iodoresiniferatoxin  (Alomone Labs)


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    Alomone Labs iodoresiniferatoxin
    Iodoresiniferatoxin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/iodoresiniferatoxin/product/Alomone Labs
    Average 90 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    iodoresiniferatoxin - by Bioz Stars, 2022-05
    90/100 stars

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    Alomone Labs 5 iodoresiniferatoxin
    Capsazepine treatment induces the production of reactive oxygen species. Notes: Quantification of intracellular levels of reactive oxygen species (ROS) as measured by DCFDA over 24 and 48 hours of treatment with capsazepine (CPZ) and <t>5′-iodoresiniferatoxin</t> (IRTX; A ). After 48 hours, 25 μM of CPZ induces a significant increase in ROS relative to dimethyl sulfoxide-treated cells ( P
    5 Iodoresiniferatoxin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/5 iodoresiniferatoxin/product/Alomone Labs
    Average 90 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    5 iodoresiniferatoxin - by Bioz Stars, 2022-05
    90/100 stars
      Buy from Supplier

    93
    Alomone Labs nav1 1α
    Effect of R1 on the expression, location, and cleavage status of sodium channel proteins after Aβ1-42 treatment. Representative Western blot (A) and densitometry quantification of the total <t>Nav1.1α</t> (B) , extracellular Nav1.1α (C) , intracellular Nav1.1α (D) , Navβ2 full-length (E) , Navβ2-CTF (F) , and BACE1 (G) expression. Data are shown as mean ± SD ( n = 5). * p
    Nav1 1α, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/nav1 1α/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    nav1 1α - by Bioz Stars, 2022-05
    93/100 stars
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    Capsazepine treatment induces the production of reactive oxygen species. Notes: Quantification of intracellular levels of reactive oxygen species (ROS) as measured by DCFDA over 24 and 48 hours of treatment with capsazepine (CPZ) and 5′-iodoresiniferatoxin (IRTX; A ). After 48 hours, 25 μM of CPZ induces a significant increase in ROS relative to dimethyl sulfoxide-treated cells ( P

    Journal: Journal of Pain Research

    Article Title: Identification of capsazepine as a novel inhibitor of system xc− and cancer-induced bone pain

    doi: 10.2147/JPR.S125045

    Figure Lengend Snippet: Capsazepine treatment induces the production of reactive oxygen species. Notes: Quantification of intracellular levels of reactive oxygen species (ROS) as measured by DCFDA over 24 and 48 hours of treatment with capsazepine (CPZ) and 5′-iodoresiniferatoxin (IRTX; A ). After 48 hours, 25 μM of CPZ induces a significant increase in ROS relative to dimethyl sulfoxide-treated cells ( P

    Article Snippet: Cell treatmentsCapsazepine (CPZ; Cayman, Madison, WI, USA) and 5-iodoresiniferatoxin (IRTX; Alomone Labs, Jerusalem, Israel) were prepared in accordance with manufacturer’s recommendations using dimethyl sulfoxide (DMSO).

    Techniques:

    Effect of R1 on the expression, location, and cleavage status of sodium channel proteins after Aβ1-42 treatment. Representative Western blot (A) and densitometry quantification of the total Nav1.1α (B) , extracellular Nav1.1α (C) , intracellular Nav1.1α (D) , Navβ2 full-length (E) , Navβ2-CTF (F) , and BACE1 (G) expression. Data are shown as mean ± SD ( n = 5). * p

    Journal: Frontiers in Cellular Neuroscience

    Article Title: Notoginsenoside R1–Induced Neuronal Repair in Models of Alzheimer Disease Is Associated With an Alteration in Neuronal Hyperexcitability, Which Is Regulated by Nav

    doi: 10.3389/fncel.2020.00280

    Figure Lengend Snippet: Effect of R1 on the expression, location, and cleavage status of sodium channel proteins after Aβ1-42 treatment. Representative Western blot (A) and densitometry quantification of the total Nav1.1α (B) , extracellular Nav1.1α (C) , intracellular Nav1.1α (D) , Navβ2 full-length (E) , Navβ2-CTF (F) , and BACE1 (G) expression. Data are shown as mean ± SD ( n = 5). * p

    Article Snippet: Proteins were then transferred to nitrocellulose membranes and incubated with primary antibodies against BACE1 (1:1,000; cat. no. ab2077; Abcam), Nav1.1α (1:800; cat. no. ASC-001; Alomone), or Navβ2 (1:500; cat. no. ASC-007; Alomone).

    Techniques: Expressing, Western Blot

    Notoginsenoside R1 altered the distribution of Nav1.1α and cleavage of Navβ2 in the brains of APP/PS1 mice. Representative expression (A,E) and densitometric quantification of BACE1 (B) , Navβ2 full-length (C) , Navβ2-CTF (D) , total expression of Nav1.1α (F) extracellular Nav1.1α (G) , and intracellular Nav1.1α (H) protein in the cortex and hippocampus lysates from WT mice, APP/PS1 mice, or APP/PS1 + R1 mice, respectively. Data are shown as mean ± SD ( n = 15). * p

    Journal: Frontiers in Cellular Neuroscience

    Article Title: Notoginsenoside R1–Induced Neuronal Repair in Models of Alzheimer Disease Is Associated With an Alteration in Neuronal Hyperexcitability, Which Is Regulated by Nav

    doi: 10.3389/fncel.2020.00280

    Figure Lengend Snippet: Notoginsenoside R1 altered the distribution of Nav1.1α and cleavage of Navβ2 in the brains of APP/PS1 mice. Representative expression (A,E) and densitometric quantification of BACE1 (B) , Navβ2 full-length (C) , Navβ2-CTF (D) , total expression of Nav1.1α (F) extracellular Nav1.1α (G) , and intracellular Nav1.1α (H) protein in the cortex and hippocampus lysates from WT mice, APP/PS1 mice, or APP/PS1 + R1 mice, respectively. Data are shown as mean ± SD ( n = 15). * p

    Article Snippet: Proteins were then transferred to nitrocellulose membranes and incubated with primary antibodies against BACE1 (1:1,000; cat. no. ab2077; Abcam), Nav1.1α (1:800; cat. no. ASC-001; Alomone), or Navβ2 (1:500; cat. no. ASC-007; Alomone).

    Techniques: Mouse Assay, Expressing