ( P = 0.2). (I,J) Comparisons of nimodipine-sensitive current densities from Ca V 1.3 WT and Ca V 1.3 KO SCN during the day (I) and night (J) . Ca V 1.3 KO nimodipine-sensitive currents were smaller than Ca V 1.3 WT currents during the day ( P = 0.009) but not at night ( P = 0.5). P

    Journal: Frontiers in Physiology

    Article Title: Contributions of CaV1.3 Channels to Ca2+ Current and Ca2+-Activated BK Current in the Suprachiasmatic Nucleus

    doi: 10.3389/fphys.2021.737291

    Figure Lengend Snippet: Nimodipine-sensitive Ca 2+ currents from Ca V 1.3 WT and Ca V 1.3 KO SCN during the day and night. Macroscopic Ca 2+ currents were elicited from a holding potential of −90 mV by 150-ms voltage steps from −90 to +50 mV in +10-mV increments. Nimodipine-sensitive LTCC currents were isolated by subtracting currents obtained in 10 μM nimodipine from the total cell current. (A,E) Representative nimodipine-sensitive (Nim-sens) current traces from Ca V 1.3 WT (A) and Ca V 1.3 KO (E) neurons during the day (top current traces) and night (bottom). (B,C) Current-voltage plot for Ca V 1.3 WT Ca 2+ currents before nimodipine (total) and the nimodipine-sensitive (Nim-sens) current from day (B) and night (C) neurons. (D) Comparison of Ca V 1.3 WT nimodipine-sensitive normalized current density between day and night. Ca V 1.3 WT nimodipine-sensitive currents were larger during the day (at −10 mV) compared to night (at 0 mV) ( P = 0.01). (E) Representative nimodipine-sensitive currents from Ca V 1.3 KO neurons during the day (top current traces) and night (bottom). (F,G) Current-voltage plot of Ca V 1.3 KO total and nimodipine-sensitive currents from day (F) and night (G) neurons. (H) Comparison of Ca V 1.3 KO nimodipine-sensitive normalized current density between day and night. Ca V 1.3 KO nimodipine-sensitive currents were not different between day (at 0 mV) and night (at −10 mV) ( P = 0.2). (I,J) Comparisons of nimodipine-sensitive current densities from Ca V 1.3 WT and Ca V 1.3 KO SCN during the day (I) and night (J) . Ca V 1.3 KO nimodipine-sensitive currents were smaller than Ca V 1.3 WT currents during the day ( P = 0.009) but not at night ( P = 0.5). P

    Article Snippet: Drugs used in these experiments were: L-type Ca2+ channel inhibitor nimodipine (Nim, 10 μM, Alomone Labs, Jerusalem, Israel, #N-150), Ryanodine Receptor inhibitor dantroline (Dan, 10 μM, Sigma, #D9175), BK current inhibitor Paxilline (Pax, 10 μM, Alomone Labs, Jerusalem, Israel, #P-450) and Sodium channel inhibitor tetrodotoxin (TTX, 1 μM, Alomone Labs, Jerusalem, Israel, #T-550).

    Techniques: Isolation

    Effects of Ca 2+ chelators and Ca 2+ channel inhibitors on BK currents recorded from SCN neurons during the day and night. Paxilline-sensitive macroscopic BK currents were recorded from C57BL6 WT (A–E) and Ca V 1.3 WT (F) SCNs. All intracellular solutions in this study were made with 0.9 mM EGTA, except where 5 mM BAPTA was substituted (A–E) . Currents were elicited from a holding potential of −90 mV by 150-ms voltage steps from −110 to +90 mV in +20-mV increments. (A,B) Representative BK currents from −90 to +90 mV are shown from day (A) and night (B) SCN neurons. (C,D) Current-voltage plot comparing BK current density recorded in either control EGTA or BAPTA during the day (C) and night (D) . (E) Summary of BK current density at +90 mV recorded with control EGTA or BAPTA with Ca 2+ channel inhibitors 10 μM nimodipine (Nim) during the day, or 10 μM dantrolene (Dan) at night. In EGTA, Nim decreased BK currents compared to controls ( P = 0.0008), with no significant difference in BAPTA. At night, BK currents were decreased with BAPTA compared to control EGTA conditions ( P

    Journal: Frontiers in Physiology

    Article Title: Contributions of CaV1.3 Channels to Ca2+ Current and Ca2+-Activated BK Current in the Suprachiasmatic Nucleus

    doi: 10.3389/fphys.2021.737291

    Figure Lengend Snippet: Effects of Ca 2+ chelators and Ca 2+ channel inhibitors on BK currents recorded from SCN neurons during the day and night. Paxilline-sensitive macroscopic BK currents were recorded from C57BL6 WT (A–E) and Ca V 1.3 WT (F) SCNs. All intracellular solutions in this study were made with 0.9 mM EGTA, except where 5 mM BAPTA was substituted (A–E) . Currents were elicited from a holding potential of −90 mV by 150-ms voltage steps from −110 to +90 mV in +20-mV increments. (A,B) Representative BK currents from −90 to +90 mV are shown from day (A) and night (B) SCN neurons. (C,D) Current-voltage plot comparing BK current density recorded in either control EGTA or BAPTA during the day (C) and night (D) . (E) Summary of BK current density at +90 mV recorded with control EGTA or BAPTA with Ca 2+ channel inhibitors 10 μM nimodipine (Nim) during the day, or 10 μM dantrolene (Dan) at night. In EGTA, Nim decreased BK currents compared to controls ( P = 0.0008), with no significant difference in BAPTA. At night, BK currents were decreased with BAPTA compared to control EGTA conditions ( P

    Article Snippet: Drugs used in these experiments were: L-type Ca2+ channel inhibitor nimodipine (Nim, 10 μM, Alomone Labs, Jerusalem, Israel, #N-150), Ryanodine Receptor inhibitor dantroline (Dan, 10 μM, Sigma, #D9175), BK current inhibitor Paxilline (Pax, 10 μM, Alomone Labs, Jerusalem, Israel, #P-450) and Sodium channel inhibitor tetrodotoxin (TTX, 1 μM, Alomone Labs, Jerusalem, Israel, #T-550).

    Techniques: